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Author index Volume 14 (2021)
Journal of Innovative Optical Health Sciences,Volume 14, Issue 06, November 2021. (Source: Journal of Innovative Optical Health Sciences)
Source: Journal of Innovative Optical Health Sciences - November 23, 2021 Category: Biomedical Science Source Type: research

Laser speckle contrast imaging for monitoring of acute pancreatitis at ischemia –reperfusion injury of the pancreas in rats
Journal of Innovative Optical Health Sciences, Ahead of Print. The influence of ischemia –reperfusion (I/R) action on pancreatic blood flow (PBF) and the development of acute pancreatitis (AP) in laboratory rats is evaluated in vivo by using the laser speckle contrast imaging (LSCI). Additionally, the optical properties in norm and under condition of AP in rats were assessed using a m odified integrating sphere spectrometer and inverse Monte Carlo (IMC) software. The results of the experimental study of microcirculation of the pancreas in 82 rats in the ischemic model are presented. The data obtained confirm the fact tha...
Source: Journal of Innovative Optical Health Sciences - November 19, 2021 Category: Biomedical Science Authors: P. A. Dyachenko Timoshina A. N. Bashkatov D. A. Alexandrov V. I. Kochubey V.  V. Tuchin Source Type: research

Optical angiography for diabetes-induced pathological changes in microvascular structure and function: An overview
Journal of Innovative Optical Health Sciences, Ahead of Print. Diabetes mellitus (DM) is a kind of metabolic disorder characterized by chronic hyperglycemia and glucose intolerance due to absolute or relative lack of insulin, leading to chronic damage of vasculature within various organ systems. These detrimental effects on the vascular networks will result in the development of various diseases associated with microvascular injury. Modern optical imaging techniques provide essential tools for accurate evaluation of the structural and functional changes of blood vessels down to capillaries level, which can offer valuable i...
Source: Journal of Innovative Optical Health Sciences - November 19, 2021 Category: Biomedical Science Authors: Jingtan Zhu Dongyu Li Tingting Yu Dan Zhu Source Type: research

Automatic segmentation of foveal avascular zone based on adaptive watershed algorithm in retinal optical coherence tomography angiography images
We presented an adaptive watershed algorithm to automatically extract FAZ from retinal optical coherence tomography angiography (OCTA) images. For the traditional watershed algorithm, “over-segmentation” is the most common problem. FAZ is often incorrectly divided into multiple regions by redundant “dams”. This paper analyzed the relationship between the “dams” length and the maximum inscribed circle radius of FAZ, and proposed an adaptive watershed algorithm to solve the problem of “over-segmentation”. Here, 132 healthy retinal images and 50 diabetic retinopathy (DR) images were used to verify the accuracy...
Source: Journal of Innovative Optical Health Sciences - November 11, 2021 Category: Biomedical Science Authors: Jian Liu Shixin Yan Nan Lu Dongni Yang Chunhui Fan Hongyu Lv Shuanglian Wang Xin Zhu Yuqian Zhao Yi Wang Zhenhe Ma Yao Yu Source Type: research

Detection of diabetic retinopathy in its early stages using textural features of optical coherence tomography angiography
Journal of Innovative Optical Health Sciences, Ahead of Print. The aim of this study is to detect whether the quantitative textural features of optical coherence tomography angiography (OCTA) images can be used to detect the eyes in the early stage of diabetic retinopathy (DR) from eyes with diabetes and no DR (NDR). Textural features including fractal dimension, contrast, correlation, entropy, energy, and homogeneity were calculated from the OCTA images. The Student ’s [math]-test was performed to identify the textural features that can be able to detect DR in the early stage. The area under the receiver operating chara...
Source: Journal of Innovative Optical Health Sciences - November 10, 2021 Category: Biomedical Science Authors: W. Gao B. Li S. Chen Y. Shi P. Lin O. O. Myakinin V. P. Zakharov Source Type: research

Cerebrospinal fluid and blood biomarkers in the diagnostic assays of Alzheimer ’s disease
Journal of Innovative Optical Health Sciences, Ahead of Print. The anti-amyloid-[math] (anti-A[math]) fibrils and soluble oligomers antibody aducanumab were approved to effectively slow down the progression of Alzheimer ’s disease (AD) at higher doses in 2019, reaffirming the therapeutic effects of targeting the core pathology of AD. A timely and accurate diagnosis in the prodromal or pre-dementia stage of AD is essential for patient recruitment, stratification, and monitoring of treatment effects. AD core biomar kers amyloid-[math] (A[math]), total tau (t-tau), and phosphorylated tau (p-tau) have been clinically validat...
Source: Journal of Innovative Optical Health Sciences - October 30, 2021 Category: Biomedical Science Authors: Liding Zhang Xiaohan Liang Zhihong Zhang Haiming Luo Source Type: research

Orthogonal Aza-BODIPY –BODIPY dyad as heavy-atom free photosensitizer for photo-initiated antibacterial therapy
Journal of Innovative Optical Health Sciences, Ahead of Print. Photodynamic antibacterial therapy shows great potential in bacterial infection and the reactive oxygen species (ROS) production of the photosensitizers is crucial for the therapeutic effect. Introducing heavy atoms is a common strategy to enhance photodynamic performance, while dark toxicity can be induced to impede further clinical application. Herein, a novel halogen-free photosensitizer Aza-BODIPY-BODIPY dyad NDB with an orthogonal molecular configuration was synthesized for photodynamic antibacterial therapy. The absorption and emission peaks of NDB photos...
Source: Journal of Innovative Optical Health Sciences - October 30, 2021 Category: Biomedical Science Authors: Dongliang Yang Liguo Sun Lei Xue Xiaorui Wang Yanling Hu Jinjun Shao Ling Fu Xiaochen Dong Source Type: research

Near-infrared spectroscopy as a promising tool in stroke: Current applications and future perspectives
Journal of Innovative Optical Health Sciences, Ahead of Print. Stroke is caused by an acute focal disruption of the vasculature in the central nervous system. Neurological-related functional deficits are the most devastating consequences for stroke survivors. Neural signals from stroke patients can reflect the functional statuses of patients and provide insights into the neuronal recovery mechanism for functioning, which could be used as the basis for designing optimal treatment strategies. Near-infrared spectroscopy (NIRS) is a low-cost, noninvasive, easily operated neuroimage method and it is compatible with various reha...
Source: Journal of Innovative Optical Health Sciences - October 25, 2021 Category: Biomedical Science Authors: Jinyan Sun Richong Pang Sisi Chen Hucheng Chen Yuanrong Xie Dandan Chen Kai Wu Jianbin Liang Kecheng Yan Zhifeng Hao Source Type: research

Research on the relationship between reduced scattering coefficient and intracranial pressure in brain edema model
Journal of Innovative Optical Health Sciences, Ahead of Print. Intracranial hypertension is a serious threat to the health of neurosurgical patients. At present, there is a lack of a safe and effective technology to monitor intracranial pressure (ICP) accurately and nondestructively. In this paper, based on near infrared technology, the continuous nondestructive monitoring of ICP change caused by brain edema was studied. The rat brain edema models were constructed by lipopolysaccharide. The ICP monitor and the self-made near infrared tissue parameter measuring instrument were used to monitor the invasive intracranial press...
Source: Journal of Innovative Optical Health Sciences - October 21, 2021 Category: Biomedical Science Authors: Shaobo Wang Yangyang Liu Yubing Liu Zhiyu Qian Zaoqin Chen Source Type: research

Polarimetry feature parameter deriving from Mueller matrix imaging and auto-diagnostic significance to distinguish HSIL and CSCC
We present results from 37 clinical patients with analysis regions of cervical squamous epithelium. The accuracy of PFP for recognizing HSIL and CSCC was 83.8% and 87.5%, respectively. This work demonstrates the ability of PFP to quantitatively characterize the cervical squamous epithelial lesions in the H&E pathological sections. Significance: Polarization detection technology provides an efficient method for digital pathological diagnosis and points out a new way for automatic screening of pathological sections. (Source: Journal of Innovative Optical Health Sciences)
Source: Journal of Innovative Optical Health Sciences - October 16, 2021 Category: Biomedical Science Authors: Anli Hou Xingjian Wang Yujuan Fan Wenbin Miao Yang Dong Xuewu Tian Jibin Zou Hui Ma Source Type: research

3-photon fluorescence and third-harmonic generation imaging of myelin sheaths in mouse digital skin in vivo: A comparative study
Journal of Innovative Optical Health Sciences, Ahead of Print. Myelin sheaths wrapping axons are key structures that help maintain the propagation speed of action potentials in both central and peripheral nervous systems (CNS and PNS). However, noninvasive, deep imaging technologies visualizing myelin sheaths in the digital skin in vivo are lacking in animal models. 3-photon fluorescence (3PF) imaging excited at the 1700-nm window enables deep imaging of myelin sheaths, but necessitates labeling by exogenous fluorescent dyes. Since myelin sheaths are lipid-rich structures which generate strong third-harmonic signals, in th...
Source: Journal of Innovative Optical Health Sciences - October 15, 2021 Category: Biomedical Science Authors: Ke Wang Yi Pan Xinlin Chen Shen Tong Huiping Liang Yuan Lu Ping Qiu Source Type: research

Meso-substituted cationic 3- and 4-N-Pyridylporphyrins and their Zn(II) derivatives for antibacterial photodynamic therapy
Journal of Innovative Optical Health Sciences, Ahead of Print. Photodynamic inactivation of microorganisms known as antibacterial photodynamic therapy (APDT) is one of the most promising and innovative approaches for the destruction of pathogenic microorganisms. Among the photosensitizers (PSs), compounds based on cationic porphyrins/metalloporphyrins are most successfully used to inactivate microorganisms. Series of meso-substituted cationic pyridylporphyrins and metalloporphyrins with various peripheral groups in the third and fourth positions of the pyrrole ring have been synthesized in Armenia. The aim of this work was...
Source: Journal of Innovative Optical Health Sciences - October 14, 2021 Category: Biomedical Science Authors: Aram G. Gyulkhandanyan Marina H. Paronyan Anna G. Gyulkhandanyan Karapet R. Ghazaryan Marina  V. Parkhats Boris M. Dzhagarov Maria V. Korchenova Ekaterina N. Lazareva Elena  S. Tuchina Grigor V. Gyulkhandanyan Valery V. Tuchin Source Type: research

Introduction to the Special Issue on Advances in Biophotonics and Biomedical Optics
Journal of Innovative Optical Health Sciences,Volume 14, Issue 05, September 2021. (Source: Journal of Innovative Optical Health Sciences)
Source: Journal of Innovative Optical Health Sciences - September 29, 2021 Category: Biomedical Science Authors: Polina Dyachenko Timoshina Tingting Yu Dan Zhu Valery V. Tuchin Source Type: research

High-resolution polarization-sensitive optical coherence tomography and optical coherence tomography angiography for zebrafish skin imaging
Journal of Innovative Optical Health Sciences, Ahead of Print. Zebrafish is an important animal model, which is used to study development, pathology, and genetic research. The zebrafish skin model is widely used in cutaneous research, and angiogenesis is critical for cutaneous wound healing. However, limited by the penetration depth, the available optical methods are difficult to describe the internal skin structure and the connection of blood vessels between the skin and subcutaneous tissue. By a homemade high-resolution polarization-sensitive optical coherence tomography (PS-OCT) system, we imaged the polarization contra...
Source: Journal of Innovative Optical Health Sciences - September 29, 2021 Category: Biomedical Science Authors: Di Yang Zhuoqun Yuan Zihan Yang Muyun Hu Yanmei Liang Source Type: research

Automated cone photoreceptor cell identification in confocal adaptive optics scanning laser ophthalmoscope images based on object detection
In this study, an object detection algorithm is used for cone cell identification in confocal adaptive optics scanning laser ophthalmoscope (AOSLO) images. An effectiveness evaluation of identification using the proposed method reveals precision, recall, and [math]-score of 95.8%, 96.5%, and 96.1%, respectively, considering manual identification as the ground truth. Various object detection and identification results from images with different cone photoreceptor cell distributions further demonstrate the performance of the proposed method. Overall, the proposed method can accurately identify cone photoreceptor cells on con...
Source: Journal of Innovative Optical Health Sciences - September 25, 2021 Category: Biomedical Science Authors: Yiwei Chen Yi He Jing Wang Wanyue Li Lina Xing Xin Zhang Guohua Shi Source Type: research