High-resolution HLA genotyping in inclusion body myositis refines 8.1 ancestral haplotype association to DRB1*03:01:01 and highlights pathogenic role of arginine-74 of DR β1 chain
CONCLUSIONS: High-resolution HLA sequencing more precisely characterised the alleles associated with IBM and defined a haplotype linked to earlier disease onset. Identification of the critical amino acid residue by advanced biostatistical analysis of immunogenetics data offers mechanistic insights and future directions into uncovering IBM aetiopathogenesis.PMID:38043487 | DOI:10.1016/j.jaut.2023.103150 (Source: Journal of Autoimmunity)
Source: Journal of Autoimmunity - December 3, 2023 Category: Allergy & Immunology Authors: Nataliya Slater Anuradha Sooda Emily McLeish Kelly Beer Anna Brusch Rakesh Shakya Christine Bundell Ian James Abha Chopra Frank L Mastaglia Merrilee Needham Jerome D Coudert Source Type: research
High-resolution HLA genotyping in inclusion body myositis refines 8.1 ancestral haplotype association to DRB1*03:01:01 and highlights pathogenic role of arginine-74 of DR β1 chain
CONCLUSIONS: High-resolution HLA sequencing more precisely characterised the alleles associated with IBM and defined a haplotype linked to earlier disease onset. Identification of the critical amino acid residue by advanced biostatistical analysis of immunogenetics data offers mechanistic insights and future directions into uncovering IBM aetiopathogenesis.PMID:38043487 | DOI:10.1016/j.jaut.2023.103150 (Source: Journal of Autoimmunity)
Source: Journal of Autoimmunity - December 3, 2023 Category: Allergy & Immunology Authors: Nataliya Slater Anuradha Sooda Emily McLeish Kelly Beer Anna Brusch Rakesh Shakya Christine Bundell Ian James Abha Chopra Frank L Mastaglia Merrilee Needham Jerome D Coudert Source Type: research
High-resolution HLA genotyping in inclusion body myositis refines 8.1 ancestral haplotype association to DRB1*03:01:01 and highlights pathogenic role of arginine-74 of DR β1 chain
CONCLUSIONS: High-resolution HLA sequencing more precisely characterised the alleles associated with IBM and defined a haplotype linked to earlier disease onset. Identification of the critical amino acid residue by advanced biostatistical analysis of immunogenetics data offers mechanistic insights and future directions into uncovering IBM aetiopathogenesis.PMID:38043487 | DOI:10.1016/j.jaut.2023.103150 (Source: Journal of Autoimmunity)
Source: Journal of Autoimmunity - December 3, 2023 Category: Allergy & Immunology Authors: Nataliya Slater Anuradha Sooda Emily McLeish Kelly Beer Anna Brusch Rakesh Shakya Christine Bundell Ian James Abha Chopra Frank L Mastaglia Merrilee Needham Jerome D Coudert Source Type: research
High-resolution HLA genotyping in inclusion body myositis refines 8.1 ancestral haplotype association to DRB1*03:01:01 and highlights pathogenic role of arginine-74 of DR β1 chain
CONCLUSIONS: High-resolution HLA sequencing more precisely characterised the alleles associated with IBM and defined a haplotype linked to earlier disease onset. Identification of the critical amino acid residue by advanced biostatistical analysis of immunogenetics data offers mechanistic insights and future directions into uncovering IBM aetiopathogenesis.PMID:38043487 | DOI:10.1016/j.jaut.2023.103150 (Source: Journal of Autoimmunity)
Source: Journal of Autoimmunity - December 3, 2023 Category: Allergy & Immunology Authors: Nataliya Slater Anuradha Sooda Emily McLeish Kelly Beer Anna Brusch Rakesh Shakya Christine Bundell Ian James Abha Chopra Frank L Mastaglia Merrilee Needham Jerome D Coudert Source Type: research
Neointimal myofibroblasts contribute to maintaining Th1/Tc1 and Th17/Tc17 inflammation in giant cell arteritis
This study aimed to investigate if MFs could also impact T-cell polarization. Confocal microscopy was used to analyze fresh fragments of temporal artery biopsies (TABs). Healthy TAB sections were cultured to obtain MFs, which were then treated or not with interferon-gamma (IFN-γ) and tumor necrosis factor-alpha (TNF-α) and analyzed by immunofluorescence and RT-PCR. After peripheral blood mononuclear cells and MFs were co-cultured for seven days, T-cell polarization was analyzed by flow cytometry. In the neointima of GCA arteries, we observed a phenotypic heterogeneity among VSMCs that was consistent with a MF phenotype (...
Source: Journal of Autoimmunity - December 1, 2023 Category: Allergy & Immunology Authors: H élène Greigert Andr é Ramon Coraline Genet Claudie Cladi ère Claire Gerard Marion Cuidad Marc Corbera-Bellalta Roser Alba-Rovira Louis Arnould Catherine Creuzot-Garcher Laurent Martin Georges Tarris Thibault Ghesqui ère Sethi Ouandji Sylvain Audia Source Type: research
Neointimal myofibroblasts contribute to maintaining Th1/Tc1 and Th17/Tc17 inflammation in giant cell arteritis
This study aimed to investigate if MFs could also impact T-cell polarization. Confocal microscopy was used to analyze fresh fragments of temporal artery biopsies (TABs). Healthy TAB sections were cultured to obtain MFs, which were then treated or not with interferon-gamma (IFN-γ) and tumor necrosis factor-alpha (TNF-α) and analyzed by immunofluorescence and RT-PCR. After peripheral blood mononuclear cells and MFs were co-cultured for seven days, T-cell polarization was analyzed by flow cytometry. In the neointima of GCA arteries, we observed a phenotypic heterogeneity among VSMCs that was consistent with a MF phenotype (...
Source: Journal of Autoimmunity - December 1, 2023 Category: Allergy & Immunology Authors: H élène Greigert Andr é Ramon Coraline Genet Claudie Cladi ère Claire Gerard Marion Cuidad Marc Corbera-Bellalta Roser Alba-Rovira Louis Arnould Catherine Creuzot-Garcher Laurent Martin Georges Tarris Thibault Ghesqui ère Sethi Ouandji Sylvain Audia Source Type: research
AIM/CD5L ameliorates autoimmune arthritis by promoting removal of inflammatory DAMPs at the lesions
J Autoimmun. 2023 Nov 24;142:103149. doi: 10.1016/j.jaut.2023.103149. Online ahead of print.ABSTRACTThe hallmark of autoimmune arthritis is the preceding autoantibody production and the following synovial inflammation with hyperplasia and tissue destruction of the joints. The joint inflammation is mediated not only by effector lymphocytes and auto-antibodies but also chronic activation of innate immunity, particularly promoted by the danger-associated molecular patterns (DAMPs). Here we show that apoptosis inhibitor of macrophage (AIM, also called CD5L) protein regulates arthritis by promoting removal of lesional DAMPs bot...
Source: Journal of Autoimmunity - November 25, 2023 Category: Allergy & Immunology Authors: Keisuke Yasuda Shieri Shimodan Natsumi Maehara Aika Hirota Ruka Iijima Akemi Nishijima Haruka Mori Ran Toyama Atsumi Ito Yuri Yoshikawa Satoko Arai Toru Miyazaki Source Type: research
AIM/CD5L ameliorates autoimmune arthritis by promoting removal of inflammatory DAMPs at the lesions
J Autoimmun. 2023 Nov 24;142:103149. doi: 10.1016/j.jaut.2023.103149. Online ahead of print.ABSTRACTThe hallmark of autoimmune arthritis is the preceding autoantibody production and the following synovial inflammation with hyperplasia and tissue destruction of the joints. The joint inflammation is mediated not only by effector lymphocytes and auto-antibodies but also chronic activation of innate immunity, particularly promoted by the danger-associated molecular patterns (DAMPs). Here we show that apoptosis inhibitor of macrophage (AIM, also called CD5L) protein regulates arthritis by promoting removal of lesional DAMPs bot...
Source: Journal of Autoimmunity - November 25, 2023 Category: Allergy & Immunology Authors: Keisuke Yasuda Shieri Shimodan Natsumi Maehara Aika Hirota Ruka Iijima Akemi Nishijima Haruka Mori Ran Toyama Atsumi Ito Yuri Yoshikawa Satoko Arai Toru Miyazaki Source Type: research
AIM/CD5L ameliorates autoimmune arthritis by promoting removal of inflammatory DAMPs at the lesions
J Autoimmun. 2023 Nov 24;142:103149. doi: 10.1016/j.jaut.2023.103149. Online ahead of print.ABSTRACTThe hallmark of autoimmune arthritis is the preceding autoantibody production and the following synovial inflammation with hyperplasia and tissue destruction of the joints. The joint inflammation is mediated not only by effector lymphocytes and auto-antibodies but also chronic activation of innate immunity, particularly promoted by the danger-associated molecular patterns (DAMPs). Here we show that apoptosis inhibitor of macrophage (AIM, also called CD5L) protein regulates arthritis by promoting removal of lesional DAMPs bot...
Source: Journal of Autoimmunity - November 25, 2023 Category: Allergy & Immunology Authors: Keisuke Yasuda Shieri Shimodan Natsumi Maehara Aika Hirota Ruka Iijima Akemi Nishijima Haruka Mori Ran Toyama Atsumi Ito Yuri Yoshikawa Satoko Arai Toru Miyazaki Source Type: research
AIM/CD5L ameliorates autoimmune arthritis by promoting removal of inflammatory DAMPs at the lesions
J Autoimmun. 2023 Nov 24;142:103149. doi: 10.1016/j.jaut.2023.103149. Online ahead of print.ABSTRACTThe hallmark of autoimmune arthritis is the preceding autoantibody production and the following synovial inflammation with hyperplasia and tissue destruction of the joints. The joint inflammation is mediated not only by effector lymphocytes and auto-antibodies but also chronic activation of innate immunity, particularly promoted by the danger-associated molecular patterns (DAMPs). Here we show that apoptosis inhibitor of macrophage (AIM, also called CD5L) protein regulates arthritis by promoting removal of lesional DAMPs bot...
Source: Journal of Autoimmunity - November 25, 2023 Category: Allergy & Immunology Authors: Keisuke Yasuda Shieri Shimodan Natsumi Maehara Aika Hirota Ruka Iijima Akemi Nishijima Haruka Mori Ran Toyama Atsumi Ito Yuri Yoshikawa Satoko Arai Toru Miyazaki Source Type: research
2023 International Consensus Guidance for the use of Tripterygium Wilfordii Hook F in the treatment of active rheumatoid arthritis
CONCLUSION: Upon full review of the evidence, the guidance panel reached consensus on recommendations for the use of TwHF in people with active RA, either as monotherapy or as combination therapy with MTX.PMID:37967495 | DOI:10.1016/j.jaut.2023.103148 (Source: Journal of Autoimmunity)
Source: Journal of Autoimmunity - November 15, 2023 Category: Allergy & Immunology Authors: Xuan Zhang Jun Xia Ying Jiang David S Pisetsky Josef S Smolen Rong Mu Shengming Dai Michael E Weinblatt Tore K Kvien Juan Li Thomas D örner Yu Zhang Liwei Lu Chengde Yang Pingting Yang Yuan Zhang Chenchen Xu Zhan Zhao Peter E Lipsky Source Type: research
2023 International Consensus Guidance for the use of Tripterygium Wilfordii Hook F in the treatment of active rheumatoid arthritis
CONCLUSION: Upon full review of the evidence, the guidance panel reached consensus on recommendations for the use of TwHF in people with active RA, either as monotherapy or as combination therapy with MTX.PMID:37967495 | DOI:10.1016/j.jaut.2023.103148 (Source: Journal of Autoimmunity)
Source: Journal of Autoimmunity - November 15, 2023 Category: Allergy & Immunology Authors: Xuan Zhang Jun Xia Ying Jiang David S Pisetsky Josef S Smolen Rong Mu Shengming Dai Michael E Weinblatt Tore K Kvien Juan Li Thomas D örner Yu Zhang Liwei Lu Chengde Yang Pingting Yang Yuan Zhang Chenchen Xu Zhan Zhao Peter E Lipsky Source Type: research
2023 International Consensus Guidance for the use of Tripterygium Wilfordii Hook F in the treatment of active rheumatoid arthritis
CONCLUSION: Upon full review of the evidence, the guidance panel reached consensus on recommendations for the use of TwHF in people with active RA, either as monotherapy or as combination therapy with MTX.PMID:37967495 | DOI:10.1016/j.jaut.2023.103148 (Source: Journal of Autoimmunity)
Source: Journal of Autoimmunity - November 15, 2023 Category: Allergy & Immunology Authors: Xuan Zhang Jun Xia Ying Jiang David S Pisetsky Josef S Smolen Rong Mu Shengming Dai Michael E Weinblatt Tore K Kvien Juan Li Thomas D örner Yu Zhang Liwei Lu Chengde Yang Pingting Yang Yuan Zhang Chenchen Xu Zhan Zhao Peter E Lipsky Source Type: research
2023 International Consensus Guidance for the use of Tripterygium Wilfordii Hook F in the treatment of active rheumatoid arthritis
CONCLUSION: Upon full review of the evidence, the guidance panel reached consensus on recommendations for the use of TwHF in people with active RA, either as monotherapy or as combination therapy with MTX.PMID:37967495 | DOI:10.1016/j.jaut.2023.103148 (Source: Journal of Autoimmunity)
Source: Journal of Autoimmunity - November 15, 2023 Category: Allergy & Immunology Authors: Xuan Zhang Jun Xia Ying Jiang David S Pisetsky Josef S Smolen Rong Mu Shengming Dai Michael E Weinblatt Tore K Kvien Juan Li Thomas D örner Yu Zhang Liwei Lu Chengde Yang Pingting Yang Yuan Zhang Chenchen Xu Zhan Zhao Peter E Lipsky Source Type: research
2023 International Consensus Guidance for the use of Tripterygium Wilfordii Hook F in the treatment of active rheumatoid arthritis
CONCLUSION: Upon full review of the evidence, the guidance panel reached consensus on recommendations for the use of TwHF in people with active RA, either as monotherapy or as combination therapy with MTX.PMID:37967495 | DOI:10.1016/j.jaut.2023.103148 (Source: Journal of Autoimmunity)
Source: Journal of Autoimmunity - November 15, 2023 Category: Allergy & Immunology Authors: Xuan Zhang Jun Xia Ying Jiang David S Pisetsky Josef S Smolen Rong Mu Shengming Dai Michael E Weinblatt Tore K Kvien Juan Li Thomas D örner Yu Zhang Liwei Lu Chengde Yang Pingting Yang Yuan Zhang Chenchen Xu Zhan Zhao Peter E Lipsky Source Type: research
