Epidemiological and clinical characteristics of non-severe and severe pediatric and adult COVID-19 patients across different geographical regions in the early phase of pandemic: a systematic review and meta-analysis of observational studies
In conclusion, patients with COVID-19 from Wuhan displayed more severe clinical disease during the early phase of the pandemic, while disease severity was significantly lesser among pediatric cases. This review suggests that biomarkers at admission may be useful for prognosis among patients with COVID-19. (Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - September 27, 2021 Category: Research Authors: Chua, P. E. Y., Shah, S. U., Gui, H., Koh, J., Somani, J., Pang, J. Tags: Open access, COVID-19 Review Source Type: research
Clinical management of immune-related adverse events following immunotherapy treatment in patients with non-small cell lung cancer
The advent of checkpoint blockade-based immunotherapy is rapidly changing the management of lung cancer. Whereas past anticancer drugs’ primary toxicity was hematologic, the newer agents have primarily autoimmune toxicity. Thus, it is no longer enough for oncology practitioners to be skilled only in hematology. They must also understand management of autoimmune conditions, leveraging the skills of the rheumatologist, endocrinologist and gastroenterologist in the process. Herein we describe the mechanism of action and toxicities associated with immune checkpoint blockade in patients with lung cancer and provide a fram...
Source: Journal of Investigative Medicine - September 27, 2021 Category: Research Authors: Green, H. E., Nieva, J. Tags: Open access Review Source Type: research
Advances in the management of pulmonary arterial hypertension
The management of pulmonary arterial hypertension (PAH) has significantly evolved over the last decades in the wake of more sensitive diagnostics and specialized clinical programs that can provide focused medical care. In the current era of PAH care, 1-year survival rates have increased to 86%–90% from 65% in the 1980s, and average long-term survival has increased to 6 years from 2.8 years. The heterogeneity in the etiology and disease course has opened doors to focusing research in phenotyping the disease and understanding the pathophysiology at a cellular and genetic level. This may eventually lead to precision med...
Source: Journal of Investigative Medicine - September 27, 2021 Category: Research Authors: Deshwal, H., Weinstein, T., Sulica, R. Tags: Open access, Editor's choice Review Source Type: research
Pulmonary arterial hypertension: promising advances and remaining challenges
(Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - September 27, 2021 Category: Research Authors: El-Kersh, K., Dickinson, J. D. Tags: Editorial Source Type: research
Call for emergency action to limit global temperature increases, restore biodiversity and protect health
(Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - September 27, 2021 Category: Research Authors: Atwoli, L., H Baqui, A., Benfield, T., Bosurgi, R., Godlee, F., Hancocks, S., Horton, R., Laybourn-Langton, L., Monteiro, C. A., Norman, I., Patrick, K., Praities, N., Rikkert, M. G. O., Rubin, E. J., Sahni, P., Smith, R., Talley, N. J., Turale, S., Vazqu Tags: Open access Editorial Source Type: research
Good news continues for JIM in 2021
(Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - September 27, 2021 Category: Research Authors: McCallum, R. Tags: Editorial Source Type: research
Correction: Association of circulating levels of total and protein-bound sphingosine 1-phosphate with osteoporotic fracture
(Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - July 26, 2021 Category: Research Tags: Miscellaneous Source Type: research
Dynamic albumin values as clinical surrogate for COVID-19 therapeutics
(Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - July 26, 2021 Category: Research Authors: van Zyl, J. S., Felius, J., Alam, A., Hall, S. A., Jamil, A. K., Spak, C. W., Gottlieb, R. L. Tags: COVID-19 Letter to the editor Source Type: research
Correlation of rate of serum albumin decline with other acute phase reactants and effect of current treatment options on serum albumin level in COVID-19
(Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - July 26, 2021 Category: Research Authors: Batth, S. K. Tags: COVID-19 Letter to the editor Source Type: research
Another new application of heparin in COVID-19: more than anticoagulation and antiviral
(Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - July 26, 2021 Category: Research Authors: Yu, X. Tags: COVID-19 Letter to the editor Source Type: research
Sensational media reporting is common when describing COVID-19 therapies, detection methods, and vaccines
(Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - July 26, 2021 Category: Research Authors: Ottwell, R., Puckett, M., Rogers, T., Nicks, S., Vassar, M. Tags: COVID-19 Letter to the editor Source Type: research
COVID-19 reinfection: a rapid systematic review of case reports and case series
The COVID-19 pandemic has infected millions of people worldwide and many countries have been suffering from a large number of deaths. Acknowledging the ability of SARS-CoV-2 to mutate into distinct strains as an RNA virus and investigating its potential to cause reinfection is important for future health policy guidelines. It was thought that individuals who recovered from COVID-19 generate a robust immune response and develop protective immunity; however, since the first case of documented reinfection of COVID-19 in August 2020, there have been a number of cases with reinfection. Many cases are lacking genomic data of the...
Source: Journal of Investigative Medicine - July 26, 2021 Category: Research Authors: Wang, J., Kaperak, C., Sato, T., Sakuraba, A. Tags: COVID-19 Brief report Source Type: research
Research on innovation management of science and technology innovation team members based on constructive conflict evolution game
How to give full play to the positive function of constructive conflicts (task conflicts and process conflicts) in the science and technology innovation team, give appropriate stimulation, mobilize the enthusiasm of employees and improve the team’s innovative ability to improve team performance and organizational effectiveness are issues that deserve both team leaders’ and scholars’ attention. Through selecting multiple medical technology R&D personnel from a specific science and technology innovation team of health organization, the research studies the constructive conflicts among the members of the...
Source: Journal of Investigative Medicine - July 26, 2021 Category: Research Authors: Wan, T., Wang, Q., Xu, K., Zhao, J., Otsuki, H. Tags: Original research Source Type: research
Indoleamine 2,3 dioxygenase, age, and immune activation in people living with HIV
This study examines the relationship of IDO activity, bacterial translocation, and aging in people living with HIV (PLWH) on ART. Samples and data from PLWH on ART from the Centers for AIDS Research Network of Integrated Clinical Systems and from matched HIV-uninfected patients (controls) from the Multicenter AIDS Cohort Study and the Women’s Interagency HIV Study were analyzed. The ratio of K to T (K:T) and neopterin were indicators of inflammation; 16S ribosomal DNA (16S rDNA) and lipopolysaccharide (LPS) were markers of bacterial translocation. Samples and data from 205 PLWH and 99 controls were analyzed. PLWH had...
Source: Journal of Investigative Medicine - July 26, 2021 Category: Research Authors: Baer, S. L., Colombo, R. E., Johnson, M. H., Wakade, S., Pacholczyk, G., Newman-Whitlow, C., Thompson, S. A., Saag, M. S., Martin, J. N., Floris-Moore, M., Huang, L., Mellor, A. L. Tags: Original research Source Type: research
Effects of human immunodeficiency virus status on symptom severity in influenza-like illness in an otherwise healthy adult outpatient cohort
The impact of HIV on influenza-like illness (ILI) has been incompletely described in the era of combination antiretroviral therapy, particularly in the post-H1N1 pandemic period. This analysis informs on ILI in an otherwise healthy, predominantly outpatient cohort of adults with HIV in the USA. From September 2010 to March 2015, this multisite observational cohort study enrolled otherwise healthy adults presenting to a participating US military medical center with ILI, a subset of whom were HIV positive. Demographics, clinical data, and self-reported symptom severity were ascertained, and enrollees completed a daily sympto...
Source: Journal of Investigative Medicine - July 26, 2021 Category: Research Authors: Colombo, R. E., Schofield, C., Richard, S. A., Fairchok, M., Chen, W.-J., Danaher, P. J., Lalani, T. N., Ridore, M., Maves, R. C., Arnold, J. C., Ganesan, A., Agan, B., Millar, E. V., Coles, C., Burgess, T. H. Tags: Open access Original research Source Type: research
