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Quantification methodologies on organization and morphology features of fiber-like structures: A review
In this study, we examined a wide range of methodologies that quantify organizational and morphological features of fibrous structures, including orientation, alignment, waviness and thickness. Each method was demonstrated with specific applications. Finally, perspectives of future quantification analysis techniques were explored. (Source: Journal of Innovative Optical Health Sciences)
Source: Journal of Innovative Optical Health Sciences - October 19, 2022 Category: Biomedical Science Authors: Chuncheng Wang Jia Meng Shuhao Qian Lingxi Zhou Shenyi Jiang Rushan Jiang Hantao Zhan Xinguo Fang Yijie Liu Zhihua Ding Zhiyi Liu Source Type: research

Lipid droplets imaging with three-photon microscopy
Journal of Innovative Optical Health Sciences, Ahead of Print. Lipid droplets (LDs) participate in many physiological processes, the abnormality of which will cause chronic diseases and pathologies such as diabetes and obesity. It is crucial to monitor the distribution of LDs at high spatial resolution and large depth. Herein, we carried three-photon imaging of LDs in fat liver. Owing to the large three-photon absorption cross-section of the luminogen named NAP-CF3 ([math][math]cm6 s2), three-photon fluorescence fat liver imaging reached the largest depth of 80[math][math]m. Fat liver diagnosis was successfully carried out...
Source: Journal of Innovative Optical Health Sciences - October 14, 2022 Category: Biomedical Science Authors: Mubin He Hojeong Park Guangle Niu Qiming Xia Hequn Zhang Ben Zhong Tang Jun Qian Source Type: research

Application and development of fluorescence probes in MINFLUX nanoscopy (invited paper)
Journal of Innovative Optical Health Sciences,Volume 16, Issue 01, January 2023. The MINimal emission FLUXes (MINFLUX) technique in optical microscopy, widely recognized as the next innovative fluorescence microscopy method, claims a spatial resolution of 1 –3[math]nm in both dead and living cells. To make use of the full resolution of the MINFLUX microscope, it is important to select appropriate fluorescence probes and labeling strategies, especially in living-cell imaging. This paper mainly focuses on recent applications and developments of fluores cence probes and the relevant labeling strategy for MINFLUX microscopy....
Source: Journal of Innovative Optical Health Sciences - October 14, 2022 Category: Biomedical Science Authors: Jing Wang Zhen Zhang Hongyu Shen Qi Wu Min Gu Source Type: research

Lipid droplets imaging with three-photon microscopy
Journal of Innovative Optical Health Sciences, Ahead of Print. Lipid droplets (LDs) participate in many physiological processes, the abnormality of which will cause chronic diseases and pathologies such as diabetes and obesity. It is crucial to monitor the distribution of LDs at high spatial resolution and large depth. Herein, we carried three-photon imaging of LDs in fat liver. Owing to the large three-photon absorption cross-section of the luminogen named NAP-CF3 ([math][math]cm6 s2), three-photon fluorescence fat liver imaging reached the largest depth of 80[math][math]m. Fat liver diagnosis was successfully carried out...
Source: Journal of Innovative Optical Health Sciences - October 14, 2022 Category: Biomedical Science Authors: Mubin He Hojeong Park Guangle Niu Qiming Xia Hequn Zhang Ben Zhong Tang Jun Qian Source Type: research

Application and development of fluorescence probes in MINFLUX nanoscopy
Journal of Innovative Optical Health Sciences, Ahead of Print. The MINimal emission FLUXes (MINFLUX) technique in optical microscopy, widely recognized as the next innovative fluorescence microscopy method, claims a spatial resolution of 1 –3[math]nm in both dead and living cells. To make use of the full resolution of the MINFLUX microscope, it is important to select appropriate fluorescence probes and labeling strategies, especially in living-cell imaging. This paper mainly focuses on recent applications and developments of fluores cence probes and the relevant labeling strategy for MINFLUX microscopy. Moreover, we disc...
Source: Journal of Innovative Optical Health Sciences - October 14, 2022 Category: Biomedical Science Authors: Jing Wang Zhen Zhang Hongyu Shen Qi Wu Min Gu Source Type: research

Cerium-based nanoparticles for cancer photodynamic therapy
Journal of Innovative Optical Health Sciences, Ahead of Print. Metal- and metal-oxide-based nanoparticles have been widely exploited in cancer photodynamic therapy (PDT). Among these materials, cerium-based nanoparticles have drawn extensive attention due to their superior biosafety and distinctive physicochemical properties, especially the reversible transition between the valence states of Ce(III) and Ce(IV). In this review, the recent advances in the use of cerium-based nanoparticles as novel photosensitizers for cancer PDT are discussed, and the activation mechanisms for electron transfer to generate singlet oxygen are...
Source: Journal of Innovative Optical Health Sciences - October 14, 2022 Category: Biomedical Science Authors: Hui Li Min Wei Xinyi Lv Yanling Hu Jinjun Shao Xuejiao Song Dongliang Yang Wenjun Wang Buhong Li Xiaochen Dong Source Type: research

Suppression of transmembrane sodium currents on the freshly isolated hippocampal neuron cell with continuous infrared light
Journal of Innovative Optical Health Sciences,Volume 16, Issue 02, March 2023. Physiotherapeutic effects of infrared lasers have been proved in clinic. These infrared-based regulations of the bioelectrical activities can roughly be classified into enhancement and suppression of action potential (AP), which are described by sodium (Na) and potassium (K) transmembrane current equations, named as Hodgkin and Huxley (HH)-model. The enhancement effect is able to evoke or strengthen the AP when infrared light is applied. Its corresponding mechanism is commonly ascribed to the changes of the cell membrane capacitance, which is tr...
Source: Journal of Innovative Optical Health Sciences - October 12, 2022 Category: Biomedical Science Authors: Fanyi Kong Xinyu Li Ruonan Jiao Kun Liu Xue Han Changkai Sun Changsen Sun Source Type: research

Label-free breast cancer detection and classification by convolutional neural network-based on exosomes surface-enhanced raman scattering
Journal of Innovative Optical Health Sciences,Volume 16, Issue 02, March 2023. Because the breast cancer is an important factor that threatens women ’s lives and health, early diagnosis is helpful for disease screening and a good prognosis. Exosomes are nanovesicles, secreted from cells and other body fluids, which can reflect the genetic and phenotypic status of parental cells. Compared with other methods for early diagnosis of cancer (such a s circulating tumor cells (CTCs) and circulating tumor DNA), exosomes have a richer number and stronger biological stability, and have great potential in early diagnosis. Thus, it ...
Source: Journal of Innovative Optical Health Sciences - October 12, 2022 Category: Biomedical Science Authors: Xiao Ma Honglian Xiong Jinhao Guo Zhiming Liu Yaru Han Mingdi Liu Yanxian Guo Mingyi Wang Huiqing Zhong Zhouyi Guo Source Type: research

Suppression of transmembrane sodium currents on the freshly isolated hippocampal neuron cell with continuous infrared light
Journal of Innovative Optical Health Sciences, Ahead of Print. Physiotherapeutic effects of infrared lasers have been proved in clinic. These infrared-based regulations of the bioelectrical activities can roughly be classified into enhancement and suppression of action potential (AP), which are described by sodium (Na) and potassium (K) transmembrane current equations, named as Hodgkin and Huxley (HH)-model. The enhancement effect is able to evoke or strengthen the AP when infrared light is applied. Its corresponding mechanism is commonly ascribed to the changes of the cell membrane capacitance, which is transiently increa...
Source: Journal of Innovative Optical Health Sciences - October 12, 2022 Category: Biomedical Science Authors: Fanyi Kong Xinyu Li Ruonan Jiao Kun Liu Xue Han Changkai Sun Changsen Sun Source Type: research

Label-free breast cancer detection and classification by convolutional neural network-based on exosomes surface-enhanced raman scattering
Journal of Innovative Optical Health Sciences, Ahead of Print. Because the breast cancer is an important factor that threatens women ’s lives and health, early diagnosis is helpful for disease screening and a good prognosis. Exosomes are nanovesicles, secreted from cells and other body fluids, which can reflect the genetic and phenotypic status of parental cells. Compared with other methods for early diagnosis of cancer (such a s circulating tumor cells (CTCs) and circulating tumor DNA), exosomes have a richer number and stronger biological stability, and have great potential in early diagnosis. Thus, it has been propose...
Source: Journal of Innovative Optical Health Sciences - October 12, 2022 Category: Biomedical Science Authors: Xiao Ma Honglian Xiong Jinhao Guo Zhiming Liu Yaru Han Mingdi Liu Yanxian Guo Mingyi Wang Huiqing Zhong Zhouyi Guo Source Type: research

Discrimination and quantification of scar tissue by Mueller matrix imaging with machine learning
This study proved tha t Mueller matrix imaging is effective in ocular scar discrimination and paves the way for its application on other forms of ocular fibrosis as a substitute or supplementary for clinical practice. (Source: Journal of Innovative Optical Health Sciences)
Source: Journal of Innovative Optical Health Sciences - October 3, 2022 Category: Biomedical Science Authors: Xi Liu Yanan Sun Weixi Gu Jianguo Sun Yi Wang Li Li Source Type: research

Stimulated Raman scattering microscopy on biological cellular machinery
Journal of Innovative Optical Health Sciences,Volume 16, Issue 02, March 2023. Benefiting from the developments of advanced optical microscopy techniques, the mysteries of biological functions at the cellular and subcellular levels have been continuously revealed. Stimulated Raman scattering (SRS) microscopy is a rapidly growing technique that has attracted broad attentions and become a powerful tool for biology and biomedicine, largely thanks to its chemical specificity, high sensitivity and fast image speed. This review paper introduces the principles of SRS, discusses the technical developments and implementations of SR...
Source: Journal of Innovative Optical Health Sciences - September 30, 2022 Category: Biomedical Science Authors: Jing Huang Minbiao Ji Source Type: research

Stimulated Raman scattering microscopy on biological cellular machinery
Journal of Innovative Optical Health Sciences, Ahead of Print. Benefiting from the developments of advanced optical microscopy techniques, the mysteries of biological functions at the cellular and subcellular levels have been continuously revealed. Stimulated Raman scattering (SRS) microscopy is a rapidly growing technique that has attracted broad attentions and become a powerful tool for biology and biomedicine, largely thanks to its chemical specificity, high sensitivity and fast image speed. This review paper introduces the principles of SRS, discusses the technical developments and implementations of SRS microscopy, th...
Source: Journal of Innovative Optical Health Sciences - September 30, 2022 Category: Biomedical Science Authors: Jing Huang Minbiao Ji Source Type: research

Fluorescence emission difference microscopy based on polarization modulation
Journal of Innovative Optical Health Sciences, Ahead of Print. In this paper, we propose a new fluorescence emission difference microscopy (FED) technique based on polarization modulation. An electro-optical modulator (EOM) is used to switch the excitation beam between the horizontal and vertical polarization states at a high frequency, which leads to solid- and donut-shaped beams after spatial light modulation. Experiment on the fluorescent nanoparticles demonstrates that the proposed method can achieve [math] spatial resolution. Using the proposed system, the dynamic imaging of subcellular structures in living cells over...
Source: Journal of Innovative Optical Health Sciences - September 28, 2022 Category: Biomedical Science Authors: Wanjie Dong Yuran Huang Zhimin Zhang Liang Xu Cuifang kuang Xiang Hao Liangcai Cao Xu Liu Source Type: research