Behavioral health clinicians endorse stellate ganglion block as a valuable intervention in the treatment of trauma-related disorders
The stellate ganglion block (SGB) procedure has been used successfully for over 10 years to treat post-traumatic stress symptoms in thousands of US military service members, civilians, and veterans in select hospitals in Europe and North America. Primarily through targeting the autonomic nervous system, the SGB procedure serves as an invaluable adjunct to trauma-focused psychotherapy. Without published best practices for emerging therapies, clinicians are left on their own to determine how best to apply new treatments to their patient populations. The aim of this qualitative research was to compile attitudes and recommenda...
Source: Journal of Investigative Medicine - June 1, 2021 Category: Research Authors: Lynch, J. H., Muench, P. D., Okiishi, J. C., Means, G. E., Mulvaney, S. W. Tags: Open access Original research Source Type: research

Insulin doses requirements in patients with type 1 diabetes using glargine U300 or degludec in routine clinical practice
There are not many real-world studies evaluating daily insulin doses requirements (DIDR) in patients with type 1 diabetes (T1D) using second-generation basal insulin analogs, and such comparison is necessary. The aim of this study was to compare DIDR in individuals with T1D using glargine 300 UI/mL (IGlar-300) or degludec (IDeg) in real clinical practice. An observational, retrospective study was designed in 412 patients with T1D (males: 52%; median age 37.0±13.4 years, diabetes duration: 18.7±12.3 years) using IDeg and IGla-300 ≥6 months to compare DIDR between groups. Patients using IGla-300 (n=187) were...
Source: Journal of Investigative Medicine - June 1, 2021 Category: Research Authors: Carral San Laureano, F., Tome Fernandez-Ladreda, M., Jimenez Millan, A. I., Garcia Calzado, C., Ayala Ortega, M. d. C. Tags: Open access Original research Source Type: research

Impact of coexisting pneumonia in the patients admitted with Clostridium difficile infection: a retrospective study from a national inpatient database
In conclusion, patients with pneumonia were associated with significantly higher rates of system-based complications and higher in-hospital mortality rates. (Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - June 1, 2021 Category: Research Authors: Kichloo, A., El-Amir, Z., Dahiya, D. S., Singh, J., Solanki, D., Wani, F., Shaka, H. Tags: Original research Source Type: research

UBR5 inhibits the radiosensitivity of non-small cell lung cancer cells via the activation of the PI3K/AKT pathway
Ubiquitin protein ligase E3 component n-recognin 5 (UBR5) has been identified as an oncogene in diverse cancers; however, whether its expression was associated with radiosensitivities of non-small cell lung cancer (NSCLC) cells remains unclear. Expression levels of UBR5 in NSCLC tissues and cell lines were examined by immunohistochemical staining and western blotting. Colony formation assay, CCK-8 cell viability assay, flow cytometry, and caspase-3 activity assay were performed to evaluate the radiosensitization of UBR5 knockdown in NSCLC cells, and the underlying mechanism in vitro was also investigated. UBR5 was highly e...
Source: Journal of Investigative Medicine - June 1, 2021 Category: Research Authors: Gu, Y.-F., Ge, X.-P. Tags: Original research Source Type: research

Hemogram as marker of in-hospital mortality in COVID-19
The clinical impact of COVID-19 disease calls for the identification of routine variables to identify patients at increased risk of death. Current understanding of moderate-to-severe COVID-19 pathophysiology points toward an underlying cytokine release driving a hyperinflammatory and procoagulant state. In this scenario, white blood cells and platelets play a direct role as effectors of such inflammation and thrombotic response. We investigate whether hemogram-derived ratios such as neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio and the systemic immune-inflammation index may help to identify patients at...
Source: Journal of Investigative Medicine - June 1, 2021 Category: Research Authors: Lopez-Escobar, A., Madurga, R., Castellano, J. M., Ruiz de Aguiar, S., Velazquez, S., Bucar, M., Jimeno, S., Ventura, P. S. Tags: COVID-19 Original research Source Type: research

Sex differences in the induction of angiotensin converting enzyme 2 (ACE-2) in mouse lungs after e-cigarette vapor exposure and its relevance to COVID-19
The COVID-19 pandemic has affected over 114 million people and has resulted in >2.5 million deaths so far. Some people have greater susceptibility which influences both SARS-CoV-2 infectivity and COVID-19 severity. Smoking is associated with increased ACE-2, the receptor for SARS-CoV-2, which facilitates its entry through the lung. However, despite the widespread use of e-cigarettes, also known as ‘vaping’, little is known regarding the effects of vaping on ACE-2 expression and how this affects SARS-CoV-2 infection. In addition, the added effect of nicotine in the vapor is also unknown. Thus, we tested wheth...
Source: Journal of Investigative Medicine - June 1, 2021 Category: Research Authors: Naidu, V., Zeki, A. A., Sharma, P. Tags: COVID-19 Original research Source Type: research

Fauci effect? When the heart is in the right place, but reality is not
(Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - June 1, 2021 Category: Research Authors: Cervantes, J. Tags: COVID-19 Editorial Source Type: research

Author index
(Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - January 10, 2018 Category: Research Tags: Author index Source Type: research

Western Medical Research conference (formerly Western Regional Meeting), January 25-27 2018, Carmel, California
(Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - January 10, 2018 Category: Research Tags: Saturday, January 27, 2018 Source Type: research

Western medical research conference (formerly western regional meeting)
(Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - January 10, 2018 Category: Research Tags: ABSTRACTS [amp ] AWARD WINNERS Source Type: research

Preoperative staging of cholangiocarcinoma and biliary carcinoma using 18F-fluorodeoxyglucose positron emission tomography: a meta-analysis
In conclusion, 18F-FDG-PET and PET/CT were found to be accurate in the evaluation of primary tumors, lymph node metastasis, and distant metastasis in patients with CCA. (Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - January 10, 2018 Category: Research Authors: Hu, J.-H., Tang, J.-h., Lin, C.-H., Chu, Y.-Y., Liu, N.-J. Tags: Hematology/Oncology Source Type: research

Clinical definition of respiratory viral infections in young children and potential bronchiolitis misclassification
Viral respiratory infections are often grouped as a single respiratory syndrome named ‘viral bronchiolitis’, independently of the viral etiology or individual risk factors. Clinical trials and guidelines have used a more stringent definition of viral bronchiolitis, including only the first episode of wheezing in children less than 12 months of age without concomitant respiratory comorbidities. There is increasing evidence suggesting that this definition is not being followed by pediatric care providers, but it is unclear to what extent viral respiratory infections are currently misclassified as viral bronchioli...
Source: Journal of Investigative Medicine - January 10, 2018 Category: Research Authors: Megalaa, R., Perez, G. F., Kilaikode-Cheruveettara, S., Kotwal, N., Rodriguez-Martinez, C. E., Nino, G. Tags: Pediatrics/Neonatology Source Type: research

MicroRNA-15b deteriorates hypoxia/reoxygenation-induced cardiomyocyte apoptosis by downregulating Bcl-2 and MAPK3
In conclusion, miRNA-15b deteriorates cardiomyocyte apoptosis by post-transcriptionally downregulating the expression of Bcl-2 and MAPK3. (Source: Journal of Investigative Medicine)
Source: Journal of Investigative Medicine - January 10, 2018 Category: Research Authors: Liu, Y., Yang, L., Yin, J., Su, D., Pan, Z., Li, P., Wang, X. Tags: Original research Source Type: research