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Monitoring of time-resolved singlet oxygen luminescence at 1270[math]nm by an optical fiber detection system
In this study, a set of highly sensitive optical fiber detection system is built up to detect the luminescence of photosensitized 1O2. We use this system to test the luminescence characteristics of 1O2 in pig skin tissue ex vivo and mouse auricle skin in vivo. The experimental results show that the designed system can quantitatively detect photosensitized 1O2 luminescence. The 1O2 luminescence signal at 1270[math]nm is successfully detected in pig skin ex vivo. Compared with RB in an aqueous solution, the lifetime of 1O2 increases to [math]s in pig skin tissue ex vivo. Experiments on living mice suggest that an enhancement...
Source: Journal of Innovative Optical Health Sciences - September 28, 2022 Category: Biomedical Science Authors: Cheng Zhang Hongxin Lin Ying Hu Jian Sui Lisheng Lin Buhong Li Source Type: research

Ultrasmall pH-responsive silicon phthalocyanine micelle for selective photodynamic therapy against tumor
Journal of Innovative Optical Health Sciences,Volume 15, Issue 06, November 2022. Targeted photodynamic therapy (TPDT) based on the photosensitizers responsive for tumor microenvironment is promising because of the better anti-tumor effect and less phototoxicity against normal tissue than the traditional PDT. Nanoparticle-based stimuli-responsive photosensitizers have been widely explored for TPDT. Based on the acidic microenvironments in solid tumors, an ultrasmall pH-responsive silicon phthalocyanine nanomicelle (PSN) (smaller than 10[math]nm) was designed for selective PDT of tumor. PSN had high drug loading efficacy (m...
Source: Journal of Innovative Optical Health Sciences - September 27, 2022 Category: Biomedical Science Authors: Yiming Zhou Wenlong Zeng Mengxuan Wang Rui Li Xiuli Yue Zhifei Dai Source Type: research

Determination of breath isoprene in 109 suspected lung cancer patients using cavity ringdown spectroscopy
Conclusion: This study demonstrates that the CRDS breath isoprene analysis system can effectively analyze a large sample of human breath isoprene, and preliminarily confirms the use of breath isoprene as a biomarker for lung diseases. (Source: Journal of Innovative Optical Health Sciences)
Source: Journal of Innovative Optical Health Sciences - September 23, 2022 Category: Biomedical Science Authors: Xin Wei Qingyuan Li Yinghua Wu Jing Li Guangkuo Zhang Meixiu Sun Yingxin Li Source Type: research

A novel BODIPY-based nano-photosensitizer with aggregation-induced emission for cancer photodynamic therapy
Journal of Innovative Optical Health Sciences, Ahead of Print. The discovery of aggregation-induced emission (AIE) effect provides opportunities for the rapid development of fluorescence imaging-guided photodynamic therapy (PDT). In this work, a boron dipyrromethene (BODIPY)-based photosensitizer (ET-BDP-O) with AIE characteristics was developed, in which the two linear arms of BODIPY group were linked with triphenylamine to form an electron Donor –Acceptor–Donor (D–A–D) architecture while side chain was equipped with triethylene glycol group. ET-BDP-O was able to directly self-assemble into nanoparticles (NPs) wit...
Source: Journal of Innovative Optical Health Sciences - September 15, 2022 Category: Biomedical Science Authors: Yuting Zhang Guojing Li Jiong Li Ming Wu Xiaolong Liu Jingfeng Liu Source Type: research

Photoinactivation of Escherichia coli using five photosensitizers and the same number of photons
Journal of Innovative Optical Health Sciences, Ahead of Print. Bacterial resistance is today a matter of great medical concern, so it is urgent to investigate alternatives to alleviate it. Photodynamic inactivation (PDI) is a method that has been endorsed to inactivate different pathogens, including bacteria, fungi and viruses. PDI is achieved by using a photosensitizer (PS) molecule which generates reactive oxygen species under visible or UV radiation. We use visible light and UV-A radiation to excite four commercial PSs (methylene blue, rose bengal, riboflavin and curcumin), and nanoparticles synthesized in our laborator...
Source: Journal of Innovative Optical Health Sciences - September 14, 2022 Category: Biomedical Science Authors: Daniel Ortega-Zambrano Denisse Fuentes-L ópez Hilda Mercado-Uribe Source Type: research

LGNet: Local and global representation learning for fast biomedical image segmentation
Journal of Innovative Optical Health Sciences, Ahead of Print. Medical image segmentation plays a crucial role in clinical diagnosis and therapy systems, yet still faces many challenges. Building on convolutional neural networks (CNNs), medical image segmentation has achieved tremendous progress. However, owing to the locality of convolution operations, CNNs have the inherent limitation in learning global context. To address the limitation in building global context relationship from CNNs, we propose LGNet, a semantic segmentation network aiming to learn local and global features for fast and accurate medical image segment...
Source: Journal of Innovative Optical Health Sciences - September 13, 2022 Category: Biomedical Science Authors: Guoping Xu Xuan Zhang Wentao Liao Shangbin Chen Xinglong Wu Source Type: research

A smartphone-based automated fluorescence analysis system for point-of-care testing of Hg(II)
Journal of Innovative Optical Health Sciences, Ahead of Print. This work demonstrates a smartphone-based automated fluorescence analysis system (SAFAS) for point-of-care testing (POCT) of Hg(II). This system consists of three modules. The smartphone module is used to provide an excitation light source, and to collect and analyze fluorescent images. The dark box module is applied to integrate the desired optical elements and offers a dark environment. The cost of the integrated dark box mainly includes the upper cover, box body, lower bottom, fixture and some optical elements which is about $109. The chip module is used for...
Source: Journal of Innovative Optical Health Sciences - September 13, 2022 Category: Biomedical Science Authors: Yafei Chen Ke Zhang Yuan Liu Chunsun Zhang Source Type: research

H2O2-sensitive nanoscale coordination polymers for photoacoustic tumors imaging via in vivo chromogenic assay
In this study, a new type of hydrogen peroxide (H2O[math]-activated photoacoustic nanoprobe [Mn-AH nanoscale coordination polymer nanodots (NCPs)] was successfully synthesized by a simple one-step method in water phase containing 2,2[math]-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), horse radish peroxidase (HRP), and manganese ion (Mn[math]. After modification by polyethylene glycol (PEG), Mn-AH NCPs exhibited excellent stability and biocompatibility for in vivo H2O2-responsive chromogenic assay with great specificity and sensitivity. In the presence of H2O2, colorless ABTS would be converted by HRP into the ...
Source: Journal of Innovative Optical Health Sciences - September 7, 2022 Category: Biomedical Science Authors: Jiayue Zhao Fei Gong Nailin Yang Huali Lei Zhihui Han Yuqi Yang Liang Cheng Source Type: research

The sparse array elements selection in sparse imaging of circular-array photoacoustic tomography
Journal of Innovative Optical Health Sciences, Ahead of Print. Photoacoustic imaging (PAI) has been developed, and photoacoustic computed tomography (PACT) is widely used for in vivo tissue and mouse imaging. Simulated annealing (SA) algorithm solves optimization problems, and compressed sensing (CS) recovers sparse signals from undersampled measurements. We aim to develop an advanced sparse imaging framework for PACT, which invloves the use of SA to find an optimal sparse array element distribution and CS to perform sparse imaging. PACT reconstructions were performed using a dummy and porcine liver phantoms. Compared to t...
Source: Journal of Innovative Optical Health Sciences - August 31, 2022 Category: Biomedical Science Authors: Zezheng Qin Yang Liu Junke Chi Yiming Ma Mingjian Sun Source Type: research

Automated apoptosis identification in fluorescence imaging of nucleus based on histogram of oriented gradients of high-frequency wavelet coefficients
Journal of Innovative Optical Health Sciences,Volume 16, Issue 02, March 2023. The automatic and accurate identification of apoptosis facilitates large-scale cell analysis. Most identification approaches using nucleus fluorescence imaging are based on specific morphological parameters. However, these parameters cannot completely describe nuclear morphology, thus limiting the identification accuracy of models. This paper proposes a new feature extraction method to improve the performance of the model for apoptosis identification. The proposed method uses a histogram of oriented gradient (HOG) of high-frequency wavelet coeff...
Source: Journal of Innovative Optical Health Sciences - August 30, 2022 Category: Biomedical Science Authors: Shutong Liu Limei Su Han Sun Tongsheng Chen Min Hu Zhengfei Zhuang Source Type: research

Automated apoptosis identification in fluorescence imaging of nucleus based on histogram of oriented gradients of high-frequency wavelet coefficients
Journal of Innovative Optical Health Sciences, Ahead of Print. The automatic and accurate identification of apoptosis facilitates large-scale cell analysis. Most identification approaches using nucleus fluorescence imaging are based on specific morphological parameters. However, these parameters cannot completely describe nuclear morphology, thus limiting the identification accuracy of models. This paper proposes a new feature extraction method to improve the performance of the model for apoptosis identification. The proposed method uses a histogram of oriented gradient (HOG) of high-frequency wavelet coefficients to extra...
Source: Journal of Innovative Optical Health Sciences - August 30, 2022 Category: Biomedical Science Authors: Shutong Liu Limei Su Han Sun Tongsheng Chen Min Hu Zhengfei Zhuang Source Type: research

Single-cell analysis reveals microbial spore responses to microwave radiation
Journal of Innovative Optical Health Sciences,Volume 16, Issue 02, March 2023. To determine the effects of microwave radiation at the molecular level as well as on the germination, growth and morphology of dry spores at the single-cell level. Dry Bacillus aryabhattai MCCC 1K02966 spores were microwave-treated at different powers and characterized using single-cell optical technology. As determined by laser tweezers Raman spectroscopy, the Ca[math]-dipicolinic acid content increased and nucleic acid denaturation occurred in response to microwave treatment. Live-cell microscopy revealed that the germination and growth rates ...
Source: Journal of Innovative Optical Health Sciences - August 20, 2022 Category: Biomedical Science Authors: Siyi Qiu Haihua Fan Lin He Source Type: research

Single-cell analysis reveals microbial spore responses to microwave radiation
Journal of Innovative Optical Health Sciences, Ahead of Print. To determine the effects of microwave radiation at the molecular level as well as on the germination, growth and morphology of dry spores at the single-cell level. Dry Bacillus aryabhattai MCCC 1K02966 spores were microwave-treated at different powers and characterized using single-cell optical technology. As determined by laser tweezers Raman spectroscopy, the Ca[math]-dipicolinic acid content increased and nucleic acid denaturation occurred in response to microwave treatment. Live-cell microscopy revealed that the germination and growth rates decreased as the...
Source: Journal of Innovative Optical Health Sciences - August 20, 2022 Category: Biomedical Science Authors: Siyi Qiu Haihua Fan Lin He Source Type: research

Photoswitchable semiconducting polymer dots with photosensitizer molecule and photochromic molecule loading for photodynamic cancer therapy
Journal of Innovative Optical Health Sciences, Ahead of Print. Photodynamic therapy (PDT) is a new and rapidly developing treatment modality for clinical cancer therapy. Semiconductor polymer dots (Pdots) doped with photosensitizers have been successfully applied to PDT, and have made progress in the field of tumor therapy. However, the problems of severe photosensitivity and limited tissue penetration depth are needed to be solved during the implementation process of PDT. Here we developed the Pdots doped with photosensitizer molecule Chlorin e6 (Ce6) and photochromic molecule 1,2-bis(2,4-dimethyl-5-phenyl-3-thiophene)-3,...
Source: Journal of Innovative Optical Health Sciences - August 13, 2022 Category: Biomedical Science Authors: Lu Guo Bo Xu Haobin Chen Ying Tang Source Type: research