Methodological studies evaluating evidence are not systematic reviews
(Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - February 8, 2019 Category: Epidemiology Authors: Livia Puljak Tags: Letter to the editor Source Type: research

Priority-setting for Cochrane Review Groups
(Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - February 8, 2019 Category: Epidemiology Authors: Chris Del Mar, of the Acute Respiratory Infections Cochrane Review Group Tags: Letter to the editor Source Type: research

Priority setting for Cochrane Review Groups
The number of clinical questions is almost infinite, whereas the resources to answer them are limited. Accordingly, Cochrane Review Groups (CRGs) must establish priorities. To do so, we need to understand the information needs of patients, their clinicians, and perhaps health administrators responsible for prioritizing health resources. In the past, this was undertaken implicitly, mostly based on pragmatic considerations (Can the proposed team achieve the review without gargantuan input from the CRG? Is there any evidence for the question? Is the question addressing currently used, or at least contemplated, clinical practi...
Source: Journal of Clinical Epidemiology - February 8, 2019 Category: Epidemiology Authors: Chris Del Mar, Acute Respiratory Infections Cochrane Review Group Tags: Letter to the Editor Source Type: research

GRADE Guidelines: 22. The GRADE approach for tests and strategies - from test accuracy to patient important outcomes and recommendations
This article describes GRADE ’s framework of moving from test accuracy to patient or population important outcomes. We focus on the common scenario when studies directly evaluating the effect of diagnostic and other tests or strategies on health outcomes are not available or are not providing the best available evidence. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - February 7, 2019 Category: Epidemiology Authors: Holger J. Sch ünemann, Reem A. Mustafa, Jan Brozek, Nancy Santesso, Patrick M. Bossuyt, Karen R. Steingart, Mariska Leeflang, Stefan Lange, Tommaso Trenti, Miranda Langendam, Rob Scholten, Lotty Hooft, Mohammad Hassan Murad, Roman Jaeschke, Anne Rutjes, Tags: Original Article Source Type: research

GRADE guidelines: 22. The GRADE approach for tests and strategies —from test accuracy to patient-important outcomes and recommendations
This article describes the Grading of Recommendations Assessment, Development and Evaluation (GRADE) Working Group's framework of moving from test accuracy to patient or population-important outcomes. We focus on the common scenario when studies directly evaluating the effect of diagnostic and other tests or strategies on health outcomes are not available or are not providing the best available evidence. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - February 7, 2019 Category: Epidemiology Authors: Holger J. Sch ünemann, Reem A. Mustafa, Jan Brozek, Nancy Santesso, Patrick M. Bossuyt, Karen R. Steingart, Mariska Leeflang, Stefan Lange, Tommaso Trenti, Miranda Langendam, Rob Scholten, Lotty Hooft, Mohammad Hassan Murad, Roman Jaeschke, Anne Rutjes, Tags: Original Article Source Type: research

Authors of trials from high-ranking anesthesiology journals were not willing to share raw data
To analyze data sharing practices among authors of randomized controlled trials (RCT) published in seven high-ranking anesthesiology journals from 2014 to 2016. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - February 6, 2019 Category: Epidemiology Authors: Mirko Gabelica, Jakica Cavar, Livia Puljak Tags: Original Article Source Type: research

An evidence rating service provided valid correlates of the clinical importance of medical articles and journals
To determine reliability and validity of McMaster PLUS measures of scientific merit and clinical importance of articles in medical journals. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - February 4, 2019 Category: Epidemiology Authors: R Brian Haynes, Dalton Budhram, John Cherian, Emma Iserman, Alfonso Iorio, Cynthia Lokker Tags: Original Article Source Type: research

Reviews and meta-analyses in Ethiopia had poor methodological quality: overview of evidence 1970 to 2018
The aims of this overview are to assess the trend of narrative and systematic reviews in Ethiopia, examine their methodological quality and suggest future directions for improvement. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - February 2, 2019 Category: Epidemiology Authors: Tesfa Dejenie Habtewold, Sisay Mulugeta Alemu, Shimels Hussien Mohammed, Aklilu Endalamaw, Mohammed Akibu Mohammed, Andreas A. Teferra, Abera Kenay Tura, Nigus Gebremedhin Asefa, Balewgizie Sileshi Tegegne Tags: Review Source Type: research

Biomedical and public health reviews and meta-analyses in Ethiopia had poor methodological quality: overview of evidence from 1970 to 2018
The aims of this overview are to assess the trend of narrative and systematic reviews in Ethiopia, examine their methodological quality, and suggest future directions for improvement. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - February 2, 2019 Category: Epidemiology Authors: Tesfa Dejenie Habtewold, Sisay Mulugeta Alemu, Shimels Hussien Mohammed, Aklilu Endalamaw, Mohammed Akibu Mohammed, Andreas A. Teferra, Abera Kenay Tura, Nigus Gebremedhin Asefa, Balewgizie Sileshi Tegegne Tags: Review Source Type: research

Real-world evidence was feasible for estimating effectiveness of chemotherapy in breast cancer; a cohort study
This study aims to determine whether using administrative healthcare data – Real World Data (RWD) - and econometric methods for causal analysis to provide ‘Real World Evidence’ (RWE) are feasible methods for addressing this gap. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - January 31, 2019 Category: Epidemiology Authors: Ewan Gray, Joachim Marti, David H. Brewster, Jeremy C. Wyatt, Romain Piaget-Rossel, Peter S. Hall Tags: Original Article Source Type: research

Real-world evidence was feasible for estimating effectiveness of chemotherapy in breast cancer: a cohort study
This study aims to determine whether using administrative health care data —real world data—and econometric methods for causal analysis to provide “real world evidence” (RWE) are feasible methods for addressing this gap. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - January 31, 2019 Category: Epidemiology Authors: Ewan Gray, Joachim Marti, David H. Brewster, Jeremy C. Wyatt, Romain Piaget-Rossel, Peter S. Hall Tags: Original Article Source Type: research

Details about informed consent procedures of randomized controlled trials should be reported transparently
Informing potential participants about the aims and procedures of a trial is mandatory when seeking their consent. A description of the potential benefits and harms of the intervention and control conditions is an integral part of the information that should be provided. The World Medical Association's Declaration of Helsinki from 1964 [1] is the most often used guideline when it comes to the content of informed consent. It states that “the nature, the purpose and the risk of clinical research must be explained to the subject by the doctor.” In addition, the Declaration of Helsinki explicitly states that consen...
Source: Journal of Clinical Epidemiology - January 29, 2019 Category: Epidemiology Authors: Daniel Kotz, Wolfgang Viechtbauer, Mark Spigt, Rik Crutzen Tags: Commentary Source Type: research

The ecosystem of evidence cannot thrive without efficiency of knowledge generation, synthesis and translation
Evidence-based medicine (EBM) has experienced numerous advances since its inception over two decades ago. Yet a persistent gulf remains between how medicine is actually practiced and the goal of providing care based on best available research evidence integrated with patient perspective and clinical expertise. A primary source of challenge for EBM is induced by inefficiencies in the generation, synthesis, and translation of evidence. During the 8th International Conference for Evidence-based Healthcare Teachers and Developers, GIMBE Foundation presented an innovative approach by defining an ecosystem of evidence. (Source: ...
Source: Journal of Clinical Epidemiology - January 29, 2019 Category: Epidemiology Authors: Antonino Cartabellotta, Julie K. Tilson Tags: Commentary Source Type: research

The timing and frequency of trial inclusion in systematic reviews of type 2 diabetes drugs was associated with trial characteristics
To determine whether certain trial characteristics are associated with faster or more frequent inclusion in systematic reviews for drug interventions in type 2 diabetes. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - January 29, 2019 Category: Epidemiology Authors: Adam G. Dunn, Liat Orenstein, Enrico Coiera, Kenneth D. Mandl, Florence T. Bourgeois Tags: Original Article Source Type: research

A Scoping Review describes Methods Used to Identify, Prioritize and Display Gaps in Health Research
This study aimed to describe the methods used to identify, prioritize and display gaps in health research. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - January 29, 2019 Category: Epidemiology Authors: Linda Nyanchoka, Catrin Tudur-Smith, Van Nguyen Thu, Valentia Iversen, Andrea C. Tricco, Rapha ël Porcher Tags: Review Source Type: research

Details about informed consent procedures of randomised controlled trials should be reported transparently
(Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - January 29, 2019 Category: Epidemiology Authors: Daniel Kotz, Wolfgang Viechtbauer, Mark Spigt, Rik Crutzen Tags: Commentary Source Type: research

The timing and frequency of trial inclusion in systematic reviews of type  2 diabetes drugs was associated with trial characteristics
To determine whether certain trial characteristics are associated with faster or more frequent inclusion in systematic reviews for drug interventions in type 2 diabetes. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - January 29, 2019 Category: Epidemiology Authors: Adam G. Dunn, Liat Orenstein, Enrico Coiera, Kenneth D. Mandl, Florence T. Bourgeois Tags: Original Article Source Type: research

The ecosystem of evidence cannot thrive without efficiency of knowledge generation, synthesis, and translation
Evidence-based medicine (EBM) has experienced numerous advances since its inception over 2  decades ago. Yet a persistent gulf remains between how medicine is actually practiced and the goal of providing care based on best available research evidence integrated with patient perspective and clinical expertise. A primary source of challenge for EBM is induced by inefficiencies in the gener ation, synthesis, and translation of evidence. During the 8th International Conference for Evidence-based Healthcare Teachers and Developers, GIMBE Foundation presented an innovative approach by defining an ecosystem of evidence. (Sou...
Source: Journal of Clinical Epidemiology - January 29, 2019 Category: Epidemiology Authors: Antonino Cartabellotta, Julie K. Tilson Tags: Commentary Source Type: research

Overview authors rarely defined systematic reviews that are included in their overviews
To report systematic review definitions that are published in overviews of reviews and to propose a new classification of systematic reviews. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - January 23, 2019 Category: Epidemiology Authors: Clovis Mariano Faggion, Karla Diaz Cavero Tags: Original Article Source Type: research

Cover 2 Editorial Board
(Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - January 15, 2019 Category: Epidemiology Source Type: research

Table of Contents
(Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - January 15, 2019 Category: Epidemiology Source Type: research

Noblesse oblige: critical issues at the highest level of clinical evidence
Systematic reviews and meta-analyses are considered to represent the highest level of clinical evidence, especially when it comes to the assessment of all available research data on the efficacy and effectiveness of interventions. This of course requires that the evaluated research is relevant for the question under study, and that the reviews and meta-analyses meet essential criteria of methodological quality, reproducibility and objectivity. Also, independence and impartiality are crucial. Preferably avoidance of –but at least appropriately and transparently managing–any potential conflicts of interest so tha...
Source: Journal of Clinical Epidemiology - January 15, 2019 Category: Epidemiology Authors: J. Andr é Knottnerus, Peter Tugwell Tags: Editorial Source Type: research

Different Evidence-Summaries have Implications for Contextualizing Findings of Meta-Analysis of Diagnostic Tests
To evaluate diagnostic tests, analysts use meta-analyses to provide inputs to parameters in decision models. Choosing parameter estimands from meta-analyses requires understanding the meta-analytic and decision-making contexts. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - January 14, 2019 Category: Epidemiology Authors: Anja Zgodic, Christopher H. Schmid, Ingram Olkin, Thomas A. Trikalinos Tags: Original Article Source Type: research

Different evidence summaries have implications for contextualizing findings of meta-analysis of diagnostic tests
To evaluate diagnostic tests, analysts use meta-analyses to provide inputs to parameters in decision models. Choosing parameter estimands from meta-analyses requires understanding the meta-analytic and decision-making contexts. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - January 14, 2019 Category: Epidemiology Authors: Anja Zgodic, Christopher H. Schmid, Ingram Olkin, Thomas A. Trikalinos Tags: Original Article Source Type: research

Medical diagnoses showed low relatedness in an explorative mutual information analysis of 190,837 inpatient cases
We aimed to quantify the shared information between medical diagnoses of an adult inpatient population in order to explore both multimorbidity patterns and vice versa the unrelatedness of medical diagnoses. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - January 11, 2019 Category: Epidemiology Authors: Jan A. Roth, Thomas Sakoparnig, Simon Neubauer, Eleonore Kuenzel-Pawlik, Martin Gerber, Andreas F. Widmer, Balthasar L. Hug, the PATREC Study Group, Christian Abshagen, Geoffrey Fucile, Martin Gerber, Balthasar L. Hug, Bernd Jaegle, Eleonore Kuenzel-Pawli Tags: Original Article Source Type: research

A Glimpse of the Difference between Predictive Modeling and Classification Modeling
(Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - January 10, 2019 Category: Epidemiology Authors: Uri Kartoun Tags: Letter to the editor Source Type: research

Rapid reviews may produce different results to systematic reviews: a meta-epidemiological study
To simulate possible changes in systematic review results if rapid review methods were used. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - December 24, 2018 Category: Epidemiology Authors: Iain Marshall, Rachel Marshall, Byron Wallace, Jon Brassey, James Thomas Tags: Original Article Source Type: research

Rapid reviews may produce different results to systematic reviews: a  meta-epidemiological study
To simulate possible changes in systematic review results if rapid review methods were used. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - December 24, 2018 Category: Epidemiology Authors: Iain J. Marshall, Rachel Marshall, Byron C. Wallace, Jon Brassey, James Thomas Tags: Original Article Source Type: research

Software engineering principles address current problems in the systematic review ecosystem
Systematic reviewers are simultaneously unable to produce systematic reviews fast enough to keep up with the availability of new trial evidence while overproducing systematic reviews that are unlikely to change practice because they are redundant or biased. Although the transparency and completeness of trial reporting has improved with changes in policy and new technologies, systematic reviews have not yet benefited from the same level of effort. We found that new methods and tools used to automate aspects of systematic review processes have focused on improving the efficiency of individual systematic reviews rather than t...
Source: Journal of Clinical Epidemiology - December 21, 2018 Category: Epidemiology Authors: Rabia Bashir, Adam G. Dunn Tags: Commentary Source Type: research

Applying software engineering principles to address current problems in the systematic review ecosystem
Systematic reviewers are simultaneously unable to produce systematic reviews fast enough to keep up with the availability of new trial evidence while over-producing systematic reviews that are unlikely to change practice because they are redundant or biased. While the transparency and completeness of trial reporting has improved with changes in policy and new technologies, systematic reviews have not yet benefited from the same level of effort, but systematic reviews have not yet benefited from the same level of effort. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - December 21, 2018 Category: Epidemiology Authors: Rabia Bashir, Adam G. Dunn Tags: Commentary Source Type: research

The methodological quality of robotic surgical meta-analyses needed to be improved: a cross-sectional study
To assess the methodological quality of robotic surgical meta-analyses (MAs) using AMSTAR-2 (A MeaSurement Tool to Assess systematic Reviews), and to explore the factors of methodological quality. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - December 20, 2018 Category: Epidemiology Authors: Peijing Yan, Liang Yao, Huijuan Li, Min Zhang, Yangqin Xun, Meixuan Li, Hui Cai, Cuncun Lu, Lidong Hu, Tiankang Guo, Rong Liu, Kehu Yang Tags: Original Article Source Type: research

Trajectories of balance skill development in a British birth cohort
To describe the natural history of balance skill development in terms of its trajectories from childhood to adolescence. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - December 17, 2018 Category: Epidemiology Authors: Paola Matiko Martins Okuda, Walter Swardfager, Paricia Silva Lucio, George B. Ploubidis, Melissa Pangelinan, Hugo Cogo-Moreira Tags: Original Article Source Type: research

The trajectory of balance skill development from childhood to adolescence was influenced by birthweight; a latent transition analysis in a British birth cohort
To describe the natural history of balance skill development in terms of its trajectories from childhood to adolescence. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - December 17, 2018 Category: Epidemiology Authors: Paola Matiko Martins Okuda, Walter Swardfager, Paricia Silva Lucio, George B. Ploubidis, Melissa Pangelinan, Hugo Cogo-Moreira Tags: Original Article Source Type: research

Participation weighting based on sociodemographic register data improved external validity in a population-based cohort study
To investigate if inverse probability of participation weighting (IPPW) using register data on sociodemographic and disease history variables can improve external validity in a cohort study with selective participation. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - December 15, 2018 Category: Epidemiology Authors: Carl Bonander, Anton Nilsson, Jonas Bj örk, Göran M.L. Bergström, Ulf Strömberg Tags: Original Article Source Type: research

Higher number of items associated with significantly lower response rates in COS Delphi surveys
The objective of this study was to explore the impact of design characteristics on response rates in Delphi surveys within COS development. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - December 14, 2018 Category: Epidemiology Authors: Elizabeth Gargon, Richard Crew, Girvan Burnside, Paula R. Williamson Tags: Original Article Source Type: research

Justification and reporting of subgroup analyses were lacking or inadequate in randomised controlled trials
To assess the appropriateness and rationales of subgroup analyses planned in protocols of randomised controlled trials and reported in subsequent corresponding trial publications. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - December 14, 2018 Category: Epidemiology Authors: Jingchun Fan, Fujian Song, Max O. Bachmann Tags: Original Article Source Type: research

Justification and reporting of subgroup analyses were lacking or inadequate in randomized controlled trials
The aim of the article was to assess the appropriateness and rationales of subgroup analyses planned in protocols of randomized controlled trials and reported in subsequent corresponding trial publications. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - December 14, 2018 Category: Epidemiology Authors: Jingchun Fan, Fujian Song, Max O. Bachmann Tags: Review Source Type: research

Living network meta-analysis is feasible when considering the pace of evidence generation
To assess the feasibility of live cumulative network meta-analysis (NMA) taking into account the pace of evidence generation across different medical areas. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - December 13, 2018 Category: Epidemiology Authors: Perrine Cr équit, Tania Martin-Montoya, Nassima Attiche, Ludovic Trinquart, Alexandre Vivot, Philippe Ravaud Tags: Original Article Source Type: research

Over a third of systematic reviews did not fully report the adverse events outcome
To assess the risk for adverse events reporting bias in systematic reviews of healthcare interventions registered to PROSPERO. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - December 13, 2018 Category: Epidemiology Authors: Rachael Parsons, Su Golder, Ian Watt Tags: Original Article Source Type: research

More than one-third of systematic reviews did not fully report the adverse events outcome
The aim of the study was to assess the risk for adverse events reporting bias in systematic reviews of health care interventions registered to PROSPERO. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - December 13, 2018 Category: Epidemiology Authors: Rachael Parsons, Su Golder, Ian Watt Tags: Original Article Source Type: research

Living network meta-analysis was feasible when considering the pace of evidence generation
To assess the feasibility of living network meta-analysis (NMA) taking into account the pace of evidence generation across different medical areas. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - December 12, 2018 Category: Epidemiology Authors: Perrine Cr équit, Tania Martin-Montoya, Nassima Attiche, Ludovic Trinquart, Alexandre Vivot, Philippe Ravaud Tags: Original Article Source Type: research

Firm human evidence on harms of endocrine disrupting chemicals (EDCs) was unlikely to be obtainable for methodological reasons
Despite plausible laboratory evidence about harms of endocrine disrupting chemicals (EDCs), systematic reviews and meta-analyses of epidemiological studies do not consistently find such harms. Indeed, there are insurmountable methodological limitations in human studies. They include unpredictable net effects of diverse EDC mixtures, low reliability of exposure assessment, non-monotonic dose-response relationships, non-existence of an unexposed group, and complicated interactions with diet and obesity. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - December 10, 2018 Category: Epidemiology Authors: Duk-Hee Lee, David R. Jacobs Tags: Original Article Source Type: research

Methodological review showed correct absolute effect size estimates for time-to-event outcomes in less than one-third of cancer-related systematic reviews
To evaluate in how many cancer-related Cochrane reviews hazard ratio (HR) based absolute effects in Summary of Findings (SoF) tables have been correctly calculated and reported. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - December 10, 2018 Category: Epidemiology Authors: Nicole Skoetz, Marius Goldkuhle, Aaron Weigl, Kerry Dwan, Val érie Labonté, Philipp Dahm, Joerg J. Meerpohl, Benjamin Djulbegovic, Elvira C. van Dalen Tags: Original Article Source Type: research

Minor differences were found between AMSTAR 2 and ROBIS in the assessment of systematic reviews including both randomized and non-randomized studies
To compare A Measurement Tool to Assess Systematic Reviews (AMSTAR 2) with a tool to assess risk of bias in systematic reviews (ROBIS) in terms of validity, reliability and applicability. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - December 10, 2018 Category: Epidemiology Authors: Dawid Pieper, Livia Puljak, Marien Gonzalez-Lorenzo, Silvia Minozzi Tags: Original Article Source Type: research

Firm human evidence on harms of endocrine-disrupting chemicals was unlikely to be obtainable for methodological reasons
Despite plausible laboratory evidence about harms of endocrine-disrupting chemicals (EDCs), systematic reviews and meta-analyses of epidemiological studies do not consistently find such harms. The purpose of this article was to discuss why solid human evidence on EDCs was unlikely to be obtainable even though they are truely harmful to humans. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - December 10, 2018 Category: Epidemiology Authors: Duk-Hee Lee, David R. Jacobs Tags: Original Article Source Type: research

A systematic review of measures estimates adherence and persistence to multiple medications
We reviewed measures used to estimate adherence and persistence to multiple cardiometabolic medications from prescription data, particularly for blood pressure-lowering, lipid-lowering, and/or glucose-lowering medication, and give guidance on which measures to choose. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - December 8, 2018 Category: Epidemiology Authors: Sofa D. Alfian, Ivan S. Pradipta, Eelko Hak, Petra Denig Tags: Review Source Type: research

A systematic review finds inconsistency in the measures used to estimate adherence and persistence to multiple cardiometabolic medications
We reviewed measures used to estimate adherence and persistence to multiple cardiometabolic medications from prescription data, particularly for blood pressure-lowering, lipid-lowering, and/or glucose-lowering medication, and give guidance on which measures to choose. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - December 8, 2018 Category: Epidemiology Authors: Sofa D. Alfian, Ivan S. Pradipta, Eelko Hak, Petra Denig Tags: Review Source Type: research

Noninferiority drug trials fail to report adequate methodological detail: an assessment of noninferiority trials from 2010 to 2015
Noninferiority (NI) trials are prevalent in many therapeutic areas and are used to evaluate new drugs [1 –4]. When reading NI trials, one must pay special attention to the justification for the NI margin [5,6]. With the NI margin being a key part of NI trial design, any questionable justification for the choice of the NI margin can lead to incorrectly declaring a new drug a reasonable alternative to the current standard therapy. Many comprehensive reviews have assessed the quality of reporting in NI trials and revealed considerable problems in reporting of the justification for NI margins [7–9]. (Source: Journa...
Source: Journal of Clinical Epidemiology - December 7, 2018 Category: Epidemiology Authors: Jenny Hong, Anthony Tung, Angus Kinkade, Aaron M. Tejani Tags: Letter to the Editor Source Type: research

An overview of statistical methods for handling non-adherence to intervention protocol in randomised control trials (RCTs): A methodological review
To undertake a methodological review of statistical methods used in randomised controlled trials (RCTs) for handling intervention non-adherence. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - December 7, 2018 Category: Epidemiology Authors: Mohammod Mostazir, Rod S. Taylor, William Henley, Ed Watkins Tags: Review Source Type: research

Automatic screening using word embeddings achieved high sensitivity and workload reduction for updating living network meta-analyses
We aimed to develop and evaluate an algorithm for automatically screening citations when updating living network meta-analysis (NMA). (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - December 7, 2018 Category: Epidemiology Authors: Ivan Lerner, Perrine Cr équit, Philippe RAVAUD, Ignacio ATAL Tags: Original Article Source Type: research