Using Generalized Polyspike Train to Predict Drug-Resistant Idiopathic Generalized Epilepsy
Conclusions: The findings support the hypothesis that GPT is associated with drug-resistant IGE. Prolonged EEG recording is required to identify this feature. Thus,>24-hour EEG recording early in the evaluation of patients with IGE may facilitate prognostication. (Source: Journal of Clinical Neurophysiology)
Source: Journal of Clinical Neurophysiology - September 1, 2022 Category: Neurology Tags: Original Research Source Type: research

Non-neurophysiologist Physicians and Nurses Can Detect Subclinical Seizures in Children Using a Panel of Quantitative EEG Trends and a Seizure Detection Algorithm
Conclusions: A panel of QEEG trends can be used by non-neurophysiologists in a pediatric critical care setting to detect nonconvulsive seizures with a reasonable accuracy, which may expedite subclinical seizure identification and timely intervention. (Source: Journal of Clinical Neurophysiology)
Source: Journal of Clinical Neurophysiology - September 1, 2022 Category: Neurology Tags: Original Research Source Type: research

Epileptiform Abnormalities in Acute Ischemic Stroke: Impact on Clinical Management and Outcomes
Conclusions: Despite the high incidence of EA, the rate of Sz in AIS is relatively lower and is associated with the presence of LPDs. These continuous EEG findings resulted in anti-Sz drug changes in one-fifth of the cohort. Epileptiform abnormality and Sz did not affect mortality or discharge functional outcomes. (Source: Journal of Clinical Neurophysiology)
Source: Journal of Clinical Neurophysiology - September 1, 2022 Category: Neurology Tags: Original Research Source Type: research

Electroencephalographic Seizures in Emergency Department Patients After Treatment for Convulsive Status Epilepticus
Conclusions: Electrographic seizures may occur in patients who stop seizing clinically after treatment of convulsive status epilepticus. Clinical correlates might not be present during electrographic seizures. These findings support early initiation of EEG recordings in patients suffering from convulsive status epilepticus, including those with clinical evidence of treatment success. (Source: Journal of Clinical Neurophysiology)
Source: Journal of Clinical Neurophysiology - September 1, 2022 Category: Neurology Tags: Original Research Source Type: research

Minimum Technical Requirements for Performing Ambulatory EEG
Summary: Ambulatory EEG (AEEG) devices offer portable, multichannel, digital EEG recording with or without video in the patient's natural environment. The technology applied for AEEG recording is like the technology for routine EEG and inpatient long-term video-EEG monitoring but designed to be compact and wearable. Computer-based AEEG technology is well-suited to digital recording, signal processing, and visual display. However, acquiring interpretable EEG outside of the hospital setting presents its own technical challenges. Published guidelines have established technical standards for performing routine EEG and inpa...
Source: Journal of Clinical Neurophysiology - September 1, 2022 Category: Neurology Tags: ACNS Guideline Source Type: research

Bilateral Reappearance of the N20 Potential in a Normothermic Young Woman Post-Anoxic Brain Injury
Summary: Hypoxic–ischemic brain injury is a well-known consequence of cardiac arrest and providing an accurate prognostication remains a challenge, especially in decisions related to withdrawal of care. Bilateral absence of the cortical response (N20 potential) on median somatosensory evoked potentials, on days 1 to 3 after the return of spontaneous circulation, is widely considered as the most reliable predictor of poor outcome with a high specificity and a low false-positive rate. The authors describe the case of a young comatose woman after hypoxic injury because of cardiac arrest whose initial median somatosensor...
Source: Journal of Clinical Neurophysiology - July 1, 2022 Category: Neurology Tags: Case Report Source Type: research

Neurological Prognostication Using Raw EEG Patterns and Spectrograms of Frontal EEG in Cardiac Arrest Patients
Conclusions: Frontal EEG monitoring is useful for predicting poor neurological outcomes. Brain function monitoring using both raw EEG patterns and color density spectral arrays is more helpful for predicting poor prognosis than raw EEG alone. (Source: Journal of Clinical Neurophysiology)
Source: Journal of Clinical Neurophysiology - July 1, 2022 Category: Neurology Tags: Original Research Source Type: research

Acute Toxicity and Triphasic Waves—The Example of Cefepime
Purpose: Triphasic waves (TWs) have been associated with a host of medication toxicities, and cefepime has emerged recently as a frequently encountered offending agent. This investigation aims to evaluate cefepime-induced encephalopathy and to report the associated clinical, EEG expression with TWs, and the radiologic findings. Methods: A retrospective multicenter observational study examining adult patients with cefepime-induced encephalopathy with generalized periodic discharges on either routine or continuous EEG between January 2014 and January 2020. Clinical, electrographic, and radiologic data were collect...
Source: Journal of Clinical Neurophysiology - July 1, 2022 Category: Neurology Tags: Original Research Source Type: research

The Referential Montage Inadequately Localizes Corticocortical Evoked Potentials in Stereoelectroencephalography
Conclusions: Both the Laplacian and bipolar montages were superior to the common average or referential montage in localizing CCEPs to gray matter. These montages may be more appropriate for interpreting CCEPs when using depth electrodes than the referential montage, which has typically been used in prior studies of CCEPs with subdural grids. (Source: Journal of Clinical Neurophysiology)
Source: Journal of Clinical Neurophysiology - July 1, 2022 Category: Neurology Tags: Original Research Source Type: research

Do Spike Domain Analysis Interictally Correlate With the Ictal Patterns in Temporal Lobe Epilepsy?
Conclusions: Type A IEDs signify a focal ictal onset and type B IEDs suggest a diffuse ictal onset in patients with MTS on one side. Significance: Interictal spike domain analysis helps predicting ictal patterns in temporal lobe epilepsy. (Source: Journal of Clinical Neurophysiology)
Source: Journal of Clinical Neurophysiology - July 1, 2022 Category: Neurology Tags: Original Research Source Type: research

Motor Evoked Potentials Double Train Stimulation: Optimal Number of Pulses per Train
Purpose: In neurophysiologic intraoperative monitoring, double train transcranial electrical stimulation (dt-TES) for motor evoked potentials (MEP) consists of an initial, facilitating train of stimuli followed by a second, testing, train. The optimal number of pulses per train has not been determined. The authors wanted to determine the optimal combination of pulses per train that produced the highest MEP amplitude. Methods: Dt-TES of 4 + 4, 2 + 7, and 7 + 2 pulses were attempted in 20 patients and compared with single train TES of nine pulses. Latencies of the MEP responses were also compared. Additionally, st...
Source: Journal of Clinical Neurophysiology - July 1, 2022 Category: Neurology Tags: Original Research Source Type: research

Comparison of Proximal and Distal Techniques for the Medial Antebrachial Cutaneous Sensory Nerve Conduction Study
Purpose: The medial antebrachial cutaneous (MAC) sensory nerve conduction study (NCS) is a technique performed to evaluate for medial cord/lower trunk plexopathies. Low-amplitude responses and muscle artifact pose technical challenges for MAC NCS. To compare the recorded sensory NCS responses using a proximal MAC (pMAC) NCS technique with a distal (dMAC) technique. To compare the recorded sensory NCS responses using a proximal MAC (pMAC) NCS technique with a distal (dMAC) technique. Methods: Adults referred to our neurophysiology laboratory for whom MAC NCS were clinically indicated were included. Medial ante...
Source: Journal of Clinical Neurophysiology - July 1, 2022 Category: Neurology Tags: Original Research Source Type: research

Cognitive Event-Related Potentials–The P300 Wave Is a Prognostic Factor of Long-Term Disability Progression in Patients With Multiple Sclerosis
Purpose: Multiple sclerosis (MS) is a chronic disorder with a variable course. The aim of our study was to find out whether cognitive event-related potentials are prognostic for patient disability at the 15-year follow-up. Methods: In the observed cohort of patients with MS, we examined the event-related potentials at baseline (2003). Functional status (Expanded Disability Status Scale score) was then assessed 15 years later, and the prognostic model was developed using binary logistic regression analysis. The independent variables included demographic (age, sex, and education), clinical (disability in 2003), ra...
Source: Journal of Clinical Neurophysiology - July 1, 2022 Category: Neurology Tags: Original Research Source Type: research

Relationship Between Brainstem Auditory Evoked Potentials and Clinical Function in Patients With Cerebral Infarction
Conclusions: In patients with ischemic stroke with the poor clinical outcome at discharge, there were delayed latencies of waveforms I, III, and V of BAEP performed in the early phase of stroke. (Source: Journal of Clinical Neurophysiology)
Source: Journal of Clinical Neurophysiology - July 1, 2022 Category: Neurology Tags: Original Research Source Type: research

Sleep Spindles and K-Complexes Are Favorable Prognostic Biomarkers in Critically Ill Patients
Summary: In this narrative review, we summarize recent research on the prognostic significance of biomarkers of sleep in continuous EEG and polysomnographic recordings in intensive care unit patients. Recent studies show the EEG biosignatures of non-rapid eye movement 2 sleep (sleep spindles and K-complexes) on continuous EEG in critically ill patients better predict functional outcomes and mortality than the ictal–interictal continuum patterns. Emergence of more complex and better organized sleep architecture has been shown to parallel neurocognitive recovery and correlate with functional outcomes in traumatic brain...
Source: Journal of Clinical Neurophysiology - July 1, 2022 Category: Neurology Tags: Invited Review Source Type: research