Journal of Innovative Optical Health Sciences This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

SERS devices with “hedgehog-like” nanosphere arrays for detection of trace pesticides
Journal of Innovative Optical Health Sciences, Ahead of Print. The development of surface-enhanced Raman scattering (SERS) devices for detection of trace pesticides has attracted more and more attention. In this work, a large-area self-assembly approach assisted with reactive ion etching (RIE) is proposed for preparing SERS devices consisting of Ag-covered “hedgehog-like” nanosphere arrays (Ag/HLNAs). Such a SERS device has an enhancement factor of [math], a limit of detection (LOD) up to 10[math][math]M for Rhodamine 6G (R6G) analytes, and a relative standard deviation (RSD) smaller than 10%, demonstrating high unifor...
Source: Journal of Innovative Optical Health Sciences - June 23, 2021 Category: Biomedical Science Authors: Yang Liu Xin Li Jie Cheng Na Zhou Lingqian Zhang Haiyang Mao Chengjun Huang Source Type: research

Plasmonic nanoparticles and nucleic acids hybrids for targeted gene delivery, bioimaging, and molecular recognition
Journal of Innovative Optical Health Sciences, Ahead of Print. Promising biomedical applications of hybrid materials composed of gold nanoparticles and nucleic acids have attracted strong interest from the nanobiotechnological community. The particular interest is owing to the robust and easy-to-make synthetic approaches, to the versatile optical and catalytic properties of gold nanoparticles combined with the molecular recognition and programmable properties of nucleic acids. The significant progress is made in the development of DNA –gold nanostructures and their applications, such as molecular recognition, cell and ti...
Source: Journal of Innovative Optical Health Sciences - June 23, 2021 Category: Biomedical Science Authors: Timofey Pylaev Elena Avdeeva Nikolai Khlebtsov Source Type: research

Assessment of cerebral oxygenation response to hemodialysis using near-infrared spectroscopy (NIRS): Challenges and solutions
In this study, we present novel techniques to address the challenges of using NIRS to monitor ambulatory patients with kidney disease during approximately eight hours of hemodialysis (HD) treatment. People with end-stage kidney disease who require HD are at higher risk for cognitive impairment and dementia than age-matched controls. Recent studies have suggested that HD-related declines in cerebral blood flow might explain some of the adverse outcomes of HD treatment. However, there are currently no established paradigms for monitoring cerebral perfusion in real-time during HD treatment. In this study, we used NIRS to asse...
Source: Journal of Innovative Optical Health Sciences - June 17, 2021 Category: Biomedical Science Authors: Ardy Wong Lucy Robinson Seena Soroush Aditi Suresh Dia Yang Kelechi Madu Meera N. Harhay Kambiz Pourrezaei Source Type: research

Ex-vivo confocal Raman microspectroscopy of porcine skin with 633/785-NM laser excitation and optical clearing with glycerol/water/DMSO solution
Journal of Innovative Optical Health Sciences, Ahead of Print. Confocal Raman microspectroscopy (CRM) with 633- and 785-nm excitation wavelengths combined with optical clearing (OC) technique was used for ex-vivo study of porcine skin in the Raman fingerprint region. The optical clearing has been performed on the skin samples by applying a mixture of glycerol and distilled water and a mixture of glycerol, distilled water and chemical penetration enhancer dimethyl sulfoxide (DMSO) during 30[math]min and 60[math]min of treatment. It was shown that the combined use of the optical clearing technique and CRM at 633[math]nm allo...
Source: Journal of Innovative Optical Health Sciences - May 31, 2021 Category: Biomedical Science Authors: Ali Jaafar Malik H. Mahmood Roman Holomb L ászló Himics Tam ás Váczi Anton Y. Sdobnov Valery V. Tuchin Mikl ós Veres Source Type: research

Availability and safety assessment of infrared neural stimulation at high repetition rate through an implantable optrode
Journal of Innovative Optical Health Sciences,Volume 14, Issue 03, May 2021. An implantable optrode with micro-thermal detectors was designed to investigate the availability and safety of INS using high repetition rates. Optical auditory brainstem responses (oABRs) were recorded in normal-hearing guinea pigs, and the energy thresholds, pulse durations, and amplitudes evoked by the varied stimulus repetitions were analyzed. Stable oABRs could be evoked through INS even as the repetition rate of stimulation reached 19[math]kHz. The energy threshold of oABRs was elevated, the amplitudes decreased as pulse durations increased ...
Source: Journal of Innovative Optical Health Sciences - May 17, 2021 Category: Biomedical Science Authors: Yaqin Wan Meiqun Wang Shaorong Zhang Bingbin Xie Source Type: research

Nonlinear scanning structured illumination microscopy based on nonsinusoidal modulation
Journal of Innovative Optical Health Sciences, Ahead of Print. Structured illumination microscopy (SIM) is an essential super-resolution microscopy technique that enhances resolution. Several images are required to reconstruct a super-resolution image. However, linear SIM resolution enhancement can only increase the spatial resolution of microscopy by a factor of two at most because the frequency of the structured illumination pattern is limited by the cutoff frequency of the excitation point spread function. The frequency of the pattern generated by the nonlinear response in samples is not limited; therefore, nonlinear SI...
Source: Journal of Innovative Optical Health Sciences - May 11, 2021 Category: Biomedical Science Authors: Meiting Wang Lei Wang Xiaomin Zheng Jie Zhou Jiajie Chen Youjun Zeng Junle Qu Yonghong Shao Bruce Zhi Gao Source Type: research

Cytochrome-c aptamer functionalized Pt nanoclusters for enhanced chemodynamic therapy
Journal of Innovative Optical Health Sciences, Ahead of Print. Catalysis-based chemodynamic therapy (CDT) is an emerging cancer treatment strategy which uses a Fenton-like reaction to kill tumor cells by catalyzing endogenous hydrogen peroxide (H2O[math] into a toxic hydroxyl radical ([math]OH). The performance of CDT is greatly dependent on PDT agent. Herein, mitochondria-targeting Pt nanoclusters were synthesized using cytochrome c aptamer (CytcApt) as template. The obtained CytcApt-PtNCs can produce [math]OH by H2O2 under the acidic conditions. Moreover, CytcApt-PtNCs could kill 4T1 tumor cells in a pH-dependent manner,...
Source: Journal of Innovative Optical Health Sciences - May 6, 2021 Category: Biomedical Science Authors: Bo Feng Dan Zhao Yaowei Peng Fu Wang Source Type: research

Construction of Au@Metal-organic framework for sensitive determination of creatinine in urine
Journal of Innovative Optical Health Sciences, Ahead of Print. Creatinine level in urine is an important biomarker for renal function diseases, such as renal failure, glomerulonephritis, and chronic nephritis. The Au@MIL-101(Fe) was prepared by in situ growth of Au nanoparticles in MIL-101(Fe) as a selective SERS substrate. The Au@MIL-101(Fe) offers the great local surface plasmon resonance (SPR) effect due to gold nanoparticles aggregation inside metal-organic frameworks. The framework structure could enrich trace target samples and drag them into SPR hot spots. The optimal Au@MIL-101(Fe) composite substrate is used for a...
Source: Journal of Innovative Optical Health Sciences - May 6, 2021 Category: Biomedical Science Authors: Yuning Jiang Yanzheng Cai Sen Hu Xiaoyu Guo Ye Ying Ying Wen Yiping Wu Haifeng Yang Source Type: research

In vivo evaluation of laser-induced choroidal neovascularization in rats simultaneously using optical coherence tomography and photoacoustic microscopy
Journal of Innovative Optical Health Sciences, Ahead of Print. Determination of the precise location and the degree of the Choroidal neovascularization (CNV) lesion is essential for diagnosation Neovascular age-related macular degeneration (AMD) and evaluation the efficacy of treatment. Noninvasive imaging techniques with specific contrast for CNV evaluation are demanded. In this paper, two noninvasive imaging techniques, namely Optical coherence tomography (OCT) and Photoacoustic microscopy (PAM), are combined to provide specific detection of CNV for their complimentary contrast mechanisms. In vivo time-serial evaluation ...
Source: Journal of Innovative Optical Health Sciences - May 6, 2021 Category: Biomedical Science Authors: Fengxian Du Lei Gao Lin Li Qian Li Fenghua Wang Chuanqing Zhou Cuixia Dai Source Type: research

A novel indocyanine green-based fluorescent marker for guiding surgical tumor resection
Journal of Innovative Optical Health Sciences, Ahead of Print. Surgical tumor resection is a common approach to cancer treatment. India Ink tattoos are widely used to aid tumor resection by localizing and mapping the tumor edge at the surface. However, India Ink tattoos are easily obscured during electrosurgical resection, and fade in intensity over time. In this work, a novel near-infrared (NIR) fluorescent marker is introduced as an alternative. The NIR marker was made by mixing indocyanine green (ICG), biocompatible cyanoacrylate, and acetone. The marking strategy was evaluated in a chronic ex vivo feasibility study usi...
Source: Journal of Innovative Optical Health Sciences - April 23, 2021 Category: Biomedical Science Authors: Jiawei Ge Justin D. Opfermann Hamed Saeidi Katherine A. Huenerberg Christopher D. Badger Jaepyeong Cha Martin J. Schnermann Arjun S. Joshi Axel Krieger Source Type: research

A pilot study of the dynamics of tissue oxygenation in vivo using time-resolved phosphorescence imaging
Journal of Innovative Optical Health Sciences, Ahead of Print. Oxygenation of tissues plays an important role in the development and progression of tumor to treatment effects. Method of metalloporphyrines phosphorescence quenching by oxygen is one of the ways to measure dynamics of the oxygen concentration in the tissues by phosphorescence lifetime imaging of meso-tetra(sulfopheny1)tetrabenzoporphyrin Pd (II) (TBP) using the time-correlated single photon counting (TCSPC) method. It has been shown that phosphorescence lifetime of the sensor in S37 tumor in vivo varied in the range of 130 to 290 [math]s after both topical an...
Source: Journal of Innovative Optical Health Sciences - April 14, 2021 Category: Biomedical Science Authors: Natalia Kazachkina Julia Lymar Vladislav Shcheslavskiy Alexander Savitsky Source Type: research

Model eye tool for retinal optical coherence tomography instrument calibration
Journal of Innovative Optical Health Sciences, Ahead of Print. Optical coherence tomography (OCT) has been extensively used as noninvasive tool for biological tissues owing to its three-dimensional imaging ability and high axial resolution. OCT quality assurance is vital in these occasions to keep the reliability and accuracy in medical diagnosis. It is necessary to develop a calibration tool for OCT product manufacture, calibration, and quality control. A practical tool is demanded in the OCT quality control and calibration of OCT. So far, there is no such a practical tool that can test all the key parameters of OCT. We d...
Source: Journal of Innovative Optical Health Sciences - April 7, 2021 Category: Biomedical Science Authors: Hongting Wang Wenli Liu Zhixiong Hu Xiuyu Li Fei Li Liangcheng Duan Source Type: research

Investigation of artifacts by mapping SAR in thermoacoustic imaging
In this study, to reveal the underlying mechanisms of artifacts, we deeply investigate the distribution of specific absorption rate (SAR) inside tissue-mimicking phantoms with varied morphological features using both mathematical simulations and corresponding experiments. Our simulated results, which are confirmed by the associated experimental results, show that the SAR distribution highly depends on the geometries of the imaging targets and the polarizing features of the microwave. In addition, we propose the potential mechanisms including Mie-scattering, Fabry-Perot-feature, small curvature effect to interpret the diffr...
Source: Journal of Innovative Optical Health Sciences - April 5, 2021 Category: Biomedical Science Authors: Xiao Liang Qiang Liu Zezhou Sun Weizhi Qi Yubin Gong Lei Xi Source Type: research

Depth perception on fundus images using a single-channel stereomicroscopy
Journal of Innovative Optical Health Sciences, Ahead of Print. Typical fundus photography produces a two-dimensional image. This makes it difficult to observe the microvascular and neural abnormalities, because the depth of the image is missing. To provide depth appreciation, we develop a single-channel stereoscopic fundus video imaging system based on a rotating refractor. With respect to the pupil center, the rotating refractor laterally displaces the optical path and the illumination. This allows standard monocular fundus cameras to generate stereo-parallax and image disparity through sequential image acquisition. We op...
Source: Journal of Innovative Optical Health Sciences - March 29, 2021 Category: Biomedical Science Authors: Edalat Radfar Hyunseon Yu Tien Son Ho Seung Ho Choi Byungjo Jung Source Type: research

Differentiation of different antifungals with various mechanisms using dynamic surface-enhanced Raman spectroscopy combined with machine learning
Journal of Innovative Optical Health Sciences, Ahead of Print. With the increase in mortality caused by pathogens worldwide and the subsequent serious drug resistance owing to the abuse of antibiotics, there is an urgent need to develop versatile analytical techniques to address this public issue. Vibrational spectroscopy, such as infrared (IR) or Raman spectroscopy, is a rapid, noninvasive, nondestructive, real-time, low-cost, and user-friendly technique that has recently gained considerable attention. In particular, surface-enhanced Raman spectroscopy (SERS) can provide a highly sensitive readout for bio-detection with u...
Source: Journal of Innovative Optical Health Sciences - March 25, 2021 Category: Biomedical Science Authors: Hao Li Yongbing Cao Feng Lu Source Type: research