Recognizing and Correcting MEG Artifacts
Summary: Noise sources in magnetoencephalography (MEG) include: (1) interference from outside the shielded room, (2) other people and devices inside the shielded room, (3) physiologic or nonphysiologic sources inside the patient, (4) activity from inside the head that is unrelated to the signal of interest, (5) intrinsic sensor and recording electronics noise, and (6) artifacts from other apparatus used during recording such as evoked response stimulators. There are other factors which corrupt MEG recording and interpretation and should also be considered “artifacts”: (7) inadequate positioning of the patient, (8) ...
Source: Journal of Clinical Neurophysiology - November 1, 2020 Category: Neurology Tags: Invited Review Source Type: research

Towards Best Practices in Clinical Magnetoencephalography: Patient Preparation and Data Acquisition
This article aims to comprehensively address these matters for practitioners of clinical MEG in a helpful and practical way. Based on the authors' experiences in recording over three thousand patients between them, presented here are a collection of techniques for implementation into daily routines that ensure good operation and high data quality. The techniques address a gap in the clinical literature addressing the multitude of potential sources of error during patient preparation and data acquisition, and how to prevent, recognize, or correct those. (Source: Journal of Clinical Neurophysiology)
Source: Journal of Clinical Neurophysiology - November 1, 2020 Category: Neurology Tags: Invited Review Source Type: research

The 10 Common Evidence-Supported Indications for MEG in Epilepsy Surgery: An Illustrated Compendium
Summary: Unfamiliarity with the indications for and benefits of magnetoencephalography (MEG) persists, even in the epilepsy community, and hinders its acceptance to clinical practice, despite the evidence. The wide treatment gap for patients with drug-resistant epilepsy and immense underutilization of epilepsy surgery had similar effects. Thus, educating referring physicians (epileptologists, neurologists, and neurosurgeons) both about the value of epilepsy surgery and about the potential benefits of MEG can achieve synergy and greatly improve the process of selecting surgical candidates. As a practical step toward a c...
Source: Journal of Clinical Neurophysiology - November 1, 2020 Category: Neurology Tags: Invited Review Source Type: research

The Wisdom and Vision From the ACMEGS Inaugural Decade
Summary: Concise history of fascinating magnetoencephalography (MEG) technology and catalog of very selected milestone preclinical and clinical MEG studies are provided as the background. The focus is the societal context defining a journey of MEG to and through clinical practice and formation of the American Clinical MEG Society (ACMEGS). We aspired to provide an objective historic perspective and document contributions of many professionals while focusing on the role of ACMEGS in the growth and maturation of clinical MEG field. The ACMEGS was born (2006) out of inevitability to address two vital issues—fair reimbur...
Source: Journal of Clinical Neurophysiology - November 1, 2020 Category: Neurology Tags: Invited Review Source Type: research

SQUIDs Pro Quorum
No abstract available (Source: Journal of Clinical Neurophysiology)
Source: Journal of Clinical Neurophysiology - November 1, 2020 Category: Neurology Tags: Guest Editorial Source Type: research

Therapeutic Uses of Cannabis on Sleep Disorders and Related Conditions: ERRATUM
No abstract available (Source: Journal of Clinical Neurophysiology)
Source: Journal of Clinical Neurophysiology - September 1, 2020 Category: Neurology Tags: Erratum Source Type: research

Easy EMG: A Guide to Performing Nerve Conduction Studies and Electromyography, Second Edition
No abstract available (Source: Journal of Clinical Neurophysiology)
Source: Journal of Clinical Neurophysiology - September 1, 2020 Category: Neurology Tags: Book Review Source Type: research

Seizure Activity Across Scales From Neuronal Population Firing to Clonic Motor Semiology
This report demonstrates the electrophysiologic signatures of focal seizures at the level of neuronal firing, high-frequency oscillations, and EEG as they organize from microscale to macroscale, with clinical correlation. (Source: Journal of Clinical Neurophysiology)
Source: Journal of Clinical Neurophysiology - September 1, 2020 Category: Neurology Tags: Case Report Source Type: research

Acceptability of Standardized EEG Reporting in an Electronic Health Record
Conclusions: Overall electroencephalographer satisfaction with the new EEG report system was high, as were the scores for perceived usefulness (assessed as standardization, documentation quality, and education) and ease of use (assessed as workflow efficiency). Future study is needed to determine whether implementation yields useful data for clinical research and quality improvement studies or improves EEG report standardization. (Source: Journal of Clinical Neurophysiology)
Source: Journal of Clinical Neurophysiology - September 1, 2020 Category: Neurology Tags: Original Research Source Type: research

Gender Disparity and Potential Strategies for Improvement in Neurology and Clinical Neurophysiology
Summary: Discrimination in the workplace when documented is illegal but is seen to still exist in some forms whether based on culture, race, or gender. Each of these disparities warrants further discussion and study because of their significant impacts on hiring decisions, career advancement, and compensation. In this article, the authors have focused their attention on gender disparity in the fields of neurology and clinical neurophysiology and shared the data currently available to them. At a time when the field of clinical neurophysiology has seen enormous growth, gender disparity in leadership and compensation remain...
Source: Journal of Clinical Neurophysiology - September 1, 2020 Category: Neurology Tags: Special Article Source Type: research

Drug Trials in Status Epilepticus: Current Evidence and Future Concepts
Summary: Status epilepticus (SE) is a neurologic emergency with high morbidity and mortality. After many advances in the field, several unanswered questions remain for optimal treatment after the early stage of SE. This narrative review describes some of the important drug trials for SE treatment that have shaped the understanding of the treatment of SE. The authors also propose possible clinical trial designs for the later stages of SE that may allow assessment of currently available and new treatment options. Status epilepticus can be divided into four stages for treatment purposes: early, established, refractory, and ...
Source: Journal of Clinical Neurophysiology - September 1, 2020 Category: Neurology Tags: Invited Review Source Type: research

Status Epilepticus in Children
Summary: For various reasons, status epilepticus in children is different than in adults. Pediatric specificities include status epilepticus epidemiology, underlying etiologies, pathophysiological mechanisms, and treatment options. Relevant data from the literature are presented for each of them, and questions remaining open for future studies on status epilepticus in childhood are listed. (Source: Journal of Clinical Neurophysiology)
Source: Journal of Clinical Neurophysiology - September 1, 2020 Category: Neurology Tags: Invited Review Source Type: research

Markers in Status Epilepticus Prognosis
Summary: Status epilepticus (SE) is a neurologic emergency with high morbidity and mortality. The assessment of a patient's prognosis is crucial in making treatment decisions. In this review, we discuss various markers that have been used to prognosticate SE in terms of recurrence, mortality, and functional outcome. These markers include demographic, clinical, electrophysiological, biochemical, and structural data. The heterogeneity of SE etiology and semiology renders development of prognostic markers challenging. Currently, prognostication in SE is limited to a few clinical scores. Future research should integrate clin...
Source: Journal of Clinical Neurophysiology - September 1, 2020 Category: Neurology Tags: Invited Review Source Type: research

Periodic Discharges: How to Approach, When to Treat
We present the challenges and unanswered questions pertaining to periodic discharges, along with several next steps and future directions to help enhance our understanding of periodic discharges. We also present an algorithmic approach to management centered on clinicoelectrographic and clinicoradiologic data. (Source: Journal of Clinical Neurophysiology)
Source: Journal of Clinical Neurophysiology - September 1, 2020 Category: Neurology Tags: Invited Review Source Type: research

EEG Monitoring After Convulsive Status Epilepticus
Summary: After convulsive status epilepticus, patients of all ages may have ongoing EEG seizures identified by continuous EEG monitoring. Furthermore, high EEG seizure exposure has been associated with unfavorable neurobehavioral outcomes. Thus, recent guidelines and consensus statements recommend many patients with persisting altered mental status after convulsive status epilepticus undergo continuous EEG monitoring. This review summarizes the available epidemiologic data and related recommendations provided by recent guidelines and consensus statements. (Source: Journal of Clinical Neurophysiology)
Source: Journal of Clinical Neurophysiology - September 1, 2020 Category: Neurology Tags: Invited Review Source Type: research