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Nonlinear optical microscopy for skin in vivo: Basics, development and applications
Journal of Innovative Optical Health Sciences, Ahead of Print. Multi-photon microscopy (MPM) and coherent anti-Stokes Raman scattering (CARS) are two advanced nonlinear optical imaging techniques, which provide complementary information and have great potential in combination for noninvasive in vivo biomedical applications. This paper provides a detailed discussion of the basics, development and applications of these technologies for in vivo skin research, covering the following topics: The principle and advantage of MPM and CARS, instrumentation development for in vivo applications, MPM and CARS of normal skin, applicatio...
Source: Journal of Innovative Optical Health Sciences - January 13, 2023 Category: Biomedical Science Authors: Jianhua Zhao Yuan Zhao Zhenguo Wu Yunxian Tian Haishan Zeng Source Type: research

A novel [math]-ketoamide reactivity-based two-photon fluorogenic probe for visualizing peroxynitrite in Parkinson ’s disease models
Journal of Innovative Optical Health Sciences, Ahead of Print. Peroxynitrite (ONOO[math] contributes to oxidative stress and neurodegeneration in Parkinson ’s disease (PD). Developing a peroxynitrite probe would enable in situ visualization of the overwhelming ONOO− flux and understanding of the ONOO− stress-induced neuropathology of PD. Herein, a novel [math]-ketoamide-based fluorogenic probe (DFlu) was designed for ONOO− monitoring in multip le PD models. The results demonstrated that DFlu exhibits a fluorescence turn-on response to ONOO− with high specificity and sensitivity. The efficacy of DFlu for intracel...
Source: Journal of Innovative Optical Health Sciences - January 9, 2023 Category: Biomedical Science Authors: Tao Shao Xianning Xu Lan Wang Yu Shen Jun Zhao Huizi Li Duoteng Zhang Wei Du Hua Bai Bo Peng Lin Li Source Type: research

1.3 [math]m broadband swept sources with enhanced nonlinear effects
Journal of Innovative Optical Health Sciences, Ahead of Print. In this work, a new structure is used to enhance the nonlinear effect in the cavity, which improves the performance of the 1.3[math][math]m broadband swept source. The swept source adopts a semiconductor optical amplifier (SOA), a circulator, a coupler, and a tunable filter. In the structure, the light passes through the nonlinear medium (SOA) twice in two opposite directions, which excites the nonlinear effect and increases the performance of the swept source. The tunable filter is based on a polygon rotating mirror and gratings. Traditionally, multiple SOAs a...
Source: Journal of Innovative Optical Health Sciences - December 31, 2022 Category: Biomedical Science Authors: Panqiu Jiang Jiale Mu Yuxing Liu Pinghe Wang Guohua Shi Source Type: research

Hybrid reconstruction framework for model-based multispectral bioluminescence tomography based on Alpha-divergence
Journal of Innovative Optical Health Sciences, Ahead of Print. Bioluminescence tomography (BLT) is a promising imaging modality that can provide noninvasive three-dimensional visualization information on tumor distribution. In BLT reconstruction, the widely used methods based on regularization or greedy strategy face problems such as over-sparsity, over-smoothing, spatial discontinuity, poor robustness, and poor multi-target resolution. To deal with these problems, combining the advantages of the greedy strategies as well as regularization methods, we propose a hybrid reconstruction framework for model-based multispectral ...
Source: Journal of Innovative Optical Health Sciences - December 12, 2022 Category: Biomedical Science Authors: Ying Liu Hongbo Guo Yinglong Xiao Wenjing Li Jingjing Yu Source Type: research

Correlation of image textures of a polarization feature parameter and the microstructures of liver fibrosis tissues
This study demonstrates the potential of deriving a fiber-sensitive PFP to reduce the multiple staining process and provide textures-based quantitative diagnostic indicators for the staging of liver fibrosis. (Source: Journal of Innovative Optical Health Sciences)
Source: Journal of Innovative Optical Health Sciences - December 7, 2022 Category: Biomedical Science Authors: Yue Yao Jiachen Wan Fengdi Zhang Yang Dong Lihong Chen Hui Ma Source Type: research

Deep-learning-based methods for super-resolution fluorescence microscopy
Journal of Innovative Optical Health Sciences, Ahead of Print. The algorithm used for reconstruction or resolution enhancement is one of the factors affecting the quality of super-resolution images obtained by fluorescence microscopy. Deep-learning-based algorithms have achieved state-of-the-art performance in super-resolution fluorescence microscopy and are becoming increasingly attractive. We firstly introduce commonly-used deep learning models, and then review the latest applications in terms of the network architectures, the training data and the loss functions. Additionally, we discuss the challenges and limits when u...
Source: Journal of Innovative Optical Health Sciences - December 7, 2022 Category: Biomedical Science Authors: Jianhui Liao Junle Qu Yongqi Hao Jia Li Source Type: research

Research on the detection of early caries based on hyperspectral imaging
Conclusion: The results have shown that the interference of tooth surface pigment can be eliminated in the near-infrared (NIR) waveband, and the caries can be effectively identified from the pigmented areas. Thus, it could be used to detect carious areas of teeth in place of the traditional visual inspection method or white light endoscopy. Clinical significance: The NIR diffused light signal enables the identification of early caries from pigment and other interference, providing a reasonable detection tool for early detection and early treatment of teeth diseases. (Source: Journal of Innovative Optical Health Sciences)
Source: Journal of Innovative Optical Health Sciences - November 28, 2022 Category: Biomedical Science Authors: Cheng Wang Haoying Zhang Guangyun Lai Songzhu Hu Jun Wang Dawei Zhang Source Type: research

Coherent Raman scattering imaging of lipid metabolism in cancer
Journal of Innovative Optical Health Sciences, Ahead of Print. Cancer cells dysregulate lipid metabolism to accelerate energy production and biomolecule synthesis for rapid growth. Lipid metabolism is highly dynamic and intrinsically heterogeneous at the single cell level. Although fluorescence microscopy has been commonly used for cancer research, bulky fluorescent probes can hardly label small lipid molecules without perturbing their biological activities. Such a challenge can be overcome by coherent Raman scattering (CRS) microscopy, which is capable of chemically selective, highly sensitive, submicron resolution and hi...
Source: Journal of Innovative Optical Health Sciences - November 24, 2022 Category: Biomedical Science Authors: Shuo Zhang Yexuan He Shuhua Yue Source Type: research

Nonlinear optical imaging by detection with optical parametric amplification (invited paper)
Journal of Innovative Optical Health Sciences, Ahead of Print. Nonlinear optical imaging is a versatile tool that has been proven to be exceptionally useful in various research fields. However, due to the use of photomultiplier tubes (PMTs), the wide application of nonlinear optical imaging is limited by the incapability of imaging under ambient light. In this paper, we propose and demonstrate a new optical imaging detection method based on optical parametric amplification (OPA). As a nonlinear optical process, OPA intrinsically rejects ambient light photons by coherence gating. Periodical poled lithium niobate (PPLN) crys...
Source: Journal of Innovative Optical Health Sciences - November 21, 2022 Category: Biomedical Science Authors: Yi Sun Haohua Tu Stephen A. Boppart Source Type: research