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MACS-W: A modified optical clearing agent for imaging 3D cell cultures
Journal of Innovative Optical Health Sciences, Ahead of Print. Three-dimensional (3D) cell cultures have contributed to a variety of biological research fields by filling the gap between monolayers and animal models. The modern optical sectioning microscopic methods make it possible to probe the complexity of 3D cell cultures but are limited by the inherent opaqueness. While tissue optical clearing methods have emerged as powerful tools for investigating whole-mount tissues in 3D, they often have limitations, such as being too harsh for fragile 3D cell cultures, requiring complex handling protocols, or inducing tissue defo...
Source: Journal of Innovative Optical Health Sciences - July 12, 2023 Category: Biomedical Science Authors: Xiang Zhong Chao Gao Hui Li Yuening He Peng Fei Zaozao Chen Zhongze Gu Dan Zhu Tingting Yu Source Type: research

Optical manipulation of neuronal mitochondria using scanning optical tweezers
Journal of Innovative Optical Health Sciences, Ahead of Print. Mitochondria play a crucial role in the physiological functions and energy metabolism of neurons, which can help in the understanding of complex biochemical reactions associated with various neurodegenerative diseases. Neurons, being highly differentiated terminal cells, require a greater number of mitochondria than ordinary cells to generate significant amounts of ATP, which is necessary for the growth of differentiated neuronal structures like axons and dendrites and the transmission of electrical signals along neuronal axons. Advancements in imaging technolo...
Source: Journal of Innovative Optical Health Sciences - June 30, 2023 Category: Biomedical Science Authors: Zhiyong Gong Tianli Wu Xixi Chen Ping Wang Jinghui Guo Yuchao Li Baojun Li Source Type: research

A simple Bessel module with tunable focal depth and constant resolution for commercial two-photon microscope
Journal of Innovative Optical Health Sciences, Ahead of Print. The volumetric imaging of two-photon microscopy expands the focal depth and improves the throughput, which has unparalleled superiority for three-dimension samples, especially in neuroscience. However, emerging in volumetric imaging is still largely customized, which limits the integration with commercial two-photon systems. Here, we analyzed the key parameters that modulate the focal depth and lateral resolution of polarized annular imaging and proposed a volumetric imaging module that can be directly integrated into commercial two-photon systems using convent...
Source: Journal of Innovative Optical Health Sciences - June 30, 2023 Category: Biomedical Science Authors: Ting Mo Yiran Liu Fatao Bie Zimin Dai Jin Chang Hui Gong Wei Zhou Source Type: research

Intravascular photoacoustic and optical coherence tomography imaging dual-mode system for detecting spontaneous coronary artery dissection: A feasibility study
Journal of Innovative Optical Health Sciences, Ahead of Print. In this work, we present an intravascular dual-mode endoscopic system capable of both intravascular photoacoustic imaging (IVPAI) and intravascular optical coherence tomography (IVOCT) for recognizing spontaneous coronary artery dissection (SCAD) phantoms. IVPAI provides high-resolution and high-penetration images of intramural hematoma (IMH) at different depths, so it is especially useful for imaging deep blood clots associated with imaging phantoms. IVOCT can readily visualize the double-lumen morphology of blood vessel walls to identify intimal tears. We als...
Source: Journal of Innovative Optical Health Sciences - June 28, 2023 Category: Biomedical Science Authors: Yongwei Wang Yuyang Wan Zhongjiang Chen Source Type: research

Deep neural network based on multi-level wavelet and attention for structured illumination microscopy
In this study, we propose a deep neural network based on multi-level wavelet and attention mechanism (MWAM) for SIM. Our results show that the MWAM network can extract high-frequency information contained in SIM raw images and accurately integrate it into the output image, resulting in superior SR images compared to those generated using wide-field images as input data. We also demonstrate that the number of SIM raw images can be reduced t o three, with one image in each illumination orientation, to achieve the optimal tradeoff between temporal and spatial resolution. Furthermore, our MWAM network exhibits superior reconst...
Source: Journal of Innovative Optical Health Sciences - June 28, 2023 Category: Biomedical Science Authors: Yanwei Zhang Song Lang Xuan Cao Hanqing Zheng Yan Gong Source Type: research

Motor network reorganization in stroke patients with dyskinesias during a shoulder-touching task: A fNIRS study
This study aimed to explore the brain activation and network reorganization of the motor cortex (MC) with functional near-infrared spectroscopy (fNIRS). T he MC hemodynamic signals were gained from 22 stroke patients and 14 healthy subjects during a shoulder-touching task with the right hand. The MC activation pattern and network attributes analyzed with the graph theory were compared between the two groups. The results revealed that healthy controls presented dominant activation in the left MC while stroke patients exhibited dominant activation in the bilateral hemispheres MC. The MC networks for the two groups had small-...
Source: Journal of Innovative Optical Health Sciences - June 19, 2023 Category: Biomedical Science Authors: Yizheng Zhang Dan Wang Dongyang Wang Kecheng Yan Li Yi Shuoshu Lin Guangjian Shao Zhiyong Shao Jinyan Sun Aoran Yang Source Type: research

Introduction to the special issue on multiphoton imaging and quantitative characterization
Journal of Innovative Optical Health Sciences,Volume 16, Issue 04, July 2023. (Source: Journal of Innovative Optical Health Sciences)
Source: Journal of Innovative Optical Health Sciences - June 17, 2023 Category: Biomedical Science Authors: Zhihua Ding Zhiyi Liu Source Type: research

Editorial: Introduction to the special issue on multiphoton imaging and quantitative characterization
Journal of Innovative Optical Health Sciences, Ahead of Print. (Source: Journal of Innovative Optical Health Sciences)
Source: Journal of Innovative Optical Health Sciences - June 17, 2023 Category: Biomedical Science Authors: Zhihua Ding Zhiyi Liu Source Type: research

Artificial neural network-based determination of denoised optical properties in double integrating spheres measurement
In this study, we propose an artificial neural network (ANN) to estimate [math] and [math] at a target wavelength from the R and T spectra measured via the DIS to reduce noise in the optical properties. Approximate models of the optical properties and Monte Carlo calculations that simulated the DIS measurements were used to generate spectral datasets comprising [math], [math], R and T. Measurement noise signals were added to R and T, and the ANN model was then trained using the noise-added datasets. Numerical results showed that the trained ANN model reduced the effects of noise in [math] and [math] estimation. Experimenta...
Source: Journal of Innovative Optical Health Sciences - June 14, 2023 Category: Biomedical Science Authors: Yusaku Takai Takahiro Nishimura Yu Shimojo Kunio Awazu Source Type: research

Laser speckle contrast imaging to predict the effect of temporary spinal cord stimulation in postherpetic neuralgia patients: A prospective observational study
Journal of Innovative Optical Health Sciences, Ahead of Print. Temporary spinal cord stimulation (tSCS) can effectively reduce the pain and severity of postherpetic neuralgia (PHN). However, there are no effective and objective methods for predicting the effects of tSCS on PHN. Laser speckle contrast imaging (LSCI) is frequently used in neurology to evaluate the effectiveness of treatment. To assess the accuracy of LSCI in predicting the impact of tSCS on PHN, 14 adult patients receiving tSCS treatments for spinal nerve-innervated (C6-T2) PHN participated in this observational study. Visual analog scale (VAS) assessments a...
Source: Journal of Innovative Optical Health Sciences - June 10, 2023 Category: Biomedical Science Authors: Xiang Huang Dacheng Tang Pan Chen Lumiao Chen Xiaohong Li Xiaoping Wang Source Type: research

Development of water-soluble AIE-based wash-free A[math] probes superior to commercial ThT
Journal of Innovative Optical Health Sciences, Ahead of Print. Alzheimer ’s disease (AD) is a typical neurodegenerative disease. [math]-amyloid (A[math] plaque is the most prominent pathological biomarker associated with the progression of AD. Conventional A[math] probes, including commercial probe ThT, usually suffer from tedious washing procedures. Herein, novel AIE- active A[math] probes with excellent water solubility, named DE-V1-PYC3 and DE-V1-PYOH, were developed for the detection and image of A[math] without tedious washing procedures. Compared with commercial probe ThT, the AIE-active A[math] probes exhibited be...
Source: Journal of Innovative Optical Health Sciences - June 10, 2023 Category: Biomedical Science Authors: Ting-Ting Hou Ying-Hao Tang Zhen-Yu Zhang Ze-Jun Li Ya-Long Wang Source Type: research

Erratum: Laser speckle contrast imaging for monitoring of acute pancreatitis at ischemia –reperfusion injury of the pancreas in rats
Journal of Innovative Optical Health Sciences, Ahead of Print. (Source: Journal of Innovative Optical Health Sciences)
Source: Journal of Innovative Optical Health Sciences - May 31, 2023 Category: Biomedical Science Authors: P. A. Dyachenko A. N. Bashkatov D. A. Alexandrov V. I. Kochubey V.  V. Tuchin Source Type: research

In vivo label-free measurement of blood flow velocity symmetry based on dual line scanning third-harmonic generation microscopy excited at the 1700 nm window
Journal of Innovative Optical Health Sciences, Ahead of Print. Measurement of blood flow velocity is key to understanding physiology and pathology in vivo. While most measurements are performed at the middle of the blood vessel, little research has been done on characterizing the instantaneous blood flow velocity distribution. This is mainly due to the lack of measurement technology with high spatial and temporal resolution. Here, we tackle this problem with our recently developed dual-wavelength line-scan third-harmonic generation (THG) imaging technology. Simultaneous acquisition of dual-wavelength THG line-scanning sign...
Source: Journal of Innovative Optical Health Sciences - May 20, 2023 Category: Biomedical Science Authors: Hui Cheng Jincheng Zhong Ping Qiu Ke Wang Source Type: research

Laser spectroscopy imaging technique coupled with nanomaterials for cancer diagnosis: A review
Journal of Innovative Optical Health Sciences, Ahead of Print. Laser spectroscopic imaging techniques have received tremendous attention in the field of cancer diagnosis due to their high sensitivity, high temporal resolution, and short acquisition time. However, the limited tissue penetration of the laser is still a challenge for the in vivo diagnosis of deep-seated lesions. Nanomaterials have been universally integrated with spectroscopic imaging techniques for deeper cancer diagnosis in vivo. The components, morphology, and sizes of nanomaterials are delicately designed, which could realize cancer diagnosis in vivo or i...
Source: Journal of Innovative Optical Health Sciences - May 19, 2023 Category: Biomedical Science Authors: Zhengying Peng Pengkun Yin Dan Li Youyuan Chen Kaiqiang Shu Qingwen Fan Yixiang Duan Qingyu Lin Source Type: research

Comparison of point detection and area detection for point-scanning structured illumination microscopy
In this study, we compared laser point scanning point detection (PS-PD) and point scanning area detection (PS-AD) imaging in nonconfocal microscopy through theoretical analysis and simulated imaging. The results revealed that the imaging resolutions of PS-PD and PS-AD depend on excitation and emission point spread functions (PSFs), respectively. Especially, we combined the second harmonic generation (SHG) of point detection (P-SHG) and area detection (A-SHG) with SIM to realize a nonlinear SIM-imaging technique that improves the imaging resolution. Moreover, we analytically and experimentally compared the nonlinear SIM per...
Source: Journal of Innovative Optical Health Sciences - May 15, 2023 Category: Biomedical Science Authors: Wenshuai Wu Jiajie Chen Meiting Wang Lei Wang Xiaomin Zheng Jia Li Junle Qu Bruce Zhi Gao Yonghong Shao Source Type: research