Serpinb3 is overexpressed in the liver in presence of iron overload
In conclusion, Serpinb3 is strongly induced by iron in the mouse liver. The molecular link between iron, ROS and SerpinB3 seems to be HIF-2α, which is induced by iron overload and was previously found capable of up-regulating SerpinB3 at the transcriptional level. (Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - January 10, 2018 Category: Research Authors: Turato, C., Kent, P., Sebastiani, G., Cannito, S., Morello, E., Terrin, L., Biasiolo, A., Simonato, D., Parola, M., Pantopoulos, K., Pontisso, P. Tags: Original research Source Type: research
Association of gender-specific risk factors in metabolic and cardiovascular diseases: an NHANES-based cross-sectional study
In the present cross-sectional study, based on National Health and Nutrition Examination Survey (NHANES, 2007–2010) cohorts, various risk factors for metabolic syndrome (MetS) and cardiovascular diseases (CVDs) were analyzed (n=12,153). The variables analyzed include, demographics, comorbidities associated with MetS or CVD, behavioral and dietary factors, while the primary endpoints were the prevalence of MetS and CVD. The prevalence of MetS and CVD was slightly higher in males as compared with females (42.50% and 7.65% vs 41.29% and 4.13%, respectively). After controlling for confounding factors, advanced age, famil...
Source: Journal of Investigative Medicine - January 10, 2018 Category: Research Authors: Zhang, X.-E., Cheng, B., Wang, Q., Wan, J.-J. Tags: Preventive Medicine Source Type: research
PAI-1 levels are related to insulin resistance and carotid atherosclerosis in subjects with familial combined hyperlipidemia
Familial combined hyperlipidemia (FCH) is a primary atherogenic dyslipidemia with insulin resistance and increased cardiovascular risk. Plasminogen activator inhibitor type 1 (PAI-1) and myeloperoxidase (MPO) activity are associated with proinflammatory and atherothrombotic risk. Our aim was to study the role played by PAI-1 and MPO activity in the carotid atherosclerosis prevalence in FCH subjects. 36 FCH unrelated subjects (17 women) were matched by age and body weight with 36 healthy normolipidemic subjects (19 female). Blood lipids, glucose, insulin, insulin resistance (homeostasis model assessment (HOMA)), MPO, and PA...
Source: Journal of Investigative Medicine - January 10, 2018 Category: Research Authors: Carratala, A., Martinez-Hervas, S., Rodriguez-Borja, E., Benito, E., Real, J. T., Saez, G. T., Carmena, R., Ascaso, J. F. Tags: Original research Source Type: research
Determining the mechanisms of dietary turnip rapeseed oil on cholesterol metabolism in men with metabolic syndrome
We have earlier reported the reduction of total cholesterol, low-density lipoprotein (LDL) cholesterol and oxidized LDL caused by short-term modification of diet with cold-pressed turnip rapeseed oil (CPTRO) instead of butter. The aim of this supplementary study was to determine whether the beneficial effects resulted from altered cholesterol metabolism during the intervention.
Thirty-seven men with metabolic syndrome (MetS) completed an open, randomized and balanced crossover study. Subjects’ usual diet was supplemented with either 37.5 g of butter or 35 mL of CPTRO for 6–8 weeks. Otherwise normal dietary habi...
Source: Journal of Investigative Medicine - January 10, 2018 Category: Research Authors: Saarinen, H. J., Sittiwet, C., Simonen, P., Nissinen, M. J., Stenman, U.-H., Gylling, H., Palomäki, A. Tags: Open access Cardiovascular/Lipidology Source Type: research
Glucagon like peptide-1 receptor agonists for the management of obesity and non-alcoholic fatty liver disease: a novel therapeutic option
Obesity is a major risk factor for the development of type 2 diabetes mellitus (T2DM), and is associated with a cluster of metabolic factors that lead to poor cardiovascular outcomes. In non-alcoholic fatty liver disease (NAFLD), liver fat (triglyceride) accumulation closely mirrors adipose tissue dysfunction and insulin resistance in obesity and T2DM. It is now recognized as the most common chronic liver disease in Westernized societies, often progressing to more severe forms of the disease such as nonalcoholic steatohepatitis (NASH), or cirrhosis and hepatocellular carcinoma. However, NAFLD remains largely overlooked by ...
Source: Journal of Investigative Medicine - January 10, 2018 Category: Research Authors: Dhir, G., Cusi, K. Tags: Editor's choice Endocrinology/Metabolism Source Type: research
Innovative strategies to increase resident scholarly activity and engage faculty support
(Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - January 10, 2018 Category: Research Authors: Das, S. U., Bar-on, M. E. Tags: PostScript Source Type: research
Analysis of nationwide trends and outcomes of percutaneous endoscopic gastrostomy (PEG) tube placement in hospitalized patients with cancer over a 13-year period
(Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - January 10, 2018 Category: Research Authors: Guddati, A. K., Kumar, G., Shapira, I. Tags: PostScript Source Type: research
Induction of deubiquitinating enzyme USP50 during erythropoiesis and its potential role in the regulation of Ku70 stability
This study suggests that DUBs like USP50 may regulate protein stability during erythropoiesis; however, more investigation is warranted. (Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - January 10, 2018 Category: Research Authors: Cai, J., Wei, J., Schrott, V., Zhao, J., Bullock, G., Zhao, Y. Tags: Basic Science/Genetics/Molecular Medicine Source Type: research
25 Culture environmental management innovation optimisation of enrichment factor lactobacillus acidophilus
ConclusionsThe best ratio of enrichment medium was: glutamate, lysine, vitamin C. Culture temperature was 37°C, initial fermentation pH was 6.5, 4% inoculation, harvest time was 20 hours after fermentation.AcknowledgementsSupported by a project grant from Longdong University doctoral research (Grant No. XYBE1605). Central finance forestry science and technology extension demonstration project [2015] ZYTG8 Qingyang science and technology support program (NK2011-41). (Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - December 5, 2017 Category: Research Authors: Li, X., Wang, D., Zhang, Z., Zhu, Y., Jia, H. Tags: Abstracts Source Type: research
24 Danggui shaoyao powder improves diabetic nephropathy without altering blood glucose in streptozotocin-induced diabetic rats
ConclusionThis study suggests that DSS could improve renal function in streptozotocin-induced DN model rats. The mechanism may be related to regulating the Th1/Th2 cell balance and improved lipid metabolism in DN rats.AcknowledgmentSupported by a project grant from The National Natural Science Foundation of China (Grant No. 81603527), Science and technology project of Henan Province (Grant No. 162102310466), Key scientific research projects of Henan Province Colleges and Universities (Grant No. 16A360010), Henan University of Traditional Chinese Medicine Scientific and technological innovation talent support program (Grant...
Source: Journal of Investigative Medicine - December 5, 2017 Category: Research Authors: Li, X., Li, Z., Zhang, L., Zhang, Y., Liu, X., Zhao, X., Liu, W., Gao, A. Tags: Abstracts Source Type: research
23 Study on mirnas prediction and co-expression patterns of the human intronic mirnas with their host genes
ConclusionsThis study not only provides some effective means for research on miRNAs prediction and co-expression prediction of intronic miRNAs with their host genes, but also gives some solid foundation for future research in this field.AcknowledgementsSupported by the National Natural Science Foundation of China (Grant No. 61402099). (Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - December 5, 2017 Category: Research Authors: Wang, H., Li, B., Wu, M. Tags: Abstracts Source Type: research
22 In vivo evaluation of ethanol extract of forsythia suspensa (thunb.) vahl (fruit) in anti-inflammatory and analgesic activities
ConclusionsThese findings indicate that FSTV-ET can produce anti-inflammatory and analgesic activities in vivo, and the mechanism is likely to be related to inhibiting lipid peroxidation and inflammation.AcknowledgementsSupported by project grants from the National Natural Science Foundation of China (Grant No. 81503269), the Funding Scheme for Young Key Teachers of Colleges and Universities in Henan Province (Grant No. 2014GGJS-072), and the Science and Technology Project of Zhengzhou (Grant No. 20150309). (Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - December 5, 2017 Category: Research Authors: Wang, J., Cui, Y., Chen, S., XB, L., Feng, W., Cai, H., Chen, R. Tags: Abstracts Source Type: research
21 Effect of jinjiang granules on intestinal mucosal immunity in mice model
ConclusionsJinjiang granules can improve the immune function of the mice models of hypoimmunity. It also improves intestinal immune function. It prevents colds when given as the initial medicine.AcknowledgementsThe Central Plains scholars (162101510003), the team of outstanding scientific and technological innovation in Henan province (TCJ2014-391), Henan University of Traditional Chinese Medicine and deep processing of geoherbs Collaborative Innovation Centre (2012)188–2. (Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - December 5, 2017 Category: Research Authors: Miao, M., Cao, L., Qiao, J., Zhang, R. Tags: Abstracts Source Type: research
20 Gut microbiota in human adults with irritable bowel syndrome differs from healthy controls
ConclusionThere were differences in faecal microbiota between IBS patients and healthy controls. The faecal microbiota of patients with IBS is associated with significant increases in detrimental and decreases in beneficial bacterial groups.AcknowledgmentSupported by grants from National Program on Key Basic Research Project (973 Program, 2013CB531405), and the National Natural Science Foundation of China (NSFC, No. 81641029 and 81370113). (Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - December 5, 2017 Category: Research Authors: Liu, Y., Wang, Y., Wen, S., Zhang, T., Tang, L. Tags: Abstracts Source Type: research
19 Experimental study on postoperative adhesions between tendon and different tissues
ConclusionPostoperative adhesions between the tendon and different tissues differ. More tissue adhesion formed between the tendon and the subcutaneous tissue than between the tendon and the remnant sheath. (Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - December 5, 2017 Category: Research Authors: Su, Y., Wang, W., Meng, X., Gu, G., Yu, M., Yan, Z., Ma, Y., Dong, X., Sun, Q., Zhao, D. Tags: Abstracts Source Type: research
