Technology-assisted risk of bias assessment in systematic reviews requires precise definitions of risk of bias
(Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - March 10, 2018 Category: Epidemiology Authors: Livia Puljak Source Type: research

Editorial Board
(Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - March 9, 2018 Category: Epidemiology Source Type: research

Table of Contents
(Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - March 9, 2018 Category: Epidemiology Source Type: research

Progress of health care is closely connected with innovation of research methodology
Improvement of health and health care is closely connected with progress in research methods. This connection is continuously becoming stronger, as if it were a process of convergence [1]. In this context, the Journal of Clinical Epidemiology's aims to promote the quality of clinical and patient-oriented health care research through the advancement and application of innovative methods of: conducting and presenting primary research; synthesizing research results; disseminating results; and translating results into optimal clinical practice. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - March 9, 2018 Category: Epidemiology Authors: J. Andr é Knottnerus, Peter Tugwell Tags: Editorial Source Type: research

Do clinicians want recommendations? A multicenter study comparing evidence summaries with and without GRADE recommendations
The objective of the study is to evaluate clinicians' preferences, and understanding of the evidence and intended course of action in response to evidence summaries with and without recommendations. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - March 9, 2018 Category: Epidemiology Authors: Ignacio Neumann, Pablo Alonso-Coello, Per Olav Vandvik, Thomas Agoritsas, Gemma Mas, Elie A. Akl, Romina Brignardello-Petersen, Jose Emparanza, Lauren McCullagh, Catherine De Sitio, Thomas McGinn, Hind Almodaimegh, Khalid Almodaimegh, Solange Rivera, Luis Tags: Original Article Source Type: research

Do clinicians want recommendations? A multi-center study comparing evidence summaries with and without GRADE recommendations
Evidence-based clinical practice guidelines provide recommendations to assist clinicians in decision-making and to reduce the gap between best current research evidence and clinical practice. However, some argue that providing pre-appraised evidence summaries alone, rather than recommendations, is more appropriate. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - March 9, 2018 Category: Epidemiology Authors: Ignacio Neumann, Pablo Alonso-Coello, Per Olav Vandvik, Thomas Agoritsas, Gemma Mas, Elie A. Akl, Romina Brignardello-Petersen, Jose Emparanza, Lauren McCullagh, Catherine De Sitio, Thomas McGinn, Hind Almodaimegh, Khalid Almodaimegh, Solange Rivera, Luis Source Type: research

Quality assessment versus risk of bias in systematic reviews: AMSTAR  and ROBIS had similar reliability but differed in their construct and applicability
The objective of the study was to assess the inter-rater reliability (IRR) of AMSTAR and ROBIS in judging individual domains and overall methodological quality/risk of bias of systematic reviews, the concurrent validity of the tools, and the time required to apply them. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - March 8, 2018 Category: Epidemiology Authors: Rita Banzi, Michela Cinquini, Marien Gonzalez-Lorenzo, Valentina Pecoraro, Matteo Capobussi, Silvia Minozzi Tags: Original Article Source Type: research

Systematic review identifies six metrics and one method for assessing literature search effectiveness but no consensus on appropriate use
To identify the metrics or methods used by researchers to determine the effectiveness of literature searching where supplementary search methods are compared to bibliographic database searching. We also aimed to determine which metrics or methods are summative or formative and how researchers defined effectiveness in their studies. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - March 8, 2018 Category: Epidemiology Authors: Chris Cooper, Joanna Varley-Campbell, Andrew Booth, Nicky Britten, Ruth Garside Tags: Original Article Source Type: research

Quality assessment versus risk of bias in systematic reviews: AMSTAR and ROBIS had similar reliability but differed in their construct and applicability
To assess the inter-rater reliability of AMSTAR and ROBIS in judging individual domains and overall methodological quality/risk of bias of systematic reviews, the concurrent validity of the tools and the time required to apply them. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - March 8, 2018 Category: Epidemiology Authors: Rita Banzi, Michela Cinquini, Marien Gonzalez-Lorenzo, Valentina Pecoraro, Matteo Capobussi, Silvia Minozzi Source Type: research

Systematic review identifies six metrics and one method for assessing literature search effectiveness but no consensus on appropriate use
(Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - March 8, 2018 Category: Epidemiology Authors: Chris Cooper, Joanna Varley-Campbell, Andrew Booth, Nicky Britten, Ruth Garside Source Type: research

Measurement error is often neglected in medical literature: a systematic review
The objective was to study common practices regarding covariate measurement error via a systematic review of general medicine and epidemiology literature. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - March 6, 2018 Category: Epidemiology Authors: Timo B. Brakenhoff, Marian Mitroiu, Ruth H. Keogh, Karel G.M. Moons, Rolf H.H. Groenwold, Maarten van Smeden Tags: Review Source Type: research

Measurement error is often neglected in medical literature: a systematic review
The objective was to study common practices regarding covariate measurement error via a systematic review of general medicine and epidemiology literature. Original research published in 2016 in 12 high impact journals was full-text searched for phrases relating to measurement error. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - March 6, 2018 Category: Epidemiology Authors: Timo B. Brakenhoff, Marian Mitroiu, Ruth H. Keogh, Karel G.M. Moons, Rolf H.H. Groenwold, Maarten van Smeden Source Type: research

Response to letter to the editor by Mc  Sween-Cadieux et al. (2017)
We thank Mc Sween-Cadieux et  al. [1] for their interest in our research into infographics for Cochrane systematic reviews. Their comments and observations are very interesting, and we are glad to have an opportunity to address their concerns. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - March 5, 2018 Category: Epidemiology Authors: Ivan Buljan, Mario Mali čki, Elizabeth Wager, Livia Puljak, Darko Hren, Frances Kellie, Helen West, Žarko Alfirević, Ana Marušić Tags: Letter to the Editor Source Type: research

Most response-inducing strategies do not increase participation in observational studies: a systematic review and meta-analysis
To evaluate response-inducing strategies for observational studies using health-related questionnaires or interviews. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - March 5, 2018 Category: Epidemiology Authors: Marleen M.H.J. van Gelder, Richelle Vlenterie, Joanna IntHout, Lucien J.L.P.G. Engelen, Alina Vrieling, Tom H. van de Belt Tags: Review Source Type: research

Imbalance control in clinical trial subject randomization —from philosophy to strategy
Randomized controlled clinical trial (RCT) is considered the gold standard for efficacy evaluation of medical treatments, as well as for many other types of empirical research [1,2]. The core characteristic of RCT is the random treatment assignment, which 1) protects the integrity of trial results against selection bias and 2) provides the foundation for statistical analyses of trial data. Unrestricted randomization is rarely used in practice. Various restricted randomization designs have been proposed in the literature to control the imbalances in the sizes of and the baseline covariate distributions among the treatment g...
Source: Journal of Clinical Epidemiology - March 5, 2018 Category: Epidemiology Authors: Wenle Zhao, Vance Berger Tags: Commentary Source Type: research

Letter to the editor in response to “No difference in knowledge obtained from infographic or plain language summary of a Cochrane systematic review: three randomized controlled trials” by Buljan et al. (2017)
Buljan et  al. [1] conducted three randomized controlled trials to examine the effect of different summary formats (i.e., scientific abstract, plain language summary (PLS), and infographic) of a Cochrane systematic review on knowledge acquired, reading experience, and perceived user-friendliness of three gro ups (i.e., students, consumers, and doctors). As researchers in knowledge translation (KT), we were interested in this innovative and useful study. However, we have identified some issues that are worth considering. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - March 5, 2018 Category: Epidemiology Authors: Esther Mc Sween-Cadieux, Amandine Fillol, Val éry Ridde, Christian Dagenais Tags: Letter to the editor Source Type: research

Response to letter to the editor by Mc Sween-Cadieux et  al. (2017)
We thank Mc Sween-Cadieux et  al. [1] for their interest in our research into infographics for Cochrane systematic reviews. Their comments and observations are very interesting, and we are glad to have an opportunity to address their concerns. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - March 5, 2018 Category: Epidemiology Authors: Ivan Buljan, Mario Mali čki, Elizabeth Wager, Livia Puljak, Darko Hren, Frances Kellie, Helen West, Žarko Alfirević, Ana Marušić Tags: Letter to the editor Source Type: research

Imbalance control in clinical trial subject randomization —from philosophy to strategy
Randomized controlled clinical trial (RCT) is considered the gold standard for efficacy evaluation of medical treatments, as well as for many other types of empirical research [1,2]. The core characteristic of RCT is the random treatment assignment, which 1) protects the integrity of trial results against selection bias and 2) provides the foundation for statistical analyses of trial data. Unrestricted randomization is rarely used in practice. Various restricted randomization designs have been proposed in the literature to control the imbalances in the sizes of and the baseline covariate distributions among the treatment g...
Source: Journal of Clinical Epidemiology - March 5, 2018 Category: Epidemiology Authors: Wenle Zhao, Vance Berger Tags: Commentary Source Type: research

Letter to the editor in response to “No difference in knowledge obtained from infographic or plain language summary of a Cochrane systematic review: three randomized controlled trials” by Buljan et al. (2017)
Buljan et  al. [1] conducted three randomized controlled trials to examine the effect of different summary formats (i.e., scientific abstract, plain language summary (PLS), and infographic) of a Cochrane systematic review on knowledge acquired, reading experience, and perceived user-friendliness of three gro ups (i.e., students, consumers, and doctors). As researchers in knowledge translation (KT), we were interested in this innovative and useful study. However, we have identified some issues that are worth considering. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - March 5, 2018 Category: Epidemiology Authors: Esther Mc Sween-Cadieux, Amandine Fillol, Val éry Ridde, Christian Dagenais Tags: Letter to the editor Source Type: research

Response to letter to the editor by Mc Sween-Cadieux et  al. (2017)
We thank Mc Sween-Cadieux et  al. [1] for their interest in our research into infographics for Cochrane systematic reviews. Their comments and observations are very interesting, and we are glad to have an opportunity to address their concerns. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - March 5, 2018 Category: Epidemiology Authors: Ivan Buljan, Mario Mali čki, Elizabeth Wager, Livia Puljak, Darko Hren, Frances Kellie, Helen West, Žarko Alfirević, Ana Marušić Tags: Letter to the editor Source Type: research

Most response-inducing strategies do not increase participation in observational studies: a systematic review and meta-analysis
To evaluate response-inducing strategies for observational studies using health-related questionnaires or interviews. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - March 5, 2018 Category: Epidemiology Authors: Marleen M.H.J. van Gelder, Richelle Vlenterie, Joanna IntHout, Lucien J.L.P.G. Engelen, Alina Vrieling, Tom H. van de Belt Source Type: research

Imbalance control in clinical trial subject randomization – from philosophy to strategy
(Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - March 5, 2018 Category: Epidemiology Authors: Wenle Zhao, Vance Berger Source Type: research

Letter to the editor in response to «No difference in knowledge obtained from infographic or plain language summary of a Cochrane systematic review: three randomized controlled trials» by Buljan et al. (2017)
(Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - March 5, 2018 Category: Epidemiology Authors: Esther Mc Sween-Cadieux, Amandine Fillol, Val éry Ridde, Christian Dagenais Source Type: research

Response to letter to the editor by Mc Sween-Cadieux et al (2017)
(Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - March 5, 2018 Category: Epidemiology Authors: Ivan Buljan, Mario Mali čki, Elizabeth Wager, Livia Puljak, Darko Hren, Frances Kellie, Helen West, Žarko Alfirević, Ana Marušić Source Type: research

An observational study showed that explaining randomization using gambling-related metaphors and computer-agency descriptions impeded randomized clinical trial recruitment
To explore how the concept of randomization is described by clinicians and understood by patients in randomized controlled trials (RCTs) and how it contributes to patient understanding and recruitment. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - March 2, 2018 Category: Epidemiology Authors: Marcus Jepson, Daisy Elliott, Carmel Conefrey, Julia Wade, Leila Rooshenas, Caroline Wilson, David Beard, Jane M. Blazeby, Alison Birtle, Alison Halliday, Rob Stein, Jenny L. Donovan, CSAW study group, Chemorad study group, POUT study group, ACST-2 study Tags: Original Article Source Type: research

Systematic reviews do not adequately report or address missing outcome data in their analyses: a methodological survey
To describe how systematic review authors report and address categories of participants with potential missing outcome data of trial participants. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - March 2, 2018 Category: Epidemiology Authors: Lara A. Kahale, Batoul Diab, Romina Brignardello-Petersen, Arnav Agarwal, Reem A. Mustafa, Joey Kwong, Ignacio Neumann, Ling Li, Luciane Cruz Lopes, Matthias Briel, Jason W. Busse, Alfonso Iorio, Per Olav Vandvik, Paul Elias Alexander, Gordon Guyatt, Elie Tags: Review Source Type: research

An observational study showed that explaining randomization using gambling-related metaphors and computer-agency descriptions impeded RCT recruitment
To explore how the concept of randomisation is described by clinicians and understood by patients in randomised clinical trials (RCTs), and how it contributes to patient understanding and recruitment. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - March 2, 2018 Category: Epidemiology Authors: Marcus Jepson, Daisy Elliott, Carmel Conefrey, Julia Wade, Leila Rooshenas, Caroline Wilson, David Beard, Jane M. Blazeby, Alison Birtle, Alison Halliday, Rob Stein, Jenny L. Donovan, CSAW study group, Chemorad study group, POUT study group, ACST-2 study Source Type: research

Systematic reviews do not adequately report, or address missing outcome data in their analyses: a methodological survey
To describe how systematic review authors report and address categories of participants with potential missing outcome data of trial participants. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - March 2, 2018 Category: Epidemiology Authors: Lara A. Kahale, Batoul Diab, Romina Brignardello-Petersen, Arnav Agarwal, Reem A. Mustafa, Joey Kwong, Ignacio Neumann, Ling Li, Luciane Cruz Lopes, Matthias Briel, Jason W. Busse, Alfonso Iorio, Per Olav Vandvik, Paul Elias Alexander, Gordon Guyatt, Elie Source Type: research

Regression discontinuity was a valid design for dichotomous outcomes in three randomized trials
Regression discontinuity (RD) is a quasi-experimental design that may provide valid estimates of treatment effects in case of continuous outcomes. We aimed to evaluate validity and precision in the RD design for dichotomous outcomes. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - February 24, 2018 Category: Epidemiology Authors: Nikki van Leeuwen, Hester F. Lingsma, Simon P. Mooijaart, Daan Nieboer, Stella Trompet, Ewout W. Steyerberg Tags: Original Article Source Type: research

Increasing the efficiency of clinical trials in neurodegenerative disorders using group sequential trial designs
Clinical trials in neurodegenerative disorders are facing high futility rates and rising development costs. We aim to review and exemplify the value of group sequential trial designs (i.e., designs with one or more prospectively planned interim analyses) within the field of amyotrophic lateral sclerosis. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - February 24, 2018 Category: Epidemiology Authors: Ruben P.A. van Eijk, Stavros Nikolakopoulos, Toby A. Ferguson, Dawei Liu, Marinus J.C. Eijkemans, Leonard H. van den Berg Tags: Review Source Type: research

Regression discontinuity was a valid design for dichotomous outcomes in three randomized trials
Regression discontinuity (RD) is a quasi-experimental design that may provide valid estimates of treatment effects in case of continuous outcomes. We aimed to evaluate validity and precision in the RD design for dichotomous outcomes.We performed validation studies in three large RCTs (CRASH, GUSTO and PROSPER). To mimic the RD design, we selected patients above and below a cut-off (e.g. age 75 years) randomized to treatment and control respectively. Adjusted logistic regression models using restricted cubic splines (RCS) and polynomials, and local logistic regression models estimated the odds ratio (OR) for treatment, with...
Source: Journal of Clinical Epidemiology - February 24, 2018 Category: Epidemiology Authors: Nikki van Leeuwen, Hester F. Lingsma, Simon P. Mooijaart, Daan Nieboer, Stella Trompet, Ewout W. Steyerberg Source Type: research

Increasing the efficiency of clinical trials in neurodegenerative disorders using group sequential trial designs
Clinical trials in neurodegenerative disorders are facing high futility rates and rising development costs. We aim to review and exemplify the value of group sequential trial designs (i.e. designs with one or more prospectively planned interim analyses) within the field of amyotrophic lateral sclerosis (ALS). (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - February 24, 2018 Category: Epidemiology Authors: Ruben P.A. van Eijk, Stavros Nikolakopoulos, Toby A. Ferguson, Dawei Liu, Marinus J.C. Eijkemans, Leonard H. van den Berg Source Type: research

Preregistration and publication of nonregulated intervention trials are here to stay (letter commenting Wallach et  al 2018, 93, 88-93)
In their timely and interesting article, Wallach et  al. [1] discussed, among other relevant topics, prospective registration of most interventional studies (i.e., clinical trials) of drug, biological and device products regulated by the US Food and Drug Administration, and the mandatory requirement to report trial results on clinicaltrials.gov. The se requirements are also mandatory in the European Union: sponsors are required to preregister and to post medicines trial results on European Union-Clinical Trials Register. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - February 23, 2018 Category: Epidemiology Authors: Rafael Dal-R é Tags: Letter to the Editor Source Type: research

Pre-registration and publication of non-regulated intervention trials are here to stay (Letter commenting Wallach et al 2018, 93, 88-93)
(Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - February 23, 2018 Category: Epidemiology Authors: Rafael Dal-R é Source Type: research

Editorial Board
(Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - February 22, 2018 Category: Epidemiology Source Type: research

Table of Contents
(Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - February 22, 2018 Category: Epidemiology Source Type: research

Importance of including harms as well as benefits in all clinical trials
As the capacity for running well designed trials expands to lower and middle income countries, if the results are to be useful, so too must there be harmonization of reporting requirements of not only benefits but also harms in randomised trials and systematic reviews; Tedesco et  al. show how rarely reporting of harms happens in pediatric trials. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - February 22, 2018 Category: Epidemiology Authors: Peter Tugwell, J. Andr é Knottnerus Tags: Editorial Source Type: research

The search and selection for primary studies in systematic reviews published in dental journals indexed in MEDLINE was not fully reproducible
To evaluate whether the reporting of search strategies and the primary study selection process in dental systematic reviews is reproducible. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - February 21, 2018 Category: Epidemiology Authors: Clovis Mariano Faggion, Raquel Huivin, Luisiana Aranda, Nikolaos Pandis, Marco Alarcon Tags: Review Source Type: research

Component network meta-analysis identifies the most effective components of psychological preparation for adults undergoing surgery under general anesthesia
To apply component network meta-analysis (CNMA) models to an existing Cochrane review of psychological preparation interventions for adults undergoing surgery and to extend the models to account for covariates to identify the most effective components for improving postoperative outcomes. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - February 21, 2018 Category: Epidemiology Authors: Suzanne C. Freeman, Neil W. Scott, Rachael Powell, Marie Johnston, Alex J. Sutton, Nicola J. Cooper Tags: Review Article Source Type: research

The search and selection for primary studies in systematic reviews published in dental journals indexed in MEDLINE was not fully reproducibleI was not able to extract the web only files from the word doc
To evaluate whether the reporting of search strategies and the primary study selection process in dental systematic reviews is reproducible. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - February 21, 2018 Category: Epidemiology Authors: Clovis Mariano Faggion, Raquel Huivin, Luisiana Aranda, Nikolaos Pandis, Marco Alarcon Source Type: research

Component network meta-analysis identifies the most effective components of psychological preparation for adults undergoing surgery under general anaesthesiaonline only appendix present
To apply component network meta-analysis (CNMA) models to an existing Cochrane review of psychological preparation interventions for adults undergoing surgery and to extend the models to account for covariates to identify the most effective components for improving postoperative outcomes. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - February 21, 2018 Category: Epidemiology Authors: Suzanne C. Freeman, Neil W. Scott, Rachael Powell, Marie Johnston, Alex J. Sutton, Nicola J. Cooper Source Type: research

Using decision thresholds for ranking treatments in network meta-analysis results in more informative rankings
To evaluate how the rank probabilities obtained from network meta-analysis (NMA) change with the use of increasingly stringent criteria for the relative effect comparing two treatments which ranks one treatment better than the other. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - February 15, 2018 Category: Epidemiology Authors: Romina Brignardello-Petersen, Bradley C. Johnston, Alejandro R. Jadad, George Tomlinson Tags: Review Source Type: research

Using decision thresholds for ranking treatments in network meta-analysis results in more informative rankings
To evaluate how the rank probabilities obtained from NMA change with the use of increasingly stringent criteria for the relative effect comparing two treatments that ranks one treatment better than the other. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - February 15, 2018 Category: Epidemiology Authors: Romina Brignardello-Petersen, Bradley C. Johnston, Alejandro R. Jadad, George Tomlinson Source Type: research

A scoping review and survey provides the rationale, perceptions, and preferences for the integration of randomized and nonrandomized studies in evidence syntheses and GRADE assessments
To review the literature and obtain preferences and perceptions from experts regarding the role of randomized studies (RSs) and nonrandomized studies (NRSs) in systematic reviews of intervention effects. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - February 13, 2018 Category: Epidemiology Authors: Carlos A. Cuello-Garcia, Rebecca L. Morgan, Jan Brozek, Nancy Santesso, Jos Verbeek, Kris Thayer, Gordon Guyatt, Holger J. Sch ünemann Tags: Review Source Type: research

Essential medicines availability is still suboptimal in many countries: a scoping review
To identify uses of WHO Model list of essential medicines (EMs) and summarize studies examining EM and national EM lists (NEMLs). (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - February 13, 2018 Category: Epidemiology Authors: Mersiha Mahmi ć-Kaknjo, Antonia Jeličić-Kadić, Ana Utrobičić, Kit Chan, Lisa Bero, Ana Marušić Tags: Review Source Type: research

Methods for analyzing matched designs with double controls: excess risk is easily estimated and misinterpreted when evaluating traffic deaths
To demonstrate analytic approaches for matched studies where two controls are linked to each case and events are accumulating counts rather than binary outcomes. A secondary intent is to clarify the distinction between total risk and excess risk (unmatched vs. matched perspectives). (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - February 13, 2018 Category: Epidemiology Authors: Donald A. Redelmeier, Robert J. Tibshirani Tags: Original Article Source Type: research

GRADE Guidelines: 19. Assessing the certainty of evidence in the importance of outcomes or values and preferences —Risk of bias and indirectness
The Grading of Recommendations Assessment, Development, and Evaluation (GRADE) working group defines patient values and preferences as the relative importance patients place on the main health outcomes. We provide GRADE guidance for assessing the risk of bias and indirectness domains for certainty of evidence about the relative importance of outcomes. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - February 13, 2018 Category: Epidemiology Authors: Yuan Zhang, Pablo Alonso-Coello, Gordon H. Guyatt, Juan Jos é Yepes-Nuñez, Elie A. Akl, Glen Hazlewood, Hector Pardo-Hernandez, Itziar Etxeandia-Ikobaltzeta, Amir Qaseem, John W. Williams, Peter Tugwell, Signe Flottorp, Yaping Chang, Yuqing Zhang, Reem Tags: Original Article Source Type: research

GRADE Guidelines: 19. Assessing the certainty of evidence in the importance of outcomes or values and preferences -- Risk of bias and indirectness
The GRADE working group defines patient values and preferences as the relative importance patients place on the main health outcomes. We provide GRADE guidance for assessing the risk of bias and indirectness domains for certainty of evidence about the relative importance of outcomes. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - February 13, 2018 Category: Epidemiology Authors: Yuan Zhang, Pablo Alonso Coello, Gordon Guyatt, Juan Jose Yepes-Nunez, Elie A. Akl, Glen Hazlewood, Hector Pardo-Hernandez, Itziar Etxeandia-Ikobaltzeta, Amir Qaseem, John W. Williams, Peter Tugwell, Signe Flottorp, Yaping Chang, Yuqing Zhang, Reem A. Mus Source Type: research