Dissemination of research during the first year of the coronavirus disease 2019 pandemic
(Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - September 27, 2021 Category: Research Authors: Brandt, J. S., Grover, S., Ananth, C. V. Tags: COVID-19 Letter to the editor Source Type: research
Importance of preserving the resident microflora of the skin to improve immunological response
(Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - September 27, 2021 Category: Research Authors: Rinaldi, F., Giuliani, G., Pinto, D. Tags: Open access, COVID-19 Letter to the editor Source Type: research
Tumor invasive ability of papillary thyroid carcinomas is not conferred by acquired gene mutations
This study aimed to determine whether genomic mutations contribute to the acquisition of the tumor invasion phenotype and to investigate the genetic features of invasive cancer cells in patients with PTC. We performed customized 48-gene deep exon sequencing in samples obtained from 88 patients with PTC via fine needle aspiration; the results revealed that no genetic changes were specifically associated with the tumor aggressiveness phenotype. Our results indicate that genetic mutations do not cause indolent PTCs to become invasive. (Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - September 27, 2021 Category: Research Authors: Tong, M., Li, S., Li, Y., Li, Y., Feng, Y., Che, Y. Tags: Brief report Source Type: research
Effects of non-surgical treatment of chronic periodontitis on insulin resistance and glucose tolerance in subjects without diabetes (PARODIA 2 study)
This study aimed to assess the effects of non-surgical periodontal treatment (NSPT) of chronic periodontitis on insulin sensitivity, glucose tolerance, and serum C reactive protein (CRP) level in individuals without diabetes. Twenty individuals without diabetes with chronic periodontitis underwent NSPT, which consisted of complete scaling, polishing, root planing, and irrigation of the periodontal pockets with a 10% povidone-iodine solution. Periodontal indices (plaque index, gingival bleeding index, pocket depth, and clinical attachment loss), insulin sensitivity using the Short Insulin Tolerance Test index (KITT), glucos...
Source: Journal of Investigative Medicine - September 27, 2021 Category: Research Authors: Nana Nana, A. R., Tsobgny Tsague, N.-F., Lontchi-Yimagou, E., Bengondo Messanga, C., Tankeu, A., Katte, J.-C., Balti Vounsia, E., Dehayem, M., Sobngwi, E. Tags: Open access Brief report Source Type: research
Ambulatory cardiology telemedicine: a large academic pediatric center experience
We performed a retrospective study of cardiology telemedicine visits at a large academic pediatric center between 2016 and 2019 (pre COVID-19). Telemedicine patient visits were matched to data from their previous in-person visits, to evaluate any significant differences in total charge, insurance compensation, patient payment, percent reimbursement and zero reimbursement. Miles were measured between patient’s home and the address of previous visit. We found statistically significant differences in mean charges of telemedicine versus in-person visits (2019US$) (172.95 vs 218.27, p=0.0046), patient payment for telemedi...
Source: Journal of Investigative Medicine - September 27, 2021 Category: Research Authors: Phillips, A. A., Sable, C. A., Atabaki, S. M., Waggaman, C., Bost, J. E., Harahsheh, A. S. Tags: Brief report Source Type: research
Relationship between cerebral venous sinus thrombosis and intracranial arteritis during pregnancy and post partum
Our study was conducted to explore the relationship between cerebral venous sinus thrombosis (CVST) and intracranial arteritis during the time of pregnancy as well as puerperium. The current retrospective case study involved a total of 153 patients with pregnancy-related CVST. CVST was diagnosed mainly based on clinical manifestations and imaging results. Detailed information on demographics, risk factors (excluding intracranial arteritis), and pregnancy outcomes was systematically recorded. The average age of patients diagnosed with CVST was 28.67±3.54 years old. Among these patients, there were 62 cases of puerper...
Source: Journal of Investigative Medicine - September 27, 2021 Category: Research Authors: Li, X., Dong, J., Sun, Y., Li, Q., Shi, L. Tags: Original research Source Type: research
Protective effect of Shenfu on gut epithelium in a porcine model of hemorrhagic shock
This study aimed to explore the protective effect of Shenfu on the hemodynamics and gut integrity in a porcine model of hemorrhagic shock. Hemorrhagic shock was induced in 32 domestic pigs with a rapid bleeding via the arterial sheath to a mean arterial pressure of 40 mm Hg within 10 min. Animals with hemorrhagic shock were then randomly assigned into the negative control group (n=8), receiving neither blood transfusion nor drug treatment; the blood transfusion group, in which animals were given blood transfusion alone; the saline group, in which animals were blood transfused and resuscitated with saline (3 mL/kg); and the...
Source: Journal of Investigative Medicine - September 27, 2021 Category: Research Authors: Liang, Y., Li, C., Yuan, W., Wu, J., Zhang, Q., Zhang, M., Qin, H., Li, Z. Tags: Original research Source Type: research
Importance of beta-lactam pharmacokinetics and pharmacodynamics on the recovery of microbial diversity in the airway of persons with cystic fibrosis
Cystic fibrosis (CF) is a chronic lung disease characterized by acute pulmonary exacerbations (PExs) that are frequently treated with antibiotics. The impact of antibiotics on airway microbial diversity remains a critical knowledge gap. We sought to define the association between beta-lactam pharmacokinetic (PK) and pharmacodynamic target attainment on richness and alpha diversity. Twenty-seven children <18 years of age with CF participated in the prospective study. Airway samples were collected at hospital admission for PEx, end of antibiotic treatment (Tr), and >1 month in follow-up (FU). Metagenomic sequencing was...
Source: Journal of Investigative Medicine - September 27, 2021 Category: Research Authors: Hahn, A., Burrell, A., Chaney, H., Sami, I., Koumbourlis, A. C., Freishtat, R. J., Zemanick, E. T., Louie, S., Crandall, K. A. Tags: Open access Original research Source Type: research
Diagnosis values of IL-6 and IL-8 levels in serum and bronchoalveolar lavage fluid for invasive pulmonary aspergillosis in chronic obstructive pulmonary disease
Among immunologically normal hosts, patients with chronic obstructive pulmonary disease (COPD) are considered to be at high risk of invasive pulmonary aspergillosis (IPA), and early diagnosis and treatment are the key to improving the prognosis of patients. Here we aimed to evaluate whether interleukin (IL)-6 and IL-8 might be used in the detection and diagnosis of IPA in patients with COPD. We prospectively collected 106 patients with COPD and divided them into non-IPA (n=74), probable/possible IPA (n=26) and proven IPA (n=6). Platelia Aspergillus kit was used to detect galactomannan in bronchoalveolar lavage fluid (BALF)...
Source: Journal of Investigative Medicine - September 27, 2021 Category: Research Authors: Liu, F., Zhang, X., Du, W., Du, J., Chi, Y., Sun, B., Song, Z., Shi, J. Tags: Original research Source Type: research
Comparison of a new predictive model with other critical scores for predicting in-hospital mortality among children with pneumonia-related bacteremia
In conclusion, a nomogram-illustrated model incorporating TTFP, ALB and LDH for predicting in-hospital mortality in children with pneumonia-related bacteremia at the early stage was established and validated. It performed better than PRISM III, PEWS and PCIS. (Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - September 27, 2021 Category: Research Authors: Lin, J., Zhang, Y., Song, A., Yang, N., Ying, L., Dai, J. Tags: Original research Source Type: research
Hyperbaric oxygen treatment impacts oxidative stress markers in patients with necrotizing soft-tissue infection
In conclusion, HBO2 treatment was associated with an increase in MPO and SOD in patients with NSTI, and oxidative stress was more pronounced in patients with septic shock. (Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - September 27, 2021 Category: Research Authors: Hedetoft, M., Jensen, P. O., Moser, C., Vinkel, J., Hyldegaard, O. Tags: Open access Original research Source Type: research
Serum high-molecular-weight adiponectin and response to dapagliflozin in patients with type 2 diabetes and non-alcoholic fatty liver disease
In conclusion, a lower serum level of HMW adiponectin was associated with a better response to dapagliflozin in patients with type 2 diabetes and NAFLD.
Trial registration number
UMIN000022155. (Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - September 27, 2021 Category: Research Authors: Aso, Y., Sagara, M., Niitani, T., Kato, K., Iijima, T., Tomaru, T., Jojima, T., Usui, I. Tags: Original research Source Type: research
Role of serum adropin measurement in the assessment of insulin resistance in obesity
Obesity has recently been mentioned as a metabolic pandemic in developed and developing countries and is an important known risk factor for type 2 diabetes and cardiovascular diseases. The main mechanism responsible for obesity is insulin resistance. Adropin is a peptide-structured regulatory hormone that is suggested to play a role in insulin resistance and metabolic regulation. We aimed to evaluate the associations of serum adropin with insulin resistance and clarify the factors affecting serum adropin concentrations. The study included 50 obese patients and 22 healthy controls. Patients with chronic disease and drug use...
Source: Journal of Investigative Medicine - September 27, 2021 Category: Research Authors: Erman, H., Ozdemir, A., Sitar, M. E., Cetin, S. I., Boyuk, B. Tags: Original research Source Type: research
Circulating lipid and lipoprotein profiles and their correlation to cardiac function and cardiovascular outcomes in patients with acute myocardial infarction
Recent studies showed that lipoproteins represent major risk factors, both positive and negative, for atherosclerotic cardiovascular disease. The aim of the present study was to describe the relationship between plasma lipid profile and cardiac function and cardiovascular outcomes in patients with acute myocardial infarction (AMI) after percutaneous coronary intervention (PCI). Two independent groups of subjects including a total of 797 patients diagnosed of AMI undergoing PCI admitted to the First Affiliated Hospital of Xi’an Jiaotong University were included in the present study. We performed a cross-sectional stud...
Source: Journal of Investigative Medicine - September 27, 2021 Category: Research Authors: Wu, H., Wang, C., Tuerhongjiang, G., Qiao, X., Hua, Y., She, J., Yuan, Z. Tags: Open access Original research Source Type: research
Overview of severe asthma, with emphasis on pediatric patients: a review for practitioners
Asthma is the most common life-threatening chronic disease in children. Although guidelines exist for the diagnosis and treatment of asthma, treatment of severe, pediatric asthma remains difficult. Limited studies in the pediatric population on new asthma therapies, complex issues with adolescence and adherence, health disparities, and unequal access to guideline-based care complicate the care of children with severe, persistent asthma. The purpose of this review is to provide an overview of asthma, including asthma subtypes, comorbidities, and risk factors, to discuss diagnostic considerations and pitfalls and existing tr...
Source: Journal of Investigative Medicine - September 27, 2021 Category: Research Authors: Abellard, A., Pappalardo, A. A. Tags: Review Source Type: research
