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Noninvasive in vivo study of NADH fluorescence and its real-time intrinsic dynamical changes: Experiments and seven-layered skin model Monte Carlo simulations
Journal of Innovative Optical Health Sciences, Ahead of Print. Reduced nicotinamide adenine dinucleotide (NADH) plays a crucial role in many biochemical reactions in human metabolism. In this work, a flow-mediated skin fluorescence (FMSF) –post-occlusion reactive hyperaemia (PORH) system was developed for noninvasive and in vivo measurement of NADH fluorescence and its real-time dynamical changes in human skin tissue. The real-time dynamical changes of NADH fluorescence were analyzed with the changes of skin blood flow measured by laser speckle contrast imaging (LSCI) experiments simultaneously with FMSF-PORH measurement...
Source: Journal of Innovative Optical Health Sciences - March 25, 2022 Category: Biomedical Science Authors: Huayi Hou Gongzhi Du Yuancheng Wang Chunping Su Lianbo Guo Xiangbai Chen Source Type: research

Study on response of metal wire in thermoacoustic imaging
Journal of Innovative Optical Health Sciences, Ahead of Print. Thermoacoustic imaging (TAI) is an emerging high-resolution and high-contrast imaging technology. In recent years, metal wires have been used in TAI experiments to quantitatively evaluate the spatial resolution of different systems. However, there is still a lack of analysis of the response characteristics and principles of metal wires in TAI. Through theoretical and simulation analyses, this paper proposes that the response of metal (copper) wires during TAI is equivalent to the response of antennas. More critically, the response of the copper wire is equivale...
Source: Journal of Innovative Optical Health Sciences - March 17, 2022 Category: Biomedical Science Authors: Zheng Liang Weipeng Wang Shuaiqi Qiao Lin Huang Source Type: research

Monitoring microenvironment of Hep G2 cell apoptosis using two-photon fluorescence lifetime imaging microscopy
Journal of Innovative Optical Health Sciences, Ahead of Print. Apoptosis is very important for the maintenance of cellular homeostasis and is closely related to the occurrence and treatment of many diseases. Mitochondria in cells play a crucial role in programmed cell death and redox processes. Nicotinamide adenine dinucleotide (NAD(P)H) is the primary producer of energy in mitochondria, changing NAD(P)H can directly reflect the physiological state of mitochondria. Therefore, NAD(P)H can be used to evaluate metabolic response. In this paper, we propose a noninvasive detection method that uses two-photon fluorescence lifeti...
Source: Journal of Innovative Optical Health Sciences - March 3, 2022 Category: Biomedical Science Authors: Kexin Wang Shiyao Tang Shiqi Wang Fangrui Lin Gengjin Zou Junle Qu Liwei Liu Source Type: research

Comparison of two reader modes of computer-aided diagnosis in lung nodules on low-dose chest CT scan
In this study, we prospectively evaluated the efficiency of a CAD system ’s SR and CR modes in detecting pulmonary nodules on LDCT. We found that the SR mode improves pulmonary nodule detection regardless of the dose and experience level, especially for interns in the low-dose setting. The CR mode maintains the sensitivity of SR mode while significantly decreasing read ing times. (Source: Journal of Innovative Optical Health Sciences)
Source: Journal of Innovative Optical Health Sciences - February 18, 2022 Category: Biomedical Science Authors: Qiongjie Hu Shaofang Wang Chong Chen Shichao Kang Ziyan Sun Yujin Wang Min Xiang Hanxiong Guan Yiwen Liu Liming Xia Source Type: research

Modulated illumination localization microscopy-enabled sub-10 nm resolution
Journal of Innovative Optical Health Sciences, Ahead of Print. Optical microscopy is an essential tool for exploring the structures and activities of cells and tissues. To break the limit of resolution caused by diffraction, researchers have made continuous advances and innovations to improve the resolution of optical microscopy since the 1990s. These contributions, however, still make sub-10[math]nm imaging an obstacle. Here, we name a series of technologies as modulated illumination localization microscopy (MILM), which makes ultra-high-resolution imaging practical. Besides, we review the recent progress since 2017 when ...
Source: Journal of Innovative Optical Health Sciences - February 16, 2022 Category: Biomedical Science Authors: Yile Sun Lu Yin Mingxuan Cai Hanmeng Wu Xiang Hao Cuifang Kuang Xu Liu Source Type: research

Different types of drug abusers prefrontal cortex activation patterns and based on machine-learning classification
This study enrolled drug abusers to determine the effects of different drugs on brain activation. A functional near-infrared spectroscopy (fNIRS) device was used for the research. This study was designed with an experimental paradigm that included the induction of resting and drug addiction cravings. We collected the fNIRS data of 30 drug users, including 10 who used heroin, 10 who used Methamphetamine, and 10 who used mixed drugs. First, using Statistical Analysis, the study analyzed the activations of eight functional areas of the left and right hemispheres of the prefrontal cortex of drug addicts who respectively used h...
Source: Journal of Innovative Optical Health Sciences - February 9, 2022 Category: Biomedical Science Authors: Banghua Yang Xuelin Gu Shouwei Gao Lin Feng Yan Ding Xu Wen Wang Source Type: research

Application of super-resolution fluorescence microscopy in hematologic malignancies
Journal of Innovative Optical Health Sciences, Ahead of Print. Hematologic malignancies are one of the most common malignant tumors caused by the clonal proliferation and differentiation of hematopoietic and lymphoid stem cells. The examination of bone marrow cells combined with immunodeficiency typing is of great significance to the diagnostic type, treatment and prognosis of hematologic malignancies. Super-resolution fluorescence microscopy (SRM) is a special kind of optical microscopy technology, which breaks the resolution limit and was awarded the Nobel Prize in Chemistry in 2014. With the development of SRM, many rel...
Source: Journal of Innovative Optical Health Sciences - February 9, 2022 Category: Biomedical Science Authors: Yalan Yu Jianing Yu Zhen-Li Huang Fuling Zhou Source Type: research

Comparative study on Photobiomodulation between 630 nm and 810 nm LED in diabetic wound healing both in vitro and in vivo
Journal of Innovative Optical Health Sciences, Ahead of Print. Photobiomodulation (PBM) promoting wound healing has been demonstrated by many studies. Currently, 630 nm and 810 nm light-emitting diodes (LEDs), as light sources, are frequently used in the treatment of diabetic foot ulcers (DFUs) in clinics. However, the dose –effect relationship of LED-mediated PBM is not fully understood. Furthermore, among the 630[math]nm and 810[math]nm LEDs, which one gets a better effect on accelerating the wound healing of diabetic ulcers is not clear. The aim of this study is to evaluate and compare the effects of 630[math]nm a nd ...
Source: Journal of Innovative Optical Health Sciences - January 31, 2022 Category: Biomedical Science Authors: Hongyou Zhao Tengda Ji Tianzhen Sun Haolin Liu Yidi Liu Defu Chen Ying Wang Yizhou Tan Jing Zeng Haixia Qiu Ying Gu Source Type: research

Blood glucose sensors and recent advances: A review
Journal of Innovative Optical Health Sciences, Ahead of Print. Blood glucose (BG) concentration of the human body serves as an important index for diagnosis of diabetes, and its detection methods need to be more efficient due to high mortality rates for diabetes. Typical household BG meters are invasive products based on electrochemistry and rely on finger pricks to procure blood, which might result in skin damage and bacterial infections. Moreover, such BG meters can only detect the BG concentration at a certain time while ignoring the BG level at other times. Recently, to achieve microinvasive, noninvasive and continuous...
Source: Journal of Innovative Optical Health Sciences - January 31, 2022 Category: Biomedical Science Authors: Zhiqing Peng Xiangyu Xie Qilong Tan Hu Kang Ji Cui Xia Zhang Wang Li Guoying Feng Source Type: research

Early diagnosis and bioimaging of lung adenocarcinoma cells/organs based on spectroscopy machine learning
Journal of Innovative Optical Health Sciences, Ahead of Print. Early diagnosis and fast detection with a high accuracy rate of lung cancer are important to improve the treatment effect. In this research, an early fast diagnosis and in vivo imaging method for lung adenocarcinoma are proposed by collecting the spectral data from normal and patients ’ cells/tissues, such as Fourier infrared spectroscopy (FTIR), UV-vis absorbance, and fluorescence spectra using anthocyanin. The FTIR spectra of human normal lung epithelial cells (BEAS-2B cells) and human lung adenocarcinoma cells (A549 cells) were collected. After the data is...
Source: Journal of Innovative Optical Health Sciences - January 20, 2022 Category: Biomedical Science Authors: Xiangrong Peng Ruiyi Dai Yaqun Ma Bi Lin Xin Hui Xueli Chen Ruichan Lv Source Type: research

Computer-aided diagnosis of retinopathy based on vision transformer
Journal of Innovative Optical Health Sciences, Ahead of Print. Age-related Macular Degeneration (AMD) and Diabetic Macular Edema (DME) are two common retinal diseases for elder people that may ultimately cause irreversible blindness. Timely and accurate diagnosis is essential for the treatment of these diseases. In recent years, computer-aided diagnosis (CAD) has been deeply  investigated and effectively used for rapid and early diagnosis. In this paper, we proposed a method of CAD using vision transformer to analyze optical coherence tomography (OCT) images and to automatically discriminate AMD, DME, and normal eyes. ...
Source: Journal of Innovative Optical Health Sciences - January 17, 2022 Category: Biomedical Science Authors: Zhencun Jiang Lingyang Wang Qixin Wu Yilei Shao Meixiao Shen Wenping Jiang Cuixia Dai Source Type: research

Introduction to the Special Issue on Advances in Biophotonics and Biomedical Optics: Part II
Journal of Innovative Optical Health Sciences,Volume 15, Issue 01, January 2022. (Source: Journal of Innovative Optical Health Sciences)
Source: Journal of Innovative Optical Health Sciences - January 12, 2022 Category: Biomedical Science Authors: Polina Dyachenko Timoshina Tingting Yu Dan Zhu Valery V. Tuchin Source Type: research

Serum folate status among blood donors in south-central China
This study aims to evaluate the serum folate status of blood donors in south-central China. In this study, 248 blood donors were included. The information on subjects was collected by a brief questionnaire concerning alcohol consumption habits, smoking habits, fruit and vegetable consumption and physical activity. The serum folate concentration was measured by electrochemiluminescence immunoassay. The geometric mean serum folate concentration was 13.4[math]nmol[math]l[math] (95% CI, 12.7 –14.1). The prevalence of serum folate concentrations below 6.8[math]nmol[math]l[math] was 5.2% (95% CI, 2.5–8.0). There were signifi...
Source: Journal of Innovative Optical Health Sciences - December 29, 2021 Category: Biomedical Science Authors: Yan Ma Huan Deng Mingdi He Ru Yang Gang Shen Source Type: research

Development of a poly(arylene sulfide sulfone) antibacterial electrospun film as a skin wound dressing application
Journal of Innovative Optical Health Sciences, Ahead of Print. Tissue engineering has become a hot issue for skin wound healing because it can be used as an alternative treatment to traditional grafts. Nanofibrous films have been widely used due to their excellent properties. In this work, an organic/inorganic composite poly(arylene sulfide sulfone)/ZnO/graphene oxide (PASS/ZnO/GO) nanofibrous film was fabricated with the ZnO nanoparticles blending in an electrospun solution and post-treated with the GO deposition. The optimal PASS/ZnO/GO nanofibrous film was prepared by 2% ZnO nanoparticles, 3.0[math]g/mL PASS electrospun...
Source: Journal of Innovative Optical Health Sciences - November 24, 2021 Category: Biomedical Science Authors: Xuzhi Lang Zhurong Tang Zhimei Wei Xiaojun Wang Shengru Long Gang Zhang Jie Yang Qingyu Lin Source Type: research

Optical neuroimaging of executive function impairments in food addiction
In conclusion, the use of fNIRS in the context of eating disorders studies represents a valuable application, noninvasive, and patient-friendly tool, providing new insights into understanding the addiction cycle and treatment guidelines. (Source: Journal of Innovative Optical Health Sciences)
Source: Journal of Innovative Optical Health Sciences - November 24, 2021 Category: Biomedical Science Authors: Tania Alexandra Couto Meng-Yun Wang Zhen Yuan Source Type: research