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Refractive index characteristics of edible oils based on spectrometry and effects of oil dispersion on OCT
In this study, by deriving the refractive index equations of the double glass sheet holding device and oil, the reflectance spectra of three different types of oil samples, namely, peanut oil, colza oil, and kitchen waste oil, were measured via a spectrometer. Furthermore, the refractive index model of these different types of oil samples was investigated. Additionally, based on the oil dispersion characteristics, the dispersion of oil in optical coherence tomography (OCT) was compensated via deconvolution. In the wavelength range of [math] (380, 1500)[math]nm, the analytical expressions of the double glass sheet holding d...
Source: Journal of Innovative Optical Health Sciences - January 27, 2021 Category: Biomedical Science Authors: ShiJun Xu XiaoKang Li Source Type: research

Swept source intraoperative OCT angiography
Journal of Innovative Optical Health Sciences, Ahead of Print. To accurately guide surgical instruments during ophthalmic procedures, some necessary intraoperative depth perception is required, which standard surgical microscopes supply limitedly. Intraoperative optical coherence tomography (iOCT), combining optical coherence tomography (OCT) technology and surgical microscope, enables noninvasive, real-time and high-resolution cross-sectional imaging. Currently, though iOCT enables structural imaging, little research has been done on intraoperative angiography. In this work, we presented a swept-source intraoperative OCT ...
Source: Journal of Innovative Optical Health Sciences - January 19, 2021 Category: Biomedical Science Authors: Ziyi Zhang Tiepei Zhu Tongtong Cao Zhaoyu Gong Lin Yao Kaiyuan Liu Juan Ye Peng Li Source Type: research

ID-OCTA: OCT angiography based on inverse SNR and decorrelation features
Journal of Innovative Optical Health Sciences, Ahead of Print. Optical coherence tomography angiography (OCTA) takes the flowing red blood cells (RBCs) as intrinsic contrast agents, enabling fast and three-dimensional visualization of vasculature perfusion down to capillary level, without a requirement of exogenous fluorescent injection. Various motion-contrast OCTA algorithms have been proposed to effectively extract dynamic blood flow from static tissues utilizing the different components of OCT signals (including amplitude, phase and complex) with various operations (such as differential, variance and decorrelation). Th...
Source: Journal of Innovative Optical Health Sciences - January 18, 2021 Category: Biomedical Science Authors: Huakun Li Kaiyuan Liu Lin Yao Xiaofeng Deng Ziyi Zhang Peng Li Source Type: research

Constrained polynomial fit-based [math]-domain interpolation in swept-source optical coherence tomography
Journal of Innovative Optical Health Sciences, Ahead of Print. We propose a [math]-domain spline interpolation method with constrained polynomial fit based on spectral phase in swept-source optical coherence tomography (SS-OCT). A Mach –Zehnder interferometer (MZI) unit is connected to the swept-source of the SS-OCT system to generate calibration signal in sync with the fetching of interference spectra. The spectral phase of the calibration signal is extracted by Hilbert transformation. The fitted phase–time relationship is ob tained by polynomial fitting with the constraint of passing through the central spectral phas...
Source: Journal of Innovative Optical Health Sciences - January 13, 2021 Category: Biomedical Science Authors: Tao Han Jianrong Qiu Di Wang Jia Meng Zhiyi Liu Zhihua Ding Source Type: research

The biostimulative effectiveness of photobiomodulation therapy application on thawed dental pulp stem cells
This study was conducted to understand the cellular proliferative effect of Photobiomodulation Therapy (PBMT) on thawed dental pulp stem cells (DPSCs) stored for 2 years. For this purpose, cells were exposed to PBMT for short period of time to evaluate the most appropriate PBMT parameter for stimulating cellular proliferation that can be used for future tissue engineering therapies. Fully characterized DPSCs were seperated into three groups according to the laser energy densities (5[math]J/cm2 or 7[math]J/cm2) applied and a group was served as control in which cells did not receive any laser irradiation. The cells in laser...
Source: Journal of Innovative Optical Health Sciences - January 11, 2021 Category: Biomedical Science Authors: Cenk Serhan Özverel Aylin İslam Hasan G üney Yılmaz Source Type: research

Research on optical properties of cardiovascular tissues based on OCT data
Journal of Innovative Optical Health Sciences, Ahead of Print. As a high-resolution optical imaging technology, Optical Coherence Tomography (OCT) has been widely used in the diagnosis and treatment of cardiovascular diseases. It has played an important role in the detection and identification of atherosclerotic plaques and has significant advantages. In this paper, we realized to extract the optical characteristic parameters of the target sample based on the OCT data by establishing optical transmission models conforming to the OCT principle. The optical phantoms and coronary artery of domestic pig were used as research s...
Source: Journal of Innovative Optical Health Sciences - January 9, 2021 Category: Biomedical Science Authors: Na Qin Yana Liu Lin Huang Yi Xin Xiao Zhang Xiaoming Hu Qin Li Source Type: research

Monitoring of edema progression in permanent and transient MCAO model using SS-OCT
In this study, we have monitored the edema formation and progression in both permanent and transient middle cerebral artery occlusion models in rats. Edema was reflected by the decrease of optical attenuation coefficient (OAC) value in OCT system. By utilizing swept-source optical coherence tomography (SS-OCT), we found that in photochemically induced permanent focal stroke model, both the edema size and edema index, steadily developed until the end of monitor (7[math]h). Comparatively, when transient ischemia was introduced with endothelin-1 (ET-1), the edema was detected as early as 15[math]min, and began to recover afte...
Source: Journal of Innovative Optical Health Sciences - January 4, 2021 Category: Biomedical Science Authors: Yao Yu Ziyue Meng Ang Li Yang Lin Jian Liu Yushu Ma Yi Wang Zhenhe Ma Source Type: research

Determination of diffusion coefficient by image-based fluorescence recovery after photobleaching and single particle tracking system implemented in a single platform
Journal of Innovative Optical Health Sciences,Volume 14, Issue 02, March 2021. Fluorescence recovery after photobleaching (FRAP) and single particle tracking (SPT) techniques determine the diffusion coefficient from average diffusive motion of high-concentration molecules and from trajectories of low-concentration single molecules, respectively. Lateral diffusion coefficients measured by FRAP and SPT techniques for the same biomolecule on cell membrane have exhibited inconsistent values across laboratories and platforms with larger diffusion coefficient determined by FRAP, but the sources of the inconsistency have not been...
Source: Journal of Innovative Optical Health Sciences - December 30, 2020 Category: Biomedical Science Authors: Donghee Lee Jeonghoon Lee Jung Kyung Kim Source Type: research

Determination of diffusion coefficient by image-based fluorescence recovery after photobleaching and single particle tracking system implemented in a single platform
Journal of Innovative Optical Health Sciences, Ahead of Print. Fluorescence recovery after photobleaching (FRAP) and single particle tracking (SPT) techniques determine the diffusion coefficient from average diffusive motion of high-concentration molecules and from trajectories of low-concentration single molecules, respectively. Lateral diffusion coefficients measured by FRAP and SPT techniques for the same biomolecule on cell membrane have exhibited inconsistent values across laboratories and platforms with larger diffusion coefficient determined by FRAP, but the sources of the inconsistency have not been investigated th...
Source: Journal of Innovative Optical Health Sciences - December 30, 2020 Category: Biomedical Science Authors: Donghee Lee Jeonghoon Lee Jung Kyung Kim Source Type: research

Development of a hydrogen peroxide-responsive and oxygen-carrying nanoemulsion for photodynamic therapy against hypoxic tumors using phase inversion composition method
Journal of Innovative Optical Health Sciences,Volume 14, Issue 02, March 2021. Photodynamic therapy (PDT) has become an attractive tumor treatment modality because of its noninvasive feature and low side effects. However, extreme hypoxia inside solid tumors severely impedes PDT therapeutic outcome. To overcome this obstacle, various strategies have been developed recently. Among them, in situ oxygen generation, which relies on the decomposition of tumor endogenous H2O2, and oxygen delivery tactic using high oxygen loading capacity of hemoglobin or perfluorocarbons, have been widely studied. The in situ oxygen generation st...
Source: Journal of Innovative Optical Health Sciences - December 23, 2020 Category: Biomedical Science Authors: Liang Hong Jia Zhang Junxian Geng Junle Qu Liwei Liu Source Type: research

Development of a hydrogen peroxide-responsive and oxygen-carrying nanoemulsion for photodynamic therapy against hypoxic tumors using phase inversion composition method
Journal of Innovative Optical Health Sciences, Ahead of Print. Photodynamic therapy (PDT) has become an attractive tumor treatment modality because of its noninvasive feature and low side effects. However, extreme hypoxia inside solid tumors severely impedes PDT therapeutic outcome. To overcome this obstacle, various strategies have been developed recently. Among them, in situ oxygen generation, which relies on the decomposition of tumor endogenous H2O2, and oxygen delivery tactic using high oxygen loading capacity of hemoglobin or perfluorocarbons, have been widely studied. The in situ oxygen generation strategy has high ...
Source: Journal of Innovative Optical Health Sciences - December 23, 2020 Category: Biomedical Science Authors: Liang Hong Jia Zhang Junxian Geng Junle Qu Liwei Liu Source Type: research

Deep learning algorithms to segment and quantify the choroidal thickness and vasculature in swept-source optical coherence tomography images
Journal of Innovative Optical Health Sciences, Ahead of Print. Accurate segmentation of choroidal thickness (CT) and vasculature is important to better analyze and understand the choroid-related ocular diseases. In this paper, we proposed and implemented a novel and practical method based on the deep learning algorithms, residual U-Net, to segment and quantify the CT and vasculature automatically. With limited training data and validation data, the residual U-Net was capable of identifying the choroidal boundaries as precise as the manual segmentation compared with an experienced operator. Then, the trained deep learning a...
Source: Journal of Innovative Optical Health Sciences - December 23, 2020 Category: Biomedical Science Authors: Gu Zheng Yanfeng Jiang Ce Shi Hanpei Miao Xiangle Yu Yiyi Wang Sisi Chen Zhiyang Lin Weicheng Wang Fan Lu Meixiao Shen Source Type: research

Corneal damage effects induced by infrared optical parametric oscillator radiation at 3743 nm
Journal of Innovative Optical Health Sciences,Volume 14, Issue 02, March 2021. The main aim of this paper is to investigate the corneal damage effects induced by mid-infrared optical parametric oscillator (OPO) radiation. Experiments were performed to determine the corneal damage thresholds of New Zealand white rabbit at the wavelength of 3743[math]nm for exposure durations of 0.1[math]s, 1.0[math]s and 10.0[math]s. Through slit-lamp biomicroscope and histopathology, corneal injury characteristics were revealed. The damage thresholds were 3.73[math]J/cm2, 7.91[math]J/cm2 and 31.1[math]J/cm2, respectively, for exposure dura...
Source: Journal of Innovative Optical Health Sciences - December 21, 2020 Category: Biomedical Science Authors: Luguang Jiao Chao Wang Kaizeng Zhang Jiarui Wang Zaifu Yang Source Type: research

Corneal damage effects induced by infrared optical parametric oscillator radiation at 3743 nm
Journal of Innovative Optical Health Sciences, Ahead of Print. The main aim of this paper is to investigate the corneal damage effects induced by mid-infrared optical parametric oscillator (OPO) radiation. Experiments were performed to determine the corneal damage thresholds of New Zealand white rabbit at the wavelength of 3743[math]nm for exposure durations of 0.1[math]s, 1.0[math]s and 10.0[math]s. Through slit-lamp biomicroscope and histopathology, corneal injury characteristics were revealed. The damage thresholds were 3.73[math]J/cm2, 7.91[math]J/cm2 and 31.1[math]J/cm2, respectively, for exposure durations of 0.1[mat...
Source: Journal of Innovative Optical Health Sciences - December 21, 2020 Category: Biomedical Science Authors: Luguang Jiao Chao Wang Kaizeng Zhang Jiarui Wang Zaifu Yang Source Type: research