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Combination of multi-focus Raman spectroscopy and compressive sensing for parallel monitoring of single-cell dynamics
Journal of Innovative Optical Health Sciences, Ahead of Print. To overcome the low efficiency of conventional confocal Raman spectroscopy, many efforts have been devoted to parallelizing the Raman excitation and acquisition, in which the scattering from multiple foci is projected onto different locations on a spectrometer ’s CCD, along either its vertical, horizontal dimension, or even both. While the latter projection scheme relieves the limitation on the row numbers of the CCD, the spectra of multiple foci are recorded in one spectral channel, resulting in spectral overlapping. Here, we developed a method under a compr...
Source: Journal of Innovative Optical Health Sciences - September 24, 2021 Category: Biomedical Science Authors: Zhenzhen Li Xiujuan Zhang Chengui Xiao Da Chen Shushi Huang Pengfei Zhang Guiwen Wang Source Type: research

Numerical model for evaluating the speckle activity and characteristics of bone tissue under the biospeckle laser system
Journal of Innovative Optical Health Sciences, Ahead of Print. This paper discusses and studies the composition and characteristics of biospeckle on the surface of bone tissues. We used a laser speckle device to capture biospeckle patterns from fresh pig bone tissue. Traditional speckle activity metrics were used to measure the speckle activity of ex vivo bone tissue over time. Both Gaussian and Lorentzian correlation functions were used to characterize the ordered and disordered motion of the bone surface, together with volume scattering, to construct the model. Using the established mathematical model of the spatio-tempo...
Source: Journal of Innovative Optical Health Sciences - September 17, 2021 Category: Biomedical Science Authors: Xin Tang Ping Zhong Yinrui Gao Haowei Hu Source Type: research

Glycerol effects on optical, weight and geometrical properties of skin tissue
Journal of Innovative Optical Health Sciences, Ahead of Print. Complex study of glycerol effects on the skin tissue was performed. The change in optical, weight and geometrical parameters of the rat skin under the action of the glycerol solutions was studied ex vivo. Possible mechanisms of the skin optical clearing under the action of glycerol solutions of different concentrations were discussed. The results can be helpful for refinement of models developed to evaluate the effective diffusion coefficients of glycerol in tissues. (Source: Journal of Innovative Optical Health Sciences)
Source: Journal of Innovative Optical Health Sciences - September 15, 2021 Category: Biomedical Science Authors: Vadim D. Genin Elina A. Genina Valery V. Tuchin Alexey N. Bashkatov Source Type: research

In vivo imaging and tracking of exosomes for theranostics
Journal of Innovative Optical Health Sciences, Ahead of Print. Exosomes are lipid bilayer vesicles released by cells and serve as natural carriers for cell –cell communication. Exosomes provide a promising approach to the diagnosis and treatment of diseases and are considered as an alternative to cell therapy. However, one main restriction in their clinical application is that the current understanding of these vesicles, especially their in vivo beha viors and distributions, remains inadequate. Here, we reviewed the current and emerging methods for in vivo imaging and tracking of exosomes, including fluorescence imaging,...
Source: Journal of Innovative Optical Health Sciences - September 10, 2021 Category: Biomedical Science Authors: Ning Ma Changfeng Wu Zihui Meng Source Type: research

Forces of RBC interaction with single endothelial cells in stationary conditions: Measurements with laser tweezers
Journal of Innovative Optical Health Sciences, Ahead of Print. Red blood cells (RBCs) are able to interact and communicate with endothelial cells (ECs). Under some pathological or even normal conditions, the adhesion of RBCs to the endothelium can be observed. Presently, the mechanisms and many aspects of the interaction between RBCs and ECs are not fully understood. In this work, we considered the interaction of single RBCs with single ECs in vitro aiming to quantitatively determine the force of this interaction using laser tweezers. Measurements were performed under different concentrations of proaggregant macromolecules...
Source: Journal of Innovative Optical Health Sciences - September 3, 2021 Category: Biomedical Science Authors: Arseniy A. Kapkov Alexey N. Semenov Petr B. Ermolinskiy Andrei E. Lugovtsov Alexander V. Priezzhev Source Type: research

Varying of up-conversion nanoparticles luminescence from the muscle tissue depth during the compression
This study shows the possibility to use upconverting nanoparticles (UCNPs) both for studying the dynamics of the optical clearing of biological tissue under compression and to detect moments of cell wall damage under excessive pressure. The advantage of using UCNPs is the presence of several bands in their luminescence spectra, located both at close wavelengths and far apart. (Source: Journal of Innovative Optical Health Sciences)
Source: Journal of Innovative Optical Health Sciences - August 18, 2021 Category: Biomedical Science Authors: Marina Kozintseva Vyacheslav Kochubey Julia Konyukhova Valery Tuchin Source Type: research

Synthesis and characterization of reporter molecules embedded core-shell nanoparticles as SERS nanotags
Journal of Innovative Optical Health Sciences,Volume 14, Issue 04, July 2021. Surface-enhanced Raman scattering (SERS) spectroscopy is presented as a sensitive and specific molecular tool for clinical diagnosis and prognosis monitoring of various diseases including cancer. In order for clinical application of SERS technique, an ideal method of bulk synthesis of SERS nanoparticles is necessary to obtain sensitive, stable and highly reproducible Raman signals. In this contribution, we determined the ideal conditions for bulk synthesis of Raman reporter (Ra) molecules embedded silver-gold core-shell nanoparticles (Au@Ra@ AgNP...
Source: Journal of Innovative Optical Health Sciences - July 27, 2021 Category: Biomedical Science Authors: Chloe Duffield Nana Lyu Yuling Wang Source Type: research

The Application of Inorganic Optical Nanoprobes in Bacterial Infection
Journal of Innovative Optical Health Sciences, Ahead of Print. Bacterial infection is an acute infection caused by pathogens or conditional pathogens, which leads to severe disease and even death. It has become a significant reason for diseases and deaths worldwide. Therefore, rapid and precise detection, diagnosis, and treatment in the early stage are the key to deal with bacterial infections. Over recent years, along with the advances in biomaterials and nanotechnology, numerous nanomaterial-based multifunctional probes have been extensively explored in the biomedical field. Because of their excellent optical properties,...
Source: Journal of Innovative Optical Health Sciences - July 15, 2021 Category: Biomedical Science Authors: Linyu Ding Lai Jiang Gang Liu Source Type: research

Long-term changes in mandibular bone microchemical quality after radiation therapy and underlying systemic malignancy: A pilot study
Journal of Innovative Optical Health Sciences, Ahead of Print. Radiation therapy (RT) is a treatment option for head and neck cancer (HNC), but 2% of RT patients may experience damage to the jawbone, resulting in osteoradionecrosis (ORN). The ORN can manifest years after RT exposure. Changes in the local microchemical bone quality prior to the clinical manifestation of ORN could play a key role in ORN pathogenesis. Chemical bone quality can be analyzed using Fourier transform infrared spectroscopy (FTIR), that is applied to examine the effects of cancer, chemotherapy, and RT on the quality of human mandibular bone. Cortica...
Source: Journal of Innovative Optical Health Sciences - July 7, 2021 Category: Biomedical Science Authors: A. Palander H. Dekker M. Hyv ärinen L. Rieppo I. Lyijynen E. A. J. M. Schulten C. M. Ten Bruggenkate A. Koistinen A. Kullaa M. J. Turunen Source Type: research

A comparative study on machine learning-based classification to find photothrombotic lesion in histological rabbit brain images
In this study, we established machine learning-based algorithms to detect photothrombotic lesions in histological images of photothrombosis-induced rabbit brains. Six machine learning-based algorithms for binary classification were applied, and the accuracies were compared to classify normal tissues and photothrombotic lesions. The lesion classification model consisting of a 3-layered neural network with a rectified linear unit (ReLU) activation function, Xavier initialization, and Adam optimization using datasets with a unit size of [math] pixels yielded the highest accuracy (0.975). In the validation using the tested his...
Source: Journal of Innovative Optical Health Sciences - July 2, 2021 Category: Biomedical Science Authors: Sang Hee Jo Yoonhee Kim Yoon Bum Lee Sung Suk Oh Jong-ryul Choi Source Type: research

Design and validation of a handheld capnography device for cardiopulmonary assessment based on the Arduino platform
Journal of Innovative Optical Health Sciences, Ahead of Print. The design of a handheld capnography device is in great demand because of its effective and practical uses in all cardiac arrest resuscitations, according to the recommendation of the American Heart Association. Herein, a handheld capnography device that can be used in clinical settings and the home environment is reported. The proposed device was developed by using an infrared CO2 sensor, Arduino Mega2560, and a high-resolution display (2.8 ”). Furthermore, two rechargeable batteries (7.6[math]V, 0.99[math]A) and a secure digital card with a capacity of 16[m...
Source: Journal of Innovative Optical Health Sciences - June 28, 2021 Category: Biomedical Science Authors: Om Prakash Singh Ismail M. El-Badawy M. B. Malarvili Source Type: research

Tumor cell death visualization of renal cell carcinoma under the combined effect of the Gratiola officinalis extract and cyclophosphamide using fluorescent staining methods
Conclusion: Fl uorescence methods of investigation in the “alive and dead” test allowed us to visualize the forms of cell death of human kidney carcinoma A498 by combined exposure to the flavonoid-containing extract of Gratiola officinalis and cytostatic (cyclophosphamide) 24 h after exposure. We found that th e combination with a concentration ratio of the extract and cyclophosphamide of 3:1 has the greatest effectiveness due to stimulation of the cytostatic effect and cytotoxic effect. (Source: Journal of Innovative Optical Health Sciences)
Source: Journal of Innovative Optical Health Sciences - June 28, 2021 Category: Biomedical Science Authors: Artyom Mylnikov Nikita Navolokin Dmitry Mudrak Natalya Polukonova Alla Bucharskaya Galina Maslyakova Source Type: research

Introduction to the special issue on surface-enhanced Raman spectroscopy and functionalized plasmonic nanoparticles for biomedical applications
Journal of Innovative Optical Health Sciences, Ahead of Print. (Source: Journal of Innovative Optical Health Sciences)
Source: Journal of Innovative Optical Health Sciences - June 28, 2021 Category: Biomedical Science Authors: Jian Ye Haifeng Yang Nikolai Khlebtsov Source Type: research

Fusion of clathrin and caveolae endocytic vesicles revealed by line-switching dual-color STED microscopy
In this study, we proposed the line-switching scanning imaging mode for dual-color triplet-state relaxation (T-Rex) stimulated emission depletion (STED) super-resolution microscopy. With this line-switching mode, the cross-talk between the two channels, the side effects from pulse picker and image drift in frame scanning mode can be effectively eliminated. The dual-color super-resolution imaging results in mixed fluorescent beads validated the excellent performance. With this super-resolution microscope, not only the ring-shaped structure of clathrin and caveolae endocytic vesicles, but also their semi-fused structures und...
Source: Journal of Innovative Optical Health Sciences - June 23, 2021 Category: Biomedical Science Authors: Hefei Ruan Jianqiang Yu Yayun Wu Xiaojun Tang Jinghe Yuan Xiaohong Fang Source Type: research

Surface-enhanced raman spectroscopy of serum predicts sensitivity to docetaxel-based chemotherapy in patients with metastatic castration-resistant prostate cancer
This study aimed to establish models to predict sensitivity to docetaxel chemotherapy in patients with mCRPC by using serum surface-enhanced Raman spectroscopy (SERS). A total of 32 mCPRC patients who underwent docetaxel chemotherapy at our center from July 2016 to March 2018 were included in this study. Patients were dichotomized in prostate-specific antigen (PSA) response group ([math]) versus PSA failure group ([math]) according to the response to docetaxel. 64 matched spectra from 32 mCRPC patients were obtained by using SERS of serum at baseline ([math]0) and after 1 cycle of docetaxel chemotherapy ([math]1). Comparin...
Source: Journal of Innovative Optical Health Sciences - June 23, 2021 Category: Biomedical Science Authors: Jianian Hu Xiaoguang Shao Chenfei Chi Yinjie Zhu Zhixiang Xin Jianjun Sha Baijun Dong Jiahua Pan Wei Xue Source Type: research