Table of Contents
(Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - August 29, 2018 Category: Epidemiology Source Type: research

The evidence arena: a multilevel playing field
Health problems are often perceived as problems of individuals who struggle to develop a healthier life style or to find effective treatment. But this is by far not the whole story. In promoting healthy living, contextual factors play an essential –and sometimes the most important - role. And for good prevention and care appropriate staff, knowledge and expertise, and state-of-the-art health care services must be available. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - August 29, 2018 Category: Epidemiology Authors: J. Andr é Knottnerus, Peter Tugwell Tags: Editorial Source Type: research

SMOOTH: Self-Management of Open Online Trials in Health analysis  found improvements were needed for reporting methods of internet-based trials
The growth of trials conducted over the internet has increased, but with little practical guidance for their conduct, and it is sometimes challenging for researchers to adapt the conventions used in face-to-face trials and maintain the validity of the work. The aim of the study is to systematically explore existing self-recruited online randomized trials of self-management interventions and analyze the trials to assess their strengths and weaknesses, the quality of reporting, and the involvement of lay persons as collaborators in the research process. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - August 29, 2018 Category: Epidemiology Authors: Amy Price, Lenny Vasanthan, Mike Clarke, Su May Liew, Anne Brice, Amanda Burls Tags: Review Source Type: research

SMOOTH (Self-Management of Open Online Trials in Health) analysis found improvements were needed for reporting methods of internet-based trials
The growth of trials conducted over the internet has increased, but with little practical guidance for their conduct and it is sometimes challenging for researchers to adapt the conventions used in face-to-face trials and maintain the validity of the work. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - August 29, 2018 Category: Epidemiology Authors: Amy Price, Lenny Vasanthan, Mike Clarke, Su May Liew, Anne Brice, Amanda Burls Tags: Review Source Type: research

Nutrition Guidelines vary widely in methodological quality: An overview of reviews
To identify, describe and map contemporary nutrition guidelines (NGs) from reviews that used the AGREE tool. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - August 29, 2018 Category: Epidemiology Authors: Montserrat Rabassa, S ònika Garcia-Ribera Ruiz, Ivan Solà, Hector Pardo-Hernandez, Pablo Alonso-Coello, Laura Martínez García Tags: Review Source Type: research

Integrated prediction and decision models are valuable in informing personalized decision making
To show how prediction models can be incorporated in decision models, to allow for personalized decisions; and to assess the value of this approach using the management of the neck in early stage oral cavity squamous cell carcinoma (OCSCC) as an example. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - August 28, 2018 Category: Epidemiology Authors: Tim M. Govers, Maroeska M. Rovers, Marieke T. Brands, Emilie A.C. Dronkers, Robert J. Baatenburg de Jong, Matthias A.W. Merkx, Robert P. Takes, Janneke P.C. Grutters Tags: Original Article Source Type: research

Comparability of treatment arms does not prevent  correlated trial results
In a simulation study [1], we identified possible dependence between trial results when conducting multiple trials within a cohort multiple randomized controlled trial (cmRCT) setting [2]. In their letter, Verkooijen et  al. [3] argue that contrary to our results, there is “no concern for dependency” as long as eligible patients for any given new trial are randomly selected into either of its arms. We disagree with this assertion. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - August 23, 2018 Category: Epidemiology Authors: Rolf H.H. Groenwold, Maarten van Smeden Tags: Letter to the Editor Source Type: research

Sample size calculations are poorly conducted and reported in many  randomized trials of hip and knee osteoarthritis: results of a systematic review
To review the methodology and reporting of sample size calculations in a contemporary sample of trials in osteoarthritis. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - August 23, 2018 Category: Epidemiology Authors: Bethan Copsey, Jacqueline Y. Thompson, Karan Vadher, Usama Ali, Susan J. Dutton, Raymond Fitzpatrick, Sarah E. Lamb, Jonathan A. Cook Tags: Review Source Type: research

Don't forget about the “R” in cmRCT: reply to Groenwold and van Smeden
With great interest, we read the paper “Investigation of the ‘m’ in the cmRCT design revealed dependence between trial results” [1]. We were particularly triggered by the rather alarming title. Upon reading the paper, however, our worries disappeared. It seems that, while focusing on the “m” in cmRCT, the authors forgot to th ink about the “R.” (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - August 23, 2018 Category: Epidemiology Authors: Helena M. Verkooijen, Alice Couwenberg, Anne May, Brett Thombs, Linda Kwakkenbos, Merrick Zwarenstein Tags: Letter to the Editor Source Type: research

Comparability of treatment arms does not prevent correlated trial results
In a simulation study [1], we identified possible dependence between trial results when conducting multiple trials within a cohort multiple randomized controlled trial (cmRCT) setting [2]. In their letter, Verkooijen et  al. [3] argue that contrary to our results, there is “no concern for dependency” as long as eligible patients for any given new trial are randomly selected into either of its arms. We disagree with this assertion. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - August 23, 2018 Category: Epidemiology Authors: Rolf H.H. Groenwold, Maarten van Smeden Tags: Letter to the Editor Source Type: research

Certainty ranges facilitated explicit and transparent judgments regarding evidence credibility
The GRADE approach to rating certainty of evidence includes five domains of reasons for rating down certainty. Only one of these, precision, is easily amenable – through the confidence interval – to quantitation. The other four (risk of bias, inconsistency, indirectness, publication bias) are not. Nevertheless, conceptually, one could consider a quantified “certainty range” within which the true effect lies. The certainty range would be at least as wide as the confidence interval, and would expand with each additional reason for uncertainty. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - August 23, 2018 Category: Epidemiology Authors: Kari A.O. Tikkinen, Samantha Craigie, Holger J. Sch ünemann, Gordon H. Guyatt Tags: Original Article Source Type: research

Sample size calculations are poorly conducted and reported in many randomised trials of hip and knee osteoarthritis: results of a systematic review
To review the methodology and reporting of sample size calculations in a contemporary sample of trials in osteoarthritis. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - August 23, 2018 Category: Epidemiology Authors: B. Copsey, J. Thompson, K. Vadher, U. Ali, S. Dutton, R. Fitzpatrick, S.E. Lamb, J.A. Cook Source Type: research

Don ’t forget about the ‘R’ in cmRCT; Reply to Groenwold and van Smeden
(Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - August 23, 2018 Category: Epidemiology Authors: Helena M. Verkooijen, Alice Couwenberg, Anne May, Brett Thombs, Linda Kwakkenbos, Merrick Zwarenstein Tags: Letter to the editor Source Type: research

Comparability of treatment arms does not prevent correlated trial results: Author response
(Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - August 23, 2018 Category: Epidemiology Authors: Rolf Groenwold, Maarten van Smeden Source Type: research

Letter re: Christiansen DH, de Vos Andersen N-B,  Poulsen PH, Ostelo RW, The smallest worthwhile effect of primary care physiotherapy did not differ across musculoskeletal pain sites, Journal of clinical epidemiology (2018), doi: 10.1016/j.jclinepi.2018.05.019
We read with great interest the recent paper titled “The smallest worthwhile effect of primary care physiotherapy did not differ across musculoskeletal pain sites.” We commend the authors for investigating this important topic and believe this paper makes very useful contributions. We agree that the widely used anchor or distribution-based method s for obtaining clinically important effect estimates are flawed. The approach of investigating smallest worthwhile effects (SWEs) using the benefit–harm trade-off is, in our opinion, a more valid approach. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - August 22, 2018 Category: Epidemiology Authors: Mark J. Hancock, Peter Kent Tags: Letter to the Editor Source Type: research

Reply to Hancock and Kent. Clinical important differences: a step toward a more intervention-specific approach
We thank Hancock and Kent for their letter [1]. We agree with them that the smallest worthwhile effect (SWE) estimates might be prone to erroneous interpretations, and we thank them for the opportunity to provide a more in-depth discussion of our study results. Indeed, the key finding of our study is that the median SWE was 20% (IQR 10% –30%) [2]. The interpretation of this figure should take into account our method of estimating the SWE. For this estimation we used the scripts as presented in Appendix A. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - August 22, 2018 Category: Epidemiology Authors: David H. Christiansen, Nils-Bo de Vos Andersen, Per H. Poulsen, Raymond W. Ostelo Tags: Letter to the Editor Source Type: research

Letter re: Christiansen DH, de Vos Andersen N-B, Poulsen PH, Ostelo RW, The smallest worthwhile effect of primary care physiotherapy did not differ across musculoskeletal pain sites
(Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - August 22, 2018 Category: Epidemiology Authors: Peter Kent, Mark Hancock Tags: Letter to the editor Source Type: research

Reply to Hancock and Kent Clinical important differences: a step towards a more intervention specific approach
(Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - August 22, 2018 Category: Epidemiology Authors: de Vos Andersen Nils-Bo, Per H. Poulsen, Raymond Ostelo, David H. Christiansen Tags: Letter to the editor Source Type: research

Subgroup analyses are seldom possible and subgroup effects are rare in Cochrane HIV systematic reviews
(Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - August 20, 2018 Category: Epidemiology Authors: Lawrence Mbuagbaw, Gian Paolo Morgano, Daeria Lawson, Agatha Nyambi, Mark Youssef, Oluwatobi Olaiya, Lehana Thabane Tags: Letter to the editor Source Type: research

Cover 2 Editorial Board
(Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - August 18, 2018 Category: Epidemiology Source Type: research

Table of Contents
(Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - August 18, 2018 Category: Epidemiology Source Type: research

Scoring of methods indices
Better description of interventions is important to improve replication in clinical practice and reduce waste in research so the development of the Template for Intervention Description and Replication (TIDieR) has been welcomed. Yamato et  al. now propose a method based on Rasch analysis construct a score to provide an overall summary number to reflect the multiple components in the checklist, that if it is shown to work on other datasets, will be useful for decision-makers. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - August 18, 2018 Category: Epidemiology Authors: Peter Tugwell, J. Andr é Knottnerus Tags: Editorial Source Type: research

A digital media strategy to obtain unpublished data for a systematic review yields a very high author response rate
What is new? (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - August 18, 2018 Category: Epidemiology Authors: Claire Godard-Sebillotte, M élanie Le Berre, Sathya Karunananthan, Quan Nha Hong, Isabelle Vedel Tags: Letter to the editor Source Type: research

Toward a theory-led metaframework for considering socioeconomic health inequalities within systematic reviews
To develop a theory-led framework to inform reviewers ’ understanding of what, how, and why health care interventions may lead to differential effects across socioeconomic groups. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - August 17, 2018 Category: Epidemiology Authors: Michelle Maden, Naoimh McMahon, Andrew Booth, Rumona Dickson, Suzy Paisley, Mark Gabbay Tags: Original Article Source Type: research

Towards a theory-led meta-framework for considering socioeconomic health inequalities within systematic reviews
To develop a theory-led framework to inform reviewers ’ understanding of what, how and why healthcare interventions may lead to differential effects across socio-economic groups. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - August 17, 2018 Category: Epidemiology Authors: Michelle Maden, Naoimh McMahon, Andrew Booth, Rumona Dickson, Suzy Paisley, Mark Gabbay Tags: Original Article Source Type: research

The transitional risk and incident questionnaire was valid and reliable for measuring transitional patient safety from the patients' perspective
This study describes the development and validation of the Transitional Risk and Incident Questionnaire (TRIQ), which measures transitional patient safety from the patients ’ perspective. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - August 16, 2018 Category: Epidemiology Authors: Marije A. van Melle, Henk F. van Stel, Judith M. Poldervaart, Niek J. de Wit, Dorien L.M. Zwart Tags: Original Article Source Type: research

Controversy and debate: memory-based methods paper 1: the fatal flaws of food frequency questionnaires and other memory-based dietary assessment methods
There is an escalating debate over the value and validity of self-reported dietary intake as estimated by Food Frequency Questionnaires and other forms of memory-based dietary assessment methods. Proponents argue that despite limitations, memory-based methods provide valid and valuable information about consumed foods and beverages and therefore can be used to assess diet-disease relations. In fact, over the past 60  years, thousands of memory-based dietary research reports were used to inform public policy and establish the Dietary Guidelines for Americans. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - August 16, 2018 Category: Epidemiology Authors: Edward Archer, Michael L. Marlow, Carl J. Lavie Tags: Original Article Source Type: research

Controversy and debate: memory-based methods paper 4
We appreciate the opportunity to end up this debate by rebutting the response by Edward Archer, Michael Marlow, and Carl Lavie. Once again, we want to show our deepest disagreement with their opinions and philosophical –theoretical considerations about the self reported dietary assessment methods (SR-Ms) in nutritional epidemiology. Expert debates are, without any doubt, a highly valuable tool to guarantee the progress of scientific knowledge. However, a fair debate requires that scientists conform to the truth and be unbiased in their arguments. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - August 16, 2018 Category: Epidemiology Authors: Nerea Mart ín-Calvo, Miguel Ángel Martínez-González Tags: Commentary Source Type: research

Controversy and debate: Memory-Based Dietary Assessment Methods paper 2
We strongly disagree with the assertions made by Dr Archer E. et  al. regarding the validity and usefulness of food frequency questionnaires and other Self Reported Dietary Assessment Methods (SR-Ms) to assess diet–disease relationships in epidemiologic studies. We believe that their arguments are based on a fallacious philosophy, lack of understanding of bas ic principles of nutritional epidemiology, and lack of original research expertice in conducting large-scale observational or interventional research in nutritional sciences and policy evaluations. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - August 16, 2018 Category: Epidemiology Authors: Nerea Mart ín-Calvo, Miguel Ángel Martínez-González Tags: Commentary Source Type: research

Controversy and Debate: Memory based Methods Paper 2: Why epidemiologic cohorts using Food Frequency Questionnaires are providing valid answers?
(Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - August 16, 2018 Category: Epidemiology Authors: Nerea Mart ín-Calvo, Miguel Ángel Martínez-González Tags: Commentary Source Type: research

Controversy and Debate: Memory based Methods Paper 4: Please, no more idle talk on Memory-Based Methods in science
(Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - August 16, 2018 Category: Epidemiology Authors: Nerea Mart ín-Calvo, Miguel Ángel Martínez-González Tags: Commentary Source Type: research

Controversy and Debate: Memory based Methods Paper 1: The Fatal Flaws of Food Frequency Questionnaires and other Memory-Based Dietary Assessment Methods
There is an escalating debate over the value and validity of memory-based dietary assessment methods (M-BMs). Proponents argue that despite limitations, M-BMs such as food frequency questionnaires (FFQs), provide valid and valuable information about consumed foods and beverages, and therefore can be used to assess diet-disease relations and inform public policy. In fact, over the past 60 years thousands of research reports using these methods were published and used to populate the United States Department of Agriculture ’s National Evidence Library, inform public policy, and establish the Dietary Guidelines for Amer...
Source: Journal of Clinical Epidemiology - August 16, 2018 Category: Epidemiology Authors: Edward Archer, Michael L. Marlow, Carl J. Lavie Tags: Original Article Source Type: research

The Transitional Risk and Incident Questionnaire (TRIQ) was valid and reliable for measuring transitional patient safety from the patients' perspective
This study describes the development and validation of the Transitional Risk and Incident Questionnaire (TRIQ), which measures transitional patient safety from the patients ’ perspective. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - August 16, 2018 Category: Epidemiology Authors: Marije A. van Melle, Henk F. van Stel, Judith M. Poldervaart, Niek J. de Wit, Dorien LM. Zwart Tags: Original Article Source Type: research

The Fatal Flaws of Food Frequency Questionnaires and Other Memory-Based Dietary Assessment Methods
There is an escalating debate over the value and validity of memory-based dietary assessment methods (M-BMs). Proponents argue that despite limitations, M-BMs such as food frequency questionnaires (FFQs), provide valid and valuable information about consumed foods and beverages, and therefore can be used to assess diet-disease relations and inform public policy. In fact, over the past 60 years thousands of research reports using these methods were published and used to populate the United States Department of Agriculture ’s National Evidence Library, inform public policy, and establish the Dietary Guidelines for Amer...
Source: Journal of Clinical Epidemiology - August 16, 2018 Category: Epidemiology Authors: Edward Archer, Michael L. Marlow, Carl J. Lavie Tags: Original Article Source Type: research

Controversy and Debate: Memory based Methods Paper 4
(Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - August 16, 2018 Category: Epidemiology Authors: Nerea Mart ín-Calvo, Miguel Ángel Martínez-González Tags: Commentary Source Type: research

Controversy and Debate: Memory based Methods Paper 2
(Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - August 16, 2018 Category: Epidemiology Authors: Nerea Mart ín-Calvo, Miguel Ángel Martínez-González Tags: Commentary Source Type: research

Clinical trials on drug-drug interactions registered in ClinicalTrials.gov reported incongruent safety data in published articles: an observational study
To assess safety data of trials on DDIs reported in ClinicalTrials.gov and published in journal articles, since drug-drug interactions (DDIs) are a growing concern. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - August 3, 2018 Category: Epidemiology Authors: Diana Juri ć, Shelly Pranić, Ružica Tokalić, Ana Marija Milat, Ivana Mudnić, Ivančica Pavličević, Ana Marušić Tags: Original Article Source Type: research

Orchestrated efforts to foster responsible research
(Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - August 2, 2018 Category: Epidemiology Authors: Li Tang, Guangyuan Hu Tags: Letter to the editor Source Type: research

Biomarker discovery study of inflammatory proteins for colorectal cancer early detection demonstrated importance of screening setting validation
Most studies identifying inflammatory markers for early detection of colorectal cancer (CRC) were conducted using clinically manifest cases. We aimed to identify circulating inflammatory biomarkers for early detection of CRC and validate them in both a clinical setting and a true screening setting. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - August 1, 2018 Category: Epidemiology Authors: Jing Qian, Kaja Tikk, Simone Werner, Yesilda Balavarca, Maral Saadati, Marlene Hechtner, Hermann Brenner Tags: Original Article Source Type: research

Crowdsourcing Critical Appraisal of Research Evidence (CrowdCARE) was found to be a valid approach to assessing clinical research quality
We developed a free, online tool (CrowdCARE: crowdcare.unimelb.edu.au) to crowdsource research critical appraisal. The aim was to examine the validity of this approach for assessing the methodological quality of systematic reviews. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - August 1, 2018 Category: Epidemiology Authors: Michael J. Pianta, Eve Makrai, Karin M. Verspoor, Trevor A. Cohn, Laura E. Downie Tags: Original Article Source Type: research

A cohort study of mammography screening finds that comorbidity measures are insufficient for controlling selection bias
To examine the potential of claims-based comorbidity measures for controlling selection bias in observational studies of mammography screening. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - August 1, 2018 Category: Epidemiology Authors: Jonas Czwikla, Klaus Giersiepen, Ingo Langner, Dirk Enders, Franziska Heinze, Heinz Rothgang, Ulrike Haug, Hajo Zeeb, Hans-Werner Hense Tags: Original Article Source Type: research

Unsuccessful replication is not a sign of research misconduct
(Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - August 1, 2018 Category: Epidemiology Authors: Lex M. Bouter Source Type: research

Controversy and Debate: Memory Based Methods Paper 3: Nutrition's ‘Black Swans’: Our reply
We sincerely appreciate the response from our esteemed colleagues, Nerea Mart ín-Calvo and Miguel Ángel Martínez-González, and welcome the opportunity to continue the scientific discourse. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - July 28, 2018 Category: Epidemiology Authors: Edward Archer, Michael L. Marlow, Carl J. Lavie Tags: Commentary Source Type: research

Validation in prediction research: the waste by data splitting
In conclusion, random data splitting should be abolished for validation of prediction models. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - July 28, 2018 Category: Epidemiology Authors: Ewout W. Steyerberg Tags: Commentary Source Type: research

Controversy and Debate: Memory-Based Dietary Assessment Methods Paper #3
(Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - July 28, 2018 Category: Epidemiology Authors: Edward Archer, Michael L. Marlow, Carl J. Lavie Tags: Commentary Source Type: research

Validation in prediction research: the waste by data-splitting
(Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - July 28, 2018 Category: Epidemiology Authors: Ewout W. Steyerberg Tags: Commentary Source Type: research

The Consensus on Exercise Reporting Template (CERT) applied to exercise interventions in musculoskeletal trials demonstrated good rater agreement and incomplete reporting
To determine inter-rater agreement and utility of the Consensus on Exercise Reporting Template (CERT) for evaluating reporting of musculoskeletal exercise trials. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - July 25, 2018 Category: Epidemiology Authors: Slade SC, Finnegan S, Dionne CE, Underwood M, Buchbinder R Tags: Original Article Source Type: research

Guidance was developed on how to write a plain language summary for diagnostic test accuracy reviews
To develop guidance for authors of diagnostic test accuracy (DTA) reviews to help them write a plain language summary (PLS) of the results of their review. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - July 20, 2018 Category: Epidemiology Authors: Penny Whiting, Mariska Leeflang, Isabel de Salis, Reem A. Mustafa, Nancy Santesso, Gowri Gopalakrishna, Geraldine Cooney, Emily Jesper, Joanne Thomas, Clare Davenport Tags: Original Article Source Type: research

Handling the reflective-formative measurement conundrum: A practical illustration based on sustainable employability
Constructs capturing health or functioning can have reflective and/or formative measurement models. Although a construct ’s measurement model has extensive implications on the construction, validation and use of a measurement instrument, measurement models are frequently wrongly or not explicitly specified. As this is likely due to a lack of guidelines, this study uses sustainable employability as an example to demo nstrate a) the applicability of an adapted checklist for establishing a construct’s measurement model; and b) the use of structural equation modelling to handle formative constructs. (Source: Journa...
Source: Journal of Clinical Epidemiology - July 18, 2018 Category: Epidemiology Authors: Bram P.I. Fleuren, Ludovic G.P.M. van Amelsvoort, Fred R.H. Zijlstra, Andries de Grip, IJmert Kant Tags: Original Article Source Type: research

Using a single noninferiority margin or preserved fraction for an entire pharmacological class was found to be inappropriate
To assess the impact on noninferiority decisions when using a single margin or single preserved fraction (PF) for all noninferiority trials within a pharmacological class. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - July 15, 2018 Category: Epidemiology Authors: Turki A. Althunian, Anthonius de Boer, Rolf H.H. Groenwold, Olaf H. Klungel Tags: Original Article Source Type: research