Scalp EEG Could Record Both Ictal Direct Current Shift and High-Frequency Oscillation Together Even With a Time Constant of 2 Seconds
Summary: Herein, the authors report for the first time, scalp-recorded (1) focal ictal direct current (DC) shifts (active DC shifts; that precede conventional pattern) from the chronic focus of focal epilepsy and (2) ictal high-frequency oscillation after ictal DC shifts (passive DC shifts; that follow both conventional and high-frequency oscillation ictal patterns) from the acute focus of acute symptomatic seizures (Szs) in a 77-year-old man. Sixteen episodes of clinical Szs were recorded by scalp EEG with a 2-seconds time constant. Among the 16 recorded episodes of Sz, four EEG Sz patterns originated from the left post...
Source: Journal of Clinical Neurophysiology - March 1, 2020 Category: Neurology Tags: Case Report Source Type: research

Transcranial Magnetic Stimulation–Induced Motor Evoked Potentials in Hirayama Disease: Systematic Review of the Literature
Conclusions: Although MEP parameters may be abnormal in some HD patients, these have not been thoroughly assessed. Further studies are indispensable to evaluate their usefulness in assessing pyramidal tract damage in HD. (Source: Journal of Clinical Neurophysiology)
Source: Journal of Clinical Neurophysiology - March 1, 2020 Category: Neurology Tags: Invited Review Source Type: research

Cortical Excitability, Synaptic Plasticity, and Cognition in Benign Epilepsy With Centrotemporal Spikes: A Pilot TMS-EMG-EEG Study
Conclusions: Transcranial magnetic stimulation is safe and feasible for children with benign epilepsy with centrotemporal spikes, and TMS-EEG provides more reliable outcome measures than TMS-EMG in this group because many children have unmeasurably high resting motor thresholds. Net cortical excitability decreases with age, and motor cortex plasticity predicts not only motor learning but also language learning, suggesting a mechanism by which motor cortex seizures may interact with language development. (Source: Journal of Clinical Neurophysiology)
Source: Journal of Clinical Neurophysiology - March 1, 2020 Category: Neurology Tags: Invited Review Source Type: research

Safety and Tolerability of Repetitive Transcranial Magnetic Stimulation During Pregnancy: A Case Report and Literature Review
We present a case of repetitive transcranial magnetic stimulation treatment as an adjunct therapy for a patient experiencing refractory epileptic seizures during the third trimester of pregnancy. Notably, the patient tolerated repetitive transcranial magnetic stimulation well, without adverse events, and delivered a healthy child. We also summarize the current literature pertaining to therapeutic repetitive transcranial magnetic stimulation use during pregnancy. (Source: Journal of Clinical Neurophysiology)
Source: Journal of Clinical Neurophysiology - March 1, 2020 Category: Neurology Tags: Invited Review Source Type: research

Enhancing Stroke Recovery Across the Life Span With Noninvasive Neurostimulation
Summary: Stroke is the leading cause of neurologic disability not only in adults but perinatal and childhood stroke affect millions of children as well worldwide with deficits that last a lifetime. The rapidly increasing evidence base for how noninvasive neuromodulation may enhance stroke recovery in adults may be applicable to the youngest stroke survivors. In return, how the plasticity of the developing brain contributes to stroke recovery and its modulation may provide equally valuable insight toward mechanisms and opportunities for enhancing recovery in all stroke patients. Despite this synergistic relationship, exam...
Source: Journal of Clinical Neurophysiology - March 1, 2020 Category: Neurology Tags: Invited Review Source Type: research

Application of Navigated Transcranial Magnetic Stimulation to Map the Supplementary Motor Area in Healthy Subjects
Conclusions: Repetitive navigated transcranial magnetic stimulation is capable of influencing the performance of healthy participants in a task relying on hand coordination. Our approach can serve as a mapping tool for the supplementary motor area, potentially relevant for preoperative diagnostics in patients with brain tumors, epilepsy, or other brain lesions to improve outcome and potentially predict clinical course and postoperative recovery. (Source: Journal of Clinical Neurophysiology)
Source: Journal of Clinical Neurophysiology - March 1, 2020 Category: Neurology Tags: Invited Review Source Type: research

Intranetwork and Internetwork Effects of Navigated Transcranial Magnetic Stimulation Using Low- and High-Frequency Pulse Application to the Dorsolateral Prefrontal Cortex: A Combined rTMS–fMRI Approach
Conclusions: This is one of the first studies using neuronavigated TMS with independent component analysis–based target selection to explore frequency-dependent stimulation effects in a combined rTMS–fMRI approach. Future studies including higher subject numbers may define the underlying mechanisms for the different responses to low- and high-frequency rTMS. (Source: Journal of Clinical Neurophysiology)
Source: Journal of Clinical Neurophysiology - March 1, 2020 Category: Neurology Tags: Invited Review Source Type: research

Noninvasive Brain Stimulation in Epilepsy
Summary: Neurostimulation in epilepsy is a long standing established concept, and through experimental and clinical uses, our understanding of neurostimulation and neuromodulation has grown substantially. Noninvasive brain stimulation techniques use electromagnetic principles to noninvasively modulate brain activity in a spatiotemporally targeted manner. This review focused on the two predominant forms of noninvasive neurostimulation: transcranial magnetic stimulation (TMS) and transcranial direct current stimulation, and their current applications in the diagnosis and management of epilepsy. A number of small randomized...
Source: Journal of Clinical Neurophysiology - March 1, 2020 Category: Neurology Tags: Invited Review Source Type: research

Therapeutic Potentials of Localized Blood–Brain Barrier Disruption by Noninvasive Transcranial Focused Ultrasound: A Technical Review
Summary: The demands for region-specific, noninvasive therapies for neurologic/psychiatric conditions are growing. The rise of transcranial focused ultrasound technology has witnessed temporary and reversible disruptions of the blood–brain barrier in the brain with exceptional control over the spatial precisions and depth, all in a noninvasive manner. Starting with small animal studies about a decade ago, the technique is now being explored in nonhuman primates and humans for the assessment of its efficacy and safety. The ability to transfer exogenous/endogenous therapeutic agents, cells, and biomolecules across the bl...
Source: Journal of Clinical Neurophysiology - March 1, 2020 Category: Neurology Tags: Invited Review Source Type: research

The Clinical Utility of Transcranial Magnetic Stimulation in Determining Hemispheric Dominance for Language: A Magnetoencephalography Comparison Study
Conclusions: In this first large-scale comparative study in a clinical population, we demonstrate that TMS is a safe and reliable noninvasive tool in determining HD for language. Improving the accuracy of TMS by optimizing TMS parameters and improving task choice will further facilitate the use of TMS to characterize language function, especially in pediatrics. (Source: Journal of Clinical Neurophysiology)
Source: Journal of Clinical Neurophysiology - March 1, 2020 Category: Neurology Tags: Invited Review Source Type: research

Emerging Applications of Noninvasive Brain Stimulation
No abstract available (Source: Journal of Clinical Neurophysiology)
Source: Journal of Clinical Neurophysiology - March 1, 2020 Category: Neurology Tags: Guest Editorial Source Type: research

The Role of EEG in the Diagnosis and Classification of Epilepsy Syndromes: A Tool for Clinical Practice by the ILAE Neurophysiology Task Force
No abstract available (Source: Journal of Clinical Neurophysiology)
Source: Journal of Clinical Neurophysiology - December 31, 2019 Category: Neurology Tags: Book Review Source Type: research

Lesion-Constrained Electrical Source Imaging: A Novel Approach in Epilepsy Surgery for Tuberous Sclerosis Complex
Conclusions: Lesion-constrained electrical source imaging on low-resolution EEG data provides complementary information in the presurgical workup for patients with tuberous sclerosis complex, although further validation is required. In the appropriate clinical context, the yield of source localization on low-resolution EEG data may be increased by reduction of the solution space. (Source: Journal of Clinical Neurophysiology)
Source: Journal of Clinical Neurophysiology - December 31, 2019 Category: Neurology Tags: Original Research Source Type: research

Changes in Vital Signs During Epileptic and Psychogenic Nonepileptic Attacks: A Video-EEG Study
Introduction: Epilepsy is a common disorder. Psychogenic nonepileptic attack (PNEA) is one of the epilepsy mimics. Video EEG is still the gold standard tool that differentiates between epileptic seizures (ES) and PNEA. Oxygen saturation (SaO2) and ictal vital signs, including heart rate (HR), respiration rate (RR), body temperature, systolic blood pressure (SBP), and diastolic blood pressure show crucial changes during ES and PNEA. Purpose: To analyze, compare, and find relationships of changes in ictal vital sign during ES and PNEA. Methods: Ninety-four adults had video EEG monitoring. SaO2, HR, RR, body temperatu...
Source: Journal of Clinical Neurophysiology - December 31, 2019 Category: Neurology Tags: Original Research Source Type: research

Establishing Normal Values for F-Wave Latencies in Diagnosing Peripheral Neuropathies for the Pediatric Population
Conclusions: The F-wave estimated deviance is independent of age and can be accurately applied to the electrodiagnostic testing of pediatric patients with suspected neuropathy. (Source: Journal of Clinical Neurophysiology)
Source: Journal of Clinical Neurophysiology - December 31, 2019 Category: Neurology Tags: Original Research Source Type: research