Correspondence on 'Prospective predictive performance comparison between clinical gestalt and validated COVID-19 mortality scores by Soto-Mota et al
(Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - April 11, 2022 Category: Research Authors: Meza-Comparan, H. D. Tags: COVID-19 Letter to the editor Source Type: research
Clinical relevance of the relationship between Trabecular Bone Score and metabolic syndrome
The Trabecular Bone Score (TBS) is an indirect measurement of bone quality, and studies have shown that TBS is an independent predictor of fracture risk. This cross-sectional investigation aimed to explore the relationship between metabolic syndrome (MetS) and TBS using data from the 2005–2006 US National Health and Nutrition Examination Survey. The association between individual MetS components and TBS was examined. There was a significant linear decrease in TBS with an increase in the number of MetS components. The β coefficients of TBS among participants with 3 and ≥4 MetS components were –0.015 and ...
Source: Journal of Investigative Medicine - April 11, 2022 Category: Research Authors: Shih, C.-W., Fang, W.-H., Chen, W.-L. Tags: Original research Source Type: research
Metabolic derangement in patients with vitiligo: a cross-sectional study
In conclusion, screening of patients with vitiligo in regard to their lipid profile as well as blood pressure should be considered, especially in patients with longer disease duration or those who have other cardiovascular risk factors to prevent morbidity and mortality as a result of developing cardiovascular events. (Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - April 11, 2022 Category: Research Authors: Aryanian, Z., Shirzadian, A., Farzaneh, S., Goodarzi, A., Azizpour, A., Hatami, P. Tags: Open access Original research Source Type: research
Deferasirox combination with eltrombopag shows anti-myelodysplastic syndrome effects by enhancing iron deprivation-related apoptosis
Iron overload (IO) affected the survival of patients with myelodysplastic syndrome (MDS). Deferasirox (DFX) is widely used in patients with MDS for iron chelation therapy, but is not suitable for MDS patients with severe thrombocytopenia. Eltrombopag (ELT) is a type of thrombopoietin receptor (TPOR) analog used in the treatment of thrombocytopenia. Therefore, we sought to explore the synergistic effects and possible mechanisms of DFX combination with ELT in MDS cells. In our study, the combination of DFX with ELT synergistically inhibited proliferation, induced apoptosis and arrested cell cycle of MDS cells. Through the RN...
Source: Journal of Investigative Medicine - April 11, 2022 Category: Research Authors: Huang, L., Tian, M., Liu, Z., Liu, C., Fu, R. Tags: Original research Source Type: research
Association between genetic variant rs2267716 of CRHR2 gene with colorectal cancer
Colorectal cancer (CRC) is the third most common cancer and one of the main causes of death around the world. Multiple lines of evidence have suggested the role of the corticotropin-releasing hormone (CRH) family in CRC induction, including the low expression of corticotropin-releasing hormone receptor 2 (CRHR2), which is an angiogenesis inhibitor and inflammatory modulator. Previous research suggests that CRHR2 expression in colonic intestinal cells can regulate migration, proliferation and apoptosis through the modulation of several pathways. The aim of this study was to analyze the association of the rs10250835, rs22677...
Source: Journal of Investigative Medicine - April 11, 2022 Category: Research Authors: Ramirez-Guerrero, A. A., Gonzalez-Villasenor, C. O., Leal-Ugarte, E., Gutierrez-Angulo, M., Ramirez-Flores, M., Delgado-Enciso, I., Macias-Gomez, N. M. Tags: Original research Source Type: research
Immune checkpoint inhibitor-induced hypophysitis: lessons learnt from a large cancer cohort
Immune checkpoint inhibitors (ICIs) can cause pituitary dysfunction due to hypophysitis. We aimed to characterize ICI-induced hypophysitis and examine its association with overall survival in this single-center retrospective cohort study of adult patients with cancer who received an ICI from January 1, 2012 through December 31, 2016. A total of 896 patients were identified who received ipilimumab alone (n=120); ipilimumab and nivolumab (n=50); ipilimumab before or after pembrolizumab (n=70); pembrolizumab alone (n=406); and nivolumab alone (n=250). Twenty-six patients (2.9%) developed hypophysitis after a median of 2.3 mon...
Source: Journal of Investigative Medicine - April 11, 2022 Category: Research Authors: Kotwal, A., Rouleau, S. G., Dasari, S., Kottschade, L., Ryder, M., Kudva, Y. C., Markovic, S., Erickson, D. Tags: Original research Source Type: research
Specific changes of erythroid regulators and hepcidin in patients infected by SARS-COV-2
Iron metabolism is tightly linked to infectious and inflammatory signals through hepcidin synthesis. To date, iron homeostasis during SARS-CoV-2 infection has not yet been described. The aim of this study is to characterize the hepcidin and erythroid regulators (growth differentiation factor 15 (GDF-15) and erythroferrone (ERFE)) by measuring concentrations in plasma in context of COVID-19 disease.
We performed a single-center observational study of patients with COVID-19 to evaluate concentrations of main regulatory proteins involved in iron homeostasis, namely: hepcidin, ERFE and GDF-15. SARS-CoV-2 infection (COVID-19+) ...
Source: Journal of Investigative Medicine - April 11, 2022 Category: Research Authors: Delaye, J.-B., Alarcan, H., Vallet, N., Veyrat-Durebex, C., Bernard, L., Herault, O., Ropert, M., Marlet, J., Gyan, E., Andres, C., Blasco, H., Piver, E. Tags: Editor's choice, COVID-19 Original research Source Type: research
Latin Americans and US Hispanics show differences in IBD phenotype: a systematic review with meta-analysis
Latin America has experienced a rise in the prevalence and incidence of inflammatory bowel disease (IBD). Differences in IBD phenotype between Hispanics in Latin America and those in the USA have not been described. We conducted a systematic review with meta-analysis of population-based and cohort studies comparing the phenotype of ulcerative colitis (UC) and Crohn’s disease (CD) in Latin Americans and US Hispanics. A systematic search was conducted up to March 2019 using MEDLINE, EMBASE and Google Scholar. Inclusion criterion includes studies describing IBD phenotype in Latin Americans or in US Hispanics. Exclusion ...
Source: Journal of Investigative Medicine - April 11, 2022 Category: Research Authors: Avalos, D. J., Satiya, J., Contreras, A., Trivedi, S., Alvarado, L., Dodoo, C., Dwivedi, A. K., Zuckerman, M. J. Tags: Original research Source Type: research
Utility of itraconazole and terbinafine in mucormycosis: a proof-of-concept analysis
An epidemic of mucormycosis followed the second wave of COVID 19 in the state of Uttar Pradesh, India in May 2021. This epidemic, however, had additional challenges to offer in the form of acute shortage of all forms of amphotericin B, posaconazole and isavuconazole. It was, therefore, planned to assess the trends in minimum inhibitory concentration (MIC) of antifungal agents, viz itraconazole and terbinafine, and provide a template for personalized therapy to see whether the results could be translated clinically. This is an observational, single-center study. Samples comprising nasal swab, nasal and paranasal sinus tissu...
Source: Journal of Investigative Medicine - April 11, 2022 Category: Research Authors: Gupta, P., Malhotra, H. S., Saxena, P., Singh, R., Shukla, D., Hasan, M. S., Verma, V., Banerjee, G., Puri, B., Dandu, H. Tags: COVID-19 Original research Source Type: research
Basic fibroblast growth factor inhibits aortic valvular interstitial cells calcification via Notch1 pathway
Calcific aortic valve disease (CAVD) is an active pathological process mediated by abnormal activation and transdifferentiation of valvular interstitial cells (VICs). The present study aims to investigate the function and underlying mechanism of the basic fibroblast growth factor (BFGF) on osteogenic differentiation of VICs. Porcine VICs cultured with osteogenic induction medium are supplemented with or without BFGF. Morphology of VICs is identified by fluorescein isothiocyanate-labeled phalloidin, the cell viability is assessed by the cell counting kit-8 method, and protein and mRNA expression level of osteogenic differen...
Source: Journal of Investigative Medicine - April 11, 2022 Category: Research Authors: Gao, Y., Li, N., Xue, Q., Fan, X., Liu, X., Han, L. Tags: Original research Source Type: research
Impact of atrial fibrillation on in-hospital outcomes among hospitalizations for cardiac surgery: an analysis of the National Inpatient Sample
The short-term impact of atrial fibrillation (AF) on cardiac surgery hospitalizations has been previously reported in cohorts of various sizes, but results have been variable. Using the 2005–2014 National Inpatient Sample, we identified all adult hospitalizations for cardiac surgery using the International Classification of Diseases, Ninth Revision, Clinical Modification as any procedure code and AF as any diagnosis code. We estimated the impact of AF on inpatient mortality, length of stay (LOS), and cost of hospitalization using survey-weighted, multivariable logistic, accelerated failure-time log-normal, and log-tr...
Source: Journal of Investigative Medicine - April 11, 2022 Category: Research Authors: Agnihotri, K., Charilaou, P., Voruganti, D., Gunasekaran, K., Mehta, J., Paydak, H., Briasoulis, A. Tags: Original research Source Type: research
Diagnosis of coronary artery rethrombosis after effective systemic thrombolytic therapy in patients with ST-segment elevation myocardial infarction
The aim of the study was to evaluate the diagnostic significance of ST-segment re-elevation episodes registered with telemetric ECG monitoring in patients with ST-segment elevation myocardial infarction (STEMI) treated with thrombolytic therapy (TLT). The study included 117 patients with STEMI following effective TLT. The elective coronary angiography followed by percutaneous coronary interventions was performed in the interval from 3 to 24 hours after a successful systemic TLT. Before and after cardiac catheterization, the telemetric ECG monitoring was performed using AstroCard Telemetry system (Meditec, Russia). During t...
Source: Journal of Investigative Medicine - April 11, 2022 Category: Research Authors: Oleynikov, V. E., Matskeplishvili, S., Shigotarova, E., Kulyutsin, A., Burko, N. Tags: Original research Source Type: research
Cancer immunotherapy in adult patients with HIV
The availability of antiretroviral therapy (ART) has increased the life expectancy of people with HIV (PWH) and reduced the incidence of AIDS-associated malignancies, yet PWH have a significantly increased incidence of malignancy and less favorable outcomes of cancer treatment compared with the general population.
Immunotherapy has revolutionized cancer therapy, becoming the standard of care for various malignancy treatments. However, PWH are an underserved population with limited access to clinical trials and cancer treatment.
This review of the available evidence on different classes of cancer immunotherapy in PWH is mos...
Source: Journal of Investigative Medicine - April 11, 2022 Category: Research Authors: Abu Khalaf, S., Dandachi, D., Granwehr, B. P., Rodriguez-Barradas, M. C. Tags: Review Source Type: research
Mitochondria signaling pathways in allergic asthma
Mitochondria, as the powerhouse organelle of cells, are greatly involved in regulating cell signaling pathways, including those related to the innate and acquired immune systems, cellular differentiation, growth, death, apoptosis, and autophagy as well as hypoxic stress responses in various diseases. Asthma is a chronic complicated airway disease characterized by airway hyperresponsiveness, eosinophilic inflammation, mucus hypersecretion, and remodeling of airway. The asthma mortality and morbidity rates have increased worldwide, so understanding the molecular mechanisms underlying asthma progression is necessary for new a...
Source: Journal of Investigative Medicine - April 11, 2022 Category: Research Authors: Qian, L., Mehrabi Nasab, E., Athari, S. M., Athari, S. S. Tags: Open access Review Source Type: research
Hepcidin, iron, and COVID-19: is there an erythroid connection?
(Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - April 11, 2022 Category: Research Authors: Means Jr, R. T. Tags: COVID-19 Editorial Source Type: research
