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Quantitative analysis of collagen morphology in breast cancer from millimeter scale using multiphoton microscopy
In this study, we used MPM for large-scale imaging of early invasive breast cancer from the tumor center to normal tissues far from the tumor. We found that there were significant differences in collagen morphology between breast cancer tumor boundary, near tumor transition region and normal tissues far from the tumor. Furthermore, the morphological feature of eight collagen fibers was extracted to quantify the variation trend of collagen in three regions. These results may provide a new perspective for the optimal negative margin width of breast-conserving surgery and the understanding of tumor metastasis. (Source: Journa...
Source: Journal of Innovative Optical Health Sciences - August 12, 2022 Category: Biomedical Science Authors: Yulan Liu Shunwu Xu Deyong Kang Xingxin Huang Shuoyu Xu Lianhuang Li Liqin Zheng Lida Qiu Zhenlin Zhan Xiahui Han Jianxin Chen Source Type: research

Multivariate analysis of serum surface-enhanced Raman spectroscopy of liver cancer patients
Journal of Innovative Optical Health Sciences, Ahead of Print. Early diagnosis of liver cancer plays a significant role in reducing its high mortality. In this preliminary study, the feasibility of using serum surface-enhanced Raman spectroscopy (SERS) to identify liver cancer was studied. Serum samples were obtained from liver cancer patients and healthy controls. The differences between the SERS spectra of pre-operation and post-operation of liver cancer patients were also analyzed. The general shape and trend of SERS spectra of health control and liver cancer patients were similar. Multivariate analysis, e.g., PLS-SVM, ...
Source: Journal of Innovative Optical Health Sciences - August 12, 2022 Category: Biomedical Science Authors: Qiwen Wang Sen Wang Shengdong Cui Deyuan Yang Zheng Huang Shusen Xie Source Type: research

Three-dimensional quantification of protoporphyrin IX in photodynamic therapy using SFDI/DFT: A pilot experimental validation
Journal of Innovative Optical Health Sciences, Ahead of Print. Photodynamic therapy (PDT) dosimetry, including light dose, photosensitizer dose and tissue oxygen, has been a research focus in PDT. In this work, we present a three-dimensional (3D) quantification of protoporphyrin IX (PpIX) using combined spatial frequency domain imaging (SFDI) and diffuse fluorescence tomography (DFT). The SFDI maps both the distributions of tissue absorption and scattering properties at three wavelengths an d accordingly provides the optical background for DFT and extracts the tissue oxygenation for assessing the therapeutic outcomes, wh...
Source: Journal of Innovative Optical Health Sciences - August 6, 2022 Category: Biomedical Science Authors: Mai Dan Weijie Song Meihui Liu Yaru Zhang Feng Gao Source Type: research

U-Net-based deep learning for tracking and quantitative analysis of intracellular vesicles in time-lapse microscopy images
Journal of Innovative Optical Health Sciences, Ahead of Print. Fluorescence microscopy has become an essential tool for biologists, to visualize the dynamics of intracellular structures with specific labeling. Quantitatively measuring the dynamics of moving objects inside the cell is pivotal for understanding of the underlying regulatory mechanism. Protein-containing vesicles are involved in various biological processes such as material transportation, organelle interaction, and hormonal regulation, whose dynamic characteristics are significant to disease diagnosis and drug screening. Although some algorithms have been dev...
Source: Journal of Innovative Optical Health Sciences - July 29, 2022 Category: Biomedical Science Authors: Zhichao Liu Heng Zhang Luhong Jin Jincheng Chen Alexander Nedzved Sergey Ablameyko Qing Ma Jiahui Yu Yingke Xu Source Type: research

Introduction to the special issue on enhanced photodynamic therapy
Journal of Innovative Optical Health Sciences, Ahead of Print. (Source: Journal of Innovative Optical Health Sciences)
Source: Journal of Innovative Optical Health Sciences - July 29, 2022 Category: Biomedical Science Authors: Buhong Li Lothar Lilge Source Type: research

Single-cell volumetric imaging with light field microscopy: Advances in systems and algorithms
Journal of Innovative Optical Health Sciences,Volume 16, Issue 02, March 2023. Single-cell volumetric imaging is essential for researching individual characteristics of cells. As a nonscanning imaging technique, light field microscopy (LFM) is a critical tool to achieve real-time three-dimensional imaging with the advantage of single-shot. To address the inherent limits including nonuniform resolution and block-wise artifacts, various modified LFM strategies have been developed to provide new insights into the structural and functional information of cells. This review will introduce the principle and development of LFM, d...
Source: Journal of Innovative Optical Health Sciences - July 23, 2022 Category: Biomedical Science Authors: Beibei Gao Lu Gao Fu Wang Source Type: research

Single-cell volumetric imaging with light field microscopy: Advances in systems and algorithms
Journal of Innovative Optical Health Sciences, Ahead of Print. Single-cell volumetric imaging is essential for researching individual characteristics of cells. As a nonscanning imaging technique, light field microscopy (LFM) is a critical tool to achieve real-time three-dimensional imaging with the advantage of single-shot. To address the inherent limits including nonuniform resolution and block-wise artifacts, various modified LFM strategies have been developed to provide new insights into the structural and functional information of cells. This review will introduce the principle and development of LFM, discuss the impro...
Source: Journal of Innovative Optical Health Sciences - July 23, 2022 Category: Biomedical Science Authors: Beibei Gao Lu Gao Fu Wang Source Type: research

Novel intense pulsed light-photodynamic therapy strategy in the treatment of facial actinic keratoses concomitant with rosacea
Journal of Innovative Optical Health Sciences, Ahead of Print. Rosacea presents as transient or persistent erythema, papules, pustules, flushing, and telangiectasia on the middle of the face, which has some clinical similarity with actinic keratosis (AK). These two conditions can coexist in the same patient. Dermoscopy and reflectance confocal microscopy (RCM) could be useful methods for diagnosis and monitoring treatment efficacy. Novel intense pulsed light-photodynamic therapy (IPL-PDT) may have better tolerance and curative effect than traditional red-light 5-aminolevulinic acid photodynamic therapy (ALA-PDT). Herein, w...
Source: Journal of Innovative Optical Health Sciences - July 18, 2022 Category: Biomedical Science Authors: Shuzhan Shen Yajing Cao Jiandan Li Xiaojing Liu Zhongxia Zhou Xiuli Wang Peiru Wang Source Type: research

A “donor–acceptor” structured semiconductor polymer for near infrared fluorescence imaging guided photodynamic therapy
Journal of Innovative Optical Health Sciences, Ahead of Print. Near infrared (NIR) fluorescence imaging guided photodynamic therapy (PDT) is a technique which has been developed in many clinical trials due to its advantage of real-time optical monitoring, specific spatiotemporal selectivity, and minimal invasiveness. For this, photosensitizers with NIR fluorescence emission and high 1O2 generation quantum yield are highly desirable. Herein, we designed and synthesized a “donor–acceptor” (D-A) structured semiconductor polymer (SP), which was then wrapped with an amphiphilic compound (Pluronic[math] F127) to prepare wa...
Source: Journal of Innovative Optical Health Sciences - July 14, 2022 Category: Biomedical Science Authors: Baoling Li Ting Xu Xiaosha Wang Shaojing Zhao Benhua Wang Lihui Jiang Xiangzhi Song Minhuan Lan Source Type: research

Implementation and uniformity calibration of LED array for photodynamic therapy
Journal of Innovative Optical Health Sciences, Ahead of Print. Irradiance uniformity is an important parameter for a Photodynamic Therapy (PDT) device. The calibration and verification of a LED array light source based on computer vision technology were implemented and carried out. First, the correlation coefficients between the pulse width modulate value and the irradiance were calibrated. Then, the correction of the actual light center and divergence angle were solved by image processing to reduce errors from each LED lens. Finally, uniformity was optimized according to the irradiance formula of the Lambertian source. Th...
Source: Journal of Innovative Optical Health Sciences - July 14, 2022 Category: Biomedical Science Authors: Xu Wang Jiyuan Xiong Xiaoming Hu Qin Li Source Type: research

Quantitative tracing of bioprobes by simultaneously monitoring radiative and nonradiative relaxations
Journal of Innovative Optical Health Sciences, Ahead of Print. Bioprobe based on fluorescence is widely used in biological and medical research due to its high sensitivity and selectivity. Yet, its quantification in vivo is complicated and often compromised by the interaction between the fluorophore with the environmental factors, as well as the optical scattering and absorption by the tissue. A high florescence quantum yield and minimal interference by the environment are key requirements for designing an effective bioprobe, and the pre-requisitions severely limit the available options. We propose that a comprehensive eva...
Source: Journal of Innovative Optical Health Sciences - June 10, 2022 Category: Biomedical Science Authors: Hongjiang Chen Xiaoyu Tang Guangshuai Nie Zhen Wang Jia Hu Jun Hu Huan Qin Source Type: research

Diagnosis of knee osteoarthritis by OCT and surface-enhanced Raman spectroscopy
Journal of Innovative Optical Health Sciences, Ahead of Print. In this paper, optical coherence tomography (OCT) and surface-enhanced Raman spectroscopy (SERS) were used to characterize normal knee joint (NKJ) tissue and knee osteoarthritis (KOA) tissue ex vivo. OCT images show that there is a clear hierarchical structure in NKJ tissue, including surface layer, transitional layer, radiation layer and cartilage matrix calcification layer tissue structure, while the hierarchical structure of KOA tissue is not clear and unevenly distributed, and the pathological tissues at different stages also show significant differences. S...
Source: Journal of Innovative Optical Health Sciences - June 9, 2022 Category: Biomedical Science Authors: Ran An Huaimin Gu Zhouyi Guo Huiqing Zhong Huajiang Wei Guoyong Wu Yonghong He Shusen Xie Hongqin Yang Source Type: research

Photokilling of waterborne-resistant pathogenic bacteria using cobalt-doped zinc oxide doped on reduced graphene oxide nanoparticles
This study is aimed at the chemical synthesis of light-activated cobalt-doped zinc oxide and its further doping on reduced graphene oxide (RGO) and assessment of its antibacterial activity on antibiotic-resistant waterborne pathogens including Enterococcus faecalis, Staphylococcus aureus, Klebsiella pneumonia, and Pseudomonas aeruginosa. The synthesized nanoparticles were characterized via UV –vis spectroscopy, scanning electron microscopy (SEM), and energy-dispersive X-ray spectroscopy (EDS). The minimal inhibitory concentration (MIC) of nanoparticles portrayed a significant killing of both Gram-positive and Gram-negati...
Source: Journal of Innovative Optical Health Sciences - June 9, 2022 Category: Biomedical Science Authors: Ameer Muhammad Khan Laiba Pervez Jonathan Celli Mutiullah Khattak Maqdad Ullah ZiaUllah Shah Muhammad Mustafa Khan Muhammad Nadeem Sulaiman Faisal Akhtar Nadhman Source Type: research