LIGHT signaling through LT βR and HVEM in keratinocytes promotes psoriasis and atopic dermatitis-like skin inflammation
J Autoimmun. 2024 Feb 17;144:103177. doi: 10.1016/j.jaut.2024.103177. Online ahead of print.ABSTRACTPsoriasis (PS) and atopic dermatitis (AD) are common skin inflammatory diseases characterized by hyper-responsive keratinocytes. Although, some cytokines have been suggested to be specific for each disease, other cytokines might be central to both diseases. Here, we show that Tumor necrosis factor superfamily member 14 (TNFSF14), known as LIGHT, is required for experimental PS, similar to its requirement in experimental AD. Mice devoid of LIGHT, or deletion of either of its receptors, lymphotoxin β receptor (LTβR) and herp...
Source: Journal of Autoimmunity - February 18, 2024 Category: Allergy & Immunology Authors: Rinkesh K Gupta Daniela Salgado Figueroa Kai Fung Haruka Miki Jacqueline Miller Ferhat Ay Michael Croft Source Type: research
Risk factors for damage accrual in primary antiphospholipid syndrome: A retrospective single-center cohort study
CONCLUSIONS: APS patients had a higher frequency of damage accrual. Microangiopathy and non-criteria manifestations were independent risk factors for damage accrual.PMID:38368768 | DOI:10.1016/j.jaut.2024.103180 (Source: Journal of Autoimmunity)
Source: Journal of Autoimmunity - February 18, 2024 Category: Allergy & Immunology Authors: Ariela Hoxha Nicola Perin Marco Lovisotto Antonia Calligaro Teresa Del Ross Maria Favaro Marta Tonello Andrea Doria Paolo Simioni Source Type: research
The enigma of sclera-specific autoimmunity in scleritis
In conclusion, scleral nerve autoantibody reactivity was more common in scleritis and uveitis patients in contrast to healthy controls. Further research is needed to characterize these scleral-nerve directed antibodies and assess their clinical value.PMID:38368769 | DOI:10.1016/j.jaut.2024.103178 (Source: Journal of Autoimmunity)
Source: Journal of Autoimmunity - February 18, 2024 Category: Allergy & Immunology Authors: Daphne P C Vergouwen Adriaan A van Beek Joeri de Hoog Joke H de Boer Leonoor I Los Marlies Gijs Roel J Erckens Rob M Verdijk Geert W Haasnoot Dave L Roelen Aniki Rothova Johan R önnelid Josianne C Ten Berge Marco W J Schreurs Source Type: research
LIGHT signaling through LT βR and HVEM in keratinocytes promotes psoriasis and atopic dermatitis-like skin inflammation
J Autoimmun. 2024 Feb 17;144:103177. doi: 10.1016/j.jaut.2024.103177. Online ahead of print.ABSTRACTPsoriasis (PS) and atopic dermatitis (AD) are common skin inflammatory diseases characterized by hyper-responsive keratinocytes. Although, some cytokines have been suggested to be specific for each disease, other cytokines might be central to both diseases. Here, we show that Tumor necrosis factor superfamily member 14 (TNFSF14), known as LIGHT, is required for experimental PS, similar to its requirement in experimental AD. Mice devoid of LIGHT, or deletion of either of its receptors, lymphotoxin β receptor (LTβR) and herp...
Source: Journal of Autoimmunity - February 18, 2024 Category: Allergy & Immunology Authors: Rinkesh K Gupta Daniela Salgado Figueroa Kai Fung Haruka Miki Jacqueline Miller Ferhat Ay Michael Croft Source Type: research
Risk factors for damage accrual in primary antiphospholipid syndrome: A retrospective single-center cohort study
CONCLUSIONS: APS patients had a higher frequency of damage accrual. Microangiopathy and non-criteria manifestations were independent risk factors for damage accrual.PMID:38368768 | DOI:10.1016/j.jaut.2024.103180 (Source: Journal of Autoimmunity)
Source: Journal of Autoimmunity - February 18, 2024 Category: Allergy & Immunology Authors: Ariela Hoxha Nicola Perin Marco Lovisotto Antonia Calligaro Teresa Del Ross Maria Favaro Marta Tonello Andrea Doria Paolo Simioni Source Type: research
The enigma of sclera-specific autoimmunity in scleritis
In conclusion, scleral nerve autoantibody reactivity was more common in scleritis and uveitis patients in contrast to healthy controls. Further research is needed to characterize these scleral-nerve directed antibodies and assess their clinical value.PMID:38368769 | DOI:10.1016/j.jaut.2024.103178 (Source: Journal of Autoimmunity)
Source: Journal of Autoimmunity - February 18, 2024 Category: Allergy & Immunology Authors: Daphne P C Vergouwen Adriaan A van Beek Joeri de Hoog Joke H de Boer Leonoor I Los Marlies Gijs Roel J Erckens Rob M Verdijk Geert W Haasnoot Dave L Roelen Aniki Rothova Johan R önnelid Josianne C Ten Berge Marco W J Schreurs Source Type: research
LIGHT signaling through LT βR and HVEM in keratinocytes promotes psoriasis and atopic dermatitis-like skin inflammation
J Autoimmun. 2024 Feb 17;144:103177. doi: 10.1016/j.jaut.2024.103177. Online ahead of print.ABSTRACTPsoriasis (PS) and atopic dermatitis (AD) are common skin inflammatory diseases characterized by hyper-responsive keratinocytes. Although, some cytokines have been suggested to be specific for each disease, other cytokines might be central to both diseases. Here, we show that Tumor necrosis factor superfamily member 14 (TNFSF14), known as LIGHT, is required for experimental PS, similar to its requirement in experimental AD. Mice devoid of LIGHT, or deletion of either of its receptors, lymphotoxin β receptor (LTβR) and herp...
Source: Journal of Autoimmunity - February 18, 2024 Category: Allergy & Immunology Authors: Rinkesh K Gupta Daniela Salgado Figueroa Kai Fung Haruka Miki Jacqueline Miller Ferhat Ay Michael Croft Source Type: research
Risk factors for damage accrual in primary antiphospholipid syndrome: A retrospective single-center cohort study
CONCLUSIONS: APS patients had a higher frequency of damage accrual. Microangiopathy and non-criteria manifestations were independent risk factors for damage accrual.PMID:38368768 | DOI:10.1016/j.jaut.2024.103180 (Source: Journal of Autoimmunity)
Source: Journal of Autoimmunity - February 18, 2024 Category: Allergy & Immunology Authors: Ariela Hoxha Nicola Perin Marco Lovisotto Antonia Calligaro Teresa Del Ross Maria Favaro Marta Tonello Andrea Doria Paolo Simioni Source Type: research
The enigma of sclera-specific autoimmunity in scleritis
In conclusion, scleral nerve autoantibody reactivity was more common in scleritis and uveitis patients in contrast to healthy controls. Further research is needed to characterize these scleral-nerve directed antibodies and assess their clinical value.PMID:38368769 | DOI:10.1016/j.jaut.2024.103178 (Source: Journal of Autoimmunity)
Source: Journal of Autoimmunity - February 18, 2024 Category: Allergy & Immunology Authors: Daphne P C Vergouwen Adriaan A van Beek Joeri de Hoog Joke H de Boer Leonoor I Los Marlies Gijs Roel J Erckens Rob M Verdijk Geert W Haasnoot Dave L Roelen Aniki Rothova Johan R önnelid Josianne C Ten Berge Marco W J Schreurs Source Type: research
T cell-mediated skin-brain axis: Bridging the gap between psoriasis and psychiatric comorbidities
J Autoimmun. 2024 Feb 15;144:103176. doi: 10.1016/j.jaut.2024.103176. Online ahead of print.ABSTRACTPsoriasis, a chronic inflammatory skin condition, is often accompanied by psychiatric comorbidities such as anxiety, depression, suicidal ideation, and other mental disorders. Psychological disorders may also play a role in the development and progression of psoriasis. The intricate interplay between the skin diseases and the psychiatric comorbidities is mediated by the 'skin-brain axis'. Understanding the mechanisms underlying psoriasis and psychiatric comorbidities can help improve the efficacy of treatment by breaking the...
Source: Journal of Autoimmunity - February 16, 2024 Category: Allergy & Immunology Authors: Juexi Yang Song Zhang Qixuan Wu Pu Chen Yan Dai Junhao Long Yan Wu Yun Lin Source Type: research
T cell-mediated skin-brain axis: Bridging the gap between psoriasis and psychiatric comorbidities
J Autoimmun. 2024 Feb 15;144:103176. doi: 10.1016/j.jaut.2024.103176. Online ahead of print.ABSTRACTPsoriasis, a chronic inflammatory skin condition, is often accompanied by psychiatric comorbidities such as anxiety, depression, suicidal ideation, and other mental disorders. Psychological disorders may also play a role in the development and progression of psoriasis. The intricate interplay between the skin diseases and the psychiatric comorbidities is mediated by the 'skin-brain axis'. Understanding the mechanisms underlying psoriasis and psychiatric comorbidities can help improve the efficacy of treatment by breaking the...
Source: Journal of Autoimmunity - February 16, 2024 Category: Allergy & Immunology Authors: Juexi Yang Song Zhang Qixuan Wu Pu Chen Yan Dai Junhao Long Yan Wu Yun Lin Source Type: research
Aberrant B cell receptor signaling in circulating na ïve and IgA < sup > + < /sup > memory B cells from newly-diagnosed autoantibody-positive rheumatoid arthritis patients
CONCLUSION: Collectively, the isotype-specific analysis of multiple key components of the BCR signalosome identified aberrant BCR signaling responses in treatment-naïve autoantibody-positive RA patients, particularly in naïve B cells and IgA+ memory B cells. Our findings support differential involvement of dysregulated BCR signaling in the pathogenesis of autoantibody-positive and autoantibody-negative RA.PMID:38350168 | DOI:10.1016/j.jaut.2024.103168 (Source: Journal of Autoimmunity)
Source: Journal of Autoimmunity - February 13, 2024 Category: Allergy & Immunology Authors: Stefan F H Neys Judith W Heutz Jennifer A C van Hulst Madelief Vink Ingrid M Bergen Pascal H P de Jong Erik Lubberts Rudi W Hendriks Odilia B J Corneth Source Type: research
Aberrant B cell receptor signaling in circulating na ïve and IgA < sup > + < /sup > memory B cells from newly-diagnosed autoantibody-positive rheumatoid arthritis patients
CONCLUSION: Collectively, the isotype-specific analysis of multiple key components of the BCR signalosome identified aberrant BCR signaling responses in treatment-naïve autoantibody-positive RA patients, particularly in naïve B cells and IgA+ memory B cells. Our findings support differential involvement of dysregulated BCR signaling in the pathogenesis of autoantibody-positive and autoantibody-negative RA.PMID:38350168 | DOI:10.1016/j.jaut.2024.103168 (Source: Journal of Autoimmunity)
Source: Journal of Autoimmunity - February 13, 2024 Category: Allergy & Immunology Authors: Stefan F H Neys Judith W Heutz Jennifer A C van Hulst Madelief Vink Ingrid M Bergen Pascal H P de Jong Erik Lubberts Rudi W Hendriks Odilia B J Corneth Source Type: research
Age-related bone diseases: Role of inflammaging
This article primarily examines the mechanisms underlying inflammaging and its association with age-related bone diseases, to elucidate the potential mechanisms of inflammaging in age-related bone diseases and offer insights for developing preventive and therapeutic strategies for such conditions.PMID:38340675 | DOI:10.1016/j.jaut.2024.103169 (Source: Journal of Autoimmunity)
Source: Journal of Autoimmunity - February 10, 2024 Category: Allergy & Immunology Authors: Jiaming Bi Caimei Zhang Caihong Lu Chuzi Mo Jiawei Zeng Mingyan Yao Bo Jia Zhongjun Liu Peiyan Yuan Shuaimei Xu Source Type: research
Phenotypes in antiphospholipid syndrome: A hierarchical cluster analysis based on two independent databases
CONCLUSIONS: We identified three phenotypes of APS defined based on preferential associations of organ involvements and differences in presentation. These observations may help clinicians to detect organ involvement and to manage treatment.PMID:38330544 | DOI:10.1016/j.jaut.2024.103173 (Source: Journal of Autoimmunity)
Source: Journal of Autoimmunity - February 8, 2024 Category: Allergy & Immunology Authors: Dov Taieb Quentin Moyon Raphael Lhote Isabella Annesi-Maesano Julien Haroche Ricard Cervera Zahir Amoura Fleur Cohen Aubart Source Type: research
