Neutrophil activation biomarker pentraxin 3 for diagnosis and monitoring of macrophage activation syndrome occurrence in adult-onset Still's disease
In this study, we demonstrated that pentraxin 3 (PTX3), an acute phase protein, was associated with AOSD disease activity and served as a biomarker for AOSD-MAS. PTX3 levels were significantly increased in AOSD patients compared to other autoimmune diseases and healthy controls. Plasma PTX3 levels showed positive correlations with inflammatory markers, the systemic score and the HScore. In active AOSD with MAS, PTX3 levels were higher compared to those in non-AOSD haemophagocytic lymphohistiocytosis (HLH) patients. Moreover, the PTX3's area under the curve value for distinguishing AOSD with MAS exceeded that of soluble int...
Source: Journal of Autoimmunity - March 9, 2024 Category: Allergy & Immunology Authors: Dehao Zhu Longfang Chen Jianfen Meng Mengyan Wang Yuning Ma Xia Chen Yu Xiao Da Yi Hui Shi Yue Sun Honglei Liu Xiaobing Cheng Yutong Su Junna Ye Huihui Chi Zhuochao Zhou Chengde Yang Jialin Teng Jinchao Jia Qiongyi Hu Source Type: research
Neutrophil activation biomarker pentraxin 3 for diagnosis and monitoring of macrophage activation syndrome occurrence in adult-onset Still's disease
In this study, we demonstrated that pentraxin 3 (PTX3), an acute phase protein, was associated with AOSD disease activity and served as a biomarker for AOSD-MAS. PTX3 levels were significantly increased in AOSD patients compared to other autoimmune diseases and healthy controls. Plasma PTX3 levels showed positive correlations with inflammatory markers, the systemic score and the HScore. In active AOSD with MAS, PTX3 levels were higher compared to those in non-AOSD haemophagocytic lymphohistiocytosis (HLH) patients. Moreover, the PTX3's area under the curve value for distinguishing AOSD with MAS exceeded that of soluble int...
Source: Journal of Autoimmunity - March 9, 2024 Category: Allergy & Immunology Authors: Dehao Zhu Longfang Chen Jianfen Meng Mengyan Wang Yuning Ma Xia Chen Yu Xiao Da Yi Hui Shi Yue Sun Honglei Liu Xiaobing Cheng Yutong Su Junna Ye Huihui Chi Zhuochao Zhou Chengde Yang Jialin Teng Jinchao Jia Qiongyi Hu Source Type: research
Neutrophil activation biomarker pentraxin 3 for diagnosis and monitoring of macrophage activation syndrome occurrence in adult-onset Still's disease
In this study, we demonstrated that pentraxin 3 (PTX3), an acute phase protein, was associated with AOSD disease activity and served as a biomarker for AOSD-MAS. PTX3 levels were significantly increased in AOSD patients compared to other autoimmune diseases and healthy controls. Plasma PTX3 levels showed positive correlations with inflammatory markers, the systemic score and the HScore. In active AOSD with MAS, PTX3 levels were higher compared to those in non-AOSD haemophagocytic lymphohistiocytosis (HLH) patients. Moreover, the PTX3's area under the curve value for distinguishing AOSD with MAS exceeded that of soluble int...
Source: Journal of Autoimmunity - March 9, 2024 Category: Allergy & Immunology Authors: Dehao Zhu Longfang Chen Jianfen Meng Mengyan Wang Yuning Ma Xia Chen Yu Xiao Da Yi Hui Shi Yue Sun Honglei Liu Xiaobing Cheng Yutong Su Junna Ye Huihui Chi Zhuochao Zhou Chengde Yang Jialin Teng Jinchao Jia Qiongyi Hu Source Type: research
Neutrophil activation biomarker pentraxin 3 for diagnosis and monitoring of macrophage activation syndrome occurrence in adult-onset Still's disease
In this study, we demonstrated that pentraxin 3 (PTX3), an acute phase protein, was associated with AOSD disease activity and served as a biomarker for AOSD-MAS. PTX3 levels were significantly increased in AOSD patients compared to other autoimmune diseases and healthy controls. Plasma PTX3 levels showed positive correlations with inflammatory markers, the systemic score and the HScore. In active AOSD with MAS, PTX3 levels were higher compared to those in non-AOSD haemophagocytic lymphohistiocytosis (HLH) patients. Moreover, the PTX3's area under the curve value for distinguishing AOSD with MAS exceeded that of soluble int...
Source: Journal of Autoimmunity - March 9, 2024 Category: Allergy & Immunology Authors: Dehao Zhu Longfang Chen Jianfen Meng Mengyan Wang Yuning Ma Xia Chen Yu Xiao Da Yi Hui Shi Yue Sun Honglei Liu Xiaobing Cheng Yutong Su Junna Ye Huihui Chi Zhuochao Zhou Chengde Yang Jialin Teng Jinchao Jia Qiongyi Hu Source Type: research
Targeting macrophages with phosphatidylserine-rich liposomes as a potential antigen-specific immunotherapy for type 1 diabetes
J Autoimmun. 2024 Mar 7;145:103196. doi: 10.1016/j.jaut.2024.103196. Online ahead of print.ABSTRACTType 1 diabetes (T1D) results from a breakdown in immunological tolerance, with pivotal involvement of antigen-presenting cells. In this context, antigen-specific immunotherapies have been developed to arrest autoimmunity, such as phosphatidylserine (PS)-liposomes. However, the role of certain antigen-presenting cells in immunotherapy, particularly human macrophages (Mφ) in T1D remains elusive. The aim of this study was to determine the role of Mφ in antigen-specific immune tolerance and T1D. To that end, we evaluated Mφ a...
Source: Journal of Autoimmunity - March 8, 2024 Category: Allergy & Immunology Authors: Ivan Garcia-Loza David Perna-Barrull Eva Aguilera Lidia Almenara-Fuentes Laia Gomez-Mu ñoz Daniela Greco Maria Vila Miriam Salvado Montserrat Mancera-Arteu Michael W Olszowy Jordi Petriz Marti Dalmases Silvia Rodriguez-Vidal Bruna Barneda-Zahonero Marta Source Type: research
Identifying the genetic association between systemic lupus erythematosus and the risk of autoimmune liver diseases
CONCLUSIONS: We are the first to use MR analysis to explore the causal relationships between SLE and various AILDs, revealing an increased risk of PBC and PSC in individuals with SLE.PMID:38458076 | DOI:10.1016/j.jaut.2024.103188 (Source: Journal of Autoimmunity)
Source: Journal of Autoimmunity - March 8, 2024 Category: Allergy & Immunology Authors: Wei Huang Tianyu Jin Wei Zheng Qiaoqiao Yin Qiqi Yan Hongying Pan Chengan Xu Source Type: research
Ectopic CD4 < sup > + < /sup > T cells in choroid plexus mediate neuropsychiatric lupus symptoms in mice via interferon- γ induced microglia activation
In conclusion, CP-resident lupus CD4+ T cells contribute to NPSLE-like symptoms in mice via Interferon-γ induced microglia activation. Depleting CP-resident lupus CD4+ T cells, interferon-γ, or activated microglia may be potential therapeutic targets for NPSLE.PMID:38452512 | DOI:10.1016/j.jaut.2024.103199 (Source: Journal of Autoimmunity)
Source: Journal of Autoimmunity - March 7, 2024 Category: Allergy & Immunology Authors: Keer Wang Xiaoxiao Hou Haimei Lu Ning Han Meijuan Xie Anran Xi Zhenghao Xu Source Type: research
Ectopic CD4 < sup > + < /sup > T cells in choroid plexus mediate neuropsychiatric lupus symptoms in mice via interferon- γ induced microglia activation
In conclusion, CP-resident lupus CD4+ T cells contribute to NPSLE-like symptoms in mice via Interferon-γ induced microglia activation. Depleting CP-resident lupus CD4+ T cells, interferon-γ, or activated microglia may be potential therapeutic targets for NPSLE.PMID:38452512 | DOI:10.1016/j.jaut.2024.103199 (Source: Journal of Autoimmunity)
Source: Journal of Autoimmunity - March 7, 2024 Category: Allergy & Immunology Authors: Keer Wang Xiaoxiao Hou Haimei Lu Ning Han Meijuan Xie Anran Xi Zhenghao Xu Source Type: research
CADHERIN-11 regulation of myeloid phagocytes and autoimmune inflammation in murine lupus
CONCLUSION: This study highlights a novel role of CDH11 in regulating myeloid cells and efferocytosis and its potential as a contributor to development in autoimmunity murine lupus. Despite the increase in autoimmunity, Cdh11-/- mice developed decreased tissue inflammation and damage.PMID:38447248 | DOI:10.1016/j.jaut.2024.103197 (Source: Journal of Autoimmunity)
Source: Journal of Autoimmunity - March 6, 2024 Category: Allergy & Immunology Authors: Thandiwe Chavula Sarah To Jennifer Smith Mesias Pedroza Jena Nimri Sridevi Devaraj Scott Wenderfer Tiphanie P Vogel Sandeep K Agarwal Source Type: research
CADHERIN-11 regulation of myeloid phagocytes and autoimmune inflammation in murine lupus
CONCLUSION: This study highlights a novel role of CDH11 in regulating myeloid cells and efferocytosis and its potential as a contributor to development in autoimmunity murine lupus. Despite the increase in autoimmunity, Cdh11-/- mice developed decreased tissue inflammation and damage.PMID:38447248 | DOI:10.1016/j.jaut.2024.103197 (Source: Journal of Autoimmunity)
Source: Journal of Autoimmunity - March 6, 2024 Category: Allergy & Immunology Authors: Thandiwe Chavula Sarah To Jennifer Smith Mesias Pedroza Jena Nimri Sridevi Devaraj Scott Wenderfer Tiphanie P Vogel Sandeep K Agarwal Source Type: research
Extracellular microRNAs induce dendritic cell-dependent joint inflammation and potentiate osteoclast differentiation via TLR7/8 engagement
CONCLUSIONS: This work represents a proof of concept that the pool of extracellular miRNAs overexpressed in RA joints can act as a physiological activator of inflammation via the stimulation of TLR8 expressed by human DCs, which in turn exert arthritogenic functions. In this scenario, pharmacological inhibition of TLR8 might offer a new therapeutic option to reduce inflammation and osteoclast-mediated bone destruction in RA.PMID:38442677 | DOI:10.1016/j.jaut.2024.103189 (Source: Journal of Autoimmunity)
Source: Journal of Autoimmunity - March 5, 2024 Category: Allergy & Immunology Authors: Carolina Gaudenzi Tiziana Schioppa Mauro Passari Giovanni Zucchi Laura Tiberio Yasmin Vahidi Sara Scutera Tiziana Musso Silvano Sozzani Annalisa Del Prete Valentina Salvi Daniela Bosisio Source Type: research
Application of laboratory models for sarcoidosis research
J Autoimmun. 2024 Mar 4:103184. doi: 10.1016/j.jaut.2024.103184. Online ahead of print.ABSTRACTThis manuscript will review the implications and applications of sarcoidosis models towards advancing our understanding of sarcoidosis disease mechanisms, identification of biomarkers, and preclinical testing of novel therapies. Emerging disease models and innovative research tools will also be considered.PMID:38443221 | DOI:10.1016/j.jaut.2024.103184 (Source: Journal of Autoimmunity)
Source: Journal of Autoimmunity - March 5, 2024 Category: Allergy & Immunology Authors: Maneesh Bhargava Elliott D Crouser Source Type: research
Extracellular microRNAs induce dendritic cell-dependent joint inflammation and potentiate osteoclast differentiation via TLR7/8 engagement
CONCLUSIONS: This work represents a proof of concept that the pool of extracellular miRNAs overexpressed in RA joints can act as a physiological activator of inflammation via the stimulation of TLR8 expressed by human DCs, which in turn exert arthritogenic functions. In this scenario, pharmacological inhibition of TLR8 might offer a new therapeutic option to reduce inflammation and osteoclast-mediated bone destruction in RA.PMID:38442677 | DOI:10.1016/j.jaut.2024.103189 (Source: Journal of Autoimmunity)
Source: Journal of Autoimmunity - March 5, 2024 Category: Allergy & Immunology Authors: Carolina Gaudenzi Tiziana Schioppa Mauro Passari Giovanni Zucchi Laura Tiberio Yasmin Vahidi Sara Scutera Tiziana Musso Silvano Sozzani Annalisa Del Prete Valentina Salvi Daniela Bosisio Source Type: research
Application of laboratory models for sarcoidosis research
J Autoimmun. 2024 Mar 4:103184. doi: 10.1016/j.jaut.2024.103184. Online ahead of print.ABSTRACTThis manuscript will review the implications and applications of sarcoidosis models towards advancing our understanding of sarcoidosis disease mechanisms, identification of biomarkers, and preclinical testing of novel therapies. Emerging disease models and innovative research tools will also be considered.PMID:38443221 | DOI:10.1016/j.jaut.2024.103184 (Source: Journal of Autoimmunity)
Source: Journal of Autoimmunity - March 5, 2024 Category: Allergy & Immunology Authors: Maneesh Bhargava Elliott D Crouser Source Type: research
Impact of muscle biopsy on the clinical decision-making process in patients with suspected idiopathic inflammatory myopathy
CONCLUSION: In patients with clinically suspected IIM, approximately 50% of biopsies revealed features indicative of IIM. Diagnostic performance of muscle biopsy was moderate to high depending on clinical pre-test probability.PMID:38428109 | DOI:10.1016/j.jaut.2024.103185 (Source: Journal of Autoimmunity)
Source: Journal of Autoimmunity - March 1, 2024 Category: Allergy & Immunology Authors: Kastriot Kastrati Nasim Nakhost Lotfi Marwa G Tawfik Ellen Gelpi Simon Hametner Romana H öftberger Fritz Zimprich Hakan Cetin Elisabeth Lindeck-Pozza Peter Maximilian Heil Hans P Kiener Leonhard X Heinz Daniel Mrak Daniel Aletaha Michael Bonelli Helga Ra Source Type: research
