Non-classical circulating monocytes expressing high levels of microsomal prostaglandin E2 synthase-1 tag an aberrant IFN-response in systemic sclerosis
J Autoimmun. 2023 Aug 24;140:103097. doi: 10.1016/j.jaut.2023.103097. Online ahead of print.ABSTRACTSystemic sclerosis (SSc) is a complex disease that affects the connective tissue, causing fibrosis. SSc patients show altered immune cell composition and activation in the peripheral blood (PB). PB monocytes (Mos) are recruited into tissues where they differentiate into macrophages, which are directly involved in fibrosis. To understand the role of CD14+ PB Mos in SSc, a single-cell transcriptome analysis (scRNA-seq) was conducted on 8 SSc patients and 8 controls. Using unsupervised clustering methods, CD14+ cells were assig...
Source: Journal of Autoimmunity - August 26, 2023 Category: Allergy & Immunology Authors: Gonzalo Villanueva-Martin Marialbert Acosta-Herrera Elio G Carmona Martin Kerick Norberto Ortego-Centeno Jose Luis Callejas-Rubio Norbert Mages Sven Klages Stefan B örno Bernd Timmermann Lara Bossini-Castillo Javier Martin Source Type: research
Differential changes in the gut microbiota between extrinsic and intrinsic atopic dermatitis
J Autoimmun. 2023 Aug 24:103096. doi: 10.1016/j.jaut.2023.103096. Online ahead of print.ABSTRACTElevated serum level of total and (or) allergen-specific IgE is one of the key features of atopic dermatitis (AD). Previous studies have shown that the gut microbiome mediates interactions between external exposures and the immune system in AD; however, the relationship between the gut microbiota and IgE remains unclear. In the present study, analyses of environmental exposures for 250 AD patients and 138 healthy volunteers revealed an association between hygiene levels in the residential environment and the occurrence of AD and...
Source: Journal of Autoimmunity - August 26, 2023 Category: Allergy & Immunology Authors: Xiaochun Liu Jing Xu Zhifeng Wang Xiaoqiang Xu He Wen Huichun Su Yue Han Yang Luo Yu Zhang Wei Li Xu Yao Source Type: research
Non-classical circulating monocytes expressing high levels of microsomal prostaglandin E2 synthase-1 tag an aberrant IFN-response in systemic sclerosis
J Autoimmun. 2023 Aug 24;140:103097. doi: 10.1016/j.jaut.2023.103097. Online ahead of print.ABSTRACTSystemic sclerosis (SSc) is a complex disease that affects the connective tissue, causing fibrosis. SSc patients show altered immune cell composition and activation in the peripheral blood (PB). PB monocytes (Mos) are recruited into tissues where they differentiate into macrophages, which are directly involved in fibrosis. To understand the role of CD14+ PB Mos in SSc, a single-cell transcriptome analysis (scRNA-seq) was conducted on 8 SSc patients and 8 controls. Using unsupervised clustering methods, CD14+ cells were assig...
Source: Journal of Autoimmunity - August 26, 2023 Category: Allergy & Immunology Authors: Gonzalo Villanueva-Martin Marialbert Acosta-Herrera Elio G Carmona Martin Kerick Norberto Ortego-Centeno Jose Luis Callejas-Rubio Norbert Mages Sven Klages Stefan B örno Bernd Timmermann Lara Bossini-Castillo Javier Martin Source Type: research
Differential changes in the gut microbiota between extrinsic and intrinsic atopic dermatitis
J Autoimmun. 2023 Aug 24:103096. doi: 10.1016/j.jaut.2023.103096. Online ahead of print.ABSTRACTElevated serum level of total and (or) allergen-specific IgE is one of the key features of atopic dermatitis (AD). Previous studies have shown that the gut microbiome mediates interactions between external exposures and the immune system in AD; however, the relationship between the gut microbiota and IgE remains unclear. In the present study, analyses of environmental exposures for 250 AD patients and 138 healthy volunteers revealed an association between hygiene levels in the residential environment and the occurrence of AD and...
Source: Journal of Autoimmunity - August 26, 2023 Category: Allergy & Immunology Authors: Xiaochun Liu Jing Xu Zhifeng Wang Xiaoqiang Xu He Wen Huichun Su Yue Han Yang Luo Yu Zhang Wei Li Xu Yao Source Type: research
Chronic inflammation in high-fat diet-fed mice: Unveiling the early pathogenic connection between liver and adipose tissue
In this study, we observed a time-dependent response to a high-fat diet in the liver and epididymal white adipose tissue using gene set enrichment analysis. Our findings revealed a correlation between early abnormal innate immune responses in the liver and late inflammatory response in the adipose tissue, that eventually leads to systemic inflammation. Specifically, our data suggest that the dysregulated NADH homeostasis in the mitochondrial matrix, interacting with the mitochondrial translation process, could serve as a sign marking the transition from liver inflammation to adipose tissue inflammation. Taken together, our...
Source: Journal of Autoimmunity - August 18, 2023 Category: Allergy & Immunology Authors: Heekyong R Bae Su-Kyung Shin Ji-Hyeon Yoo Suntae Kim Howard A Young Eun-Young Kwon Source Type: research
Chronic inflammation in high-fat diet-fed mice: Unveiling the early pathogenic connection between liver and adipose tissue
In this study, we observed a time-dependent response to a high-fat diet in the liver and epididymal white adipose tissue using gene set enrichment analysis. Our findings revealed a correlation between early abnormal innate immune responses in the liver and late inflammatory response in the adipose tissue, that eventually leads to systemic inflammation. Specifically, our data suggest that the dysregulated NADH homeostasis in the mitochondrial matrix, interacting with the mitochondrial translation process, could serve as a sign marking the transition from liver inflammation to adipose tissue inflammation. Taken together, our...
Source: Journal of Autoimmunity - August 18, 2023 Category: Allergy & Immunology Authors: Heekyong R Bae Su-Kyung Shin Ji-Hyeon Yoo Suntae Kim Howard A Young Eun-Young Kwon Source Type: research
Chronic inflammation in high-fat diet-fed mice: Unveiling the early pathogenic connection between liver and adipose tissue
In this study, we observed a time-dependent response to a high-fat diet in the liver and epididymal white adipose tissue using gene set enrichment analysis. Our findings revealed a correlation between early abnormal innate immune responses in the liver and late inflammatory response in the adipose tissue, that eventually leads to systemic inflammation. Specifically, our data suggest that the dysregulated NADH homeostasis in the mitochondrial matrix, interacting with the mitochondrial translation process, could serve as a sign marking the transition from liver inflammation to adipose tissue inflammation. Taken together, our...
Source: Journal of Autoimmunity - August 18, 2023 Category: Allergy & Immunology Authors: Heekyong R Bae Su-Kyung Shin Ji-Hyeon Yoo Suntae Kim Howard A Young Eun-Young Kwon Source Type: research
Chronic inflammation in high-fat diet-fed mice: Unveiling the early pathogenic connection between liver and adipose tissue
In this study, we observed a time-dependent response to a high-fat diet in the liver and epididymal white adipose tissue using gene set enrichment analysis. Our findings revealed a correlation between early abnormal innate immune responses in the liver and late inflammatory response in the adipose tissue, that eventually leads to systemic inflammation. Specifically, our data suggest that the dysregulated NADH homeostasis in the mitochondrial matrix, interacting with the mitochondrial translation process, could serve as a sign marking the transition from liver inflammation to adipose tissue inflammation. Taken together, our...
Source: Journal of Autoimmunity - August 18, 2023 Category: Allergy & Immunology Authors: Heekyong R Bae Su-Kyung Shin Ji-Hyeon Yoo Suntae Kim Howard A Young Eun-Young Kwon Source Type: research
Chronic inflammation in high-fat diet-fed mice: Unveiling the early pathogenic connection between liver and adipose tissue
In this study, we observed a time-dependent response to a high-fat diet in the liver and epididymal white adipose tissue using gene set enrichment analysis. Our findings revealed a correlation between early abnormal innate immune responses in the liver and late inflammatory response in the adipose tissue, that eventually leads to systemic inflammation. Specifically, our data suggest that the dysregulated NADH homeostasis in the mitochondrial matrix, interacting with the mitochondrial translation process, could serve as a sign marking the transition from liver inflammation to adipose tissue inflammation. Taken together, our...
Source: Journal of Autoimmunity - August 18, 2023 Category: Allergy & Immunology Authors: Heekyong R Bae Su-Kyung Shin Ji-Hyeon Yoo Suntae Kim Howard A Young Eun-Young Kwon Source Type: research
Chronic inflammation in high-fat diet-fed mice: Unveiling the early pathogenic connection between liver and adipose tissue
In this study, we observed a time-dependent response to a high-fat diet in the liver and epididymal white adipose tissue using gene set enrichment analysis. Our findings revealed a correlation between early abnormal innate immune responses in the liver and late inflammatory response in the adipose tissue, that eventually leads to systemic inflammation. Specifically, our data suggest that the dysregulated NADH homeostasis in the mitochondrial matrix, interacting with the mitochondrial translation process, could serve as a sign marking the transition from liver inflammation to adipose tissue inflammation. Taken together, our...
Source: Journal of Autoimmunity - August 18, 2023 Category: Allergy & Immunology Authors: Heekyong R Bae Su-Kyung Shin Ji-Hyeon Yoo Suntae Kim Howard A Young Eun-Young Kwon Source Type: research
Chronic inflammation in high-fat diet-fed mice: Unveiling the early pathogenic connection between liver and adipose tissue
In this study, we observed a time-dependent response to a high-fat diet in the liver and epididymal white adipose tissue using gene set enrichment analysis. Our findings revealed a correlation between early abnormal innate immune responses in the liver and late inflammatory response in the adipose tissue, that eventually leads to systemic inflammation. Specifically, our data suggest that the dysregulated NADH homeostasis in the mitochondrial matrix, interacting with the mitochondrial translation process, could serve as a sign marking the transition from liver inflammation to adipose tissue inflammation. Taken together, our...
Source: Journal of Autoimmunity - August 18, 2023 Category: Allergy & Immunology Authors: Heekyong R Bae Su-Kyung Shin Ji-Hyeon Yoo Suntae Kim Howard A Young Eun-Young Kwon Source Type: research
Gut dysbiosis promotes islet-autoimmunity by increasing T-cell attraction in islets via CXCL10 chemokine
J Autoimmun. 2023 Aug 10;140:103090. doi: 10.1016/j.jaut.2023.103090. Online ahead of print.ABSTRACTCXCL10 is an IFNγ-inducible chemokine implicated in the pathogenesis of type 1 diabetes. T-cells attracted to pancreatic islets produce IFNγ, but it is unclear what attracts the first IFNγ -producing T-cells in islets. Gut dysbiosis following administration of pathobionts induced CXCL10 expression in pancreatic islets of healthy non-diabetes-prone (C57BL/6) mice and depended on TLR4-signaling, and in non-obese diabetic (NOD) mice, gut dysbiosis induced also CXCR3 chemokine receptor in IGRP-reactive islet-specific T-cells ...
Source: Journal of Autoimmunity - August 12, 2023 Category: Allergy & Immunology Authors: Sakari P öysti Satu Siloj ärvi Thomas C Brodnicki Tara Catterall Xin Liu Leanne Mackin Andrew D Luster Thomas W H Kay Urs Christen Helen E Thomas Arno H änninen Source Type: research
Gut dysbiosis promotes islet-autoimmunity by increasing T-cell attraction in islets via CXCL10 chemokine
J Autoimmun. 2023 Aug 10;140:103090. doi: 10.1016/j.jaut.2023.103090. Online ahead of print.ABSTRACTCXCL10 is an IFNγ-inducible chemokine implicated in the pathogenesis of type 1 diabetes. T-cells attracted to pancreatic islets produce IFNγ, but it is unclear what attracts the first IFNγ -producing T-cells in islets. Gut dysbiosis following administration of pathobionts induced CXCL10 expression in pancreatic islets of healthy non-diabetes-prone (C57BL/6) mice and depended on TLR4-signaling, and in non-obese diabetic (NOD) mice, gut dysbiosis induced also CXCR3 chemokine receptor in IGRP-reactive islet-specific T-cells ...
Source: Journal of Autoimmunity - August 12, 2023 Category: Allergy & Immunology Authors: Sakari P öysti Satu Siloj ärvi Thomas C Brodnicki Tara Catterall Xin Liu Leanne Mackin Andrew D Luster Thomas W H Kay Urs Christen Helen E Thomas Arno H änninen Source Type: research
Gut dysbiosis promotes islet-autoimmunity by increasing T-cell attraction in islets via CXCL10 chemokine
J Autoimmun. 2023 Aug 10;140:103090. doi: 10.1016/j.jaut.2023.103090. Online ahead of print.ABSTRACTCXCL10 is an IFNγ-inducible chemokine implicated in the pathogenesis of type 1 diabetes. T-cells attracted to pancreatic islets produce IFNγ, but it is unclear what attracts the first IFNγ -producing T-cells in islets. Gut dysbiosis following administration of pathobionts induced CXCL10 expression in pancreatic islets of healthy non-diabetes-prone (C57BL/6) mice and depended on TLR4-signaling, and in non-obese diabetic (NOD) mice, gut dysbiosis induced also CXCR3 chemokine receptor in IGRP-reactive islet-specific T-cells ...
Source: Journal of Autoimmunity - August 12, 2023 Category: Allergy & Immunology Authors: Sakari P öysti Satu Siloj ärvi Thomas C Brodnicki Tara Catterall Xin Liu Leanne Mackin Andrew D Luster Thomas W H Kay Urs Christen Helen E Thomas Arno H änninen Source Type: research
Gut dysbiosis promotes islet-autoimmunity by increasing T-cell attraction in islets via CXCL10 chemokine
J Autoimmun. 2023 Aug 10;140:103090. doi: 10.1016/j.jaut.2023.103090. Online ahead of print.ABSTRACTCXCL10 is an IFNγ-inducible chemokine implicated in the pathogenesis of type 1 diabetes. T-cells attracted to pancreatic islets produce IFNγ, but it is unclear what attracts the first IFNγ -producing T-cells in islets. Gut dysbiosis following administration of pathobionts induced CXCL10 expression in pancreatic islets of healthy non-diabetes-prone (C57BL/6) mice and depended on TLR4-signaling, and in non-obese diabetic (NOD) mice, gut dysbiosis induced also CXCR3 chemokine receptor in IGRP-reactive islet-specific T-cells ...
Source: Journal of Autoimmunity - August 12, 2023 Category: Allergy & Immunology Authors: Sakari P öysti Satu Siloj ärvi Thomas C Brodnicki Tara Catterall Xin Liu Leanne Mackin Andrew D Luster Thomas W H Kay Urs Christen Helen E Thomas Arno H änninen Source Type: research
