Validity Of Health Transition Questions Is Supported By Larger Clinical Improvements In Purposive Samples Enriched For Improvers
(Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - June 19, 2019 Category: Epidemiology Authors: Michael M. Ward, Lori C. Guthrie Tags: Letter to the editor Source Type: research

Collection of antirheumatic medication data from both patients and rheumatologists shows strong agreement in a real-world clinical cohort: the Ontario Best Practices Research Initiative —a rheumatoid arthritis cohort
The objective of the study was to examine the agreement between patient- and rheumatologist-reported antirheumatic medication (ARM) use in the Ontario Best Practices Research Initiative. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - June 18, 2019 Category: Epidemiology Authors: Mohammad Movahedi, Angela Cesta, Xiuying Li, Claire Bombardier, OBRI Investigators Tags: Original Article Source Type: research

Using health insurance reimbursement data to identify incident cancer cases
The objective of this study was to establish an optimal population-level follow-up strategy for identifying incident cancers using health insurance reimbursement data in rural China. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - June 18, 2019 Category: Epidemiology Authors: Chao Shi, Mengfei Liu, Zhen Liu, Chuanhai Guo, Fenglei Li, Ruiping Xu, Fangfang Liu, Ying Liu, Jingjing Li, Hong Cai, Zhonghu He, Yang Ke Tags: Original Article Source Type: research

Limited evidence exists on the effectiveness of education and training interventions on trial recruitment; a systematic review
The objective of this study was to examine the effectiveness of education and training interventions on recruitment to randomized and non-randomized trials. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - June 18, 2019 Category: Epidemiology Authors: Hannah Delaney, Declan Devane, Andrew Hunter, Marita Hennessy, Adwoa Parker, Louise Murphy, Patricia Cronin, Valerie Smith Tags: Review Source Type: research

Collection of Anti-Rheumatic Medication Data from Both Patients and Rheumatologists Shows Strong Agreement in a Real World Clinical Cohort: The Ontario Best Practices Research Initiative (OBRI) a Rheumatoid Arthritis Cohort
To examine the agreement between patient and rheumatologist reported Anti-Rheumatic Medication (ARM) use in the Ontario Best Practices Research Initiative (OBRI). (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - June 18, 2019 Category: Epidemiology Authors: Mohammad Movahedi, Angela Cesta, Xiuying Li, Claire Bombardier, OBRI investigators Tags: Original Article Source Type: research

Using Health Insurance Reimbursement Data to Identified Incident Cancer Cases
To establish an optimal population-level follow-up strategy for identifying incident cancers using health insurance reimbursement data in rural China. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - June 18, 2019 Category: Epidemiology Authors: Chao Shi, Mengfei Liu, Zhen Liu, Chuanhai Guo, Fenglei Li, Ruiping Xu, Fangfang Liu, Ying Liu, Jingjing Li, Hong Cai, Zhonghu He, Yang Ke Tags: Original Article Source Type: research

Rapid network meta-analysis using data from Food and Drug Administration approval packages is feasible but with limitations
To test rapid approaches that use Drugs@FDA (a public database of approved drugs) and ClinicalTrials.gov to identify trials and to compare these two sources with bibliographic databases as an evidence base for a systematic review and network meta-analysis (NMA). (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - June 18, 2019 Category: Epidemiology Authors: Lin Wang, Benjamin Rouse, Arielle Marks-Anglin, Rui Duan, Qiyuan Shi, Kevin Quach, Yong Chen, Christopher Cameron, Christopher H. Schmid, Tianjing Li Tags: Original Article Source Type: research

Clinical replicability of rehabilitation interventions in Randomized Controlled Trials reported in main journals is inadequate
To study if Randomized Controlled Trials (RCTs) in rehabilitation (a field where complex interventions prevail) published in main journals include all the details needed to replicate the intervention in clinical practice (clinical replicability). (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - June 17, 2019 Category: Epidemiology Authors: Stefano Negrini, Chiara Arienti, Joel Pollet, Julia Patrick Engkasan, Gerard E. Francisco, Walter R. Frontera, Silvia Galeri, Kamila Gworys, Jolanta Kujawa, Mazlina Mazlan, Farooq A. Rathore, Fabienne Schillebeeckx, Carlotte Kiekens, REREP study participa Tags: Original Article Source Type: research

A limited number of medicines pragmatic trials had potential for waived informed consent following the 2016 CIOMS ethical guidelines
European regulations do not allow modification or waiver of informed consent for medicines randomized controlled trials (RCTs) where the three 2016 Council for International Organizations of Medical Sciences (CIOMS) provisions are met (consent would be impractical or unfeasible, yet the trial would have high social value and pose no or minimal risk to participants). We aimed to identify whether any such trials of medicines were being conducted in Europe. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - June 15, 2019 Category: Epidemiology Authors: Rafael Dal −Ré, Cristina Avendaño−Solà, Anthonius de Boer, Stephan K. James, Frits R. Rosendaal, Richard Stephens, John PA Ioannidis Tags: Original Article Source Type: research

Care and research concepts should be revised to practice outcome-based medical care
A central question of medical care ethics is: what is ‘good medical practice?’ We will defend the argument that medical ethics must include care research -not only to find out what ‘good’ practice will turn out to be in the future once results are available- but also to guide practice in the meantime, when no one knows what to do, optimizing pa tient outcomes in real time. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - June 14, 2019 Category: Epidemiology Authors: Jean Raymond, Tim E. Darsaut, David Roy Tags: Commentary Source Type: research

Apparently conclusive meta-analyses on interventions in critical care may be inconclusive —a meta-epidemiological study
Risks of random type I and II errors are associated with false positive and false negative findings. In conventional meta-analyses, the risks of random errors are insufficiently evaluated. Many meta-analyses, which appear conclusive, might, in fact, be inconclusive because of risks of random errors. We hypothesize that, for interventions in critical care, false positive and false negative findings frequently become apparent when accounting for the risks of random error. We aim to investigate to which extent apparently conclusive conventional meta-analyses remain conclusive when adjusting statistical significance levels and...
Source: Journal of Clinical Epidemiology - June 11, 2019 Category: Epidemiology Authors: Thijs M. Koster, J ørn Wetterslev, Christian Gluud, Janus C. Jakobsen, Thomas Kaufmann, Ruben J. Eck, Geert Koster, Bart Hiemstra, Iwan C.C. van der Horst, Eric Keus Tags: Review Source Type: research

Apparently conclusive meta-analyses on interventions in critical care may be inconclusive − a meta-epidemiological study
Risks of random type I and II errors are associated with false positive and negative findings. In conventional meta-analyses, the risks of random errors are insufficiently evaluated. Many meta-analyses which appear conclusive might in fact be inconclusive due to risks of random errors. We hypothesize that for interventions in critical care, false positive and negative findings frequently become apparent when accounting for the risks of random error. We aim to investigate to which extent apparently conclusive conventional meta-analyses remain conclusive when adjusting statistical significance levels and confidence intervals...
Source: Journal of Clinical Epidemiology - June 11, 2019 Category: Epidemiology Authors: T.M. Koster, J. Wetterslev, C. Gluud, J.C. Jakobsen, T. Kaufmann, R.J. Eck, G. Koster, B. Hiemstra, I.C.C. van der Horst, F. Keus Tags: Review Source Type: research

Stepped wedge trials with continuous recruitment require new ways of thinking
(Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - June 11, 2019 Category: Epidemiology Authors: Richard Hooper, Andrew Copas Tags: Commentary Source Type: research

Result dissemination from clinical trials conducted at German university medical centers was delayed and incomplete
Timely and comprehensive reporting of clinical trial results builds the backbone of evidence-based medicine and responsible research. The proportion of timely disseminated trial results can inform alternative national and international benchmarking of university medical centers (UMCs). (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - June 10, 2019 Category: Epidemiology Authors: Susanne Wieschowski, Nico Riedel, Katharina Wollmann, Hannes Kahrass, Stephanie M üller-Ohlraun, Christopher Schürmann, Sean Kelley, Ute Kszuk, Bob Siegerink, Ulrich Dirnagl, Jörg Meerpohl, Daniel Strech Tags: Original Article Source Type: research

Models with interactions overestimated heterogeneity of treatment effects and were prone to treatment mistargeting
We aimed to compare the performance of different regression modelling approaches for the prediction of heterogeneous treatment effects. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - June 10, 2019 Category: Epidemiology Authors: David van Klaveren, Theodor A. Balan, Ewout W. Steyerberg, David M. Kent Tags: Original Article Source Type: research

Results dissemination from clinical trials conducted at German university medical centres was delayed and incomplete
Timely and comprehensive reporting of clinical trial results build the backbone of evidence-based medicine and responsible research. The proportion of timely disseminated trial results can inform alternative national and international benchmarking of university medical centers (UMCs). (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - June 10, 2019 Category: Epidemiology Authors: Susanne Wieschowski, Nico Riedel, Katharina Wollmann, Hannes Kahrass, Stephanie M üller-Ohlraun, Christopher Schürmann, Sean Kelley, Ute Kszuk, Bob Siegerink, Ulrich Dirnagl, Jörg Meerpohl, Daniel Strech Tags: Original Article Source Type: research

Delphi consensus reached to produce a decision tool for SelecTing Approaches for Rapid Reviews (STARR)
This study aimed to reach consensus among international rapid review experts outlining areas to consider when selecting approaches for rapid reviews. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - June 8, 2019 Category: Epidemiology Authors: Abdullah Pandor, Eva Kaltenthaler, Marrissa Martyn-St James, Ruth Wong, Katy Cooper, Munya Dimairo, Alicia O ’Cathain, Fiona Campbell, Andrew Booth Tags: Original Article Source Type: research

Should the fragility index be routinely reported for systematic reviews?
Statistical significance can be very fragile. Given the strength of the comprehensiveness of systematic reviews, the robustness of the statistical meta-analyses is of substantial importance to those using them as the evidence basis for practice and policy. The clinical importance of the magnitude of the effect size and its statistical significance are most commonly used to assess this. In this issue Atal et  al. add another- the fragility index. This is defined as the extent to which the statistical significance of meta-analyses can be changed (from statistically significant to non-significant, or vice versa) after mo...
Source: Journal of Clinical Epidemiology - June 7, 2019 Category: Epidemiology Authors: Peter Tugwell, Andre Knottnerus Tags: Editorial Source Type: research

Cover 2 Editorial Board
(Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - June 7, 2019 Category: Epidemiology Source Type: research

Table of Contents
(Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - June 7, 2019 Category: Epidemiology Source Type: research

Letter re: stratification by quality is not recommended in meta-analysis
We read with interest the letter by Page et  al. [1] who disagree with the conclusions of our paper, “Stratification by quality induced selection bias in a meta-analysis of clinical trials” [2]. Page et al. [1] critique the directed acyclic graph (DAG) we presented and suggest that conditioning on quality stratum does not imply that the results within strata defined by quality ranking are biased. We believe that bias occurs when studies are selected into strata such that systematic differences between larger and smaller studies emerge (where none initially existed), as shown in the funnel or Doi plot ...
Source: Journal of Clinical Epidemiology - June 7, 2019 Category: Epidemiology Authors: Jennifer Stone, Usha Gurunathan, Kathryn Glass, Zachary Munn, Peter Tugwell, Suhail A.R. Doi Tags: Letter to the Editor Source Type: research

Psychometric evaluation supported construct validity, temporal stability, and responsiveness of the Osteoarthritis Questionnaire (OA-Quest)
This study describes the psychometric evaluation of the OA-Quest. Specifically, temporal stability, convergent and discriminant validity, and responsiveness of the OA-Quest to joint replacement surgery were examined. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - June 7, 2019 Category: Epidemiology Authors: Ljoudmila Busija, Richard H. Osborne, Gemma Tatangelo, Silvana Niutta, Rachelle Buchbinder Tags: Original Article Source Type: research

Letter re: Sub-groups by quality is not recommended in meta-analysis
(Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - June 7, 2019 Category: Epidemiology Authors: Jennifer Stone, Usha Gurunathan, Kathryn Glass, Zachary Munn, Peter Tugwell, Suhail A.R. Doi Tags: Letter to the editor Source Type: research

Letter re: Stratification of meta-analyses based on risk of bias is appropriate and does not induce selection bias
(Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - June 6, 2019 Category: Epidemiology Authors: Matthew J. Page, Asbj ørn Hróbjartsson, Camilla Hansen, Jonathan AC. Sterne Tags: Letter to the editor Source Type: research

The reply to Sharpe et al.: Hawthorne effect in the YourCall trial suggested by participants qualitative responses
Reductions in self-reported drinking in control groups in alcohol trials have been consistently reported for more than 40  years [1,2]. The qualitative data reported here by Sharpe et al [3] from approximately half the trial participants identify interesting sources of such reductions. Their observations provide new evidence for previously suggested explanations [4], and add to a qualitative literature on research pa rticipation effects which is in its infancy [5,6]. Sharpe et al discuss various causes of change, although omit here the effects of social desirability considerations on reporting on one's own b...
Source: Journal of Clinical Epidemiology - June 5, 2019 Category: Epidemiology Authors: Jim McCambridge, Amanda Wilson, John Attia, Natasha Weaver, Kypros Kypri Tags: Letter to the Editor Source Type: research

Reply to Sharpe et al. Nested qualitative study provides valuable data on research participation effects which does not demonstrate bias in parent trial
(Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - June 5, 2019 Category: Epidemiology Authors: J. McCambridge, A. Wilson, J. Attia, N. Weaver, K. Kypri Source Type: research

Delphi panelists for a core outcome set project suggested both new and existing dissemination strategies that were feasibly implemented by a research infrastructure project
Although many fields of research are developing standardized core outcome sets (COS) and associated core outcome measurement sets (COMS) to help mitigate heterogeneity in outcomes evaluations, there are multiple barriers to their dissemination and uptake. These barriers include a lack of involvement of relevant stakeholders in developing COS/COMS; disagreement among researchers, clinicians, and policymakers; and lack of buy-in and incentives among users and stakeholders [1 –3]. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - June 4, 2019 Category: Epidemiology Authors: Ayodele Akinremi, Alison E. Turnbull, Caroline M. Chessare, Clifton O. Bingham, Dale M. Needham, Victor D. Dinglas Tags: Letter to the Editor Source Type: research

Dissemination strategies for core outcome set recommendations: A survey of Delphi panelists and activity profile of a research infrastructure project
To solicit dissemination ideas from core outcome set (COS) stakeholders and describe a strategy of actual dissemination activities undertaken by a NIH-funded research infrastructure project. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - June 4, 2019 Category: Epidemiology Authors: Ayodele Akinremi, Alison E. Turnbull, Caroline M. Chessare, Clifton O. Bingham, Dale M. Needham, Victor D. Dinglas Tags: Letter to the editor Source Type: research

Factors associated with trial recruitment, preferences, and treatments received were elucidated in a comprehensive cohort study
Recruitment to pragmatic trials is often difficult, and little is known about factors associated with key participation and treatment decisions. These were explored in the Prostate cancer testing and Treatment (ProtecT) study. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - June 3, 2019 Category: Epidemiology Authors: Jenny L. Donovan, Brent Opmeer, Grace J. Young, Nicola Mills, Richard M. Martin, J. Athene Lane, Chris Metcalfe, Tim J. Peters, Michael Davis, Emma L. Turner, Eleanor Walsh, David E. Neal, Freddie C. Hamdy, ProtecT Study Group Tags: Original Article Source Type: research

Factors associated with trial recruitment, preferences and treatments received were elucidated in a comprehensive-cohort study
Recruitment to pragmatic trials is often difficult, and little is known about factors associated with key participation and retention decisions. These were explored in the ProtecT (Prostate cancer testing and Treatment) study. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - June 3, 2019 Category: Epidemiology Authors: Jenny L. Donovan, Brent Opmeer, Grace J. Young, Nicola Mills, Richard M. Martin, J Athene Lane, Chris Metcalfe, Tim J. Peters, Michael Davis, Emma L. Turner, Eleanor Walsh, David E. Neal, Freddie C. Hamdy, ProtecT study group Tags: Original Article Source Type: research

Hawthorne effect in the YourCall trial suggested by participants ’ qualitative responses
(Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - June 3, 2019 Category: Epidemiology Authors: Sarah Sharpe, Bridget Kool, Robyn Whittaker, Shanthi Ameratunga Tags: Letter to the editor Source Type: research

Single pivotal trials with few corroborating characteristics were used for FDA approval of cancer therapies
Novel cancer therapies are often approved with evidence from a single pivotal trial alone. There are concerns about the credibility of this evidence. Higher validity may be indicated by five methodological and statistical characteristics of pivotal trial evidence that were described by the US Food and Drug Administration (FDA) which may corroborate the reliance on a single trial alone for approval decisions. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - May 31, 2019 Category: Epidemiology Authors: Aviv Ladanie, Benjamin Speich, Matthias Briel, Francesco Sclafani, Heiner C. Bucher, Arnav Agarwal, John P.A. Ioannidis, Tiago V. Pereira, Benjamin Kasenda, Lars G. Hemkens Tags: Original Article Source Type: research

Retrieval of individual patient data depended on study characteristics: a randomized controlled trial
The aim of the study was to examine the effect of providing a financial incentive to authors of randomized clinical trials (RCTs) to obtain individual patient data (IPD). (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - May 30, 2019 Category: Epidemiology Authors: Areti Angeliki Veroniki, Huda M. Ashoor, Susan P.C. Le, Patricia Rios, Lesley A. Stewart, Mike Clarke, Dimitris Mavridis, Sharon E. Straus, Andrea C. Tricco Tags: Original Article Source Type: research

Consolidated Standards of Reporting Trials (CONSORT) extensions covered most types of randomized controlled trials, but the potential workload for authors was high
Our aim was to determine the coverage of randomized controlled trials (RCTs) by the Consolidated Standards of Reporting Trial (CONSORT) Statement and its extensions and to evaluate the potential workload for authors to adhere to the guidelines. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - May 30, 2019 Category: Epidemiology Authors: Lina Ghosn, Isabelle Boutron, Philippe Ravaud Tags: Review Source Type: research

Retrieval of individual patient data depended on study characteristics: A randomised controlled trial
To examine the effect of providing a financial incentive to authors of randomized clinical trials (RCTs) to obtain individual patient data (IPD). (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - May 30, 2019 Category: Epidemiology Authors: Areti Angeliki Veroniki, Huda M. Ashoor, Susan P.C. Le, Patricia Rios, Lesley A. Stewart, Mike Clarke, Dimitris Mavridis, Sharon E. Straus, Andrea C. Tricco Tags: Original Article Source Type: research

sCONSORT extensions covered most types of RCTs, but the potential workload for authors was high
Our aim was to determine the coverage of randomized trials (RCTs) by the CONSORT Statement and its extensions and to evaluate the potential workload for authors to adhere to the guidelines. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - May 30, 2019 Category: Epidemiology Authors: Lina Ghosn, Isabelle Boutron, Philippe Ravaud Tags: Review Source Type: research

Contacting authors by telephone increased response proportions compared with emailing: results of a randomized study
The aim of the study was to compare response proportions and research costs of telephone calling vs. continued emailing nonresponding authors of studies included in a systematic review. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - May 29, 2019 Category: Epidemiology Authors: Kristin J. Danko, Issa J. Dahabreh, Noah M. Ivers, David Moher, Jeremy M. Grimshaw Tags: Original Article Source Type: research

The Clinician Guideline Determinants Questionnaire was developed and  validated to support tailored implementation planning
The purpose of this research was to generate and validate a questionnaire that identifies determinants of guideline use from the clinician perspective. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - May 29, 2019 Category: Epidemiology Authors: Anna R. Gagliardi, Melissa J. Armstrong, Susanne Bernhardsson, Margot Fleuren, Hector Pardo-Hernandez, Robin W.M. Vernooij, Melina Willson, Guidelines International Network Implementation Working Group Tags: Original Article Source Type: research

The Clinician Guideline Determinants Questionnaire was developed and validated to support tailored implementation planning
The purpose of this research was to generate and validate a questionnaire that identifies determinants of guideline use from the clinician perspective. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - May 29, 2019 Category: Epidemiology Authors: Anna R. Gagliardi, Melissa J. Armstrong, Susanne Bernhardsson, Margot Fleuren, Hector Pardo-Hernandez, Robin WM. Vernooij, Melina Willson, Guidelines International Network Implementation Working Group Tags: Original Article Source Type: research

A psychometric study found AMSTAR 2 to be a valid and moderately reliable appraisal tool
To determine the inter-rater reliability (IRR) of AMSTAR 2 for reviews of pharmacological or psychological interventions for the treatment of major depression, to compare it to that of AMSTAR and ROBIS and to assess the convergent validity between the appraisal tools. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - May 29, 2019 Category: Epidemiology Authors: Robert C. Lorenz, Katja Matthias, Dawid Pieper, Uta Wegewitz, Johannes Morche, Marc Nocon, Olesja Rissling, Jacqueline Schirm, Anja Jacobs Tags: Original Article Source Type: research

Contacting authors by telephone increased response proportions compared to emailing: results of a randomized study
To compare response proportions and research costs of calling vs. emailing non-responding authors of studies included in a systematic review. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - May 29, 2019 Category: Epidemiology Authors: Danko KJ, Dahabreh IJ, Ivers NM, Moher D, Grimshaw JM Tags: Original Article Source Type: research

Development of practical recommendations for diagnostic accuracy studies in low-prevalence situations
Low disease prevalence poses challenges for diagnostic accuracy studies because of the large sample sizes that are required to obtain sufficient precision. The aim is to collate and discuss designs of diagnostic accuracy studies suited for use in low-prevalence situations. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - May 28, 2019 Category: Epidemiology Authors: Gea A. Holtman, Marjolein Y. Berger, Huibert Burger, Jonathan J. Deeks, Norbert Donner-Banzhoff, Thomas R. Fanshawe, Constantinos Koshiaris, Mariska M. Leeflang, Jason L. Oke, Rafael Perera, Johannes B. Reitsma, Ann Van den Bruel Tags: Original Article Source Type: research

Improvement needed in the network geometry and inconsistency of Cochrane network meta-analyses: a cross-sectional survey
The aim of the study was to investigate the general characteristics and methodological and reporting quality of network meta-analyses (NMAs) published in the Cochrane library. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - May 28, 2019 Category: Epidemiology Authors: Ya Gao, Long Ge, Xueni Ma, Xiping Shen, Meng Liu, Jinhui Tian Tags: Original Article Source Type: research

A cross-sectional audit showed that most Cochrane intervention reviews  searched trial registers
The objective of this study was to assess current Cochrane Review practice in identifying and incorporating information from clinical trial registers. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - May 28, 2019 Category: Epidemiology Authors: Slavica Berber, Ava Grace Tan-Koay, Newton Opiyo, Kerry Dwan, Julie M. Glanville, Toby J. Lasserson, Melina L. Willson Tags: Original Article Source Type: research

Overall bias and sample sizes were unchanged in ICU trials over time: a  meta-epidemiological study
To assess time trends in risk of bias (RoB) and sample sizes in randomized clinical trials (RCTs) of adult intensive care unit (ICU) patients. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - May 28, 2019 Category: Epidemiology Authors: Carl Thomas Anthon, Anders Granholm, Anders Perner, Jon Henrik Laake, Morten Hylander M øller Tags: Review Source Type: research

Development of practical recommendations for diagnostic accuracy studies in low prevalence situations
Low disease prevalence poses challenges for diagnostic accuracy studies because of the large sample sizes that are required in order to obtain sufficient precision. The aim is to collate and discuss designs of diagnostic accuracy studies suited for use in low prevalence situations. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - May 28, 2019 Category: Epidemiology Authors: Gea A. Holtman, Marjolein Y. Berger, Huibert Burger, Jonathan J. Deeks, Norbert Donner-Banzhoff, Thomas R. Fanshawe, Constantinos Koshiaris, Mariska M. Leeflang, Jason L. Oke, Rafael Perera, Johannes B. Reitsma, Ann Van den Bruel Tags: Review Source Type: research

Several reasons explained the variation in the results of 22 meta-analyses addressing the same question
To assess and to investigate the reasons for the variations between the results of meta-analyses addressing the same question. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - May 28, 2019 Category: Epidemiology Authors: Assem M. Khamis, Mohamad El Moheb, Johny Nicolas, Ghida Iskandarani, Marwan M. Refaat, Elie A. Akl Tags: Original Article Source Type: research

Methodology and reporting quality of Cochrane network meta-analyses provides the room to improve the network geometry and inconsistency
To investigate the general characteristics, methodological and reporting quality of network meta-analyses (NMAs) published in the Cochrane library. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - May 28, 2019 Category: Epidemiology Authors: Ya Gao, Long Ge, Xueni Ma, Xiping Shen, Meng Liu, Jinhui Tian Tags: Original Article Source Type: research

Overview: comprehensive and carefully constructed strategies are required when conducting searches for adverse effects data
Methodological research has been undertaken to investigate the many challenges in searching for adverse effects data. It is imperative that the search approach adopted in systematic reviews is based on the best available evidence. We provide a detailed summary of the results and implications of the current evidence base to assist future searches for adverse effects. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - May 28, 2019 Category: Epidemiology Authors: Su Golder, Guy Peryer, Yoon K. Loke Tags: Original Article Source Type: research

A cross-sectional audit showed that the majority of Cochrane intervention reviews searched trial registers
To assess current Cochrane Review practice in identifying and incorporating information from clinical trial registers. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - May 28, 2019 Category: Epidemiology Authors: Slavica Berber, Ava Grace Tan-Koay, Newton Opiyo, Kerry Dwan, Julie M. Glanville, Toby J. Lasserson, Melina L. Willson Tags: Original Article Source Type: research