2021 Midwest Clinical and Translational Research Meeting of CSCTR and MWAFMR
(Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - June 1, 2021 Category: Research Tags: Abstracts Source Type: research
Response to "Comment on 'Clopidogrel can be an effective complementary prophylactic for drug-refractory migraine with patent foramen ovale"
(Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - June 1, 2021 Category: Research Authors: Guo, Y. Tags: Letter to the editor Source Type: research
Response to 'Fools gold: diseased marijuana and cannabis hyperemesis syndrome'
(Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - June 1, 2021 Category: Research Authors: McCallum, R. Tags: Open access Letter to the editor Source Type: research
Fools gold: diseased marijuana and cannabis hyperemesis syndrome
(Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - June 1, 2021 Category: Research Authors: Dorantes, O. A. Tags: Open access Letter to the editor Source Type: research
Assessment of synovial fluid and serum cytokine levels in children with septic arthritis
Acute septic arthritis (ASA) is a common orthopedic infection of children which may produce devastating sequelae and chronic morbidity. Improved understanding of the intra-articular inflammatory response in ASA may identify cytokine targets with diagnostic or therapeutic potential, though no detailed investigations to this end have been performed. Given this, we used a multiplex cytokine assay for assessment of levels of 40 different cytokines in the synovial fluid and blood of children with ASA. Twelve children (8 controls undergoing orthopedic surgery for non-infectious conditions and 4 with ASA) were prospectively enrol...
Source: Journal of Investigative Medicine - June 1, 2021 Category: Research Authors: Dehority, W., Plaster, S., Helmig, K. C., Huff, N., Parsons, A., Tigert, S. L., Silva, S. Tags: Brief report Source Type: research
Thoughtful selection and use of scientific terms in clinical research: the case of 'pragmatic trials
Clinical research is a discipline prone to the use of technical terms that may be particularly at risk for misunderstanding given the complex interpretation that is required. In this century, what is happening with the word ‘pragmatic’ when describing a randomized controlled trial (RCT) with medicines deserves a public reflection. Explanatory trials are conducted in ideal conditions to assess the comparative efficacy of interventions and are useful to explain whether interventions work. Pragmatic trials are those conducted in a way that resembles usual clinical practice conditions to assess the comparative effe...
Source: Journal of Investigative Medicine - June 1, 2021 Category: Research Authors: Dal-Re, R., Mentz, R. J., Rosendaal, F. R. Tags: Brief report Source Type: research
Institutionally chartered Data and Safety Monitoring Boards: structured approaches to assuring participant safety in clinical research
Data and Safety Monitoring Boards (DSMBs) derived from the need to monitor large federally funded multi-center clinical trials and evolved to include commercial and other large and complex trials. Eventually, academic health centers also created institutionally focused trial monitoring mechanisms. The basic general principles that define traditional DSMBs extend to the institutional level. The primary responsibilities are assuring safety of the participants, preserving the integrity of the trial, and ensuring the reliability of the results. Institutionally chartered DSMBs meet these responsibilities but usually have fewer ...
Source: Journal of Investigative Medicine - June 1, 2021 Category: Research Authors: Holbein, B., Rape, M. T., Hammack, B. N., Melvin, A., Reider, C., Knox, T. A. Tags: Research tools and issues Source Type: research
Postchallenge glucose increment was associated with hemoglobin glycation index in subjects with no history of diabetes
We investigated the association between postchallenge glucose increment and hemoglobin glycation index (HGI), the difference between observed and predicted glycated hemoglobin (HbA1c), in subjects with no history of diabetes. We enrolled 1381 subjects who attended our outpatient clinic for an oral glucose tolerance test (OGTT) to screen for diabetes. HGI was defined as observed HbA1c minus predicted HbA1c. The predicted HbA1c was calculated by entering fasting plasma glucose (FPG) level into an equation [HbA1c(%)=FPG(mg/dL)*0.029+2.9686] determined from an HbA1c versus FPG regression analysis using data from an independent...
Source: Journal of Investigative Medicine - June 1, 2021 Category: Research Authors: Wang, J.-S., Lee, I.-T., Lee, W.-J., Lin, S.-Y., Lee, W.-L., Liang, K.-W., Sheu, W. H.-H. Tags: Original research Source Type: research
Effect of intensive blood pressure on the progression of non-diabetic chronic kidney disease at varying degrees of proteinuria
The ideal blood pressure (BP) target for renoprotection is uncertain in patients with non-diabetic chronic kidney disease (CKD), especially considering the influence exerted by pre-existing proteinuria. In this pooled analysis of landmark trials, we coalesced individual data from 5001 such subjects randomized to intensive versus standard BP targets. We employed multivariable regression to evaluate the relationship between follow-up systolic blood pressure (SBP) and diastolic blood pressure (DBP) on CKD progression (defined as glomerular filtration rate decline by 50% or end-stage renal disease), focusing on the potential f...
Source: Journal of Investigative Medicine - June 1, 2021 Category: Research Authors: Der Mesropian, P. J., Shaikh, G., Beers, K. H., Mehta, S., Monrroy Prado, M. R., Hongalgi, K., Mathew, R. O., Feustel, P. J., Salman, L. H., Perna, A., Gosmanova, E. O. Tags: Original research Source Type: research
Assessing bronchodilator response by changes in per cent predicted forced expiratory volume in one second
In this study, working on several large spirometry cohorts from two different institutions (n=31 598 tests), we redefined the novel BDR categories based on delta post-BD–pre-BD FEV1 % predicted values. Our newly proposed BDR partition is based on several distinct intervals for delta post-BD–pre-BD % predicted FEV1 using Global Lung Initiative predictive equations. In testing, training and validation cohorts, the model performed well in all BDR categories. In a validation set that included only normal baseline spirometries, the partition model had a higher rate of misclassification, possibly due to unrestricted ...
Source: Journal of Investigative Medicine - June 1, 2021 Category: Research Authors: Ioachimescu, O. C., Ramos, J. A., Hoffman, M., McCarthy, K., Stoller, J. K. Tags: Open access Original research Source Type: research
Lung involvement in systemic sclerosis is associated with adverse hospital outcomes: insights from the National Inpatient Sample
This study aimed to compare outcomes of systemic sclerosis (SSc) hospitalizations with and without lung involvement. The primary outcome was inpatient mortality while secondary outcomes were hospital length of stay (LOS) and total hospital charge. Data were abstracted from the National Inpatient Sample (NIS) 2016 and 2017 database. This database is the largest collection of inpatient hospitalization data in the USA. The NIS was searched for SSc hospitalizations with and without lung involvement as principal or secondary diagnosis using International Classification of Diseases 10th Revision (ICD-10) codes. SSc hospitalizati...
Source: Journal of Investigative Medicine - June 1, 2021 Category: Research Authors: Odion, J. O., Guraya, A., Muojieje, C. C., Idolor, O. N., Sanwo, E. J., Aihie, O. P. Tags: Editor's choice Original research Source Type: research
Contribution of hsa-miR-146a and hsa-miR-223 gene variations in patients with multiple sclerosis reveals association of rs2910164 and rs1044165 with risk of multiple sclerosis susceptibility
MicroRNAs (miRNAs) are a group of non-coding RNAs that play a role in gene regulation. Due to their possible functional importance, genetic variants within miRNA genes have been recognized as candidate biomarkers. Single-nucleotide polymorphisms (SNPs) in miRNA genes can be related to the risk of different autoimmune diseases. Some of these SNPs are rs2910164 in the miR-146a and rs1044165 in the miR-223. The aim of this study was to investigate the relationship between these polymorphisms and the risk of multiple sclerosis (MS) in an Iranian population. In this case–control study, 261 patients with MS and 250 healthy...
Source: Journal of Investigative Medicine - June 1, 2021 Category: Research Authors: Shareef, S., Ebrahimi, S. O., Reiisi, S. Tags: Original research Source Type: research
Systemic arterial blood pressure and intracerebral hemorrhage after mechanical thrombectomy in anterior cerebral circulation
This study aimed to determine the effect of BP variables on ICH after MT in patients with acute occlusions of the anterior cerebral circulation. Patients undergoing MT due to acute occlusions of the anterior cerebral circulation were enrolled in this single-center study. Non-invasive BP data following MT were obtained within the first 24 hours, including mean, maximum, minimum, difference between maximum and minimum, SD and coefficient of variation for systolic BP (SBP) and diastolic BP (DBP) and mean arterial pressure. ICH was defined and classified according to the European Cooperative Acute Stroke Study-II. In 164 enrol...
Source: Journal of Investigative Medicine - June 1, 2021 Category: Research Authors: An, J., Tang, Y., Cao, X., Yuan, H., Wei, M., Yuan, X., Zhang, A., Li, Y., Saguner, A., Li, G., Luo, G. Tags: Open access Original research Source Type: research
Association between the use of antidepressants and the risk of preterm birth among pregnant women with depression: a retrospective cohort study in Taiwan
Our study was aimed to investigate the association between the use of antidepressants and the risk of preterm birth in pregnant women who have had perinatal depression. We extracted data from the Taiwanese National Health Insurance Research Database (NHIRD) and analyzed them using multivariate Cox proportional hazard regression models. Identified from the NHIRD, we matched 1789 women aged 18–55 years who were using antidepressants during pregnancy and 1789 women who were experiencing depression but who were not using antidepressants during pregnancy for age, index date, and medical comorbidities. We enrolled the wome...
Source: Journal of Investigative Medicine - June 1, 2021 Category: Research Authors: Chen, L.-F., Lin, C.-E., Chung, C.-H., Lai, C.-H., Chien, W.-C. Tags: Original research Source Type: research
Psoriasis does not worsen outcomes in patients admitted for ischemic stroke: an analysis of the National Inpatient Sample
This study aims to compare inpatient mortality of patients admitted for ischemic stroke with and without psoriasis. The secondary outcome measures were hospital length of stay (LOS), total hospital charges, odds of receiving tissue plasminogen activator (TPA), and mechanical thrombectomy between both groups.
Data were obtained from the National Inpatient Sample (NIS) 2016 and 2017 databases using the International Classification of Diseases, Tenth Revision, Clinical Modification codes. Multivariable logistic and linear regression analysis were used accordingly to account for confounders of the outcomes.
The combined 2016 a...
Source: Journal of Investigative Medicine - June 1, 2021 Category: Research Authors: Edigin, E., Kaul, S., Eseaton, P. O., Ojemolon, P. E., Patel, A., Manadan, A. Tags: Original research Source Type: research
