Journal of Autoimmunity This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Novel and unique rheumatoid factors cross-react with viral epitopes in COVID-19
J Autoimmun. 2023 Nov 11;142:103132. doi: 10.1016/j.jaut.2023.103132. Online ahead of print.ABSTRACTRheumatoid factors (RFs), polyreactive antibodies canonically known to bind two conformational epitopes of IgG Fc, are a hallmark of rheumatoid arthritis but also can arise in other inflammatory conditions and infections. Also, infections may contribute to the development of rheumatoid arthritis and other autoimmune diseases. Recently, RFs only in rheumatoid arthritis were found to bind novel linear IgG epitopes as well as thousands of other rheumatoid arthritis autoantigens. Specific epitopes recognized by infection-induced...
Source: Journal of Autoimmunity - November 13, 2023 Category: Allergy & Immunology Authors: Maya F Amjadi Maxwell H Parker Ryan R Adyniec Zihao Zheng Alex M Robbins S Janna Bashar Michael F Denny Sara S McCoy Irene M Ong Miriam A Shelef Source Type: research

Risk factors for hypogammaglobulinemia and association with relapse and severe infections in ANCA-associated vasculitis: A cohort study
CONCLUSION: Older age, low gammaglobulin levels and pulses of methylprednisolone at induction increase the likelihood of gammaglobulin decline after induction therapy. Such decline was associated with an increased risk of severe infections but not lower risk of vasculitis relapse. Pulses of methylprednisolone at induction had an independent negative impact on gammaglobulin levels and the risk of severe infections.PMID:37956529 | DOI:10.1016/j.jaut.2023.103130 (Source: Journal of Autoimmunity)
Source: Journal of Autoimmunity - November 13, 2023 Category: Allergy & Immunology Authors: Johanne Liberatore Yann Nguyen J érôme Hadjadj Pascal Cohen Luc Mouthon Xavier Pu échal Lo ïc Guillevin Benjamin Terrier Source Type: research

Isolation and characterisation of PR3-specific B cells and their immunoglobulin sequences
CONCLUSIONS: Identifying PR3-specific B cells in the peripheral blood is possible but challenging and those we did identify exhibited features suggesting that PR3-self reactivity may occur early in B-cell development.PMID:37952292 | DOI:10.1016/j.jaut.2023.103129 (Source: Journal of Autoimmunity)
Source: Journal of Autoimmunity - November 12, 2023 Category: Allergy & Immunology Authors: Shane Kelly Katherine Jl Jackson Timothy J Peters Dan Suan Christopher C Goodnow Source Type: research

Single-cell transcriptomic profiling reveals a pathogenic role of cytotoxic CD4 + T cells in giant cell arteritis
J Autoimmun. 2023 Nov 10;142:103124. doi: 10.1016/j.jaut.2023.103124. Online ahead of print.ABSTRACTGiant cell arteritis (GCA) is a systemic vasculitis mediated by an aberrant immunological response against the blood vessel wall. Although the pathogenic mechanisms that drive GCA have not yet been elucidated, there is strong evidence that CD4+ T cells are key drivers of the inflammatory process occurring in this vasculitis. The aim of this study was to further delineate the role of CD4+ T cells in GCA by applying single-cell RNA sequencing and T cell receptor (TCR) repertoire profiling to 114.799 circulating CD4+ T cells fr...
Source: Journal of Autoimmunity - November 12, 2023 Category: Allergy & Immunology Authors: Elio G Carmona Jos é Luis Callejas-Rubio Enrique Raya Raquel R íos-Fernández Gonzalo Villanueva-Mart ín Mar ía C Cid Jos é Hernández-Rodríguez Esteban Ballestar Bernd Timmermann Norberto Ortego-Centeno Javier Mart ín Ana M árquez Source Type: research

Novel biomarker discovery through comprehensive proteomic analysis of lupus mouse serum
CONCLUSIONS: We successfully validated a novel serum proteomic screening strategy in a spontaneous murine lupus model that highlighted potential new biomarkers. Importantly, we generated a comprehensive snapshot of the serum proteome which will enable identification of other candidates and serve as a reference for future mechanistic and therapeutic studies in lupus.PMID:37944214 | DOI:10.1016/j.jaut.2023.103134 (Source: Journal of Autoimmunity)
Source: Journal of Autoimmunity - November 9, 2023 Category: Allergy & Immunology Authors: Joshua A Reynolds Yaxi Li Leal Herlitz Chandra Mohan Chaim Putterman Source Type: research

Integrative single-cell analysis reveals distinct adaptive immune signatures in the cutaneous lesions of pemphigus
J Autoimmun. 2023 Nov 6;142:103128. doi: 10.1016/j.jaut.2023.103128. Online ahead of print.ABSTRACTPemphigus, an autoimmune bullous disease affecting the skin and mucosal membranes, is primarily driven by anti-desmoglein (Dsg) autoantibodies. However, the underlying immune mechanisms of this disease remain largely elusive. Here, we compile an unbiased atlas of immune cells in pemphigus cutaneous lesions at single-cell resolution. We reveal clonally expanded antibody-secreting cells (ASCs) that exhibit variable hypermutation and accumulation of IgG4 class-switching in their immunoglobulin genes. Importantly, pathogenic Dsg-...
Source: Journal of Autoimmunity - November 8, 2023 Category: Allergy & Immunology Authors: Chuqiao Xu Tianyu Zhang Hailun Wang Lin Zhu Yue Ruan Zixuan Huang Jingying Wang Haiqin Zhu Chuanxin Huang Meng Pan Source Type: research

K 2P 2.1 is a regulator of inflammatory cell responses in idiopathic inflammatory myopathies
In this study, we investigated the role of K2P2.1 in the autoimmune response of IIMs. We detected K2P2.1 expression in primary skeletal muscle and endothelial cells of murine and human origin. We observed an increased pro-inflammatory cell response, adhesion and transmigration by pharmacological blockade or genetic deletion of K2P2.1 in vitro and in in vivo myositis mouse models. Of note, our findings were not restricted to endothelial cells as skeletal muscle cells with impaired K2P2.1 function also demonstrated a strong pro-inflammatory response. Conversely, these features were abrogated by activation of K2P2.1 and impro...
Source: Journal of Autoimmunity - November 7, 2023 Category: Allergy & Immunology Authors: Christopher Nelke Thomas M üntefering Derya Cengiz Lukas Theissen Vera Dobelmann Christina B Schroeter Helena Block Corinna Preu ße Alexander P E Michels Stefanie Lichtenberg Marc Pawlitzki Steffen Pfeuffer Niklas Huntemann Alexander Zarbock Thorben Bri Source Type: research

Targeting NF- κB signaling in B cells as a potential new treatment modality for ANCA-associated vasculitis
J Autoimmun. 2023 Nov 4;142:103133. doi: 10.1016/j.jaut.2023.103133. Online ahead of print.ABSTRACTB lineage cells are critically involved in ANCA-associated vasculitis (AAV), evidenced by alterations in circulating B cell subsets and beneficial clinical effects of rituximab (anti-CD20) therapy. This treatment renders a long-term, peripheral B cell depletion, but allows for the survival of long-lived plasma cells. Therefore, there is an unmet need for more reversible and full B lineage cell targeting approaches. To find potential novel therapeutic targets, RNA sequencing of CD27+ memory B cells of patients with active AAV ...
Source: Journal of Autoimmunity - November 6, 2023 Category: Allergy & Immunology Authors: Ana Merino-Vico Jan Piet van Hamburg Paul Tuijnenburg Giulia Frazzei Aram Al-Soudi Carlo G Bonasia Boy Helder Abraham Rutgers Wayel H Abdulahad Coen A Stegeman Jan-Stephan Sanders Laura Bergamaschi Paul A Lyons Theo Bijma Laura van Keep Kirsten Wesenhagen Source Type: research

Pathogenicity of functionally activated PD-1 + CD8 + cells and counterattacks by muscular PD-L1 through IFN γ in myositis
In conclusion, PD-1+CD8+ T cells rather than PD-1-CD8+ T cells were a pathogenic subset of IIMs. Muscular PD-L1 was regulated by IFNγ and exerted protective properties in IIMs.PMID:37931332 | DOI:10.1016/j.jaut.2023.103131 (Source: Journal of Autoimmunity)
Source: Journal of Autoimmunity - November 6, 2023 Category: Allergy & Immunology Authors: Hirokazu Sasaki Natsuka Umezawa Takuji Itakura Hideyuki Iwai Shinsuke Yasuda Source Type: research