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DecodeSTORM: A user-friendly ImageJ plug-in for quantitative data analysis in single-molecule localization microscopy
Journal of Innovative Optical Health Sciences, Ahead of Print. Quantitative data analysis in single-molecule localization microscopy (SMLM) is crucial for studying cellular functions at the biomolecular level. In the past decade, several quantitative methods were developed for analyzing SMLM data; however, imaging artifacts in SMLM experiments reduce the accuracy of these methods, and these methods were seldom designed as user-friendly tools. Researchers are now trying to overcome these difficulties by developing easy-to-use SMLM data analysis software for certain image analysis tasks. But, this kind of software did not pa...
Source: Journal of Innovative Optical Health Sciences - March 4, 2023 Category: Biomedical Science Authors: Qihang Song Cheng Wu Jianming Huang Zhiwei Zhou Zhen-Li Huang Zhengxia Wang Source Type: research

Recent advances in Raman spectroscopy for skin diagnosis
Journal of Innovative Optical Health Sciences, Ahead of Print. The skin is the largest organ in humans. It comprises about 16% of our body. Many diseases originate from the skin, including acne vulgaris, skin cancer, fungal skin disease, etc. As a common skin cancer in China, melanoma alone grows at year rate of nearly 4%. Therefore, it is crucial to develop an objective, reliable, accurate, non-invasive, and easy-to-use diagnostic method for skin diseases to support clinical decision-making. Raman spectroscopy is a highly specific imaging technique, which is sensitive, even to the single-cell level in skin diagnosis. Rama...
Source: Journal of Innovative Optical Health Sciences - March 4, 2023 Category: Biomedical Science Authors: Min Wu Beibei Gao Xunbin Wei Source Type: research

Study on the secondary structure and hydration effect of human serum albumin under acidic pH and ethanol perturbation with IR/NIR spectroscopy
In this study, infrared (IR) spectroscopy and near-infrared (NIR) spectroscopy in combination with chemometrics were used to investigate the changes in the secondary structure and hydration of HSA at acidic pH (5.6 –3.2) and isoelectric pH when ethanol concentration was varied from 0% to 40% as a perturbation. IR spectroscopy combined with the two-dimensional correlation spectroscopy (2DCOS) analysis for acid pH system proved that the secondary structure of HSA changed significantly when pH was around 4.5. W hat’s more, the IR spectroscopy and 2DCOS analysis showed different secondary structure forms under different et...
Source: Journal of Innovative Optical Health Sciences - February 28, 2023 Category: Biomedical Science Authors: Hui Zhang Mengying Liang Shuangshuang Li Mengyin Tian Xiaoying Wei Bing Zhao Haowei Wang Qin Dong Hengchang Zang Source Type: research

Depolarizing metrics in the biomedical field: Vision enhancement and classification of biological tissues
We report the suitability of a set of depolarizing observables, the indices of polarimetric purity (IPPs), for biological tissue inspection. We review some results where we demonstrate that IPPs lead to better performance than the depolarization index, which is a well-established and commonly used depolarization observable in the literature. We also provide how IPPs are able to significantly enhance contrast between different tissue structures and even to reveal structures hidden by using standard intensity images. Finally, we also explore the classificatory potential of IPPs and other depolarizing observables for the disc...
Source: Journal of Innovative Optical Health Sciences - February 23, 2023 Category: Biomedical Science Authors: M ónica Canabal-Carbia Albert Van Eeckhout Carla Rodr íguez Emilio Gonz ález-Arnay Irene Est évez Jos é J. Gil Enrique Garc ía-Caurel Razvigor Ossikovski Juan Campos Angel Lizana Source Type: research

Brain-wide N2cG compensation permits glycoprotein-deleted rabies virus to trace neural circuits across multiple synapses
This study provides new alternative methods for neuroscience researchers to analyze the input neural networks of rodents and nonhuman primates. (Source: Journal of Innovative Optical Health Sciences)
Source: Journal of Innovative Optical Health Sciences - February 22, 2023 Category: Biomedical Science Authors: Nengsong Luo Zengpeng Han Jiaxin Kou Yuxiang Cai Xin Yang Jie Wang Kunzhang Lin Fuqiang Xu Source Type: research

Deep learning method for cell count from transmitted-light microscope
Journal of Innovative Optical Health Sciences, Ahead of Print. Automatic cell counting provides an effective tool for medical research and diagnosis. Currently, cell counting can be completed by transmitted-light microscope, however, it requires expert knowledge and the counting accuracy which is unsatisfied for overlapped cells. Further, the image-translation-based detection method has been proposed and the potential has been shown to accomplish cell counting from transmitted-light microscope, automatically and effectively. In this work, a new deep-learning (DL)-based two-stage detection method (cGAN-YOLO) is designed to ...
Source: Journal of Innovative Optical Health Sciences - February 18, 2023 Category: Biomedical Science Authors: Mengyang Lu Wei Shi Zhengfen Jiang Boyi Li Dean Ta Xin Liu Source Type: research

High-throughput sorting of two-color fluorescent-labeled zebrafish embryos
Journal of Innovative Optical Health Sciences, Ahead of Print. The zebrafish embryos were widely employed in genetics, development and drug discovery studies as miniatured animal models. Sorting of two-color fluorescent embryos is often required in large-scale experiments but it is challenging to manually sort with high efficiency. Here, we reported a high-throughput sorting system for two-color fluorescent zebrafish embryos. The embryos can be automatically loaded from a sample pool and sorted based on the average fluorescent intensity. The two-color fluorescent signals were split into two lines and detected by an area ar...
Source: Journal of Innovative Optical Health Sciences - February 16, 2023 Category: Biomedical Science Authors: Hongzhen Tang Linbo Wang Xiaohu Chen Chong Chen Hui Li Guang Yang Source Type: research

SOFFLFM: Super-resolution optical fluctuation Fourier light-field microscopy
Journal of Innovative Optical Health Sciences, Ahead of Print. Fourier light-field microscopy (FLFM) uses a microlens array (MLA) to segment the Fourier plane of the microscopic objective lens to generate multiple two-dimensional perspective views, thereby reconstructing the three-dimensional (3D) structure of the sample using 3D deconvolution calculation without scanning. However, the resolution of FLFM is still limited by diffraction, and furthermore, it is dependent on the aperture division. In order to improve its resolution, a super-resolution optical fluctuation Fourier light-field microscopy (SOFFLFM) was proposed h...
Source: Journal of Innovative Optical Health Sciences - February 15, 2023 Category: Biomedical Science Authors: Haixin Huang Haoyuan Qiu Hanzhe Wu Yihong Ji Heng Li Bin Yu Danni Chen Junle Qu Source Type: research

Photoacoustic microscopy based on transparent piezoelectric ultrasound transducers
Journal of Innovative Optical Health Sciences, Ahead of Print. Photoacoustic microscopy (PAM), due to its deep penetration depth and high contrast, is playing an increasingly important role in biomedical imaging. PAM imaging systems equipped with conventional ultrasound transducers have demonstrated excellent imaging performance. However, these opaque ultrasonic transducers bring some constraints to the further development and application of PAM, such as complex optical path, bulky size, and difficult to integrate with other modalities. To overcome these problems, ultrasonic transducers with high optical transparency have ...
Source: Journal of Innovative Optical Health Sciences - February 11, 2023 Category: Biomedical Science Authors: Hangbing Peng Zhongwen Cheng Lvming Zeng Xuanrong Ji Source Type: research