Banner year for the Journal of Investigative Medicine
(Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - April 11, 2022 Category: Research Authors: McCallum, R. Tags: Editorial Source Type: research
Hepatitis E virus infection in hematopoietic stem cell transplant recipients: a systematic review and meta-analysis
In conclusion, the prevalence of HEV-IgG in HSCT recipients was about 10%, while the prevalence of HEV-RNA was only 3%. However, further studies that focus on the clinical outcomes in this population are warranted. (Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - February 25, 2022 Category: Research Authors: Trongtorsak, A., Chaisidhivej, N., Yadav, K., Kim, J., Thongprayoon, C., Cheungpasitporn, W., Hansrivijit, P. Tags: Brief report Source Type: research
Investigating the demands for mobile internet-based home nursing services for the elderly
This study describes a new mobile internet-based home nursing service system and investigates the reasons for its use among elderly patients. 520 cases of mobile internet-based home nursing services were investigated. The proportion of major reasons to use mobile internet-based home nursing services among the elderly was analyzed and the satisfaction rate was investigated. The constituent ratios of nursing care for pressure ulcers, peripherally inserted central catheter (PICC), subcutaneous injection, general stoma care, psychological care, and intramuscular injection were 61.35%, 28.85%, 6.15%, 1.92%, 1.35%, and 0.38%, re...
Source: Journal of Investigative Medicine - February 25, 2022 Category: Research Authors: Gong, Y., Zhou, J., Ding, F. Tags: Open access Original research Source Type: research
Effect of bisphosphonate on hip fracture in patients with osteoporosis or osteopenia according to age: a meta-analysis and systematic review
This meta-analysis and systematic review investigated the efficacy of bisphosphonates on the incidence of hip fracture (IHF) in patients of different ages with osteoporosis or osteopenia. We searched Web of Science, Embase, the Cochrane Database, and PubMed from inception to January 10, 2021, for trials reporting the effects of bisphosphonates on the IHF. We included only randomized, double-blind, placebo-controlled clinical trials. We pooled data using a random-effects meta-analysis with risk ratios (RRs) and reported 95% CIs. We also used the Cochran Q and I² statistics to assess the heterogeneity in the results of ...
Source: Journal of Investigative Medicine - February 25, 2022 Category: Research Authors: Zhao, S., Zhao, W., Du, D., Zhang, C., Zhao, T., Zheng, L., Jin, L., Gu, M., Xu, J., Yang, Z. Tags: Original research Source Type: research
Acceptability of HIV testing for adolescents and young adults by delivery model: a systematic review
HIV infections are prevalent among adolescents and young adults, of whom 44% remain unaware of their diagnosis. HIV screening presents numerous challenges including stigma, fear, and concerns about confidentiality, which may influence young people’s acceptance of HIV screening and linkage to care differently from individuals in other age groups. It is imperative to understand which care delivery models are most effective in facilitating these services for youth. This systematic review analyzes the rates of HIV test acceptance and linkage to care by care delivery model for adolescents and young adults. Studies were cl...
Source: Journal of Investigative Medicine - February 25, 2022 Category: Research Authors: Leistikow, P. T., Patel, V., Nouryan, C., Cervia, J. S. Tags: Original research Source Type: research
Critical illness in patients with metastatic cancer: a population-based cohort study of epidemiology and outcomes
The appropriateness of intensive care unit (ICU) admission of patients with metastatic cancer remains debated. We aimed to examine the short-term outcomes and their temporal pattern in critically ill patients with metastatic disease. We used state-wide data to identify hospitalizations aged ≥18 years with metastatic cancer admitted to ICU in Texas during 2010–2014. Multivariable logistic regression modeling was used to examine the factors associated with short-term mortality and its temporal trends among all ICU admissions and those undergoing mechanical ventilation. Among 136,644 ICU admissions with metastatic ca...
Source: Journal of Investigative Medicine - February 25, 2022 Category: Research Authors: Oud, L. Tags: Original research Source Type: research
Cohens d and physicians opinion on effect size: a questionnaire on anemia treatment
A well-known effect size (ES) indicator is Cohen’s d. Cohen defined d measures of small, medium, and large ES as 0.2, 0.5, and 0.8, respectively. This approach has been criticized because practical and clinical importance depends on the context of research. The aim of the study was to examine physicians’ perception of ES using iron deficiency anemia treatment as an example and observing the effects of pretreatment level and duration of treatment on the magnitude of ES. We prepared a questionnaire describing four different clinical studies: (1) 1 month of treatment of anemia in a group of patients with a mean he...
Source: Journal of Investigative Medicine - February 25, 2022 Category: Research Authors: Gülkesen, K. H., Bora, F., Ilhanli, N., Avsar, E., Zayim, N. Tags: Original research Source Type: research
Influence of cigarette smoking on oral microbiota in patients with recurrent aphthous stomatitis
This study provides new insight and theoretical basis for the cause and pathogenesis of RAS and better prevention and treatment. (Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - February 25, 2022 Category: Research Authors: Wang, X., Luo, N., Mi, Q., Kong, W., Zhang, W., Li, X., Gao, Q. Tags: Original research Source Type: research
Magnesium intake is associated with the metabolically healthy obese phenotype
Although magnesium intake is inversely associated with the risk of metabolic abnormalities, whether magnesium intake plays a role on metabolically healthy obese (MHO) phenotype has not been explored. Therefore, the purpose of this study was to determine whether the magnesium intake is associated with the MHO phenotype. Apparently, healthy women and men aged 20–65 years with obesity were enrolled in a cross-sectional study. Subjects were allocated into MHO (n=124) and metabolically unhealthy obese (MUO) (n=123) groups. MHO phenotype was defined by abdominal obesity (waist circumference ≥90 cm in men and ≥80 cm i...
Source: Journal of Investigative Medicine - February 25, 2022 Category: Research Authors: Guerrero-Romero, F., Morales-Gurrola, G., Preza-Rodriguez, L., Gomez-Barrientos, A., Olivas-Martinez, A. I., Simental-Mendia, L. E. Tags: Original research Source Type: research
Sequential administration of pemetrexed and cisplatin reprograms tumor immune microenvironment and potentiates PD-1/PD-L1 treatment in a lung cancer model
This article aimed to investigate the effects of the administration method of pemetrexed and cisplatin on the efficacy and safety of treating non-small cell lung cancer (NSCLC) and the intrinsic molecular mechanism. Subcutaneous injection of A549 cells into BALB/C nude mice was used to explore the efficacy of different administration methods of pemetrexed and cisplatin in vivo. Immunogenic cell death (ICD) was evaluated by ATP secretion, ecto-CALR expression, and high mobility group protein 1 release. Western blot, qRT-PCR, and immunohistochemical staining were applied to detect the expression of apoptosis, cell cycle, and...
Source: Journal of Investigative Medicine - February 25, 2022 Category: Research Authors: Yu, J., Zhang, Q., Li, J., Si, Z., Guo, Y., Xu, X., Wu, K. Tags: Original research Source Type: research
Effect of renin-angiotensin system blocker on COVID-19 in young patients with hypertension
In this study, 250 patients with hypertension (<45 years old) with COVID-19 were recruited. None of these patients had any chronic disease except for hypertension. The study population was grouped according to antihypertensive medication: ACEI/ARB user and non-ACEI/ARB user. Patients were followed for clinical prognosis and biochemical and radiological findings during their hospital stay. Adverse cardiovascular event (myocardial infarction, all-cause death, stroke), transfer to the intensive care unit, severity of symptoms during the treatment course, length of hospital stay and effort capacity in the treadmill stress t...
Source: Journal of Investigative Medicine - February 25, 2022 Category: Research Authors: Kuzeytemiz, M., Tenekecioglu, E. Tags: Open access, COVID-19 Original research Source Type: research
Relationship between circulating serum omentin-1 levels and nascent metabolic syndrome in patients with hypertension
In this study, 110 patients (54 men, 49%; average age: 49.72±11.32 years) treated for hypertension but without overt diabetes and/or CVD were enrolled. 66 patients were stratified into MetS (+) (group 1) and 44 patients into MetS (–) (group 2) according to the American Heart Association/National Heart, Lung, and Blood Institute criteria. The triglyceride glucose (TyG) index was used to assess insulin resistance. Circulating omentin-1 levels in venous blood samples were measured by an ELISA kit. Circulating omentin-1 levels in patients with MetS were significantly lower than in patients without MetS (46.35 ng/m...
Source: Journal of Investigative Medicine - February 25, 2022 Category: Research Authors: Cetin Sanlialp, S., Nar, G., Nar, R. Tags: Original research Source Type: research
Comparison of doses of heparin for venous thromboembolism and bleeding in pregnant women
The evaluation criteria for dosage of low-molecular-weight heparin (LMWH) for pregnant women at high risk of venous thromboembolism (VTE) remain unclear. A retrospective study was performed to investigate the relative appropriate LMWH administration strategy and dosage for pregnant women at risk of VTE. 219 pregnant women with perinatal and postpartum VTE were reviewed and divided into group A (fixed dose group: n=73, 5000 IU dalteparin daily for all women), group B (weight group: n=73, 2500 IU dalteparin daily for women less than 50 kg; 5000 IU dalteparin daily for women more than 50 kg), and group C (anti-factor Xa (FXa)...
Source: Journal of Investigative Medicine - February 25, 2022 Category: Research Authors: Xiao, S., Luo, Y., Guo, L., Zhang, J., Mu, L., Ye, Z. Tags: Original research Source Type: research
Serum cortisol concentration and COVID-19 severity: a systematic review and meta-analysis
In this study, we aimed to reassess the available findings on the association between cortisol level and severity of COVID-19 infection. We conducted a systematic search on Medline/PubMed, Scopus, Web of Science, and Cochrane Library databases. To pool data, a random-effects model was performed depending on the heterogeneity among studies. Sensitivity analysis was also carried out by removing each study systematically. In addition, subgroup and meta-regression analyses were performed depending on the presence of the variables of sex and age. Subsequently, 11 studies (5 observational studies and 6 case reports) were include...
Source: Journal of Investigative Medicine - February 25, 2022 Category: Research Authors: Amiri-Dashatan, N., Koushki, M., Parsamanesh, N., Chiti, H. Tags: Editor's choice, COVID-19 Review Source Type: research
Ghrelin and ghrelin/total cholesterol ratio as independent predictors for coronary artery disease: a systematic review and meta-analysis
The present meta-analysis aimed to summarize the available data regarding the circulating levels of ghrelin in patients with cardiovascular diseases (CVDs). A comprehensive search was performed in electronic databases including PubMed, Scopus, EMBASE, and Web of Science up to January 20, 2021. Since the circulating levels of ghrelin were measured in different units across the included studies, they were expressed as the standardized mean difference (SMD) and 95% CI (summary effect size). A random-effects model comprising the DerSimonian and Laird method was used to pool SMDs. Sixteen articles (20 studies) comprised of 1087...
Source: Journal of Investigative Medicine - February 25, 2022 Category: Research Authors: Niknam, M., Liaghat, T., Zarghami, M., Akrami, M., Shahnematollahi, S. M., Ahmadipour, A., Moazzen, F., Soltanabadi, S. Tags: Review Source Type: research
