Sample size calculations for randomized controlled trials with repeatedly measured continuous variables as primary outcomes need improvements: a cross-sectional study
This study aims to provide an overview of sample size calculation methods for different research questions (e.g., key time point treatment effect, treatment effect change over time) and evaluate the adequacy of current practices in trial design. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - December 8, 2023 Category: Epidemiology Authors: Yan Ren, Yulong Jia, Min Yang, Minghong Yao, Yuning Wang, Fan Mei, Qianrui Li, Ling Li, Guowei Li, Yunxiang Huang, Yuanjin Zhang, Jiayue Xu, Kang Zou, Jing Tan, Xin Sun Tags: Original Article Source Type: research
Incomplete and possibly selective recording of signs, symptoms, and measurements in free text fields of primary care electronic health records of adults with lower respiratory tract infections
To assess the completeness of recording of relevant signs, symptoms, and measurements in Dutch free text fields of primary care electronic health records (EHR) of adults with lower respiratory tract infections (LRTI). (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - December 7, 2023 Category: Epidemiology Authors: Merijn H. Rijk, Tamara N. Platteel, Marissa M.M. Mulder, Geert-Jan Geersing, Frans H. Rutten, Maarten van Smeden, Roderick P. Venekamp, Tuur M. Leeuwenberg Tags: Original Research Source Type: research
Clinical and methodological implications for research elements in systematic reviews on COVID-19 treatment were often unstructured and underreported – a meta-research study
Numerous systematic reviews (SRs) have been published in the first months of the COVID-19 pandemic and clinical trials were designed rapidly highlighting the importance of informative implications for research (IfR) sections in SRs. IfR is one item of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 checklist and the Cochrane Handbook suggests considering population, intervention, control, outcome (PICO) and Grading of Recommendations, Assessment, Development and Evaluation (GRADE) domains when developing IfR. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - December 7, 2023 Category: Epidemiology Authors: W. Siemens, G. Bantle, S. Mahler, J. Nothacker, J. Stadelmaier, E.M. Bitzer, Schmucker C, J.J. Meerpohl Tags: Original Article Source Type: research
Librarian involvement in systematic reviews was associated with higher quality of reported search methods: a cross-sectional survey of authors from Vancouver, BC
This study identifies how librarian involvement in SRs is associated with quality reported methods and examines the lack of motivation for involving a librarian in SRs. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - December 7, 2023 Category: Epidemiology Authors: Colleen Pawliuk, Shannon Cheng, Alex Zheng, Harold (Hal) Siden Tags: Original Article Source Type: research
Developing and externally validating multinomial prediction models for methotrexate treatment outcomes in patients with rheumatoid arthritis: Results from an international collaboration
In rheumatology, there is a clinical need to identify patients at high risk (>50%) of not responding to the first-line therapy methotrexate (MTX) due to lack of disease control or discontinuation due to adverse events (AEs). Despite this need, previous prediction models in this context are at high risk of bias and ignore AEs. Our objectives were to (i) develop a multinomial model for outcomes of low disease activity (LDA) and discontinuing due to AEs 6 months after starting MTX, (ii) update prognosis 3-months following treatment initiation, and (iii) externally validate these models. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - December 7, 2023 Category: Epidemiology Authors: Celina K. Gehringer, Glen P. Martin, Kimme L. Hyrich, Suzanne M.M. Verstappen, Joseph Sexton, Eirik K. Kristianslund, Sella A. Provan, Tore K. Kvien, Jamie C. Sergeant Tags: Original Article Source Type: research
Incomplete and possibly selective recording of signs, symptoms and measurements in free text fields of primary care electronic health records of adults with lower respiratory tract infections
To assess the completeness of recording of relevant signs, symptoms, and measurements in Dutch free text fields of primary care electronic health records (EHR) of adults with lower respiratory tract infections (LRTI). (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - December 7, 2023 Category: Epidemiology Authors: M.H. (Merijn) Rijk, T.N. (Tamara) Platteel, A.M.M. (Marissa) Mulder, G.J. (Geert-Jan) Geersing, F.H. (Frans) Rutten, M. (Maarten) van Smeden, R.P. (Roderick) Venekamp, A.M. (Tuur) Leeuwenberg Tags: Original Article Source Type: research
Staged design recommendations for validating relative sensitivity of self-sample human papillomavirus tests for cervical screening
To ensure that the emerging methods for human papillomavirus (HPV) testing on selfcollected samples in cervical screening are evaluated robustly. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - December 6, 2023 Category: Epidemiology Authors: Adam R. Brentnall, Kate Cuschieri, Alexandra Sargent, Johannes Berkhof, Matejka Rebolj Tags: Original Article Source Type: research
Systematic review search strategies are poorly reported and not reproducible: a cross-sectional meta-research study
To determine the reproducibility of biomedical systematic review search strategies. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - December 2, 2023 Category: Epidemiology Authors: Melissa L. Rethlefsen, Tara J. Brigham, Carrie Price, David Moher, Lex M. Bouter, Jamie J. Kirkham, Sara Schroter, Maurice P. Zeegers Tags: Original Article Source Type: research
Optimizing process and methods for a living systematic review: 30 search updates and three review updates later
To describe the living systematic review (LSR) process and to share experience of planning, searches, screening, extraction, publishing and dissemination to inform and assist authors planning their own LSR. Many LSR do not publish more than one update, we hope this paper helps to increase this. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - December 1, 2023 Category: Epidemiology Authors: Ailsa R. Butler, Jamie Hartmann-Boyce, Jonathan Livingstone-Banks, Tari Turner, Nicola Lindson Tags: Original Research Source Type: research
Editors ’ Choice: December 2023
For the final Editor ’s Choice of the year, we reflect on some of the priorities of the journal, highlighting several related papers that were published in this issue of the Journal of Clinical Epidemiology. The first theme is on research integrity, whereas the second theme is on patient engagement in research. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - December 1, 2023 Category: Epidemiology Authors: Andrea C. Tricco, Jessie McGowan, David Tovey Tags: Editors ’ Choice Source Type: research
Editorial Board
(Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - December 1, 2023 Category: Epidemiology Source Type: research
Table of Contents
(Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - December 1, 2023 Category: Epidemiology Source Type: research
Optimising process and methods for a living systematic review - 30 search updates and three review updates later
Living systematic reviews (LSR) are systematic reviews that are regularly updated, allowing new evidence to be incorporated as it becomes available. LSR are ideally suited to policy-relevant topics where there is uncertainty and new evidence will likely impact the interpretation and/or certainty of outcomes. To be of benefit, updates must be published in a timely manner. Many LSR do not publish more than one update.As authors of a systematic review that has been ‘living’ for two years, with monthly search updates and three full updates published in this time, we describe the steps in our LSR process with the aim of inf...
Source: Journal of Clinical Epidemiology - December 1, 2023 Category: Epidemiology Authors: Ailsa R. Butler, Jamie Hartmann-Boyce, Jonathan Livingstone-Banks, Tari Turner, Nicola Lindson Tags: Original Article Source Type: research
Validation and impact of algorithms for identifying variables in observational studies of routinely collected data
This study aimed to investigate the validation of algorithms for identifying study variables from RCD, and examine the impact of alternative algorithms on treatment effects. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - December 1, 2023 Category: Epidemiology Authors: Wen Wang, Mei Liu, Qiao He, Mingqi Wang, Jiayue Xu, Ling Li, Guowei Li, Lin He, Kang Zou, Xin Sun Tags: Original Article Source Type: research
Advances in Methodologies of Negative Controls: A Scoping Review
Plain language summary: We conducted a scoping review to understand the development of negative control methods (NCM). We searched methodology studies about negative control exposure (NCE: not causally affect the outcome of interest) and negative control outcome (NCO: not to be causally affected by the exposure of interest). Finally, we included 37 studies on the methods of NCE (n=11), NCO (n=13) or both (n=13). Negative controls were mainly used to detect bias, calibrate P-value or confidence interval, and correct bias for causal effect estimation. We recommend proper use of NCM to mitigate biases in epidemiological studi...
Source: Journal of Clinical Epidemiology - November 29, 2023 Category: Epidemiology Authors: Qingqing Yang, Zhirong Yang, Xianming Cai, Houyu Zhao, Jinzhu Jia, Feng Sun Tags: Review Source Type: research
