Bleeding ectopic varices: clinical presentation, natural history, and outcomes
Bleeding complications from ectopic varices are often difficult to manage. We aimed to study the natural history and outcomes of bleeding ectopic varices to better understand appropriate clinical management. This retrospective cohort study included patients admitted to the hospital with bleeding ectopic or esophageal varices from 2010 through 2019. Study subjects were identified through searching the Medical University of South Carolina’s electronic medical record, and complete demographic, clinical, and procedural data were abstracted. 25 patients with gastrointestinal bleeding from ectopic varices and a matched gro...
Source: Journal of Investigative Medicine - June 22, 2022 Category: Research Authors: Broussard, K. A., Rockey, D. C. Tags: Original research Source Type: research
Efficacy and safety of endovascular therapy versus surgical clipping for patients with unruptured middle cerebral artery bifurcation aneurysms
This study aims to evaluate the efficacy and safety of endovascular therapy versus neurosurgical clipping carried out for patients with unruptured middle cerebral artery bifurcation aneurysms (MCABAs). Patients diagnosed with MCABAs were enrolled in this prospective study according to the inclusion and exclusion standard. Enrolled patients were divided into a study group (endovascular therapy) and a control group (neurosurgical clipping), with 65 cases in each group. In terms of efficacy, we found that the proportion of Glasgow Outcome Scale (GOS) grade 1 after treatment in the study group was significantly higher than in ...
Source: Journal of Investigative Medicine - June 22, 2022 Category: Research Authors: Luo, J., Wang, C., Dai, Y., Chen, X., Tian, X., Lin, Y., Qu, X. Tags: Original research Source Type: research
Anti-apoptosis effects of codonolactone on cerebral ischemia-reperfusion injury
This study investigated the roles of codonolactone in inflammation, oxidative stress and apoptosis after cerebral ischemia-reperfusion (I/R) injury. Rats with codonolactone treatment, I/R treatment and the sham operation group were used in this study. After reperfusion for 24 hours, nerve damage was detected by nerve staining, and the neurological deficits of the rats were analyzed. The contents of superoxide dismutase (SOD), malondialdehyde (MDA), interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) in rat brain tissues were also determined. Western blot analysis was performed to determine the ...
Source: Journal of Investigative Medicine - June 22, 2022 Category: Research Authors: Chen, F., Lin, W. Tags: Original research Source Type: research
Timing of convalescent plasma administration and 28-day mortality in COVID-19 pneumonia
In conclusion, this study suggests that early administration of convalescent plasma to patients with COVID-19 pneumonia is critical to obtain therapeutic benefit. (Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - June 22, 2022 Category: Research Authors: Gonzalez, S. E., Regairaz, L., Salazar, M. R., Ferrando, N. S., Gonzalez Martinez, V. V., Carrera Ramos, P. M., Pesci, S. A., Vidal, J. M., Kreplak, N., Estenssoro, E. Tags: COVID-19 Original research Source Type: research
Area under the expiratory flow-volume curve: normative values in the National Health and Nutrition Survey (NHANES) study
The area under the expiratory flow-volume (AEX-FV) loop has been evaluated before as a spirometric tool for assessing respiratory functional impairment. We computed the AEX-FV curves in spirometry tests performed on 20,313 participants in the National Health and Nutrition Examination Survey (NHANES) study.
We analyzed 108,939 spirometry tests performed between 2007 and 2012 (5964 children; 14,349 adults). In these tests, we computed the three areas from existing NHANES raw data on instantaneous expiratory flows measured at 0.01 s intervals.
Mean best-trial measurements for AEX-FV were 3.4 in boys, 2.8 in girls, 11.8 in men...
Source: Journal of Investigative Medicine - June 22, 2022 Category: Research Authors: Ioachimescu, O. C., McCarthy, K., Stoller, J. K. Tags: Open access, Editor's choice Original research Source Type: research
Risk and protective factors for severe COVID-19 infection in a cohort of patients with sickle cell disease
Continued investigation of comorbid conditions that increase the mortality rate of COVID-19 is necessary to provide the best care for those affected. This continued push to find answers is even more important for populations with COVID-19 comorbidities that are historically under-researched. We performed a retrospective analysis of 30 patients with sickle cell disease (SCD) who tested positive for the COVID-19 virus. An analysis of each patient’s history of SCD complications, hydroxyurea usage, comorbidities, and several other factors was performed to identify the trends that will allow the practitioners to better pr...
Source: Journal of Investigative Medicine - June 22, 2022 Category: Research Authors: Cai, J., Chen-Goodspeed, A., Idowu, M. Tags: COVID-19 Original research Source Type: research
Interleukin-10 attenuates renal injury after myocardial infarction in diabetes
Acute kidney injury (AKI) is a common complication after myocardial infarction (MI) and associated with significant morbidity and mortality. AKI after MI occurs more frequently in patients with diabetes, however, the underlying mechanisms are poorly understood, and specific treatments are lacking. Using the murine MI model, we show that diabetic mice had higher expression of the kidney injury marker, neutrophil gelatinase-associated lipocalin (NGAL), 3 days after MI compared with control mice. This higher expression of NGAL was still significant after controlling for differences in myocardial infarct size between diabetic ...
Source: Journal of Investigative Medicine - June 22, 2022 Category: Research Authors: Fan, X., Zhang, X., Liu, L. C., Kim, A. Y., Curley, S. P., Chen, X., Dworkin, L. D., Cooper, C. J., Gupta, R. Tags: Original research Source Type: research
Cardiac safety and clinical efficacy of high-dose domperidone for long-term treatment of gastroparesis symptoms
Domperidone is an effective antiemetic used worldwide, but there have been reports of possible cardiotoxicity. Our goal was to explore the cardiac safety and clinical efficacy of long-term domperidone, titrated as high as 120 mg/day, in patients not responding or unable to tolerate other therapies for gastroparesis (GP).This retrospective cohort study was conducted at a single tertiary care academic center. We objectively assessed the safety and efficacy of domperidone through questionnaires, clinical follow-up and frequent ECGs as mandated by the Food and Drug Administration. We excluded patients with a history of dangero...
Source: Journal of Investigative Medicine - June 22, 2022 Category: Research Authors: Woods, K., Gajendran, M., Gonzalez, Z., Bustamante-Bernal, M., Sarosiek, I., Espino, K., Waterhouse, N., Siddiqui, T., McCallum, R. Tags: Original research Source Type: research
Efficacy and safety of intranasal dexmedetomidine versus oral chloral hydrate as sedatives for pediatric patients: a systematic review and meta-analysis
In conclusion, intranasal dexmedetomidine provides better sedation than oral CH for pediatric patients with good safety; however, the incidence of bradycardia is increased. (Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - June 22, 2022 Category: Research Authors: Wang, J., Li, Y., Xiao, S., Shi, B., Xia, Z., Huang, C., Xu, H., Li, N., Tang, W. Tags: Review Source Type: research
Exosome as a target for cancer treatment
Exosomes are small vesicles covered by a lipid bilayer, ranging in size from 50 nm to 90 nm, secreted by different cell types in the body under normal and pathological conditions. They are surrounded by cell-segregated membrane complexes and play a role in the pathological and physiological environments of target cells by transfer of different molecules such as microRNA (miRNA). Exosomes have been detected in many body fluids, such as in the amniotic fluid, urine, breast milk, blood, saliva, ascites, semen, and bile. They include proteins, lipids, and nucleic acids such as DNA, RNA, and miRNA, which have many functions in ...
Source: Journal of Investigative Medicine - June 22, 2022 Category: Research Authors: Nafar, S., Nouri, N., Alipour, M., Fallahi, J., Zare, F., Tabei, S. M. B. Tags: Review Source Type: research
New agents for sickle cell disease: patient perceptions of benefit in the real world
(Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - June 22, 2022 Category: Research Authors: Means, R. T. Tags: Editorial Source Type: research
Reflections on my presidency of American Federation of Medical Research (AFMR)
(Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - June 22, 2022 Category: Research Authors: Das, S. U. Tags: Editorial Source Type: research
Author index
(Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - April 11, 2022 Category: Research Tags: Abstracts Source Type: research
2022 Eastern Regional Meeting
(Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - April 11, 2022 Category: Research Tags: Abstracts Source Type: research
Response to: Correspondence on 'Prospective predictive performance comparison between clinical gestalt and validated COVID-19 mortality scores by Meza-Comparan
(Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - April 11, 2022 Category: Research Authors: Soto-Mota, A., Marfil-Garza, B. A. Tags: Open access, COVID-19 Letter to the editor Source Type: research
