Risk of bias assessments in individual participant data meta-analyses of test accuracy and prediction models: a review shows improvements are needed
Risk of bias assessments are important in meta-analyses of both aggregate and individual participant data (IPD). There is limited evidence on whether and how risk of bias of included studies or datasets in IPD meta-analyses (IPDMAs) is assessed. We review how risk of bias is currently assessed, reported, and incorporated in IPDMAs of test accuracy and clinical prediction model studies, and provide recommendations for improvement. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - November 2, 2023 Category: Epidemiology Authors: Brooke Levis, Kym IE. Snell, Johanna AA. Damen, Miriam Hattle, Joie Ensor, Paula Dhiman, Constanza L. Andaur Navarro, Yemisi Takwoingi, Penny F. Whiting, Thomas PA. Debray, Johannes B. Reitsma, Karel GM. Moons, Gary S. Collins, Richard D. Riley Tags: Review Source Type: research
Individual participant data from digital sources informed and improved precision in the evaluation of predictive biomarkers in Bayesian network meta-analysis.
We aimed to develop a network meta-analytic model for the evaluation of treatment effectiveness within predictive biomarker subgroups, by combining evidence from individual participant data (IPD) from digital sources (in the absence of RCTs) and aggregate data (AD). (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - October 31, 2023 Category: Epidemiology Authors: Chinyereugo M. Umemneku-Chikere, Lorna Wheaton, Heather Poad, Devleena Ray, Ilse Cuevas Andrade, Sam Khan, Paul Tappenden, Keith R. Abrams, Rhiannon K. Owen, Sylwia Bujkiewicz Tags: Original Article Source Type: research
Equipercentile equating of scores from common patient-reported outcome measures of physical function in patients with cancer
To provide equipercentile equating of physical function (PF) scores from frequently used PROMs in cancer patients to facilitate data pooling and comparisons. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - October 31, 2023 Category: Epidemiology Authors: Maria Rothmund, Micha J. Pilz, Lisa Schlosser, Juan I. Arraras, Mogens Groenvold, Bernhard Holzner, Marieke van Leeuwen, Morten Aa. Petersen, Heike Schmidt, Teresa Young, Matthias Rose, David Cella, Johannes M. Giesinger, EORTC Quality of Life Group Tags: Original Article Source Type: research
Searching a methods topic: practical challenges and implications for search design
Performing a systematic search of a methods topic (e.g., "risk of bias ”, "subgroup analysis") in biomedical databases such as MEDLINE or Embase can be challenging. In this commentary, we address common search-related challenges, including inconsistent terminology for methods and suboptimal indexing. We suggest that reviewers addressing methods topics, compared to cl inical topics, may start with specific, methods-oriented journals; invest extra time to scrutinize index terms and identify alternative terms; try citation search and machine learning assisted screening; and anticipate lower sensitivity and precision. (Sourc...
Source: Journal of Clinical Epidemiology - October 29, 2023 Category: Epidemiology Authors: Julian Hirt, Hannah Ewald, Matthias Briel, Stefan Schandelmaier Tags: Commentary Source Type: research
Clinical trials of pneumonia management assess heterogeneous outcomes and measurement instruments
To inform clinical practice guidelines, randomized controlled trials (RCTs) of the management of pneumonia need to address the outcomes that are most important to patients and health professionals using consistent instruments, to enable results to be compared, contrasted, and combined as appropriate. This systematic review describes the outcomes reported in clinical trials of pneumonia management and the instruments used to measure these outcomes. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - October 27, 2023 Category: Epidemiology Authors: Alexander G. Mathioudakis, Markus Fally, Jan Hansel, Rebecca C. Robey, Faiuna Haseeb, Thomas Williams, Ahmed Kouta, Tobias Welte, Dan G. Wootton, Mike Clarke, Grant Waterer, Paul Dark, Paula R. Williamson, J ørgen Vestbo, Timothy W. Felton, Pneumonia Out Tags: Original Article Source Type: research
Clinical judgment shows similar and sometimes superior discrimination compared to prognostic clinical prediction models. A systematic review
To systematically review the comparative statistical performance (discrimination and /or calibration) of prognostic clinical prediction models (CPMs) and clinician judgment (CJ). (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - October 27, 2023 Category: Epidemiology Authors: Luis Enrique Colunga-Lozano, Farid Foroutan, Daniel Rayner, Christopher De Luca, Benjamin Hern ández-Wolters, Rachel Couban, Quazi Ibrahim, Gordon Guyatt Tags: Original Article Source Type: research
Clinical trials of pneumonia management assess heterogeneous outcomes and measurement instruments.
To inform clinical practice guidelines, randomised controlled trials (RCTs) of the management of pneumonia need to address the outcomes that are most important to patients and health professionals using consistent instruments, to enable results to be compared, contrasted, and combined as appropriate. This systematic review describes the outcomes reported in clinical trials of pneumonia management and the instruments used to measure these outcomes. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - October 27, 2023 Category: Epidemiology Authors: Alexander G. Mathioudakis, Markus Fally, Jan Hansel, Rebecca C. Robey, Faiuna Haseeb, Thomas Williams, Ahmed Kouta, Tobias Welte, Dan G. Wootton, Mike Clarke, Grant Waterer, Paul Dark, Paula R. Williamson, J ørgen Vestbo, Timothy W. Felton, Pneumonia Out Tags: Original Article Source Type: research
GRADE Guidance 37: Rating imprecision in a body of evidence on test accuracy
To provide guidance on rating imprecision in a body of evidence assessing the accuracy of a single test. This guide will clarify when GRADE users should consider rating down the certainty of evidence by one or more levels for imprecision in test accuracy. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - October 26, 2023 Category: Epidemiology Authors: Reem A. Mustafa, Ibrahim K. El Mikati, M. Hassan Murad, Monica Hultcrantz, Karen R. Steingart, Bada Yang, Mariska M.G. Leeflang, Elie A. Akl, Philipp Dahm, Holger J. Sch ünemann Tags: Original Article Source Type: research
Open science practices need substantial improvement in prognostic model studies in oncology using machine learning
To describe the frequency of open science practices in a contemporary sample of studies developing prognostic models using machine-learning methods in the field of oncology. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - October 26, 2023 Category: Epidemiology Authors: Gary S. Collins, Rebecca Whittle, Garrett S. Bullock, Patricia Logullo, Paula Dhiman, Jennifer A. de Beyer, Richard D. Riley, Michael M. Schlussel Tags: Original Article Source Type: research
The 2-week systematic review (2weekSR) method was successfully blind-replicated by another team: a case study
To assess the replicability of a 2-week systematic review (index 2weekSR) created with the assistance of automation tools using the fidelity method. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - October 23, 2023 Category: Epidemiology Authors: Catalin Tufanaru, Didi Surian, Anna Mae Scott, Paul Glasziou, Enrico Coiera Tags: Original Article Source Type: research
The two-week systematic review (2weekSR) method was successfully blind-replicated by another team: a case study
To assess the replicability of a 2-week systematic review (index 2weekSR) created with the assistance of automation tools using the fidelity method. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - October 23, 2023 Category: Epidemiology Authors: Catalin Tufanaru, Didi Surian, Anna Mae Scott, Paul Glasziou, Enrico Coiera Tags: Original Article Source Type: research
Harms were detected but not reported in six clinical trials of gabapentin
We sought to assess and report harms that were observed but not disclosed previously in clinical trials of gabapentin. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - October 21, 2023 Category: Epidemiology Authors: Evan Mayo-Wilson, Riaz Qureshi, Hwanhee Hong, Xiwei Chen, Tianjing Li Tags: Original Article Source Type: research
Assessing real-world representativeness of prospective registry cohorts in oncology: insights from patients with esophagogastric cancer
This study aimed to explore the real-world representativeness of a prospective registry cohort with active accrual in oncology, applying a representativeness metric that is novel to health care. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - October 21, 2023 Category: Epidemiology Authors: Steven C. Kuijper, Joost Besseling, Thomas Klausch, Marije Slingerland, Charl ène J. van der Zijden, Ewout A. Kouwenhoven, Laurens V. Beerepoot, Nadia Haj Mohammad, Bastiaan R. Klarenbeek, Rob H.A. Verhoeven, Hanneke W.M. van Laarhoven Tags: Original Article Source Type: research
Prevalence of patient partner authorship and acknowledgment in child health research publications: an umbrella review
Children and families are increasingly involved as equal partners in child health research, however, considerations around authorship have received little attention and there is limited guidance on the topic. Our objective was to determine the frequency and nature of patient partner authorship and/or acknowledgement among articles focused on patient engagement in child health research. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - October 21, 2023 Category: Epidemiology Authors: Shelley Vanderhout, Dawn P. Richards, Nancy Butcher, Kim Courtney, Stuart G. Nicholls, Dean Fergusson, Beth Potter, Manav Bhalla, Pascale Nevins, Grace Fox, Valentina Ly, Monica Taljaard, Colin Macarthur Tags: Review Source Type: research
Crowd-sourcing and automation facilitated the identification and classification of randomized controlled trials in a living review
To evaluate an approach using automation and crowdsourcing to identify and classify randomized controlled trials (RCTs) for rheumatoid arthritis (RA) in a living systematic review (LSR). (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - October 19, 2023 Category: Epidemiology Authors: Mohammed Mujaab Kamso, Jordi Pardo Pardo, Samuel L. Whittle, Rachelle Buchbinder, George Wells, Vanessa Glennon, Peter Tugwell, Rob Deardon, Tolulope Sajobi, George Tomlinson, Elliott Jesse, Shannon, E. Kelly, Glen S. Hazlewood Tags: Original Article Source Type: research
