Journal of Autoimmunity This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Integrative single-cell analysis reveals distinct adaptive immune signatures in the cutaneous lesions of pemphigus
J Autoimmun. 2023 Nov 6;142:103128. doi: 10.1016/j.jaut.2023.103128. Online ahead of print.ABSTRACTPemphigus, an autoimmune bullous disease affecting the skin and mucosal membranes, is primarily driven by anti-desmoglein (Dsg) autoantibodies. However, the underlying immune mechanisms of this disease remain largely elusive. Here, we compile an unbiased atlas of immune cells in pemphigus cutaneous lesions at single-cell resolution. We reveal clonally expanded antibody-secreting cells (ASCs) that exhibit variable hypermutation and accumulation of IgG4 class-switching in their immunoglobulin genes. Importantly, pathogenic Dsg-...
Source: Journal of Autoimmunity - November 8, 2023 Category: Allergy & Immunology Authors: Chuqiao Xu Tianyu Zhang Hailun Wang Lin Zhu Yue Ruan Zixuan Huang Jingying Wang Haiqin Zhu Chuanxin Huang Meng Pan Source Type: research

K 2P 2.1 is a regulator of inflammatory cell responses in idiopathic inflammatory myopathies
In this study, we investigated the role of K2P2.1 in the autoimmune response of IIMs. We detected K2P2.1 expression in primary skeletal muscle and endothelial cells of murine and human origin. We observed an increased pro-inflammatory cell response, adhesion and transmigration by pharmacological blockade or genetic deletion of K2P2.1 in vitro and in in vivo myositis mouse models. Of note, our findings were not restricted to endothelial cells as skeletal muscle cells with impaired K2P2.1 function also demonstrated a strong pro-inflammatory response. Conversely, these features were abrogated by activation of K2P2.1 and impro...
Source: Journal of Autoimmunity - November 7, 2023 Category: Allergy & Immunology Authors: Christopher Nelke Thomas M üntefering Derya Cengiz Lukas Theissen Vera Dobelmann Christina B Schroeter Helena Block Corinna Preu ße Alexander P E Michels Stefanie Lichtenberg Marc Pawlitzki Steffen Pfeuffer Niklas Huntemann Alexander Zarbock Thorben Bri Source Type: research

Targeting NF- κB signaling in B cells as a potential new treatment modality for ANCA-associated vasculitis
J Autoimmun. 2023 Nov 4;142:103133. doi: 10.1016/j.jaut.2023.103133. Online ahead of print.ABSTRACTB lineage cells are critically involved in ANCA-associated vasculitis (AAV), evidenced by alterations in circulating B cell subsets and beneficial clinical effects of rituximab (anti-CD20) therapy. This treatment renders a long-term, peripheral B cell depletion, but allows for the survival of long-lived plasma cells. Therefore, there is an unmet need for more reversible and full B lineage cell targeting approaches. To find potential novel therapeutic targets, RNA sequencing of CD27+ memory B cells of patients with active AAV ...
Source: Journal of Autoimmunity - November 6, 2023 Category: Allergy & Immunology Authors: Ana Merino-Vico Jan Piet van Hamburg Paul Tuijnenburg Giulia Frazzei Aram Al-Soudi Carlo G Bonasia Boy Helder Abraham Rutgers Wayel H Abdulahad Coen A Stegeman Jan-Stephan Sanders Laura Bergamaschi Paul A Lyons Theo Bijma Laura van Keep Kirsten Wesenhagen Source Type: research

Pathogenicity of functionally activated PD-1 + CD8 + cells and counterattacks by muscular PD-L1 through IFN γ in myositis
In conclusion, PD-1+CD8+ T cells rather than PD-1-CD8+ T cells were a pathogenic subset of IIMs. Muscular PD-L1 was regulated by IFNγ and exerted protective properties in IIMs.PMID:37931332 | DOI:10.1016/j.jaut.2023.103131 (Source: Journal of Autoimmunity)
Source: Journal of Autoimmunity - November 6, 2023 Category: Allergy & Immunology Authors: Hirokazu Sasaki Natsuka Umezawa Takuji Itakura Hideyuki Iwai Shinsuke Yasuda Source Type: research

Lung transplantation in pulmonary sarcoidosis
J Autoimmun. 2023 Nov 1:103135. doi: 10.1016/j.jaut.2023.103135. Online ahead of print.ABSTRACTSarcoidosis is a systemic inflammatory disease of unknown etiology and variable clinical course. Pulmonary sarcoidosis is the most common presentation and accounts for most morbidity and mortality related to sarcoidosis. While sarcoidosis generally has good outcomes, few patients experience chronic disease. A minority of patients progress to a specific phenotype of sarcoidosis referred to advanced pulmonary sarcoidosis (APS) which includes advanced fibrosis, pulmonary hypertension and respiratory failure, leading to high morbidit...
Source: Journal of Autoimmunity - November 3, 2023 Category: Allergy & Immunology Authors: Jin Sun Kim Rohit Gupta Source Type: research

Pulmonary sarcoidosis: A comprehensive review: Past to present
CONCLUSION: The mortality rate for sarcoidosis over a 5 year follow up is approximately 7%. Unfortunately, 10%-40% of patients with sarcoidosis develop progressive pulmonary disease, and >60% of deaths resulting from sarcoidosis are due to advance cardiopulmonary disease. Oral glucocorticoids are the first line treatment, while methotrexate and azathioprine are considered second and anti-TNF agents are third line treatments that are used solely or as glucocorticoid sparing agents for symptomatic extrapulmonary or pulmonary sarcoidosis with infiltrates on chest radiographs and abnormal PFT. Relapse rates have ranged from...
Source: Journal of Autoimmunity - October 21, 2023 Category: Allergy & Immunology Authors: John A Belperio Michael C Fishbein Fereidoun Abtin Jessica Channick Shailesh A Balasubramanian Joseph P Lynch Iii Source Type: research

Genetic predisposition to sarcoidosis
J Autoimmun. 2023 Oct 19:103122. doi: 10.1016/j.jaut.2023.103122. Online ahead of print.ABSTRACTSarcoidosis is a complex systemic disease with clinical heterogeneity based on varying phenotypes and natural history. The detailed etiology of sarcoidosis remains unknown, but genetic predisposition as well as environmental exposures play a significant role in disease pathogenesis. We performed a comprehensive review of germline genetic (DNA) and transcriptomic (RNA) studies of sarcoidosis, including both previous studies and more recent findings. In this review, we provide an assessment of the following: genetic variants in sa...
Source: Journal of Autoimmunity - October 21, 2023 Category: Allergy & Immunology Authors: Shu-Yi Liao Tasha Fingerlin Lisa Maier Source Type: research