Burden of arrhythmias and predictors of mortality among multiple myeloma patients with arrhythmias
Arrhythmias are a major cardiac complication reported among patients with multiple myeloma (MM), but these have not been further characterized in this population. We explored the prevalence of arrhythmias and examined the predictors of mortality among patients with MM with arrhythmias. The National Inpatient Sample data collected between 2016 and 2018 were used to conduct retrospective analyses. Multivariable logistic regression analyses were done to examine the predictors of mortality among patients with MM with arrhythmias. 16.9% of patients with MM reported a diagnosis of any arrhythmias and 70.7% of these were atrial f...
Source: Journal of Investigative Medicine - August 15, 2022 Category: Research Authors: Balogun, O., Jackson, I., Oyenuga, M., Oyenuga, A., Etuk, A., Jackson, N. Tags: Original research Source Type: research
A model established using marital status and other factors from the Surveillance, Epidemiology, and End Results database for early stage gastric cancer
Currently, the postoperative prognosis of early stage gastric cancer (GC) is difficult to accurately predict. In particular, social factors are not frequently used in the prognostic assessment of early stage GC. Therefore, this study aimed to combine the clinical indicators and social factors to establish a predictive model for early stage GC based on a new scoring system. A total of 3647 patients with early stage GC from the Surveillance, Epidemiology, and End Results database were included in this study. A Kaplan-Meier survival analysis was used to compare differences in prognosis between different marital status, as an ...
Source: Journal of Investigative Medicine - August 15, 2022 Category: Research Authors: Zhang, L., Zhou, B., Luo, P., Xu, A., Han, W., Wei, Z. Tags: Open access, Press releases Original research Source Type: research
Network analysis of genes associated with esophageal squamous cell carcinoma progression
This study aims to identify possible genes associated with esophageal squamous cell carcinoma (ESCC) by bioinformatics tool and further explore the function of immunoglobulin heavy chain variable family 4 gene (IGHV4)-28 in the ESCC progression.
The ESCC-related genes in Cancer Genome Atlas (TCGA) database were analyzed by bioinformatics tools, which finally identified IGHV4-28. The expression levels of IGHV4-28 in TE-4 and EC9706 cells were detected by quantitative reverse transcription-PCR (qRT-PCR). Then oe-IGHV4-28 or sh-IGHV4-28 was transfected into TE-4 and EC9706 cells to verify the effect on cell proliferation, mig...
Source: Journal of Investigative Medicine - August 15, 2022 Category: Research Authors: Li, X., Xia, Z. Tags: Original research Source Type: research
Vinpocetine enhances cisplatin sensitivity of non-small cell lung cancer cells by reducing the nuclear factor erythroid 2-related factor 2 signaling
Vinpocetine exerts pharmacological effects against cardiovascular diseases, while few studies focused on its roles in cancer. The present study investigated the roles of vinpocetine in non-small cell lung cancer (NSCLC) and its relationship with cisplatin resistance. A549 cisplatin-resistant cells (A549/DDP) and nuclear factor erythroid 2-related factor 2 (Nrf2)-overexpressing cell lines were established. 3-(4,5-Dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium assay was conducted to determine cell viability. Annexin V-propidium iodide assay was conducted to determine cell apoptosis. RT-quan...
Source: Journal of Investigative Medicine - August 15, 2022 Category: Research Authors: Zhuang, Q., Huang, Y., Hong, Y., Zhuang, W., Zhu, K., Huang, Z. Tags: Original research Source Type: research
Process analysis of anthracycline adverse reactions in breast cancer patients with postoperative chemotherapy
This study aimed to explore the clinical adverse effects of anthracyclines on patients undergoing chemotherapy after breast cancer surgery. A total of 118 patients who received anthracycline chemotherapy after breast cancer surgery were selected as the research object, and the changes of echocardiogram, ECG, myocardial enzymes and blood biochemical indices before, during and after chemotherapy were studied. SPSS V.20 was used to conduct statistical analysis. The differences in heart rate, ST-segment abnormalities, creatine kinase, lactate dehydrogenase, hemoglobin, albumin, triglycerides and high-density lipoprotein were s...
Source: Journal of Investigative Medicine - August 15, 2022 Category: Research Authors: Liu, C., Cheng, B., Zhao, G., Yuan, H. Tags: Open access Original research Source Type: research
Meta-analysis and systematic review of the association between adverse childhood events and irritable bowel syndrome
Irritable bowel syndrome (IBS) is a disorder of gut–brain interaction characterized by abdominal pain, bowel habits alterations, constipation, and/or diarrhea. Adverse childhood experiences (ACEs) are events such as abuse and mental illness causing childhood trauma. Studies report higher prevalence of ACEs in patients with IBS with varied effect consistency and association strength. A systematic review and meta-analysis were conducted to evaluate current literature, assess heterogeneity and research gaps in this relationship. A search across PubMed, Embase, PsycINFO, and Google Scholar with keywords (‘childhood...
Source: Journal of Investigative Medicine - August 15, 2022 Category: Research Authors: Joshee, S., Lim, L., Wybrecht, A., Berriesford, R., Riddle, M. Tags: Review Source Type: research
Recently approved treatment options for patients with metastatic triple-negative and HER2-neu-positive breast cancer
Breast cancer (BC) is the most common cancer affecting women worldwide. In 2021, the estimated number of new breast cancer cases was 281 550 and about 43 500 women died from metastatic breast cancer (mBC). For women aged 20–59 years, mBC remains the leading cause of cancer death and is, therefore, an important public health concern. Only 5% of women initially present with metastatic disease. Approximately 20% of patients presenting with local or locoregional disease progress to mBC despite adjuvant therapy. Inspite of all the medicosurgical advancements, the overall prognosis for patients diagnosed with mBC remains p...
Source: Journal of Investigative Medicine - August 15, 2022 Category: Research Authors: Ghafouri, S. R., Guvvala, S., Jones, C., Philipovskiy, A. Tags: Review Source Type: research
COVID-19 vaccine efficacy in a rapidly changing landscape
(Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - August 15, 2022 Category: Research Authors: Baer, S. L., Tran, S. Tags: COVID-19 Editorial Source Type: research
Correction: Cut-off value of serum homocysteine in relation to increase of coronary artery calcification
(Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - June 22, 2022 Category: Research Tags: Open access Original research Source Type: research
Trends of sources of clinical research funding from 1990 to 2020: a meta-epidemiological study
Evidence has raised concerns regarding the association between funding sources and doubtful data. Our main outcome was to analyze trends on funding sources in articles published from 1990 to 2020 in the more influential journals of internal and general medicine. In this meta-epidemiological study, we included peer-reviewed studies from the 10 highest impact journals in general and internal medicine published between January 1990 and February 2020 based on published original research according to the 2018 InCites Journal of Citation Reports, these consisted of the following: The New England Journal of Medicine, The Lancet, ...
Source: Journal of Investigative Medicine - June 22, 2022 Category: Research Authors: Burciaga-Jimenez, E., Solis, R. C., Saenz-Flores, M., Zuniga-Hernandez, J. A., Zambrano-Lucio, M., Rodriguez-Gutierrez, R. Tags: Brief report Source Type: research
Patient perception of voxelotor treatment benefit in sickle cell disease
Patients with sickle cell disease (SCD) experience a range of clinical symptoms, including acute and chronic pain, fatigue, and respiratory problems, as well as chronic organ complications that can lead to disability and accelerated mortality. Voxelotor is a first-in-class therapy that targets sickle hemoglobin polymerization, the root cause of SCD. It is approved by the US Food and Drug Administration for treatment of SCD in patients aged 4 years and older and in the European Union and United Arab Emirates for the treatment of SCD in patients aged 12 years and older. Here, we report the single-center experience of both cl...
Source: Journal of Investigative Medicine - June 22, 2022 Category: Research Authors: Idowu, M., Haque, A., Williams, E. M., Sridhar, A. Tags: Open access Brief report Source Type: research
Association of mammographic density and benign breast calcifications individually or combined with hypertension, diabetes, and hypercholesterolemia in women >=40 years of age: a retrospective study
Recent evidence has linked certain mammographic characteristics, including breast calcifications (Bcs) and mammographic density (MD), with atherosclerotic cardiovascular disease risk factors in women, but data are limited and inconsistent. We aimed to evaluate the association of MD and/or Bcs with hypertension, diabetes, and hypercholesterolemia in women ≥40 years of age. Through hospital electronic records, we retrospectively identified mammograms of non-pregnant women aged ≥40 years and without breast cancer and retrieved reports and relevant data. MD and Bcs were recorded; risk factor status was diagnosed based on...
Source: Journal of Investigative Medicine - June 22, 2022 Category: Research Authors: Al-Mohaissen, M., Alkhedeiri, A., Al-Madani, O., Lee, T., Hamdoun, A., Al-Harbi, M. Tags: Open access Original research Source Type: research
Roles of LINC01473 and CD74 in osteoblasts in multiple myeloma bone disease
This study identifies new promising targets for further research on imbalanced bone formation and resorption and MM immune escape. (Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - June 22, 2022 Category: Research Authors: Peng, F., Yan, S., Liu, H., Liu, Z., Jiang, F., Cao, P., Fu, R. Tags: Open access Original research Source Type: research
Dual-specificity phosphatase 8 (DUSP8) induces drug resistance in breast cancer by regulating MAPK pathways
In conclusion, knockdown of DUSP8 expression in trastuzumab-resistant cells can inhibit cell migration and proliferation, and leads to decreased drug resistance by activating MAPK signaling pathway in trastuzumab-resistant cells. (Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - June 22, 2022 Category: Research Authors: Zhang, H., Wang, M., Chen, D., Luo, C. Tags: Original research Source Type: research
Stem bark of Fraxinus rhynchophylla ameliorates the severity of pancreatic fibrosis by regulating the TGF-{beta}/Smad signaling pathway
Chronic pancreatitis (CP) is a pathological fibroinflammatory syndrome of the pancreas. Currently, there are no therapeutic agents available for treating CP-associated pancreatic fibrosis. Fraxinus rhynchophylla (FR) reportedly exhibits anti-inflammatory, antioxidative and antitumor activities. Although FR possesses numerous properties associated with the regulation of diverse diseases, the effects of FR on CP remain unknown. Herein, we examined the effects of FR on CP. For CP induction, mice were intraperitoneally administered cerulein (50 μg/kg) 6 times a day, 4 days per week for 3 weeks. FR extract (100 or 400 mg/kg)...
Source: Journal of Investigative Medicine - June 22, 2022 Category: Research Authors: Choi, J.-W., Shin, J. Y., Zhou, Z., Kim, D.-U., Kweon, B., Oh, H., Kim, Y.-C., Song, H.-J., Bae, G.-S., Park, S.-J. Tags: Original research Source Type: research
