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Single-cell manipulation by two-dimensional micropatterning
Journal of Innovative Optical Health Sciences, Ahead of Print. Cells are highly sensitive to their geometrical and mechanical microenvironment that directly regulate cell shape, cytoskeleton and organelle, as well as the nucleus morphology and genetic expression. The emerging two-dimensional micropatterning techniques offer powerful tools to construct controllable and well-organized microenvironment for single-cell level investigations with qualitative analysis, cellular standardization, and in vivo environment mimicking. Here, we provide an overview of the basic principle and characteristics of the two most widely-used mi...
Source: Journal of Innovative Optical Health Sciences - January 22, 2024 Category: Biomedical Science Authors: Xuehe Ma Haimei Zhang Shiyu Deng Qiushuo Sun Qingsong Hu Yuhang Pan Fen Hu Imshik Lee Fulin Xing Leiting Pan Source Type: research

Comparison of brain functions between healthy participants and methamphetamine users with various addiction histories: Data analysis based on EEG and fNIRS
This study used 64-electrode EEG and fNIRS to conduct an experiment that analyzed the resting and craving states. The EEG and fNIRS data of 56 participants were collected, including 14 healthy participants, 14 methamphetamine users with an addiction history of 0.5 –5 years, 14 users with an addiction history of 5–10 years, and 14 users with an addiction history of 10–15 years. Isolated effective coherence (iCoh) within the brain network was used to process the EEG data. Statistical analysis was performed to compare differences in iCoh among the delta, t heta, alpha, beta, and gamma bands and explore oxyhemoglobin act...
Source: Journal of Innovative Optical Health Sciences - January 20, 2024 Category: Biomedical Science Authors: Xuelin Gu Xiaoou Li Banghua Yang Source Type: research

A refined analytical model for reconstruction problems in diffuse reflectance spectroscopy
Journal of Innovative Optical Health Sciences, Ahead of Print. A refined analytical model of spatially resolved diffuse reflectance with small source-detector separations (SDSs) for the in vivo skin studies is proposed. Compared to the conventional model developed by Farrell et  al., it accounts for the limited acceptance angle of the detector fiber. The refined model is validated in the wide range of optical parameters by Monte Carlo simulations of skin diffuse reflectance at SDSs of units of mm. Cases of uniform dermis and two-layered epidermis-dermis structures are stu died. Higher accuracy of the refined model compare...
Source: Journal of Innovative Optical Health Sciences - January 20, 2024 Category: Biomedical Science Authors: Ekaterina Sergeeva Daria Kurakina Ilya Turchin Mikhail Kirillin Source Type: research

Photoacoustic elastography based on laser-excited shear wave
In this study, we propose a new method for shear wave elastography (SWE) based on laser-excited shear wave, called photoacoustic shear wave elastography (PASWE), which combines photoacoustic (PA) technology with ultrafast ultrasound imaging. By using a focused laser to excite shear waves and ultrafast ultrasonic imaging for detection, high-frequency excitation of shear waves and noncontact elastic imaging can be realized. The laser can stimulate the tissue with the light absorption characteristic to produce the thermal expansion, thus producing the shear wave. The frequency of shear wave induced by laser is higher and the ...
Source: Journal of Innovative Optical Health Sciences - January 12, 2024 Category: Biomedical Science Authors: Yang Liu Ruoyi Shi Gang Li Mingjian Sun Source Type: research

NIR-II fluorescence imaging in liver tumor surgery: A narrative review
Journal of Innovative Optical Health Sciences, Ahead of Print. In liver tumor surgery, the recognition of tumor margin and radical resection of microcancer focis have always been the crucial points to reduce postoperative recurrence of tumor. However, naked-eye inspection and palpation have limited effectiveness in identifying tumor boundaries, and traditional imaging techniques cannot consistently locate tumors in real time. As an intraoperative real-time navigation imaging method, NIR fluorescence imaging has been extensively studied for its simplicity, reliable safety, and superior sensitivity, and is expected to improv...
Source: Journal of Innovative Optical Health Sciences - January 12, 2024 Category: Biomedical Science Authors: Zihao Liu Lifeng Yan Qingsong Hu Dalong Yin Source Type: research

Triple-path feature transform network for ring-array photoacoustic tomography image reconstruction
Journal of Innovative Optical Health Sciences, Ahead of Print. Photoacoustic imaging (PAI) is a noninvasive emerging imaging method based on the photoacoustic effect, which provides necessary assistance for medical diagnosis. It has the characteristics of large imaging depth and high contrast. However, limited by the equipment cost and reconstruction time requirements, the existing PAI systems distributed with annular array transducers are difficult to take into account both the image quality and the imaging speed. In this paper, a triple-path feature transform network (TFT-Net) for ring-array photoacoustic tomography is p...
Source: Journal of Innovative Optical Health Sciences - November 11, 2023 Category: Biomedical Science Authors: Lingyu Ma Zezheng Qin Yiming Ma Mingjian Sun Source Type: research

Effect of Sodium Nitroprusside on the microrheological properties of red blood cells in different media
Journal of Innovative Optical Health Sciences, Ahead of Print. Red blood cell (RBC) aggregation as well as their deformation significantly affects blood microrheology. These processes depend on various factors, one of which is concentration of the nitric oxide, one of the main signaling molecule in the bloodstream. The purpose of this study was to investigate the effect of nitric oxide on the microrheological properties of red blood cells (RBCs) in RBC samples of various media after the addition of nitric oxide donor sodium nitroprusside in vitro. Microrheological properties were measured using laser aggregometer and ektac...
Source: Journal of Innovative Optical Health Sciences - November 11, 2023 Category: Biomedical Science Authors: Petr Ermolinskiy Matvey Maksimov Andrei Lugovtsov Alexey Muravyov Irina Tikhomirova Alexander Priezzhev Source Type: research

Introduction to Special Issue on Neurophotonics
Journal of Innovative Optical Health Sciences,Volume 16, Issue 06, November 2023. (Source: Journal of Innovative Optical Health Sciences)
Source: Journal of Innovative Optical Health Sciences - November 10, 2023 Category: Biomedical Science Authors: Sergio Fantini Ling Fu Sabrina Brigadoi Source Type: research

Editorial: Introduction to Special Issue on Neurophotonics
Journal of Innovative Optical Health Sciences, Ahead of Print. (Source: Journal of Innovative Optical Health Sciences)
Source: Journal of Innovative Optical Health Sciences - November 10, 2023 Category: Biomedical Science Authors: Sergio Fantini Ling Fu Sabrina Brigadoi Source Type: research

Gates joint locally connected network for accurate and robust reconstruction in optical molecular tomography
Journal of Innovative Optical Health Sciences, Ahead of Print. Optical molecular tomography (OMT) is a potential pre-clinical molecular imaging technique with applications in a variety of biomedical areas, which can provide non-invasive quantitative three-dimensional (3D) information regarding tumor distribution in living animals. The construction of optical transmission models and the application of reconstruction algorithms in traditional model-based reconstruction processes have affected the reconstruction results, resulting in problems such as low accuracy, poor robustness, and long-time consumption. Here, a gates join...
Source: Journal of Innovative Optical Health Sciences - November 4, 2023 Category: Biomedical Science Authors: Minghua Zhao Yahui Xiao Jiaqi Zhang Xin Cao Lin Wang Source Type: research

Author index Volume 16 (2023)
Journal of Innovative Optical Health Sciences,Volume 16, Issue 06, November 2023. (Source: Journal of Innovative Optical Health Sciences)
Source: Journal of Innovative Optical Health Sciences - November 1, 2023 Category: Biomedical Science Source Type: research

Deep learning-based inpainting of saturation artifacts in optical coherence tomography images
Journal of Innovative Optical Health Sciences, Ahead of Print. Limited by the dynamic range of the detector, saturation artifacts usually occur in optical coherence tomography (OCT) imaging for high scattering media. The available methods are difficult to remove saturation artifacts and restore texture completely in OCT images. We proposed a deep learning-based inpainting method of saturation artifacts in this paper. The generation mechanism of saturation artifacts was analyzed, and experimental and simulated datasets were built based on the mechanism. Enhanced super-resolution generative adversarial networks were trained ...
Source: Journal of Innovative Optical Health Sciences - October 31, 2023 Category: Biomedical Science Authors: Muyun Hu Zhuoqun Yuan Di Yang Jingzhu Zhao Yanmei Liang Source Type: research

Microwave-induced thermoacoustic elastic imaging: A simulation study
Journal of Innovative Optical Health Sciences, Ahead of Print. Microwave-induced thermoacoustic imaging (MTI) has the advantages of high resolution, high contrast, non-ionization, and non-invasive. Recently, MTI was used in the field of breast cancer screening. In this paper, based on the finite element method (FEM) and COMSOL Multiphysics software, a three-dimensional breast cancer model suitable for exploring the MTI process is proposed to investigate the influence of Young ’s modulus (YM) of breast cancer tissue on MTI. It is found that the process of electromagnetic heating and initial pressure generation of the enti...
Source: Journal of Innovative Optical Health Sciences - October 20, 2023 Category: Biomedical Science Authors: Lin Huang Zheng Liang Shuaiqi Qiao Weipeng Wang Source Type: research

MMAE-loaded PLGA nanomedicine with improved biosafety to achieve efficient antitumor treatment
Journal of Innovative Optical Health Sciences, Ahead of Print. Monomethyl auristatin E (MMAE) is a derivative of the marine peptide Dolastatin 10, which has therapeutic effects against various cancers according to its antimitotic activity in multiple clinical trials. The antibody drug conjugate (ADC) of MMAE is currently used in clinical practice. However, the safety issues of MMAE-based ADC, such as high drug toxicity and poor bioavailability, still exist when using it for anticancer therapy. A sustained release of drug delivery approach should be used to reduce toxicity and achieve sufficient anticancer effects. Herein, ...
Source: Journal of Innovative Optical Health Sciences - October 7, 2023 Category: Biomedical Science Authors: Changqiang Xie Yan Wang Zhenzhen Cai Jianghai Du Zhengyu Chen Junjie Wang Xingzhou Peng Source Type: research

Self-confocal NIR-II fluorescence microscopy for multifunctional in vivo imaging
Journal of Innovative Optical Health Sciences, Ahead of Print. Fluorescence imaging in the second near-infrared window (NIR-II, 900 –1880[math]nm) with less scattering background in biological tissues has been combined with the confocal microscopic system for achieving deep in vivo imaging with high spatial resolution. However, the traditional NIR-II fluorescence confocal microscope with separate excitation focus and detection pinhole makes it possess low confocal efficiency, as well as difficultly to adjust. Two types of upgraded NIR-II fluorescence confocal microscopes, sharing the same pinhole by excitation and emissi...
Source: Journal of Innovative Optical Health Sciences - September 27, 2023 Category: Biomedical Science Authors: Jing Zhou Tianxiang Wu Runze Chen Liang Zhu Hequn Zhang Yifei Li Liying Chen Jun Qian Source Type: research