Sarcoidosis and its relation to other immune-mediated diseases: Epidemiological insights
J Autoimmun. 2023 Oct 8:103127. doi: 10.1016/j.jaut.2023.103127. Online ahead of print.ABSTRACTSeveral epidemiological studies show a co-occurrence of sarcoidosis with other immune-mediated diseases (IMD). There are many similarities between sarcoidosis and IMDs in their geographical distribution and risk factors. Understanding these similarities and identifying the differences can help us to better understand sarcoidosis and put it into context with other IMDs. In this review, we present the current knowledge about the overlap between sarcoidosis and other IMDs derived from epidemiological studies. Epidemiologic methods u...
Source: Journal of Autoimmunity - October 10, 2023 Category: Allergy & Immunology Authors: Elizabeth V Arkema Marios Rossides Yvette C Cozier Source Type: research
Comparison of circulating and excreted metals and of autoimmunity between two Great Plains Tribal communities
J Autoimmun. 2023 Oct 7:103117. doi: 10.1016/j.jaut.2023.103117. Online ahead of print.ABSTRACTMetals contaminants of the environment from mine waste have been implicated as contributing agents in autoimmune disease. The current study compares metals and autoimmunity in two Tribal communities residing in the Black Hills and the Bighorn Mountains geographical regions that are scattered with extant hard rock mines. With documented drinking water contamination in both communities, in vivo levels of more than half of the measured serum and urine metals differed between the two communities and were substantially different from ...
Source: Journal of Autoimmunity - October 9, 2023 Category: Allergy & Immunology Authors: Esther Erdei Elena R O'Donald Li Luo Kendra Enright Marcia O'Leary Debra MacKenzie John Doyle Margaret Eggers Deborah Keil Johnnye Lewis Jeffrey A Henderson Robert L Rubin Source Type: research
Quality of life in sarcoidosis
J Autoimmun. 2023 Oct 7:103123. doi: 10.1016/j.jaut.2023.103123. Online ahead of print.ABSTRACTHaving sarcoidosis often has a major impact on quality of life of patients and their families. Improving quality of life is prioritized as most important treatment aim by many patients with sarcoidosis, but current evidence and treatment options are limited. In this narrative review, we describe the impact of sarcoidosis on various aspects of daily life, evaluate determinants of health-related quality of life (HRQoL), and provide an overview of the different patient-reported outcome measures to assess HRQoL in sarcoidosis. Moreov...
Source: Journal of Autoimmunity - October 9, 2023 Category: Allergy & Immunology Authors: Catharina C Moor Ogugua Ndili Obi Vivienne Kahlmann Katharina Buschulte Marlies S Wijsenbeek Source Type: research
Comparison of circulating and excreted metals and of autoimmunity between two Great Plains Tribal communities
J Autoimmun. 2023 Oct 7:103117. doi: 10.1016/j.jaut.2023.103117. Online ahead of print.ABSTRACTMetals contaminants of the environment from mine waste have been implicated as contributing agents in autoimmune disease. The current study compares metals and autoimmunity in two Tribal communities residing in the Black Hills and the Bighorn Mountains geographical regions that are scattered with extant hard rock mines. With documented drinking water contamination in both communities, in vivo levels of more than half of the measured serum and urine metals differed between the two communities and were substantially different from ...
Source: Journal of Autoimmunity - October 9, 2023 Category: Allergy & Immunology Authors: Esther Erdei Elena R O'Donald Li Luo Kendra Enright Marcia O'Leary Debra MacKenzie John Doyle Margaret Eggers Deborah Keil Johnnye Lewis Jeffrey A Henderson Robert L Rubin Source Type: research
Quality of life in sarcoidosis
J Autoimmun. 2023 Oct 7:103123. doi: 10.1016/j.jaut.2023.103123. Online ahead of print.ABSTRACTHaving sarcoidosis often has a major impact on quality of life of patients and their families. Improving quality of life is prioritized as most important treatment aim by many patients with sarcoidosis, but current evidence and treatment options are limited. In this narrative review, we describe the impact of sarcoidosis on various aspects of daily life, evaluate determinants of health-related quality of life (HRQoL), and provide an overview of the different patient-reported outcome measures to assess HRQoL in sarcoidosis. Moreov...
Source: Journal of Autoimmunity - October 9, 2023 Category: Allergy & Immunology Authors: Catharina C Moor Ogugua Ndili Obi Vivienne Kahlmann Katharina Buschulte Marlies S Wijsenbeek Source Type: research
In cis "benign" SOCS1 variants linked to enhanced interferon signaling and autoimmunity
J Autoimmun. 2023 Oct 3;140:103119. doi: 10.1016/j.jaut.2023.103119. Online ahead of print.ABSTRACTWe aimed to characterize the genetic basis of disease in a family with multiple autoimmune manifestations, including systemic lupus erythematosus (SLE), immune thrombocytopenia, and autoimmune thyroiditis. Whole exome sequencing (WES) was conducted to identify candidate variants, which were analyzed by flow cytometry, immunoblotting, immunoprecipitation, and luciferase reporter assay in transfected 293T cells. Gene expression in peripheral blood mononuclear cells (PBMC) was profiled by bulk RNA sequencing and plasma cytokines...
Source: Journal of Autoimmunity - October 5, 2023 Category: Allergy & Immunology Authors: Yan Du Kailey E Brodeur Evan Hsu Liang Chen Qian Chen Meng Liu Qi Cheng Seymour Rosen Thomas F Michniacki Janet Chou Mindy S Lo Craig D Platt Pui Y Lee Source Type: research
Environmental exposures as risk factors for idiopathic inflammatory myopathies
J Autoimmun. 2023 Oct 3;140:103095. doi: 10.1016/j.jaut.2023.103095. Online ahead of print.ABSTRACTIdiopathic inflammatory myopathies (IIM) are a heterogeneous group of rare autoimmune diseases, with increasing incidence rates observed in the recent years. The pathogenesis of IIM remains not fully understood, and the interaction of genetic and environmental factors is suspected. It is unclear whether the observed upward trend in the IIM incidence is solely due to improved access to effective diagnostics or perhaps due to increased exposure to external risk factors. The PUBMED database was thoroughly searched for articles d...
Source: Journal of Autoimmunity - October 5, 2023 Category: Allergy & Immunology Authors: Aleksandra H Opinc-Rosiak Joanna S Makowska Source Type: research
In cis "benign" SOCS1 variants linked to enhanced interferon signaling and autoimmunity
J Autoimmun. 2023 Oct 3;140:103119. doi: 10.1016/j.jaut.2023.103119. Online ahead of print.ABSTRACTWe aimed to characterize the genetic basis of disease in a family with multiple autoimmune manifestations, including systemic lupus erythematosus (SLE), immune thrombocytopenia, and autoimmune thyroiditis. Whole exome sequencing (WES) was conducted to identify candidate variants, which were analyzed by flow cytometry, immunoblotting, immunoprecipitation, and luciferase reporter assay in transfected 293T cells. Gene expression in peripheral blood mononuclear cells (PBMC) was profiled by bulk RNA sequencing and plasma cytokines...
Source: Journal of Autoimmunity - October 5, 2023 Category: Allergy & Immunology Authors: Yan Du Kailey E Brodeur Evan Hsu Liang Chen Qian Chen Meng Liu Qi Cheng Seymour Rosen Thomas F Michniacki Janet Chou Mindy S Lo Craig D Platt Pui Y Lee Source Type: research
Environmental exposures as risk factors for idiopathic inflammatory myopathies
J Autoimmun. 2023 Oct 3;140:103095. doi: 10.1016/j.jaut.2023.103095. Online ahead of print.ABSTRACTIdiopathic inflammatory myopathies (IIM) are a heterogeneous group of rare autoimmune diseases, with increasing incidence rates observed in the recent years. The pathogenesis of IIM remains not fully understood, and the interaction of genetic and environmental factors is suspected. It is unclear whether the observed upward trend in the IIM incidence is solely due to improved access to effective diagnostics or perhaps due to increased exposure to external risk factors. The PUBMED database was thoroughly searched for articles d...
Source: Journal of Autoimmunity - October 5, 2023 Category: Allergy & Immunology Authors: Aleksandra H Opinc-Rosiak Joanna S Makowska Source Type: research
In cis "benign" SOCS1 variants linked to enhanced interferon signaling and autoimmunity
J Autoimmun. 2023 Oct 3;140:103119. doi: 10.1016/j.jaut.2023.103119. Online ahead of print.ABSTRACTWe aimed to characterize the genetic basis of disease in a family with multiple autoimmune manifestations, including systemic lupus erythematosus (SLE), immune thrombocytopenia, and autoimmune thyroiditis. Whole exome sequencing (WES) was conducted to identify candidate variants, which were analyzed by flow cytometry, immunoblotting, immunoprecipitation, and luciferase reporter assay in transfected 293T cells. Gene expression in peripheral blood mononuclear cells (PBMC) was profiled by bulk RNA sequencing and plasma cytokines...
Source: Journal of Autoimmunity - October 5, 2023 Category: Allergy & Immunology Authors: Yan Du Kailey E Brodeur Evan Hsu Liang Chen Qian Chen Meng Liu Qi Cheng Seymour Rosen Thomas F Michniacki Janet Chou Mindy S Lo Craig D Platt Pui Y Lee Source Type: research
Environmental exposures as risk factors for idiopathic inflammatory myopathies
J Autoimmun. 2023 Oct 3;140:103095. doi: 10.1016/j.jaut.2023.103095. Online ahead of print.ABSTRACTIdiopathic inflammatory myopathies (IIM) are a heterogeneous group of rare autoimmune diseases, with increasing incidence rates observed in the recent years. The pathogenesis of IIM remains not fully understood, and the interaction of genetic and environmental factors is suspected. It is unclear whether the observed upward trend in the IIM incidence is solely due to improved access to effective diagnostics or perhaps due to increased exposure to external risk factors. The PUBMED database was thoroughly searched for articles d...
Source: Journal of Autoimmunity - October 5, 2023 Category: Allergy & Immunology Authors: Aleksandra H Opinc-Rosiak Joanna S Makowska Source Type: research
Prioritization of infectious epitopes for translational investigation in type 1 diabetes etiology
J Autoimmun. 2023 Sep 27;140:103115. doi: 10.1016/j.jaut.2023.103115. Online ahead of print.ABSTRACTMolecular mimicry is one mechanism by which infectious agents are thought to trigger islet autoimmunity in type 1 diabetes. With a growing number of reported infectious agents and islet antigens, strategies to prioritize the study of infectious agents are critically needed to expedite translational research into the etiology of type 1 diabetes. In this work, we developed an in-silico pipeline for assessing molecular mimicry in type 1 diabetes etiology based on sequence homology, empirical binding affinity to specific MHC mol...
Source: Journal of Autoimmunity - September 29, 2023 Category: Allergy & Immunology Authors: Sejal Mistry Ramkiran Gouripeddi Julio C Facelli Source Type: research
Prioritization of infectious epitopes for translational investigation in type 1 diabetes etiology
J Autoimmun. 2023 Sep 27;140:103115. doi: 10.1016/j.jaut.2023.103115. Online ahead of print.ABSTRACTMolecular mimicry is one mechanism by which infectious agents are thought to trigger islet autoimmunity in type 1 diabetes. With a growing number of reported infectious agents and islet antigens, strategies to prioritize the study of infectious agents are critically needed to expedite translational research into the etiology of type 1 diabetes. In this work, we developed an in-silico pipeline for assessing molecular mimicry in type 1 diabetes etiology based on sequence homology, empirical binding affinity to specific MHC mol...
Source: Journal of Autoimmunity - September 29, 2023 Category: Allergy & Immunology Authors: Sejal Mistry Ramkiran Gouripeddi Julio C Facelli Source Type: research
Prioritization of infectious epitopes for translational investigation in type 1 diabetes etiology
J Autoimmun. 2023 Sep 27;140:103115. doi: 10.1016/j.jaut.2023.103115. Online ahead of print.ABSTRACTMolecular mimicry is one mechanism by which infectious agents are thought to trigger islet autoimmunity in type 1 diabetes. With a growing number of reported infectious agents and islet antigens, strategies to prioritize the study of infectious agents are critically needed to expedite translational research into the etiology of type 1 diabetes. In this work, we developed an in-silico pipeline for assessing molecular mimicry in type 1 diabetes etiology based on sequence homology, empirical binding affinity to specific MHC mol...
Source: Journal of Autoimmunity - September 29, 2023 Category: Allergy & Immunology Authors: Sejal Mistry Ramkiran Gouripeddi Julio C Facelli Source Type: research
Prioritization of infectious epitopes for translational investigation in type 1 diabetes etiology
J Autoimmun. 2023 Sep 27;140:103115. doi: 10.1016/j.jaut.2023.103115. Online ahead of print.ABSTRACTMolecular mimicry is one mechanism by which infectious agents are thought to trigger islet autoimmunity in type 1 diabetes. With a growing number of reported infectious agents and islet antigens, strategies to prioritize the study of infectious agents are critically needed to expedite translational research into the etiology of type 1 diabetes. In this work, we developed an in-silico pipeline for assessing molecular mimicry in type 1 diabetes etiology based on sequence homology, empirical binding affinity to specific MHC mol...
Source: Journal of Autoimmunity - September 29, 2023 Category: Allergy & Immunology Authors: Sejal Mistry Ramkiran Gouripeddi Julio C Facelli Source Type: research
