Utility of serum neuropilin-1 and angiopoietin-2 as markers of hepatocellular carcinoma
In conclusion, NRP-1 is a potential serological marker for HCC diagnosis and is better than ANG-2. It is feasible to be estimated in combination with AFP to enhance its diagnostic power. High serum NRP-1 and ANG-2 levels are associated with advanced HCC tumor characteristics. (Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - July 26, 2021 Category: Research Authors: Abdel Ghafar, M. T., Elkhouly, R. A., Elnaggar, M. H., Mabrouk, M. M., Darwish, S. A., Younis, R. L., Elkholy, R. A. Tags: Original research Source Type: research
Coexpression of EphA10 and Gli3 promotes breast cancer cell proliferation, invasion and migration
This study investigated the influences of EphA10 and Gli3 on breast cancer (BC) cell proliferation, invasion and migration. Immunohistochemistry was used to reveal the expressions of EphA10 and Gli3 in 18 intraductal carcinomas, 124 invasive carcinomas, 50 paracancerous tissues (2 cm away from the tumor, when possible or available), 50 lobular hyperplastic tissues and 30 normal breast tissues. qRT-PCR and Western blotting were applied to detect the expressions of EphA10 and Gli3 in invasive BC cells (MDA-MB-231, BT20 and Hs578T) and normal human mammary epithelial cells (MCF10A). MDA-MB-231 and BT20 cells were transfected ...
Source: Journal of Investigative Medicine - July 26, 2021 Category: Research Authors: Peng, J., Zhang, D. Tags: Open access Original research Source Type: research
Non-surgical animal model of gastroesophageal reflux disease by overeating induced in mice
Previous animal models of gastroesophageal reflux disease (GERD) were not physiological and required a variety of surgical procedures. Therefore, the animal model developed by conditions that are similar to the pathogenesis of GERD is necessary. The aim is to establish a non-surgical animal model with GERD caused by overeating induced in mice. To induce mice to overeat, we designed dietary control protocols including repetitive fasting and feeding. The esophageal tissues were evaluated with GERD markers to prove the establishment of a GERD animal model. Mice fasted every other day (group 2) showed more pronounced overeatin...
Source: Journal of Investigative Medicine - July 26, 2021 Category: Research Authors: IM, N.-R., Kim, B., Jung, K.-Y., Kim, T. H., Baek, S.-K. Tags: Open access Original research Source Type: research
Antidiabetic effect of Sophora pachycarpa seeds extract in streptozotocin-induced diabetic mice: a statistical evaluation
Undoubtedly, identification of the chemical composition of organic extracts or secondary metabolites of plant materials and evaluation of their potential bioactivity are among the main objectives of natural products-based investigations. In the present study, we report the chemical composition and antidiabetic activity of Sophora pachycarpa (Family Fabaceae) seeds extract (SPE) for the first time. First, the plant seeds were macerated in ethanol. The extract was subjected to analysis on a gas chromatography-mass spectrometry (GC-MS) system to identify the chemical composition. In vivo assay was run to evaluate the antidiab...
Source: Journal of Investigative Medicine - July 26, 2021 Category: Research Authors: Mahdavi, B., Hajar, T., Ghodsi, A., Mohammadhosseini, M., Mehmandost, M., Talebi, E. Tags: Original research Source Type: research
Comparing patient characteristics and outcomes in type 1 versus type 2 diabetes with diabetic ketoacidosis: a review and a propensity-matched nationwide analysis
Diabetic ketoacidosis (DKA) is a known complication of patients with type 1 diabetes mellitus (T1DM), but less common in type 2 diabetes mellitus (T2DM). The aim of this study was to compare the outcomes of patients admitted to the hospital with DKA in T1DM versus T2DM. This was a population-based, retrospective, cohort study using data from the Nationwide Inpatient Sample. The group of patients hospitalized for DKA was divided based on a secondary diagnosis of either T1DM or T2DM. The primary outcome was inpatient mortality, and the secondary outcomes were rate of complications, length of hospital stay (LOS) and total hos...
Source: Journal of Investigative Medicine - July 26, 2021 Category: Research Authors: Shaka, H., Wani, F., El-Amir, Z., Dahiya, D. S., Singh, J., Edigin, E., Eseaton, P., Kichloo, A. Tags: Original research Source Type: research
Diagnostic efficacy of serum and urinary netrin-1 in the early detection of diabetic nephropathy
In conclusion, netrin-1 is a potential diagnostic marker for early detection of DN with its estimation in urine has higher accuracy than that of serum. (Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - July 26, 2021 Category: Research Authors: Elkholy, R. A., Younis, R. L., Allam, A. A., Hagag, R. Y., Abdel Ghafar, M. T. Tags: Original research Source Type: research
Risk associated with estimated glomerular filtration rate and albuminuria for PAD among patients with type 2 diabetes
Chronic kidney disease (CKD) is significantly associated with peripheral arterial disease (PAD) in some studies, but data on the association of the risk of PAD across a broad range of kidney function in patients with type 2 diabetes are limited. Between October 17, 2013 and February 7, 2015, all consecutive outpatients with type 2 diabetes underwent ankle-brachial index (ABI) examination. We investigated the association of estimated glomerular filtration rate (eGFR) and albumin-to-creatinine ratio (ACR) with the risk of PAD. A total of 1254 patients were cross-classified into 12 groups based on ACR category (normoalbuminur...
Source: Journal of Investigative Medicine - July 26, 2021 Category: Research Authors: Pan, C.-F., Chuang, S.-M., Lin, K.-C., Tsai, M.-C., Liao, W.-T., Zeng, Y.-H., Lee, C.-C. Tags: Original research Source Type: research
Preoperative vitamin D deficiency is associated with increased risk of postoperative hypocalcemia after total thyroidectomy
In this study, we employ a multi-institutional, de-identified electronic health records database to address this issue. We hypothesize that total thyroidectomy patients with preoperative VDD will be at an increased associated risk of postoperative hypocalcemia and hospitalization. Using Cerner Health Facts, we identified 2447 patients who underwent total or subtotal thyroidectomy between 2008 and 2016 and who had a documented 25-hydroxyvitamin D concentration obtained within 12 months of the surgery date using International Classification of Diseases 9/10, Current Procedural Terminology and Healthcare Common Procedure Codi...
Source: Journal of Investigative Medicine - July 26, 2021 Category: Research Authors: Choi, E. H. E., Qeadan, F., Alkhalili, E., Lovato, C., Burge, M. R. Tags: Original research Source Type: research
Dynamic changes in aortic stiffness after substantial weight loss by laparoscopic sleeve gastrectomy in patients with obesity: a 1-year follow-up study
Arterial stiffness has been identified as a powerful and independent risk factor for cardiovascular disease. Obesity is associated with an increased risk of aortic stiffness (AS) and adverse cardiovascular events. Herein, we aimed to evaluate the effects of weight loss after laparoscopic sleeve gastrectomy (LSG) on AS in individuals with morbid obesity by using the transthoracic echocardiography (TTE).
A total of 53 patients with obesity (17 males, 36 females) who underwent LSG and did not have any known heart disease were included in the study. The AS parameters were measured with TTE. The demographic and echocardiographi...
Source: Journal of Investigative Medicine - July 26, 2021 Category: Research Authors: Gul, M., Inci, S., Aktas, H., Yildirim, O., Alsancak, Y., Ozkan, N. Tags: Original research Source Type: research
Gout as a risk factor for acute myocardial infarction: evidence from competing risk model analysis
Chronic inflammation, a hallmark of gout, is implicated in the pathogenesis of atherosclerosis. Thus, in theory, gout can be expected to increase the risk of acute myocardial infarction (AMI). Yet, results from several epidemiological studies have been inconclusive. A retrospective cohort study was conducted using the National Health Insurance Research Database of Taiwan dated from 2000 to 2013. The study cohort comprised 3581 patients with gout (the gout cohort) and 14,324 patients without gout (the non-gout cohort). The primary outcome was the incidence of AMI. To estimate the effect of gout on the risk of AMI, the Lunn-...
Source: Journal of Investigative Medicine - July 26, 2021 Category: Research Authors: Huang, C.-L., Wang, T.-W., Chen, Y.-C., Hu, J.-M., Ku, P.-M., Hsieh, C.-H., Lee, C.-H., Kuo, F.-C., Lu, C.-H., Su, C.-C., Liu, J.-S., Lin, F.-H., Chou, Y.-C., Sun, C.-A. Tags: Original research Source Type: research
Experimental study on alleviating atherosclerosis through intervention of mitochondrial calcium transport and calcium-induced membrane permeability transition
To investigate the effort of mitochondrial calcium transport and calcium-induced membrane permeability transition in alleviating atherosclerosis. The experimental mice were divided into three groups: the control group (C57BL/6 mice with normal diet), the atherosclerosis group (apolipoprotein E-deficient (ApoE–/–) mice with high-fat diet) and the mitochondrial targeting agent group (ApoE–/– mouse with high-fat diet). The mean fluorescence intensity of Ca2+ in the atherosclerosis group is significantly higher than control group and mitochondrial targeting agent group. But the mean fluorescence intensi...
Source: Journal of Investigative Medicine - July 26, 2021 Category: Research Authors: Chen, S., Wang, J., Zhang, L., Xia, H. Tags: Original research Source Type: research
Impact and role of pulmonary embolism response teams in venous thromboembolism associated with COVID-19
Venous thromboembolism associated with COVID-19, particularly acute pulmonary embolism, may represent a challenging and complex clinical scenario. The benefits of having a multidisciplinary pulmonary embolism response team (PERT) can be important during such a pandemic. The aim of PERT in the care of such patients is to provide fast, appropriate, multidisciplinary, team-based approach, with the common goal to tailor the best therapeutic decision making, prioritizing always optimal patient care, especially given lack of evidence-based clinical practice guidelines in the setting of COVID-19, which potentially confers a signi...
Source: Journal of Investigative Medicine - July 26, 2021 Category: Research Authors: Porres-Aguilar, M., Tapson, V. F., Rivera-Lebron, B. N., Rali, P. M., Jimenez, D., Porres-Munoz, M., Barraza, S., Munoz, O. C., Mukherjee, D. Tags: Editor's choice, COVID-19 Review Source Type: research
Can the calcium-regulating hormones counteract the detrimental impact of pro-inflammatory damage-associated molecular patterns in the development of heart failure?
Growing evidence suggests an important role of the inflammatory component in heart failure (HF). Recent developments in this field indicate an ambiguous role that innate immunity plays in immune-driven HF. Damaged or stressed cells, cardiomyocytes, in particular, emit damage-associated molecular patterns (DAMPs) including HMGB1, S100 A8/A9, HSP70, and other molecules, unfolding paracrine mechanisms that induce an innate immune response. Designed as an adaptive, regenerative reaction, innate immunity may nevertheless become overactivated and thus contribute to the development of HF by altering the pacemaker rhythm, contract...
Source: Journal of Investigative Medicine - July 26, 2021 Category: Research Authors: Adamyan, S. H., Harutyunyan, K. R., Abrahamyan, H. T., Khudaverdyan, D. N., Mkrtchian, S., Ter-Markosyan, A. S. Tags: Open access Review Source Type: research
Autophagy and cancer metastasis: a Trojan horse
(Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - July 26, 2021 Category: Research Authors: Alizadeh, J., Lorzadeh, S., Ghavami, S. Tags: Editorial Source Type: research
Author index
(Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - June 1, 2021 Category: Research Tags: Author index Source Type: research
