Validation in prediction research: the waste by data-splitting
(Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - July 28, 2018 Category: Epidemiology Authors: Ewout W. Steyerberg Tags: Commentary Source Type: research

The Consensus on Exercise Reporting Template (CERT) applied to exercise interventions in musculoskeletal trials demonstrated good rater agreement and incomplete reporting
To determine inter-rater agreement and utility of the Consensus on Exercise Reporting Template (CERT) for evaluating reporting of musculoskeletal exercise trials. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - July 25, 2018 Category: Epidemiology Authors: Slade SC, Finnegan S, Dionne CE, Underwood M, Buchbinder R Tags: Original Article Source Type: research

Guidance was developed on how to write a plain language summary for diagnostic test accuracy reviews
To develop guidance for authors of diagnostic test accuracy (DTA) reviews to help them write a plain language summary (PLS) of the results of their review. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - July 20, 2018 Category: Epidemiology Authors: Penny Whiting, Mariska Leeflang, Isabel de Salis, Reem A. Mustafa, Nancy Santesso, Gowri Gopalakrishna, Geraldine Cooney, Emily Jesper, Joanne Thomas, Clare Davenport Tags: Original Article Source Type: research

Handling the reflective-formative measurement conundrum: A practical illustration based on sustainable employability
Constructs capturing health or functioning can have reflective and/or formative measurement models. Although a construct ’s measurement model has extensive implications on the construction, validation and use of a measurement instrument, measurement models are frequently wrongly or not explicitly specified. As this is likely due to a lack of guidelines, this study uses sustainable employability as an example to demo nstrate a) the applicability of an adapted checklist for establishing a construct’s measurement model; and b) the use of structural equation modelling to handle formative constructs. (Source: Journa...
Source: Journal of Clinical Epidemiology - July 18, 2018 Category: Epidemiology Authors: Bram P.I. Fleuren, Ludovic G.P.M. van Amelsvoort, Fred R.H. Zijlstra, Andries de Grip, IJmert Kant Tags: Original Article Source Type: research

Using a single noninferiority margin or preserved fraction for an entire pharmacological class was found to be inappropriate
To assess the impact on noninferiority decisions when using a single margin or single preserved fraction (PF) for all noninferiority trials within a pharmacological class. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - July 15, 2018 Category: Epidemiology Authors: Turki A. Althunian, Anthonius de Boer, Rolf H.H. Groenwold, Olaf H. Klungel Tags: Original Article Source Type: research

Classical Test Theory and Item Response Theory produced differences on estimation of Reliable Clinical Index in WHODAS 2.0
The objective of this study is to analyze the clinically reliable change of WHODAS 2.0 by applying both Classical Test Theory (CTT) and the Item Response Theory (IRT). (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - July 15, 2018 Category: Epidemiology Authors: Oscar Lozano, Juan Jos é Mancheño, Marcos Cupani, Elena Delgado Rico, Enrique Moraleda, Pilar Cáceres-Pachón, Fermín Fernández Calderón Tags: Original Article Source Type: research

Using a single non-inferiority margin or preserved fraction for an entire pharmacological class was found to be inappropriate
To assess the impact on non-inferiority decisions when using a single margin or single preserved fraction (PF) for all non-inferiority trials within a pharmacological class. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - July 15, 2018 Category: Epidemiology Authors: Turki A. Althunian, Anthonius de Boer, Rolf H.H. Groenwold, Olaf H. Klungel Tags: Original Article Source Type: research

Two morbidity indices developed in a nationwide population permitted performant outcome-specific severity adjustment
To develop and validate two outcome-specific morbidity indices in a population-based setting: the Mortality-Related Morbidity Index (MRMI) predictive of all-cause mortality and the Expenditure-Related Morbidity Index (ERMI) predictive of healthcare expenditure. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - July 15, 2018 Category: Epidemiology Authors: Panayotis Constantinou, Philippe Tuppin, Anne Fagot-Campagna, Christelle Gastaldi-M énager, François G. Schellevis, Nathalie Pelletier-Fleury Tags: Original Article Source Type: research

The development of an ICF-based questionnaire for patients with chronic conditions in primary care
We developed a self-reported questionnaire for patients in primary care with chronic conditions aged 50 years or older. The questionnaire supports a more person-centered approach by adopting a biopsychosocial focus on functional status instead of a focus on disease. Based on the International Classification of Functioning, Disability and Health (ICF), an ICF Primary Care set for patients with chronic conditions was constructed in three phases. In the first phase, we identified relevant ICF categories for the ICF Primary Care set by using existing ICF sets for chronic health conditions. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - July 15, 2018 Category: Epidemiology Authors: S.A.E. Postma, K. van Boven, H. ten Napel, D.L. Gerritsen, W.J.J. Assendelft, H. Schers, T.C. olde Hartman Tags: Original Article Source Type: research

Application of competing risks analysis improved prognostic assessment of patients with decompensated chronic heart failure and reduced left ventricular ejection fraction
Kaplan-Meier method may overestimate absolute mortality risk (AMR) in the presence of competing risks. Urgent heart transplantation (UHT) and ventricular assist device implantation (VADi) are important competing events in heart failure. We sought to quantify the extent of bias of Kaplan-Meier method in estimating AMR in the presence of competing events and to analyse the effect of covariates on the hazard for death and competing events in the clinical model of decompensated chronic heart failure with reduced ejection fraction (DCHFrEF). (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - July 15, 2018 Category: Epidemiology Authors: Domenico Scrutinio, Pietro Guida, Andrea Passantino, Enrico Ammirati, Fabrizio Oliva, Rocco Lagioia, Maria Frigerio Tags: Original Article Source Type: research

Cover 2 Editorial Board
(Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - July 12, 2018 Category: Epidemiology Source Type: research

Table of Contents
(Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - July 12, 2018 Category: Epidemiology Source Type: research

Ethics of research methodology requires a methodology of research ethics
Integrity and ethical issues play a role throughout all phases of clinical research. First, policies and decisions that determine the research agenda, prioritizing some topics above other ones, have substantial normative impact. Second, in conducting research, ethical aspects often play a role in specifying the question, designing the study, consent methods, statistical methodology, and interpretation of the results. Third, in publishing research ethical considerations are essential. And finally, also financial and organizational arrangements and possible conflicts of interest have ethical implications. (Source: Journal of...
Source: Journal of Clinical Epidemiology - July 12, 2018 Category: Epidemiology Authors: J. Andr é Knottnerus, Peter Tugwell Tags: Editorial Source Type: research

Extending PubMed Searches to ClinicalTrials.gov Through a Machine Learning Approach for Systematic Reviews
This study aims to provide an automated approach to extend a search on PubMed to the ClinicalTrials.gov database, relying on text mining and machine learning techniques. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - July 5, 2018 Category: Epidemiology Authors: Corrado Lanera, Clara Minto, Abhinav Sharma, Dario Gregori, Paola Berchialla, Ileana Baldi Tags: Original Article Source Type: research

Statistical power of clinical trials increased while effect size remained stable: an empirical analysis of 136,212 clinical trials between 1975-2014
To study the statistical power of randomized clinical trials and examine developments over time. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - July 5, 2018 Category: Epidemiology Authors: Herm J. Lamberink, Willem M. Otte, Michel RT. Sinke, Dani ël Lakens, Paul P. Glasziou, Joeri K. Tijdink, Christiaan H. Vinkers Tags: Original Article Source Type: research

Diagnostic test guidelines based on high-quality evidence had greater rates of adherence: A meta-epidemiological study
To determine the association between the quality of guidelines for diagnostic tests (both the quality and reporting and the quality of the evidence underpinning recommendations) and non-adherence. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - July 5, 2018 Category: Epidemiology Authors: J.W. O ’Sullivan, A. Albasri, C. Koshiaris, J.K. Aronson, C. Heneghan, R. Perera Tags: Original Article Source Type: research

Patients and investigators prefer measures of absolute risk in subgroups for pragmatic randomized trials
Pragmatic randomized trials are important tools for shared decision-making, but no guidance exists on patients' preferences for types of causal information. We aimed to assess preferences of patients and investigators toward causal effects in pragmatic randomized trials. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - July 2, 2018 Category: Epidemiology Authors: Eleanor J. Murray, Ellen C. Caniglia, Sonja A. Swanson, Sonia Hern ández-Díaz, Miguel A. Hernán Tags: Original Article Source Type: research

GRADEing the un-GRADE-able: a description of challenges in applying GRADE methods to the ethical and implementation questions of pediatric organ donation guidelines
Good practice statements (GPSs) have been proposed by the GRADE working group as a way of avoiding the inappropriate characterization of evidence as low quality in support of strong recommendations justified by indirect evidence. This commentary examines how the GPS methodology was applied to the development of a recent guideline for pediatric deceased donation after circulatory determined death. This guideline was informed by a broad body of indirect literature and addressed a variety of social, legal, and ethical questions in addition to several implementation issues. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - July 2, 2018 Category: Epidemiology Authors: Matthew J. Weiss, Laura Hornby, Sam D. Shemie, Amber Appleby, Bram Rochwerg Tags: Commentary Source Type: research

Patients and investigators preferred measures of absolute risk in subgroups for pragmatic randomized trials
Pragmatic randomized trials are important tools for shared decision-making, but no guidance exists on patients ’ preferences for types of causal information. We aimed to assess preferences of patients and investigators towards causal effects in pragmatic randomized trials. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - July 2, 2018 Category: Epidemiology Authors: Eleanor J. Murray, Ellen C. Caniglia, Sonja A. Swanson, Sonia Hern ández-Díaz, Miguel A. Hernán Tags: Original Article Source Type: research

Guidelines for multiple imputations in repeated measurements with time-dependent covariates: A case study
We provide guidelines for handling the most common missing data problems in repeated measurements in observational studies and deal with practicalities in producing imputations when there are many partly missing time-varying variables and repeated measurements. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - July 2, 2018 Category: Epidemiology Authors: Frans E.S. Tan, Shahab Jolani, Hilde Verbeek Source Type: research

A Survey of Delphi Panelists after Core Outcome Set Development Revealed Positive Feedback and Methods to Facilitate Panel Member Participation
(s): To elicit feedback on consensus methodology used for core outcome set development. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - July 2, 2018 Category: Epidemiology Authors: Alison E. Turnbull, Victor D. Dinglas, Lisa Aronson Friedman, Caroline M. Chessare, Kristin A. Sep úlveda, Clifton O. Bingham, Dale M. Needham Tags: Original Article Source Type: research

Grading the un-grade-able : Methods used to develop National, Canadian pediatric donation after Circulatory determination of death (pDCD) Guidelines
Good Practice Statements (GPS) have been proposed by the GRADE working group as a way of avoiding the inappropriate characterization of evidence as low quality in support of strong recommendations justified by indirect evidence. This commentary examines how the GPS methodology was applied to the development of a recent guideline for pediatric deceased donation after circulatory determined death. This guideline was informed by a broad body of indirect literature and addressed a variety of social, legal, and ethical questions in addition to several implementation issues. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - July 2, 2018 Category: Epidemiology Authors: Matthew J. Weiss, Laura Hornby, Sam D. Shemie, Amber Appleby, Bram Rochwerg Tags: Commentary Source Type: research

Mixed-methods research revealed the need for Dementia Services and Human Resource Master Plan in an Aging Philippines
To determine the status of dementia care services and workforce in selected public and private hospitals and geriatric-care facilities in the Philippines. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - July 2, 2018 Category: Epidemiology Authors: Shelley F. Dela Vega, Cynthia P. Cordero, Leah A. Palapar, Angely P. Garcia, Josephine D. Agapito Tags: Review Source Type: research

Design Analysis Indicates Potential Overestimation of Treatment Effects in Randomized Controlled Trials Supporting FDA Cancer Drug Approvals
We examined the type S error risk – claiming a new drug is falsely beneficial – and exaggeration ratio - how estimated effects differ from true effects – to reemphasize direction and magnitude of treatment effects. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - July 2, 2018 Category: Epidemiology Authors: Emily M. Lord, Isabelle R. Weir, Ludovic Trinquart Tags: Original Article Source Type: research

Improving the Conduct of Systematic Reviews: A Process Mining Perspective
To illustrate the use of process mining concepts, techniques, and tools to improve the systematic review process. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - July 2, 2018 Category: Epidemiology Authors: Ba ’ Pham, Ebrahim Bagheri, Patricia Rios, Asef Pourmasoumi, Reid C. Robson, Jeremiah Hwee, Wanrudee Isaranuwatchai, Nazia Darvesh, Matthew J. Page, Andrea C. Tricco Tags: Original Article Source Type: research

GRADE weak or conditional recommendations mandate shared decision-making. Author Response
Thanks to Drs Schoemaker and van der Heijden [1] for  giving me an opportunity to clarify Grades of Recommendation, Assessment, Development and Evaluation (GRADE's) position with respect to weak recommendations and shared decision-making. I am delighted to provide reassurance to Drs Schoemaker and van der Heijden: GRADE's initial position on the matt er remains unchanged. That is, physicians facing weak recommendations “should recognize that different choices will be appropriate for different patients and that you must help each patient to arrive at a management decision consistent with her or his values and pre...
Source: Journal of Clinical Epidemiology - June 21, 2018 Category: Epidemiology Authors: Gordon Guyatt Tags: Letter to the Editor Source Type: research

GRADE weak or conditional recommendations mandate shared decision-making
(Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - June 21, 2018 Category: Epidemiology Authors: Gordon Guyatt Source Type: research

Does GRADE gently close the door on sharing decisions with patients?
(Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - June 20, 2018 Category: Epidemiology Authors: Casper G. Schoemaker, Geert JMG. van der Heijden Tags: Letter to the editor Source Type: research

Existing evidence summarization methods cannot guarantee trustworthy patient decision aids
Our aim was to evaluate how organizations that develop patient decision aids conduct their evidence summarization process and assess whether their current processes provide sufficient information to instill confidence that patient decision aids are trustworthy and up to date. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - June 18, 2018 Category: Epidemiology Authors: Michelle D. Dannenberg, Marie-Anne Durand, Victor M. Montori, Clifford Reilly, Glyn Elwyn Tags: Original Article Source Type: research

Existing evidence summarization methods can't guarantee trustworthy patient decision aids
Our aim was to evaluate how organizations that develop patient decision aids conduct their evidence summarization process and assess whether their current processes provide sufficient information to instill confidence that patient decision aids are trustworthy and up-to-date (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - June 18, 2018 Category: Epidemiology Authors: Michelle D. Dannenberg, Marie-Anne Durand, Victor M. Montori, Clifford Reilly, Glyn Elwyn Source Type: research

Cover 2 Editorial Board
(Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - June 16, 2018 Category: Epidemiology Source Type: research

Table of Contents
(Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - June 16, 2018 Category: Epidemiology Source Type: research

The need for consensus on consensus methods
The science of consensus-oriented-decision-making methods is still in its infancy despite the increased emphasis on patient and multiple stakeholder engagement in clinical research. This process is used for a variety of objectives including research terminology, setting research priorities, establishing core outcome domains and instrument sets, and reporting guidelines. This was a major topic at the most recent OMERACT outcomes meeting in Australia. The key elements of the approach are agreement seeking, collaborative, cooperative, egalitarian, inclusive, participatory. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - June 16, 2018 Category: Epidemiology Authors: Peter Tugwell, J. Andr é Knottnerus Tags: Editorial Source Type: research

Community-based recruitment for clinical trials poses the need for social and ethical considerations
This paper ’s objective was to describe the processes, strategies, and challenges of community-based recruitment to complement hospital-based recruitment for a global clinical outcomes trial on chronic obstructive pulmonary disease (COPD). (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - June 16, 2018 Category: Epidemiology Authors: Mary Ann J. Ladia, Olivia T. Sison, Cora A. Anonuevo, Marissa M. Alejandria Source Type: research

A Methodological Framework for Model Selection in Interrupted Time Series Studies
Interrupted time series is a powerful and increasingly popular design for evaluating public health and health service interventions. The design involves analysing trends in the outcome of interest and estimating the change in trend following an intervention relative to the counterfactual (the expected ongoing trend if the intervention had not occurred). There are two key components to modelling this effect: first, defining the counterfactual; second, defining the type of effect that the intervention is expected to have on the outcome, known as the impact model. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - June 6, 2018 Category: Epidemiology Authors: J. Lopez Bernal, S. Soumerai, A. Gasparrini Source Type: research

Inadequate diversity of information resources searched in US-affiliated systematic reviews and meta-analyses: 2005 –2016
Systematic reviews and meta-analyses (SRMAs) rely upon comprehensive searches into diverse resources that catalog primary studies. However, since what constitutes a comprehensive search is unclear, we examined trends in databases searched from 2005-2016, surrounding the publication of search guidelines in 2013, and associations between resources searched and evidence of publication bias in SRMAs involving human subjects. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - June 4, 2018 Category: Epidemiology Authors: Richeek Pradhan, Kyle Garnick, Bikramjit Barkondaj, Harmon S. Jordan, Arlene Ash, Hong Yu Tags: Original Article Source Type: research

Bayesian synthesis using prior information on fracture risk from randomized trials to analyze post-market data
To conduct a Bayesian evidence synthesis using commonly available statistical procedures to estimate fracture risk for postmenopausal women undergoing hormonal therapy for breast cancer. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - June 4, 2018 Category: Epidemiology Authors: Ava John-Baptiste, Taryn Becker, Kinwah Fung, Lorraine L. Lipscombe, Peter C. Austin, Geoffrey M. Anderson Tags: Original Article Source Type: research

Using Bayesian evidence synthesis to estimate fracture risk associated with hormonal therapy in breast cancer
To conduct a Bayesian evidence synthesis using commonly available statistical procedures in order to estimate fracture risk for postmenopausal women undergoing hormonal therapy for breast cancer. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - June 4, 2018 Category: Epidemiology Authors: Ava A. John-Baptiste, Taryn Becker, Kinwah Fung, Lorraine L. Lipscombe, Peter C. Austin, Geoffrey M. Anderson Tags: Original Article Source Type: research

Inadequate diversity of information resources searched in USA-affiliated systematic reviews and meta-analyses: 2005-2016
(Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - June 4, 2018 Category: Epidemiology Authors: Richeek Pradhan, Kyle Garnick, Bikramjit Barkondaj, Harmon S. Jordan, Arlene Ash, Hong Yu Source Type: research

Abbreviated literature searches were viable alternatives to comprehensive searches: a meta-epidemiological study
To assess the effects of abbreviated literature searches on evidence syntheses conclusions. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - June 1, 2018 Category: Epidemiology Authors: B. Nussbaumer-Streit, I. Klerings, G. Wagner, T.L. Heise, A.I. Dobrescu, S. Armijo-Olivo, J.M. Stratil, Emma Persad, S.K. Lhachimi, M.G. Van Noord, T. Mittermayr, H. Zeeb, L. Hemkens, G. Gartlehner Source Type: research

Three risk of bias tools lead to opposite conclusions in observational research synthesis
The aim of this study is to assess the agreement and compare the performance of three different instruments in assessing risk of bias (RoB) of comparative cohort studies included in a health psychology meta-analysis. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - June 1, 2018 Category: Epidemiology Authors: Josep-Maria Losilla, Isabel Oliveras, Juan A. Marin-Garcia, Jaume Vives Source Type: research

Pre-specification of statistical analysis approaches in published clinical trial protocols was inadequate
Results from randomized trials can depend upon the statistical analysis approach used. It is important to pre-specify the analysis approach in the trial protocol to avoid selective reporting of analyses based on which provides the most favourable results. We undertook a review of published trial protocols to assess how often the statistical analysis of the primary outcome was adequately pre-specified. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - June 1, 2018 Category: Epidemiology Authors: Lauren Greenberg, Vipul Jairath, Rupert Pearse, Brennan C. Kahan Source Type: research

Patient preferences for Personalized (N-of-1) Trials: A conjoint analysis
Despite their promise for increasing treatment precision, Personalized Trials (i.e., N-of-1 trials) have not been widely adopted. We aimed to ascertain patient preferences for Personalized Trials. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - May 30, 2018 Category: Epidemiology Authors: Nathalie Moise, Dallas Wood, Ying Kuen K Cheung, Naihua Duan, Tara St. Onge, Joan Duer-Hefele, Tiffany Pu, Karina W. Davidson, Ian M. Kronish, the members of the “Personalized Trial Collaboratory” Source Type: research

The smallest worthwhile effect of primary care physiotherapy did not differ across musculoskeletal pain sites
To determine and compare estimates of the smallest worthwhile effect (SWE) for physiotherapy in neck, shoulder and low back patients, and to investigate the influence of socio-demographic, clinical and psychological factors on these estimates. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - May 28, 2018 Category: Epidemiology Authors: David H. Christiansen, Nils-Bo de Vos Andersen, Per H. Poulsen, Raymond W. Ostelo Source Type: research

Relationships between abstract features and methodological quality explained variations of social media activity derived from systematic reviews about psoriasis interventions
The aim of this study was to describe the relationship among abstract structure, readability, and completeness, and how these features may influence social media activity and bibliometric results, considering systematic reviews (SRs) about interventions in psoriasis classified by methodological quality. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - May 24, 2018 Category: Epidemiology Authors: J. Ruano, M. Aguilar-Luque, B. Isla-Tejera, P. Alcalde-Mellado, J. Gay-Mimbrera, Jos é Luis Hernandez-Romero, J.L. Sanz-Cabanillas, B. Maestre-López, M. González-Padilla, P.J. Carmona-Fernández, F. Gómez-García, A. Vélez García-Nieto Tags: Original Article Source Type: research

A third perspective on the effects of general health checks may provide a less biased estimate. Author response
Bruun Larsen et  al. have performed a CACE analysis, which compares mortality among actual participants of the intervention group with a hypothesized group of participants in the control group in the Inter99 study [1]. CACE analyses could be a valuable supplement to existing analyses, if we did not have the result s from an intention-to-treat (ITT) analysis, but we have these results making CACE analyses unnecessary. The authors suggest on the basis of their CACE analyses that there is a beneficial effect of the Inter99 study on total mortality among those who participated in the health check and lifestyle in terventi...
Source: Journal of Clinical Epidemiology - May 23, 2018 Category: Epidemiology Authors: Anne Mette Bender, Charlotta Pisinger, Torben J ørgensen Tags: Letter to the Editor Source Type: research

A third perspective on the effects of general health checks may provide a less biased estimate (letter commenting J Clin Epidemiol 2016;71:120 –2)
(Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - May 23, 2018 Category: Epidemiology Authors: Lars Bruun Larsen, Trine Thilsing, Jens Sondergaard, Anne-Louise Bjerregaard Tags: Letter to the editor Source Type: research

Response to letter to the editor “A third perspective on the effects of general health checks may provide a less biased estimate”
(Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - May 23, 2018 Category: Epidemiology Authors: Anne Mette Bender, Charlotta Pisinger, Torben J ørgensen Tags: Letter to the editor Source Type: research

Cochrane acute respiratory infections group's stakeholder engagement project identified systematic review priority areas
We report the results of a prioritization project, aiming to identify highest priority systematic review topics. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - May 22, 2018 Category: Epidemiology Authors: Anna Mae Scott, Justin Clark, Liz Dooley, Ann Jones, Mark Jones, Chris Del Mar Tags: Original Article Source Type: research

Off-label prescription: experience is a gloomy lantern that does not even illuminate its bearer. Author response
We fully agree with Alain Braillon [1] that the question of whether to promote or restrict therapeutic off-label drug use is multifaceted. In our study [2], we explored the clinical trial evidence as only one of the many facets. Our findings suggest a mixed picture regarding the comparative effectiveness of off-label uses, which requires a careful consideration of the clinical evidence on a case-by-case basis. We believe that this finding should inform policy decisions on off-label drug use, but many other aspects remain clearly important and should receive equal consideration. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - May 22, 2018 Category: Epidemiology Authors: Aviv Ladanie, John P.A. Ioannidis, Randall S. Stafford, Hannah Ewald, Heiner C. Bucher, Lars G. Hemkens, Lars G. Hemkens Tags: Letter to the Editor Source Type: research