Peripheral helper T cells in human diseases
J Autoimmun. 2024 Apr 3;145:103218. doi: 10.1016/j.jaut.2024.103218. Online ahead of print.ABSTRACTPeripheral helper T cells (Tph) are a specialized subset of CD4+ T cells with the ability to help B cells and induce antibody production. Although usually located in ectopic lymphoid-like structures (ELS), inside the peripheral blood, Tph cells can also be identified. The aberrant proliferation and functions of Tph cells are commonly found in the patients with disease. In this review, first we will summarize the biological characteristics of Tph cells, such as the expression of surface molecules, transcription factors and cyt...
Source: Journal of Autoimmunity - April 4, 2024 Category: Allergy & Immunology Authors: Xueyang Zou Feifei Huo Lulu Sun Jing Huang Source Type: research
Peripheral helper T cells in human diseases
J Autoimmun. 2024 Apr 3;145:103218. doi: 10.1016/j.jaut.2024.103218. Online ahead of print.ABSTRACTPeripheral helper T cells (Tph) are a specialized subset of CD4+ T cells with the ability to help B cells and induce antibody production. Although usually located in ectopic lymphoid-like structures (ELS), inside the peripheral blood, Tph cells can also be identified. The aberrant proliferation and functions of Tph cells are commonly found in the patients with disease. In this review, first we will summarize the biological characteristics of Tph cells, such as the expression of surface molecules, transcription factors and cyt...
Source: Journal of Autoimmunity - April 4, 2024 Category: Allergy & Immunology Authors: Xueyang Zou Feifei Huo Lulu Sun Jing Huang Source Type: research
Characterization of Th17 tissue-resident memory cells in non-inflamed intestinal tissue of Crohn's disease patients
J Autoimmun. 2024 Mar 29;145:103206. doi: 10.1016/j.jaut.2024.103206. Online ahead of print.ABSTRACTCrohn's disease (CD) is a chronic inflammatory disorder affecting the bowel wall. Tissue-resident memory T (Trm) cells are implicated in CD, yet their characteristics remain unclear. We aimed to investigate the transcriptional profiles and functional characteristics of Trm cells in the small bowel of CD and their interactions with immune cells. Seven patients with CD and four with ulcerative colitis as controls were included. Single-cell RNA sequencing and paired T cell receptor sequencing assessed T cell subsets and transcr...
Source: Journal of Autoimmunity - March 30, 2024 Category: Allergy & Immunology Authors: Yoonho Lee Jiwon Baek Sojung Park Yongjae Kim Sung Wook Hwang Jong Lyul Lee Sang Hyoung Park Jihun Kim Suk-Kyun Yang Buhm Han Mi-Na Kweon Kyuyoung Song Yong Sik Yoon Byong Duk Ye Ho-Su Lee Source Type: research
Characterization of Th17 tissue-resident memory cells in non-inflamed intestinal tissue of Crohn's disease patients
J Autoimmun. 2024 Mar 29;145:103206. doi: 10.1016/j.jaut.2024.103206. Online ahead of print.ABSTRACTCrohn's disease (CD) is a chronic inflammatory disorder affecting the bowel wall. Tissue-resident memory T (Trm) cells are implicated in CD, yet their characteristics remain unclear. We aimed to investigate the transcriptional profiles and functional characteristics of Trm cells in the small bowel of CD and their interactions with immune cells. Seven patients with CD and four with ulcerative colitis as controls were included. Single-cell RNA sequencing and paired T cell receptor sequencing assessed T cell subsets and transcr...
Source: Journal of Autoimmunity - March 30, 2024 Category: Allergy & Immunology Authors: Yoonho Lee Jiwon Baek Sojung Park Yongjae Kim Sung Wook Hwang Jong Lyul Lee Sang Hyoung Park Jihun Kim Suk-Kyun Yang Buhm Han Mi-Na Kweon Kyuyoung Song Yong Sik Yoon Byong Duk Ye Ho-Su Lee Source Type: research
Characterization of Th17 tissue-resident memory cells in non-inflamed intestinal tissue of Crohn's disease patients
J Autoimmun. 2024 Mar 29;145:103206. doi: 10.1016/j.jaut.2024.103206. Online ahead of print.ABSTRACTCrohn's disease (CD) is a chronic inflammatory disorder affecting the bowel wall. Tissue-resident memory T (Trm) cells are implicated in CD, yet their characteristics remain unclear. We aimed to investigate the transcriptional profiles and functional characteristics of Trm cells in the small bowel of CD and their interactions with immune cells. Seven patients with CD and four with ulcerative colitis as controls were included. Single-cell RNA sequencing and paired T cell receptor sequencing assessed T cell subsets and transcr...
Source: Journal of Autoimmunity - March 30, 2024 Category: Allergy & Immunology Authors: Yoonho Lee Jiwon Baek Sojung Park Yongjae Kim Sung Wook Hwang Jong Lyul Lee Sang Hyoung Park Jihun Kim Suk-Kyun Yang Buhm Han Mi-Na Kweon Kyuyoung Song Yong Sik Yoon Byong Duk Ye Ho-Su Lee Source Type: research
Characterization of Th17 tissue-resident memory cells in non-inflamed intestinal tissue of Crohn's disease patients
J Autoimmun. 2024 Mar 29;145:103206. doi: 10.1016/j.jaut.2024.103206. Online ahead of print.ABSTRACTCrohn's disease (CD) is a chronic inflammatory disorder affecting the bowel wall. Tissue-resident memory T (Trm) cells are implicated in CD, yet their characteristics remain unclear. We aimed to investigate the transcriptional profiles and functional characteristics of Trm cells in the small bowel of CD and their interactions with immune cells. Seven patients with CD and four with ulcerative colitis as controls were included. Single-cell RNA sequencing and paired T cell receptor sequencing assessed T cell subsets and transcr...
Source: Journal of Autoimmunity - March 30, 2024 Category: Allergy & Immunology Authors: Yoonho Lee Jiwon Baek Sojung Park Yongjae Kim Sung Wook Hwang Jong Lyul Lee Sang Hyoung Park Jihun Kim Suk-Kyun Yang Buhm Han Mi-Na Kweon Kyuyoung Song Yong Sik Yoon Byong Duk Ye Ho-Su Lee Source Type: research
Balancing efficacy and safety of complement inhibitors
J Autoimmun. 2024 Mar 28;145:103216. doi: 10.1016/j.jaut.2024.103216. Online ahead of print.ABSTRACTComplement inhibitors have been approved for several immune-mediated diseases and they are considered the next paradigm-shifting approach in the treatment of glomerulonephritis. The hierarchical organization of the complement system offers numerous molecular targets for therapeutic intervention. However, complement is an integral element of host defense and therefore complement inhibition can be associated with serious infectious complications. Here we give a closer look to the hierarchical complement system and how interfer...
Source: Journal of Autoimmunity - March 29, 2024 Category: Allergy & Immunology Authors: Kanako Watanabe-Kusunoki Hans-Joachim Anders Source Type: research
Balancing efficacy and safety of complement inhibitors
J Autoimmun. 2024 Mar 28;145:103216. doi: 10.1016/j.jaut.2024.103216. Online ahead of print.ABSTRACTComplement inhibitors have been approved for several immune-mediated diseases and they are considered the next paradigm-shifting approach in the treatment of glomerulonephritis. The hierarchical organization of the complement system offers numerous molecular targets for therapeutic intervention. However, complement is an integral element of host defense and therefore complement inhibition can be associated with serious infectious complications. Here we give a closer look to the hierarchical complement system and how interfer...
Source: Journal of Autoimmunity - March 29, 2024 Category: Allergy & Immunology Authors: Kanako Watanabe-Kusunoki Hans-Joachim Anders Source Type: research
Developmental drugs for sarcoidosis
J Autoimmun. 2024 Mar 28:103179. doi: 10.1016/j.jaut.2024.103179. Online ahead of print.ABSTRACTSarcoidosis is a multi-organ granulomatous inflammatory disease of unknown etiology. Over 50% of patients will require treatment at some point in their disease and 10%-30% will develop a chronic progressive disease with pulmonary fibrosis leading to significant morbidity and mortality. Recently published guidelines recommend immunosuppressive therapy for sarcoidosis patients at risk of increased disease-related morbidity and mortality, and in whom disease has negatively impacted quality of life. Prednisone the currently recommen...
Source: Journal of Autoimmunity - March 28, 2024 Category: Allergy & Immunology Authors: Ogugua Ndili Obi Lesley Ann Saketkoo Lisa A Maier Robert P Baughman Source Type: research
Developmental drugs for sarcoidosis
J Autoimmun. 2024 Mar 28:103179. doi: 10.1016/j.jaut.2024.103179. Online ahead of print.ABSTRACTSarcoidosis is a multi-organ granulomatous inflammatory disease of unknown etiology. Over 50% of patients will require treatment at some point in their disease and 10%-30% will develop a chronic progressive disease with pulmonary fibrosis leading to significant morbidity and mortality. Recently published guidelines recommend immunosuppressive therapy for sarcoidosis patients at risk of increased disease-related morbidity and mortality, and in whom disease has negatively impacted quality of life. Prednisone the currently recommen...
Source: Journal of Autoimmunity - March 28, 2024 Category: Allergy & Immunology Authors: Ogugua Ndili Obi Lesley Ann Saketkoo Lisa A Maier Robert P Baughman Source Type: research
A reverse translational approach reveals the protective roles of Mangifera indica in inflammatory bowel disease
In this study, we aimed to dissect the immunomodulatory and anti-inflammatory properties of MIE using a reverse translational approach, by initially using blood from an adult IBD inception cohort and then investigating the mechanism of action in a preclinical model of T cell-driven colitis. Of clinical relevance, MIE modulates TNF-α and IL-17 levels in LPS spiked sera from IBD patients as an ex vivo model of intestinal barrier breakdown. Preclinically, therapeutic administration of MIE significantly reduced colitis severity, pathogenic T-cell intestinal infiltrate and intestinal pro-inflammatory mediators (IL-6, IL-17A, T...
Source: Journal of Autoimmunity - March 24, 2024 Category: Allergy & Immunology Authors: Anella Saviano Anna Schettino Nunzia Iaccarino Adel Abo Mansour Jenefa Begum Noemi Marigliano Federica Raucci Francesca Romano Gelsomina Riccardi Emma Mitidieri Roberta d'Emmanuele di Villa Bianca Ivana Bello Elisabetta Panza Martina Smimmo Valentina Vell Source Type: research
A reverse translational approach reveals the protective roles of Mangifera indica in inflammatory bowel disease
In this study, we aimed to dissect the immunomodulatory and anti-inflammatory properties of MIE using a reverse translational approach, by initially using blood from an adult IBD inception cohort and then investigating the mechanism of action in a preclinical model of T cell-driven colitis. Of clinical relevance, MIE modulates TNF-α and IL-17 levels in LPS spiked sera from IBD patients as an ex vivo model of intestinal barrier breakdown. Preclinically, therapeutic administration of MIE significantly reduced colitis severity, pathogenic T-cell intestinal infiltrate and intestinal pro-inflammatory mediators (IL-6, IL-17A, T...
Source: Journal of Autoimmunity - March 24, 2024 Category: Allergy & Immunology Authors: Anella Saviano Anna Schettino Nunzia Iaccarino Adel Abo Mansour Jenefa Begum Noemi Marigliano Federica Raucci Francesca Romano Gelsomina Riccardi Emma Mitidieri Roberta d'Emmanuele di Villa Bianca Ivana Bello Elisabetta Panza Martina Smimmo Valentina Vell Source Type: research
A reverse translational approach reveals the protective roles of Mangifera indica in inflammatory bowel disease
In this study, we aimed to dissect the immunomodulatory and anti-inflammatory properties of MIE using a reverse translational approach, by initially using blood from an adult IBD inception cohort and then investigating the mechanism of action in a preclinical model of T cell-driven colitis. Of clinical relevance, MIE modulates TNF-α and IL-17 levels in LPS spiked sera from IBD patients as an ex vivo model of intestinal barrier breakdown. Preclinically, therapeutic administration of MIE significantly reduced colitis severity, pathogenic T-cell intestinal infiltrate and intestinal pro-inflammatory mediators (IL-6, IL-17A, T...
Source: Journal of Autoimmunity - March 24, 2024 Category: Allergy & Immunology Authors: Anella Saviano Anna Schettino Nunzia Iaccarino Adel Abo Mansour Jenefa Begum Noemi Marigliano Federica Raucci Francesca Romano Gelsomina Riccardi Emma Mitidieri Roberta d'Emmanuele di Villa Bianca Ivana Bello Elisabetta Panza Martina Smimmo Valentina Vell Source Type: research
Quantitative and structural changes of blood platelet cytoskeleton proteins in multiple sclerosis (MS)
J Autoimmun. 2024 Mar 22;145:103204. doi: 10.1016/j.jaut.2024.103204. Online ahead of print.ABSTRACTEpidemiological studies show that cardiovascular events related to platelet hyperactivity remain the leading causes of death among multiple sclerosis (MS) patients. Quantitative or structural changes of platelet cytoskeleton alter their morphology and function. Here, we demonstrated, for the first time, the structural changes in MS platelets that may be related to their hyperactivity. MS platelets were found to form large aggregates compared to control platelets. In contrast to the control, the images of overactivated, irreg...
Source: Journal of Autoimmunity - March 23, 2024 Category: Allergy & Immunology Authors: Angela Dziedzic Sylwia Michlewska Piotr J óźwiak Janusz D ębski Micha ł Seweryn Karbownik Łukasz Łaczmański Dorota Kujawa S ława Glińska El żbieta Miller Marta Niwald Malgorzata Kloc Łucja Balcerzak Joanna Saluk Source Type: research
Kidney manifestations of sarcoidosis
J Autoimmun. 2024 Mar 22:103207. doi: 10.1016/j.jaut.2024.103207. Online ahead of print.ABSTRACTRenal involvement is a clinically relevant organ manifestation of sarcoidosis, leading to increased morbidity and complications. Although the exact incidence remains unknown, renal disease is likely to occur in up to one third of all sarcoidosis patients. Every patient with newly diagnosed sarcoidosis should receive a renal work-up and screening for disrupted calcium metabolism. Amid various forms of glomerulonephritis, granulomatous interstitial nephritis is the most common one, but it rarely leads to renal impairment. Histolog...
Source: Journal of Autoimmunity - March 23, 2024 Category: Allergy & Immunology Authors: Francesco Bonella Adriane Dm Vorselaars Benjamin Wilde Source Type: research
