Rapamycin nanoparticles increase the therapeutic window of engineered interleukin-2 and drive expansion of antigen-specific regulatory T cells for protection against autoimmune disease
J Autoimmun. 2023 Oct 14;140:103125. doi: 10.1016/j.jaut.2023.103125. Online ahead of print.ABSTRACTInterleukin-2 (IL-2) therapies targeting the high affinity IL-2 receptor expressed on regulatory T cells (Tregs) have shown promising therapeutic benefit in autoimmune diseases through nonselective expansion of pre-existing Treg populations, but are potentially limited by the inability to induce antigen-specific Tregs, as well as by dose-limiting activation of effector immune cells in settings of inflammation. We recently developed biodegradable nanoparticles encapsulating rapamycin, called ImmTOR, which induce selective imm...
Source: Journal of Autoimmunity - October 16, 2023 Category: Allergy & Immunology Authors: Takashi Kei Kishimoto Max Fournier Alicia Michaud Gina Rizzo Christopher Roy Teresa Capela Natasha Nukolova Ning Li Liam Doyle Fen-Ni Fu Derek VanDyke Peter G Traber Jamie B Spangler Sheldon S Leung Petr O Ilyinskii Source Type: research
Cognition following chimeric antigen receptor T-cell therapy: A systematic review
DISCUSSION: Results of the studies were heterogenous with studies demonstrating stable, improved, or reduced cognition across differing time points. Overall, cognitive symptoms are common particularly in the acute stage (<2 weeks) post-infusion. Most deficits that arise in the acute stage resolve within one to two weeks, however, there is a subset of patients who continue to experience and self-report persistent deficits in the subacute and chronic stages. Future studies are needed to comprehensively analyse cognition using a combination of self-report and psychometric measures following chimeric antigen receptor T-cell...
Source: Journal of Autoimmunity - October 14, 2023 Category: Allergy & Immunology Authors: Christina Kazzi Valeriya Kuznetsova Pakeeran Siriratnam Sarah Griffith Shu Wong Constantine S Tam Rubina Alpitsis Andrew Spencer Terence J O'Brien Charles B Malpas Mastura Monif Source Type: research
Cognition following chimeric antigen receptor T-cell therapy: A systematic review
DISCUSSION: Results of the studies were heterogenous with studies demonstrating stable, improved, or reduced cognition across differing time points. Overall, cognitive symptoms are common particularly in the acute stage (<2 weeks) post-infusion. Most deficits that arise in the acute stage resolve within one to two weeks, however, there is a subset of patients who continue to experience and self-report persistent deficits in the subacute and chronic stages. Future studies are needed to comprehensively analyse cognition using a combination of self-report and psychometric measures following chimeric antigen receptor T-cell...
Source: Journal of Autoimmunity - October 14, 2023 Category: Allergy & Immunology Authors: Christina Kazzi Valeriya Kuznetsova Pakeeran Siriratnam Sarah Griffith Shu Wong Constantine S Tam Rubina Alpitsis Andrew Spencer Terence J O'Brien Charles B Malpas Mastura Monif Source Type: research
Autoreactive T cells targeting type II pneumocyte antigens in COVID-19 convalescent patients
CONCLUSIONS: Our data suggest that autoreactive type II PAA-specific T cells have a protective role in SARS-CoV-2 infections and the presence of high frequencies of these autoreactive T cells indicates effective viral control in COVID-19 patients. Type II-PAA-specific T cells may therefore promote the killing of infected type II pneumocytes and viral clearance.PMID:37826919 | DOI:10.1016/j.jaut.2023.103118 (Source: Journal of Autoimmunity)
Source: Journal of Autoimmunity - October 12, 2023 Category: Allergy & Immunology Authors: Christa Lichtensteiger Maximilian Koblischke Fiamma Berner Ann-Kristin Jochum Tobias Sinnberg Beatrice Balciunaite Mette-Triin Purde Vincent Walter Marie-Therese Abdou Kathrin Hofmeister Philipp Kohler Pietro Vernazza Werner C Albrich Christian R Kahlert Source Type: research
Autoimmune pancreatitis type 2 (idiopathic duct-centric pancreatitis): A comprehensive review
J Autoimmun. 2023 Oct 10;140:103121. doi: 10.1016/j.jaut.2023.103121. Online ahead of print.ABSTRACTAutoimmune pancreatitis (AIP) is an uncommon fibro-inflammatory disorder precipitated by autoimmune/inflammatory reactions. Currently, there are two clinical subtypes of AIP (type 1 [AIP-1] and type 2 [AIP-2]) that correspond to two histologic descriptors (lymphoplasmacytic sclerosing pancreatitis and idiopathic duct-centric pancreatitis, respectively). While our understanding of AIP-1 has evolved considerably over the years, little is known about AIP-2 due to its rarity, often leading to misdiagnosis, delayed treatment, and...
Source: Journal of Autoimmunity - October 12, 2023 Category: Allergy & Immunology Authors: Yang Li Hanyi Song Xiangzhen Meng Runzhuo Li Patrick S C Leung M Eric Gershwin Shucheng Zhang Siyu Sun Junmin Song Source Type: research
Autoreactive T cells targeting type II pneumocyte antigens in COVID-19 convalescent patients
CONCLUSIONS: Our data suggest that autoreactive type II PAA-specific T cells have a protective role in SARS-CoV-2 infections and the presence of high frequencies of these autoreactive T cells indicates effective viral control in COVID-19 patients. Type II-PAA-specific T cells may therefore promote the killing of infected type II pneumocytes and viral clearance.PMID:37826919 | DOI:10.1016/j.jaut.2023.103118 (Source: Journal of Autoimmunity)
Source: Journal of Autoimmunity - October 12, 2023 Category: Allergy & Immunology Authors: Christa Lichtensteiger Maximilian Koblischke Fiamma Berner Ann-Kristin Jochum Tobias Sinnberg Beatrice Balciunaite Mette-Triin Purde Vincent Walter Marie-Therese Abdou Kathrin Hofmeister Philipp Kohler Pietro Vernazza Werner C Albrich Christian R Kahlert Source Type: research
Autoimmune pancreatitis type 2 (idiopathic duct-centric pancreatitis): A comprehensive review
J Autoimmun. 2023 Oct 10;140:103121. doi: 10.1016/j.jaut.2023.103121. Online ahead of print.ABSTRACTAutoimmune pancreatitis (AIP) is an uncommon fibro-inflammatory disorder precipitated by autoimmune/inflammatory reactions. Currently, there are two clinical subtypes of AIP (type 1 [AIP-1] and type 2 [AIP-2]) that correspond to two histologic descriptors (lymphoplasmacytic sclerosing pancreatitis and idiopathic duct-centric pancreatitis, respectively). While our understanding of AIP-1 has evolved considerably over the years, little is known about AIP-2 due to its rarity, often leading to misdiagnosis, delayed treatment, and...
Source: Journal of Autoimmunity - October 12, 2023 Category: Allergy & Immunology Authors: Yang Li Hanyi Song Xiangzhen Meng Runzhuo Li Patrick S C Leung M Eric Gershwin Shucheng Zhang Siyu Sun Junmin Song Source Type: research
Sarcoidosis and its relation to other immune-mediated diseases: Epidemiological insights
J Autoimmun. 2023 Oct 8:103127. doi: 10.1016/j.jaut.2023.103127. Online ahead of print.ABSTRACTSeveral epidemiological studies show a co-occurrence of sarcoidosis with other immune-mediated diseases (IMD). There are many similarities between sarcoidosis and IMDs in their geographical distribution and risk factors. Understanding these similarities and identifying the differences can help us to better understand sarcoidosis and put it into context with other IMDs. In this review, we present the current knowledge about the overlap between sarcoidosis and other IMDs derived from epidemiological studies. Epidemiologic methods u...
Source: Journal of Autoimmunity - October 10, 2023 Category: Allergy & Immunology Authors: Elizabeth V Arkema Marios Rossides Yvette C Cozier Source Type: research
Sarcoidosis and its relation to other immune-mediated diseases: Epidemiological insights
J Autoimmun. 2023 Oct 8:103127. doi: 10.1016/j.jaut.2023.103127. Online ahead of print.ABSTRACTSeveral epidemiological studies show a co-occurrence of sarcoidosis with other immune-mediated diseases (IMD). There are many similarities between sarcoidosis and IMDs in their geographical distribution and risk factors. Understanding these similarities and identifying the differences can help us to better understand sarcoidosis and put it into context with other IMDs. In this review, we present the current knowledge about the overlap between sarcoidosis and other IMDs derived from epidemiological studies. Epidemiologic methods u...
Source: Journal of Autoimmunity - October 10, 2023 Category: Allergy & Immunology Authors: Elizabeth V Arkema Marios Rossides Yvette C Cozier Source Type: research
Sarcoidosis and its relation to other immune-mediated diseases: Epidemiological insights
J Autoimmun. 2023 Oct 8:103127. doi: 10.1016/j.jaut.2023.103127. Online ahead of print.ABSTRACTSeveral epidemiological studies show a co-occurrence of sarcoidosis with other immune-mediated diseases (IMD). There are many similarities between sarcoidosis and IMDs in their geographical distribution and risk factors. Understanding these similarities and identifying the differences can help us to better understand sarcoidosis and put it into context with other IMDs. In this review, we present the current knowledge about the overlap between sarcoidosis and other IMDs derived from epidemiological studies. Epidemiologic methods u...
Source: Journal of Autoimmunity - October 10, 2023 Category: Allergy & Immunology Authors: Elizabeth V Arkema Marios Rossides Yvette C Cozier Source Type: research
Comparison of circulating and excreted metals and of autoimmunity between two Great Plains Tribal communities
J Autoimmun. 2023 Oct 7:103117. doi: 10.1016/j.jaut.2023.103117. Online ahead of print.ABSTRACTMetals contaminants of the environment from mine waste have been implicated as contributing agents in autoimmune disease. The current study compares metals and autoimmunity in two Tribal communities residing in the Black Hills and the Bighorn Mountains geographical regions that are scattered with extant hard rock mines. With documented drinking water contamination in both communities, in vivo levels of more than half of the measured serum and urine metals differed between the two communities and were substantially different from ...
Source: Journal of Autoimmunity - October 9, 2023 Category: Allergy & Immunology Authors: Esther Erdei Elena R O'Donald Li Luo Kendra Enright Marcia O'Leary Debra MacKenzie John Doyle Margaret Eggers Deborah Keil Johnnye Lewis Jeffrey A Henderson Robert L Rubin Source Type: research
Quality of life in sarcoidosis
J Autoimmun. 2023 Oct 7:103123. doi: 10.1016/j.jaut.2023.103123. Online ahead of print.ABSTRACTHaving sarcoidosis often has a major impact on quality of life of patients and their families. Improving quality of life is prioritized as most important treatment aim by many patients with sarcoidosis, but current evidence and treatment options are limited. In this narrative review, we describe the impact of sarcoidosis on various aspects of daily life, evaluate determinants of health-related quality of life (HRQoL), and provide an overview of the different patient-reported outcome measures to assess HRQoL in sarcoidosis. Moreov...
Source: Journal of Autoimmunity - October 9, 2023 Category: Allergy & Immunology Authors: Catharina C Moor Ogugua Ndili Obi Vivienne Kahlmann Katharina Buschulte Marlies S Wijsenbeek Source Type: research
Comparison of circulating and excreted metals and of autoimmunity between two Great Plains Tribal communities
J Autoimmun. 2023 Oct 7:103117. doi: 10.1016/j.jaut.2023.103117. Online ahead of print.ABSTRACTMetals contaminants of the environment from mine waste have been implicated as contributing agents in autoimmune disease. The current study compares metals and autoimmunity in two Tribal communities residing in the Black Hills and the Bighorn Mountains geographical regions that are scattered with extant hard rock mines. With documented drinking water contamination in both communities, in vivo levels of more than half of the measured serum and urine metals differed between the two communities and were substantially different from ...
Source: Journal of Autoimmunity - October 9, 2023 Category: Allergy & Immunology Authors: Esther Erdei Elena R O'Donald Li Luo Kendra Enright Marcia O'Leary Debra MacKenzie John Doyle Margaret Eggers Deborah Keil Johnnye Lewis Jeffrey A Henderson Robert L Rubin Source Type: research
Quality of life in sarcoidosis
J Autoimmun. 2023 Oct 7:103123. doi: 10.1016/j.jaut.2023.103123. Online ahead of print.ABSTRACTHaving sarcoidosis often has a major impact on quality of life of patients and their families. Improving quality of life is prioritized as most important treatment aim by many patients with sarcoidosis, but current evidence and treatment options are limited. In this narrative review, we describe the impact of sarcoidosis on various aspects of daily life, evaluate determinants of health-related quality of life (HRQoL), and provide an overview of the different patient-reported outcome measures to assess HRQoL in sarcoidosis. Moreov...
Source: Journal of Autoimmunity - October 9, 2023 Category: Allergy & Immunology Authors: Catharina C Moor Ogugua Ndili Obi Vivienne Kahlmann Katharina Buschulte Marlies S Wijsenbeek Source Type: research
In cis "benign" SOCS1 variants linked to enhanced interferon signaling and autoimmunity
J Autoimmun. 2023 Oct 3;140:103119. doi: 10.1016/j.jaut.2023.103119. Online ahead of print.ABSTRACTWe aimed to characterize the genetic basis of disease in a family with multiple autoimmune manifestations, including systemic lupus erythematosus (SLE), immune thrombocytopenia, and autoimmune thyroiditis. Whole exome sequencing (WES) was conducted to identify candidate variants, which were analyzed by flow cytometry, immunoblotting, immunoprecipitation, and luciferase reporter assay in transfected 293T cells. Gene expression in peripheral blood mononuclear cells (PBMC) was profiled by bulk RNA sequencing and plasma cytokines...
Source: Journal of Autoimmunity - October 5, 2023 Category: Allergy & Immunology Authors: Yan Du Kailey E Brodeur Evan Hsu Liang Chen Qian Chen Meng Liu Qi Cheng Seymour Rosen Thomas F Michniacki Janet Chou Mindy S Lo Craig D Platt Pui Y Lee Source Type: research
