Consolidated Standards of Reporting Trials (CONSORT) extensions covered most types of randomized controlled trials, but the potential workload for authors was high
Our aim was to determine the coverage of randomized controlled trials (RCTs) by the Consolidated Standards of Reporting Trial (CONSORT) Statement and its extensions and to evaluate the potential workload for authors to adhere to the guidelines. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - May 30, 2019 Category: Epidemiology Authors: Lina Ghosn, Isabelle Boutron, Philippe Ravaud Tags: Review Source Type: research

Retrieval of individual patient data depended on study characteristics: A randomised controlled trial
To examine the effect of providing a financial incentive to authors of randomized clinical trials (RCTs) to obtain individual patient data (IPD). (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - May 30, 2019 Category: Epidemiology Authors: Areti Angeliki Veroniki, Huda M. Ashoor, Susan P.C. Le, Patricia Rios, Lesley A. Stewart, Mike Clarke, Dimitris Mavridis, Sharon E. Straus, Andrea C. Tricco Tags: Original Article Source Type: research

sCONSORT extensions covered most types of RCTs, but the potential workload for authors was high
Our aim was to determine the coverage of randomized trials (RCTs) by the CONSORT Statement and its extensions and to evaluate the potential workload for authors to adhere to the guidelines. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - May 30, 2019 Category: Epidemiology Authors: Lina Ghosn, Isabelle Boutron, Philippe Ravaud Tags: Review Source Type: research

Contacting authors by telephone increased response proportions compared with emailing: results of a randomized study
The aim of the study was to compare response proportions and research costs of telephone calling vs. continued emailing nonresponding authors of studies included in a systematic review. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - May 29, 2019 Category: Epidemiology Authors: Kristin J. Danko, Issa J. Dahabreh, Noah M. Ivers, David Moher, Jeremy M. Grimshaw Tags: Original Article Source Type: research

The Clinician Guideline Determinants Questionnaire was developed and  validated to support tailored implementation planning
The purpose of this research was to generate and validate a questionnaire that identifies determinants of guideline use from the clinician perspective. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - May 29, 2019 Category: Epidemiology Authors: Anna R. Gagliardi, Melissa J. Armstrong, Susanne Bernhardsson, Margot Fleuren, Hector Pardo-Hernandez, Robin W.M. Vernooij, Melina Willson, Guidelines International Network Implementation Working Group Tags: Original Article Source Type: research

The Clinician Guideline Determinants Questionnaire was developed and validated to support tailored implementation planning
The purpose of this research was to generate and validate a questionnaire that identifies determinants of guideline use from the clinician perspective. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - May 29, 2019 Category: Epidemiology Authors: Anna R. Gagliardi, Melissa J. Armstrong, Susanne Bernhardsson, Margot Fleuren, Hector Pardo-Hernandez, Robin WM. Vernooij, Melina Willson, Guidelines International Network Implementation Working Group Tags: Original Article Source Type: research

A psychometric study found AMSTAR 2 to be a valid and moderately reliable appraisal tool
To determine the inter-rater reliability (IRR) of AMSTAR 2 for reviews of pharmacological or psychological interventions for the treatment of major depression, to compare it to that of AMSTAR and ROBIS and to assess the convergent validity between the appraisal tools. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - May 29, 2019 Category: Epidemiology Authors: Robert C. Lorenz, Katja Matthias, Dawid Pieper, Uta Wegewitz, Johannes Morche, Marc Nocon, Olesja Rissling, Jacqueline Schirm, Anja Jacobs Tags: Original Article Source Type: research

Contacting authors by telephone increased response proportions compared to emailing: results of a randomized study
To compare response proportions and research costs of calling vs. emailing non-responding authors of studies included in a systematic review. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - May 29, 2019 Category: Epidemiology Authors: Danko KJ, Dahabreh IJ, Ivers NM, Moher D, Grimshaw JM Tags: Original Article Source Type: research

Development of practical recommendations for diagnostic accuracy studies in low-prevalence situations
Low disease prevalence poses challenges for diagnostic accuracy studies because of the large sample sizes that are required to obtain sufficient precision. The aim is to collate and discuss designs of diagnostic accuracy studies suited for use in low-prevalence situations. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - May 28, 2019 Category: Epidemiology Authors: Gea A. Holtman, Marjolein Y. Berger, Huibert Burger, Jonathan J. Deeks, Norbert Donner-Banzhoff, Thomas R. Fanshawe, Constantinos Koshiaris, Mariska M. Leeflang, Jason L. Oke, Rafael Perera, Johannes B. Reitsma, Ann Van den Bruel Tags: Original Article Source Type: research

Improvement needed in the network geometry and inconsistency of Cochrane network meta-analyses: a cross-sectional survey
The aim of the study was to investigate the general characteristics and methodological and reporting quality of network meta-analyses (NMAs) published in the Cochrane library. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - May 28, 2019 Category: Epidemiology Authors: Ya Gao, Long Ge, Xueni Ma, Xiping Shen, Meng Liu, Jinhui Tian Tags: Original Article Source Type: research

A cross-sectional audit showed that most Cochrane intervention reviews  searched trial registers
The objective of this study was to assess current Cochrane Review practice in identifying and incorporating information from clinical trial registers. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - May 28, 2019 Category: Epidemiology Authors: Slavica Berber, Ava Grace Tan-Koay, Newton Opiyo, Kerry Dwan, Julie M. Glanville, Toby J. Lasserson, Melina L. Willson Tags: Original Article Source Type: research

Overall bias and sample sizes were unchanged in ICU trials over time: a  meta-epidemiological study
To assess time trends in risk of bias (RoB) and sample sizes in randomized clinical trials (RCTs) of adult intensive care unit (ICU) patients. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - May 28, 2019 Category: Epidemiology Authors: Carl Thomas Anthon, Anders Granholm, Anders Perner, Jon Henrik Laake, Morten Hylander M øller Tags: Review Source Type: research

Development of practical recommendations for diagnostic accuracy studies in low prevalence situations
Low disease prevalence poses challenges for diagnostic accuracy studies because of the large sample sizes that are required in order to obtain sufficient precision. The aim is to collate and discuss designs of diagnostic accuracy studies suited for use in low prevalence situations. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - May 28, 2019 Category: Epidemiology Authors: Gea A. Holtman, Marjolein Y. Berger, Huibert Burger, Jonathan J. Deeks, Norbert Donner-Banzhoff, Thomas R. Fanshawe, Constantinos Koshiaris, Mariska M. Leeflang, Jason L. Oke, Rafael Perera, Johannes B. Reitsma, Ann Van den Bruel Tags: Review Source Type: research

Several reasons explained the variation in the results of 22 meta-analyses addressing the same question
To assess and to investigate the reasons for the variations between the results of meta-analyses addressing the same question. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - May 28, 2019 Category: Epidemiology Authors: Assem M. Khamis, Mohamad El Moheb, Johny Nicolas, Ghida Iskandarani, Marwan M. Refaat, Elie A. Akl Tags: Original Article Source Type: research

Methodology and reporting quality of Cochrane network meta-analyses provides the room to improve the network geometry and inconsistency
To investigate the general characteristics, methodological and reporting quality of network meta-analyses (NMAs) published in the Cochrane library. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - May 28, 2019 Category: Epidemiology Authors: Ya Gao, Long Ge, Xueni Ma, Xiping Shen, Meng Liu, Jinhui Tian Tags: Original Article Source Type: research

Overview: comprehensive and carefully constructed strategies are required when conducting searches for adverse effects data
Methodological research has been undertaken to investigate the many challenges in searching for adverse effects data. It is imperative that the search approach adopted in systematic reviews is based on the best available evidence. We provide a detailed summary of the results and implications of the current evidence base to assist future searches for adverse effects. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - May 28, 2019 Category: Epidemiology Authors: Su Golder, Guy Peryer, Yoon K. Loke Tags: Original Article Source Type: research

A cross-sectional audit showed that the majority of Cochrane intervention reviews searched trial registers
To assess current Cochrane Review practice in identifying and incorporating information from clinical trial registers. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - May 28, 2019 Category: Epidemiology Authors: Slavica Berber, Ava Grace Tan-Koay, Newton Opiyo, Kerry Dwan, Julie M. Glanville, Toby J. Lasserson, Melina L. Willson Tags: Original Article Source Type: research

Overall bias and sample sizes were unchanged in ICU trials over time: a meta-epidemiological study
To assess time trends in risk of bias (RoB) and sample sizes in randomised clinical trials (RCTs) of adult intensive care unit (ICU) patients. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - May 28, 2019 Category: Epidemiology Authors: Carl Thomas Anthon, Anders Granholm, Anders Perner, Jon Henrik Laake, Morten Hylander M øller Tags: Review Source Type: research

The Trials within Cohorts design faced methodological advantages and disadvantages in the exercise oncology setting
The Trials within Cohorts (TwiCs) design is an alternative for pragmatic randomized controlled trials (RCTs) and might overcome disadvantages such as difficult recruitment, dropout after randomization to control, and contamination. We investigated the applicability of the TwiCs design in an exercise oncology study regarding the recruitment process, representativeness of the study sample, contamination, participation, and dropout. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - May 27, 2019 Category: Epidemiology Authors: Roxanne Gal, Evelyn M. Monninkhof, Carla H. van Gils, Rolf H.H. Groenwold, Desir ée H.J.G. van den Bongard, Petra H.M. Peeters, Helena M. Verkooijen, Anne M. May Tags: Original Article Source Type: research

The Trials within Cohorts (TwiCs) design faced methodological advantages and disadvantages in the exercise-oncology setting
The Trials within Cohorts (TwiCs) design is an alternative for pragmatic RCTs and might overcome disadvantages as difficult recruitment, drop-out after randomization to control and contamination. We investigated the applicability of the TwiCs design in an exercise-oncology study regarding the recruitment process, representativeness of the study sample, contamination, participation, and drop-out. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - May 27, 2019 Category: Epidemiology Authors: Roxanne Gal, Evelyn M. Monninkhof, Carla H. van Gils, Rolf H.H. Groenwold, Desir ée H.J.G. van den Bongard, Petra H.M. Peeters, Helena M. Verkooijen, Anne M. May Tags: Original Article Source Type: research

A systematic survey identified 36 criteria for assessing effect modification claims in randomized trials or meta-analyses
To systematically survey the methodological literature and collect suggested criteria for assessing the credibility of effect modification and associated rationales. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - May 24, 2019 Category: Epidemiology Authors: Stefan Schandelmaier, Yaping Chang, Niveditha Devasenapathy, Tahira Devji, Joey SW. Kwong, Luis E. Colunga Lozano, Yung Lee, Arnav Agarwal, Neera Bhatnagar, Hannah Ewald, Ying Zhang, Xin Sun, Lehana Thabane, Michael Walsh, Matthias Briel, Gordon H. Guyatt Tags: Original Article Source Type: research

Risk of bias assessments for blinding of participants and personnel in Cochrane reviews were frequently inadequate
To analyze adequacy of judgments about risk of bias (RoB) for blinding of participants and personnel (performance bias) in Cochrane systematic reviews of randomized controlled trials (RCTs). (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - May 24, 2019 Category: Epidemiology Authors: Ognjen Barcot, Matija Boric, Svjetlana Dosenovic, Tina Poklepovic Pericic, Marija Cavar, Livia Puljak Tags: Original Article Source Type: research

Engaging knowledge users in a systematic review on the comparative effectiveness of geriatrician-led models of care is possible: A cross-sectional survey using the Patient Engagement Evaluation Tool
A systematic review (SR) was conducted to evaluate the comparative effectiveness of geriatrician-led models of care, and an integrated knowledge translation (iKT) approach facilitated SR relevance. Activities to engage knowledge users (KUs) in the SR were evaluated for perceived level of engagement. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - May 23, 2019 Category: Epidemiology Authors: Charlene Soobiah, Sharon E. Straus, Gayle Manley, Sharon Marr, Elliot Paus Jenssen, Sylvia Teare, Jemila Hamid, Andrea C. Tricco, Ainsley Moore Tags: Original Article Source Type: research

Application of the Patient Engagement Evaluation Tool (PEET): A cross-sectional survey to assess knowledge user engagement in a systematic review on the comparative effectiveness of geriatrician-led models of care
A systematic review (SR) was conducted to evaluate the comparative effectiveness of geriatrician-led models of care, and an integrated knowledge translation (iKT) approach facilitated SR relevance. Activities to engage knowledge users (KUs) in the SR were evaluated for perceived level of engagement. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - May 23, 2019 Category: Epidemiology Authors: Charlene Soobiah, Sharon E. Straus, Gayle Manley, Sharon Marr, Elliot PausJenssen, Sylvia Teare, Jemila Hamid, Andrea C. Tricco, Ainsley Moore Tags: Original Article Source Type: research

The increasing complexity of the core outcomes landscape
In this project we set out to identify ways to increase the uptake of core outcome sets in clinical research. In doing so, we uncovered a growing recognition, across many different health care sectors, of the need for common, relevant outcomes to improve the quality of decision making. This has led to a plethora of projects, initiatives, and new organizations all intended to develop standardized outcomes and outcome measures for their particular fields. However, the standardized outcome sets developed across siloed initiatives do not carry over to other sectors, such as from research to quality of care. (Source: Journal of...
Source: Journal of Clinical Epidemiology - May 23, 2019 Category: Epidemiology Authors: Rachael Moloney, Donna Messner, Sean Tunis Tags: Commentary Source Type: research

Baseline P value distributions in randomized trials were uniform for continuous but not categorical variables
Comparing observed and expected distributions of baseline variables in randomized controlled trials (RCTs) has been used to investigate possible research misconduct, although the validity of this approach has been questioned. We explored this technique and introduced a novel metric to compare P values from baseline variables between treatment arms. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - May 21, 2019 Category: Epidemiology Authors: Mark J. Bolland, Greg D. Gamble, Alison Avenell, Andrew Grey, Thomas Lumley Tags: Original Article Source Type: research

Baseline p-value distributions in randomised trials were uniform for continuous but not categorical variables
Comparing observed and expected distributions of baseline variables in randomised controlled trials (RCTs) has been used to investigate possible research misconduct, although the validity of this approach has been questioned. We explored this technique and introduced a novel metric to compare p-values from baseline variables between treatment arms. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - May 21, 2019 Category: Epidemiology Authors: Mark J. Bolland, Greg D. Gamble, Alison Avenell, Andrew Grey, Thomas Lumley Tags: Original Article Source Type: research

Effect measure modification conceptualized using selection diagrams as mediation by mechanisms of varying population-level relevance
We are often confronted in public health by associations that vary by population or subpopulation. Much effort has focused on the statistical and biological interpretation of such effect measure modification (EMM) because of the importance to public health. However, EMM remains difficult to conceptualize because it apparently violates everyday understanding of causes as usually acting consistently, making it difficult to predict when EMM may occur and raises questions about how to determine the external validity of interventions without extensive retesting by population or subpopulation. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - May 20, 2019 Category: Epidemiology Authors: Priscilla M. Lopez, S.V. Subramanian, C. Mary Schooling Tags: Original Article Source Type: research

Prevalence of trial registration varies by study characteristics and risk of bias
Determine the prevalence of trial registration in health research, whether trial registration status and timing vary depending on trial characteristics, and the relationship between trial registration status and risk of bias. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - May 20, 2019 Category: Epidemiology Authors: Aidan Christopher Tan, Ivy Jiang, Lisa Askie, Kylie Hunter, Robert John Simes, Anna Lene Seidler Tags: Review Source Type: research

Funders improved the management of learning and clustering effects through design and analysis of randomised trials involving surgery
To provide insight into current practice in planning for, and acknowledging, the presence of learning and clustering effects, by treating centre and surgeon, when developing randomised surgical trials. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - May 20, 2019 Category: Epidemiology Authors: Elizabeth J Conroy, Anna Rosala-Hallas, Jane M. Blazeby, Girvan Burnside, Jonathan A. Cook, Carrol Gamble Tags: Original Article Source Type: research

Effect measure modification conceptualized using selection diagrams as medication by mechanisms of varying population-level relevance
We are often confronted in public health by associations that vary by population or sub-population. Much effort has focused on the statistical and biological interpretation of such effect measure modification (EMM) because of the importance to public health. However, EMM remains difficult to conceptualize because it apparently violates everyday understanding of causes as usually acting consistently, making it difficult to predict when EMM may occur and raises questions about how to determine the external validity of interventions without extensive re-testing by population or sub-population. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - May 20, 2019 Category: Epidemiology Authors: P. Lopez, S.V. Subramanian, C.M. Schooling Tags: Original Article Source Type: research

Why mind-body medicine is poised to set a new standard for clinical research
(Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - May 18, 2019 Category: Epidemiology Authors: Nadia M. Penrod, Jason H. Moore Tags: Commentary Source Type: research

Defining ranges for certainty ratings of diagnostic accuracy: A GRADE concept paper
To clarify how the Grading of Recommendations Assessment, Development and Evaluation (GRADE) concept of certainty of evidence applies to certainty ratings of test accuracy. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - May 18, 2019 Category: Epidemiology Authors: Monica Hultcrantz, Reem A. Mustafa, Mariska M.G. Leeflang, Val éry Lavergne, Kelly Estrada-Orozco, Mohammed T. Ansari, Ariel Izcovich, Jasvinder Singh, Lee Yee Chong, Anne Rutjes, Karen Steingart, Airton Stein, Nigar Sekercioglu, Ingrid Arévalo Rodrigue Tags: Original Article Source Type: research

Research environment of clinician –scientists in China in health policy/health services research
The aim of the study was to describe the research environment of scientists in health services and policy research in China. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - May 17, 2019 Category: Epidemiology Authors: Mingyue Gao, Linda Zhou, Kun Tang, Matthew H. Liang Tags: Original Article Source Type: research

Leveraging the entire cohort in drug safety monitoring: Part 1 Methods for Sequential surveillance that use regression adjustment or weighting to control confounding in a multi-site, rare event, distributed data setting
(Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - May 17, 2019 Category: Epidemiology Authors: Jennifer C. Nelson, Ernesto Ulloa-Pe ’rez, Jennifer F. Bobb, Judith C. Maro Tags: Review Source Type: research

Research environment of clinician-scientists in china in health policy/health services research
To describe research environment of scientists in health services and policy research in China. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - May 17, 2019 Category: Epidemiology Authors: Mingyue Gao, Linda Zhou, Kun Tang, Matthew H. Liang Tags: Original Article Source Type: research

Coherence in measurement and programming in maternal and newborn health: Experience from the BetterBirth Trial
(Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - May 17, 2019 Category: Epidemiology Authors: Natalie Panariello, Amanda Jurczak, Jonathan Spector, Vishwajeet Kumar, Katherine Semrau Tags: Commentary Source Type: research

Inadequate comparators produce misleading results – the importance of good comparison practice
While comparison is the basis of good clinical research, incorrect comparisons are likely to produce misleading results, and may cause unnecessary harm to patients. A well known example is that comparing a new drug with an inactive placebo may suggest added value, while comparison with already available drugs would have shown that the new one has no added value or is even less effective. Therefore, drug registration authorities should require head-to-head comparisons with the current standard of practice, based on comparative effectiveness research [1,2]. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - May 16, 2019 Category: Epidemiology Authors: J. Andr é Knottnerus, Peter Tugwell Tags: Editorial Source Type: research

Cover 2 Editorial Board
(Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - May 16, 2019 Category: Epidemiology Source Type: research

Table of Contents
(Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - May 16, 2019 Category: Epidemiology Source Type: research

Premarket Safety Population Size Associated with Approval of Expedited Program Drugs and Orphan Drugs
For approved expedited program and orphan drugs, the safety populations used for premarket drug risk assessments are often limited in size. The study ’s objective was to determine whether large safety populations, with the capacity for excluding uncommon adverse drug effects, influenced approval of these drugs for patients use. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - May 15, 2019 Category: Epidemiology Authors: Kachi Illoh Tags: Letter to the editor Source Type: research

Minimal clinically important difference of commonly used hip-, knee-, foot-, and ankle-specific questionnaires: a systematic review
Minimal clinically important difference (MCID) has become the most important psychometric factor for interpreting change in individual's responses over time from the patient's perspective, evaluating study results and planning sample sizes. The purpose was to synthesize and critically appraise MCID of the most frequently used hip-, knee-, foot-, and ankle-specific patient-reported outcomes (PROs). (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - May 9, 2019 Category: Epidemiology Authors: Derya Çelik, Özge Çoban, Önder Kılıçoğlu Tags: Review Source Type: research

Minimal Clinically Important Difference of Commonly Used Hip, Knee, Foot and Ankle Specific Questionnaires: A Systematic Review
Minimal clinically important difference (MCID) has become the most important psychometric property for interpreting change individual ’s responses over time from the patient’s perspective, evaluating study results and planning sample sizes. The purpose was to synthesize and critically appraise MCID of the most frequently used hip, knee and foot and ankle specific patient-reported outcomes (PROs). (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - May 9, 2019 Category: Epidemiology Authors: Derya Çelik, Özge Çoban, Önder Kılıçoğlu Source Type: research

Measuring Clinical Uncertainty as a preliminary step to randomized controlled trials
(Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - May 8, 2019 Category: Epidemiology Authors: Robert Fahed, Tim E. Darsaut, Behzad Farzin, Miguel Chagnon, Jean Raymond Tags: Letter to the editor Source Type: research

A benefit –harm analysis of adding basal insulin vs. sulfonylurea to metformin to manage type II diabetes mellitus in people with multiple chronic conditions
The benefits and harms of diabetes treatments need to be carefully weighed in people with type II diabetes mellitus (DM) and multiple chronic conditions (MCCs). Our objective was to quantitatively assess the benefits and harms of the addition of basal insulin (insulin) vs. sulfonylurea (SU) to metformin in people with DM and MCCs. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - May 3, 2019 Category: Epidemiology Authors: Wendy L. Bennett, H élène E. Aschmann, Milo A. Puhan, Craig W. Robbins, Elizabeth A. Bayliss, Renee Wilson, Richard A. Mularski, Wiley V. Chan, Bruce Leff, Orla Sheehan, Carol Glover, Katie Maslow, Karen Armacost, Suzanne Mintz, Cynthia M. Boyd Tags: Original Article Source Type: research

Characteristics and methods of incorporating randomized and nonrandomized evidence in network meta-analyses: a scoping review
The objective of the study was to conduct a scoping review of the published literature on methods used to combine randomized and nonrandomized evidence (NRE) in network meta-analyses (NMAs) and their respective characteristics. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - May 3, 2019 Category: Epidemiology Authors: Kathryn Zhang, Paul Arora, Neha Sati, Audrey B éliveau, Natalie Troke, Areti Angeliki Veroniki, Myanca Rodrigues, Patricia Rios, Wasifa Zarin, Andrea C. Tricco Tags: Review Source Type: research

A benefit-harm analysis of adding basal insulin vs. sulfonylurea to metformin to manage type 2 diabetes in people with multiple chronic conditions
The benefits and harms of diabetes treatments need to be carefully weighed in people with type 2 diabetes (DM) and multiple chronic conditions (MCCs). Our objective was to quantitatively assess the benefits and harms of the addition of basal insulin (insulin) vs. sulfonylurea (SU) to metformin in people with DM and MCCs. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - May 3, 2019 Category: Epidemiology Authors: Wendy L. Bennett, H élène E. Aschmann, Milo A. Puhan, Craig W. Robbins, Elizabeth A. Bayliss, Renee Wilson, Richard A. Mularski, Wiley V. Chan, Bruce Leff, Orla Sheehan, Carol Glover, Katie Maslow, Karen Armacost, Suzanne Mintz, Cynthia M. Boyd Tags: Original Article Source Type: research

Characteristics and methods of incorporating randomized and non-randomized evidence in network meta-analyses: a scoping review
To conduct a scoping review of the published literature on methods used to combine randomized and non-randomized evidence (NRE) in network meta-analyses (NMAs) and their respective characteristics. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - May 3, 2019 Category: Epidemiology Authors: Kathryn Zhang, Paul Arora, Neha Sati, Audrey B éliveau, Natalie Troke, Areti Angeliki Veroniki, Myanca Rodrigues, Patricia Rios, Wasifa Zarin, Andrea C. Tricco Tags: Review Source Type: research

Development of the summary of findings table for network meta-analysis
The aim of the study was to develop a Grading of Recommendations, Assessment, Development and Evaluation (GRADE) summary of findings (SoF) table format that displays the critical information from a network meta-analysis (NMA). (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - May 2, 2019 Category: Epidemiology Authors: Juan Jos é Yepes-Nuñez, Shelly-Anne Li, Gordon Guyatt, Susan M. Jack, Jan L. Brozek, Joseph Beyene, M. Hassan Murad, Bram Rochwerg, Lawrence Mbuagbaw, Yuan Zhang, Ivan D. Flórez, Reed A. Siemieniuk, Behnam Sadeghirad, Reem Mustafa, Nancy Santesso, Holg Tags: Original Article Source Type: research

Harms are assessed inconsistently and reported inadequately Part 2: nonsystematic adverse events
We examined nonsystematic adverse events (AEs) in Part 2 (of 2) of a study describing the assessment and reporting AEs in clinical trials. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - May 2, 2019 Category: Epidemiology Authors: Evan Mayo-Wilson, Nicole Fusco, Tianjing Li, Hwanhee Hong, Joseph K. Canner, Kay Dickersin, MUDS investigators Tags: Original Article Source Type: research