A “donor–acceptor” structured semiconductor polymer for near infrared fluorescence imaging guided photodynamic therapy

Journal of Innovative Optical Health Sciences, Ahead of Print. Near infrared (NIR) fluorescence imaging guided photodynamic therapy (PDT) is a technique which has been developed in many clinical trials due to its advantage of real-time optical monitoring, specific spatiotemporal selectivity, and minimal invasiveness. For this, photosensitizers with NIR fluorescence emission and high 1O2 generation quantum yield are highly desirable. Herein, we designed and synthesized a “donor–acceptor” (D-A) structured semiconductor polymer (SP), which was then wrapped with an amphiphilic compound (Pluronic[math] F127) to prepare water-soluble nanoparticles (F-SP NPs). The obtained F-SP NPs exhibit good water solubility, excellent particle size stability, strong absorbance a t deep red region, and strong NIR fluorescent emission characteristics. The maximal mass extinction coefficient and fluorescence quantum yield of these F-SPs were calculated to be 21.7 L/(g[math]cm) and 6.5%, respectively. Moreover, the 1O2 quantum yield of 89% for F-SP NPs has been achieved under 6 35 nm laser irradiation, which is higher than Methylene Blue, Ce6, and PpIX. The outstanding properties of these F-SP NPs originate from their unique D-A molecular characteristic. This work should help guide the design of novel semiconductor polymer for NIR fluorescent imaging guided PDT application s.
Source: Journal of Innovative Optical Health Sciences - Category: Biomedical Science Authors: Source Type: research