Quantitative and structural changes of blood platelet cytoskeleton proteins in multiple sclerosis (MS)
J Autoimmun. 2024 Mar 22;145:103204. doi: 10.1016/j.jaut.2024.103204. Online ahead of print.ABSTRACTEpidemiological studies show that cardiovascular events related to platelet hyperactivity remain the leading causes of death among multiple sclerosis (MS) patients. Quantitative or structural changes of platelet cytoskeleton alter their morphology and function. Here, we demonstrated, for the first time, the structural changes in MS platelets that may be related to their hyperactivity. MS platelets were found to form large aggregates compared to control platelets. In contrast to the control, the images of overactivated, irreg...
Source: Journal of Autoimmunity - March 23, 2024 Category: Allergy & Immunology Authors: Angela Dziedzic Sylwia Michlewska Piotr J óźwiak Janusz D ębski Micha ł Seweryn Karbownik Łukasz Łaczmański Dorota Kujawa S ława Glińska El żbieta Miller Marta Niwald Malgorzata Kloc Łucja Balcerzak Joanna Saluk Source Type: research
Kidney manifestations of sarcoidosis
J Autoimmun. 2024 Mar 22:103207. doi: 10.1016/j.jaut.2024.103207. Online ahead of print.ABSTRACTRenal involvement is a clinically relevant organ manifestation of sarcoidosis, leading to increased morbidity and complications. Although the exact incidence remains unknown, renal disease is likely to occur in up to one third of all sarcoidosis patients. Every patient with newly diagnosed sarcoidosis should receive a renal work-up and screening for disrupted calcium metabolism. Amid various forms of glomerulonephritis, granulomatous interstitial nephritis is the most common one, but it rarely leads to renal impairment. Histolog...
Source: Journal of Autoimmunity - March 23, 2024 Category: Allergy & Immunology Authors: Francesco Bonella Adriane Dm Vorselaars Benjamin Wilde Source Type: research
Anti-DNA antibody-targeted D-peptide nanoparticles ameliorate lupus nephritis in MRL/lpr mice
J Autoimmun. 2024 Mar 16;145:103205. doi: 10.1016/j.jaut.2024.103205. Online ahead of print.ABSTRACTPeptide ALW (ALWPPNLHAWVP) targeting anti-dsDNA antibodies has shown promising therapeutic effects in alleviating lupus nephritis, but is potentially limited by poor stability and non-kidney targeting. We recently developed a D-form modified ALW, called D-ALW, which has the capacity to widely inhibit pathogenic polyclonal anti-dsDNA antibody reactions. Further modification of D-ALW using PEG-PLGA nanoparticles to enhance good kidney-targeting ability and extend half-life. Here, we demonstrate that the D-form modified ALW mai...
Source: Journal of Autoimmunity - March 17, 2024 Category: Allergy & Immunology Authors: Yaqi Wang Shuang Wang Wei Liu Hanjiang Gu Mai Luo Tong Xiao Mingzhu Zhou Yutong Ran Shengxiang Xiao Yumin Xia Huixia Wang Source Type: research
Global and regional epidemiology of psoriatic arthritis in patients with psoriasis: A comprehensive systematic analysis and modelling study
CONCLUSIONS: This study provides valuable insights into the global epidemiology of PsA. It also serves as a useful resource for researchers in areas lacking relevant studies. These findings have important implications for clinicians managing the course of PsA and for health policymakers in resource allocation.PMID:38493674 | DOI:10.1016/j.jaut.2024.103202 (Source: Journal of Autoimmunity)
Source: Journal of Autoimmunity - March 17, 2024 Category: Allergy & Immunology Authors: Zijian Kang Xueliang Zhang Yu Du Sheng-Ming Dai Source Type: research
Anti-DNA antibody-targeted D-peptide nanoparticles ameliorate lupus nephritis in MRL/lpr mice
J Autoimmun. 2024 Mar 16;145:103205. doi: 10.1016/j.jaut.2024.103205. Online ahead of print.ABSTRACTPeptide ALW (ALWPPNLHAWVP) targeting anti-dsDNA antibodies has shown promising therapeutic effects in alleviating lupus nephritis, but is potentially limited by poor stability and non-kidney targeting. We recently developed a D-form modified ALW, called D-ALW, which has the capacity to widely inhibit pathogenic polyclonal anti-dsDNA antibody reactions. Further modification of D-ALW using PEG-PLGA nanoparticles to enhance good kidney-targeting ability and extend half-life. Here, we demonstrate that the D-form modified ALW mai...
Source: Journal of Autoimmunity - March 17, 2024 Category: Allergy & Immunology Authors: Yaqi Wang Shuang Wang Wei Liu Hanjiang Gu Mai Luo Tong Xiao Mingzhu Zhou Yutong Ran Shengxiang Xiao Yumin Xia Huixia Wang Source Type: research
Global and regional epidemiology of psoriatic arthritis in patients with psoriasis: A comprehensive systematic analysis and modelling study
CONCLUSIONS: This study provides valuable insights into the global epidemiology of PsA. It also serves as a useful resource for researchers in areas lacking relevant studies. These findings have important implications for clinicians managing the course of PsA and for health policymakers in resource allocation.PMID:38493674 | DOI:10.1016/j.jaut.2024.103202 (Source: Journal of Autoimmunity)
Source: Journal of Autoimmunity - March 17, 2024 Category: Allergy & Immunology Authors: Zijian Kang Xueliang Zhang Yu Du Sheng-Ming Dai Source Type: research
Anti-DNA antibody-targeted D-peptide nanoparticles ameliorate lupus nephritis in MRL/lpr mice
J Autoimmun. 2024 Mar 16;145:103205. doi: 10.1016/j.jaut.2024.103205. Online ahead of print.ABSTRACTPeptide ALW (ALWPPNLHAWVP) targeting anti-dsDNA antibodies has shown promising therapeutic effects in alleviating lupus nephritis, but is potentially limited by poor stability and non-kidney targeting. We recently developed a D-form modified ALW, called D-ALW, which has the capacity to widely inhibit pathogenic polyclonal anti-dsDNA antibody reactions. Further modification of D-ALW using PEG-PLGA nanoparticles to enhance good kidney-targeting ability and extend half-life. Here, we demonstrate that the D-form modified ALW mai...
Source: Journal of Autoimmunity - March 17, 2024 Category: Allergy & Immunology Authors: Yaqi Wang Shuang Wang Wei Liu Hanjiang Gu Mai Luo Tong Xiao Mingzhu Zhou Yutong Ran Shengxiang Xiao Yumin Xia Huixia Wang Source Type: research
Global and regional epidemiology of psoriatic arthritis in patients with psoriasis: A comprehensive systematic analysis and modelling study
CONCLUSIONS: This study provides valuable insights into the global epidemiology of PsA. It also serves as a useful resource for researchers in areas lacking relevant studies. These findings have important implications for clinicians managing the course of PsA and for health policymakers in resource allocation.PMID:38493674 | DOI:10.1016/j.jaut.2024.103202 (Source: Journal of Autoimmunity)
Source: Journal of Autoimmunity - March 17, 2024 Category: Allergy & Immunology Authors: Zijian Kang Xueliang Zhang Yu Du Sheng-Ming Dai Source Type: research
Anti-DNA antibody-targeted D-peptide nanoparticles ameliorate lupus nephritis in MRL/lpr mice
J Autoimmun. 2024 Mar 16;145:103205. doi: 10.1016/j.jaut.2024.103205. Online ahead of print.ABSTRACTPeptide ALW (ALWPPNLHAWVP) targeting anti-dsDNA antibodies has shown promising therapeutic effects in alleviating lupus nephritis, but is potentially limited by poor stability and non-kidney targeting. We recently developed a D-form modified ALW, called D-ALW, which has the capacity to widely inhibit pathogenic polyclonal anti-dsDNA antibody reactions. Further modification of D-ALW using PEG-PLGA nanoparticles to enhance good kidney-targeting ability and extend half-life. Here, we demonstrate that the D-form modified ALW mai...
Source: Journal of Autoimmunity - March 17, 2024 Category: Allergy & Immunology Authors: Yaqi Wang Shuang Wang Wei Liu Hanjiang Gu Mai Luo Tong Xiao Mingzhu Zhou Yutong Ran Shengxiang Xiao Yumin Xia Huixia Wang Source Type: research
Global and regional epidemiology of psoriatic arthritis in patients with psoriasis: A comprehensive systematic analysis and modelling study
CONCLUSIONS: This study provides valuable insights into the global epidemiology of PsA. It also serves as a useful resource for researchers in areas lacking relevant studies. These findings have important implications for clinicians managing the course of PsA and for health policymakers in resource allocation.PMID:38493674 | DOI:10.1016/j.jaut.2024.103202 (Source: Journal of Autoimmunity)
Source: Journal of Autoimmunity - March 17, 2024 Category: Allergy & Immunology Authors: Zijian Kang Xueliang Zhang Yu Du Sheng-Ming Dai Source Type: research
Anti-DNA antibody-targeted D-peptide nanoparticles ameliorate lupus nephritis in MRL/lpr mice
J Autoimmun. 2024 Mar 16;145:103205. doi: 10.1016/j.jaut.2024.103205. Online ahead of print.ABSTRACTPeptide ALW (ALWPPNLHAWVP) targeting anti-dsDNA antibodies has shown promising therapeutic effects in alleviating lupus nephritis, but is potentially limited by poor stability and non-kidney targeting. We recently developed a D-form modified ALW, called D-ALW, which has the capacity to widely inhibit pathogenic polyclonal anti-dsDNA antibody reactions. Further modification of D-ALW using PEG-PLGA nanoparticles to enhance good kidney-targeting ability and extend half-life. Here, we demonstrate that the D-form modified ALW mai...
Source: Journal of Autoimmunity - March 17, 2024 Category: Allergy & Immunology Authors: Yaqi Wang Shuang Wang Wei Liu Hanjiang Gu Mai Luo Tong Xiao Mingzhu Zhou Yutong Ran Shengxiang Xiao Yumin Xia Huixia Wang Source Type: research
Global and regional epidemiology of psoriatic arthritis in patients with psoriasis: A comprehensive systematic analysis and modelling study
CONCLUSIONS: This study provides valuable insights into the global epidemiology of PsA. It also serves as a useful resource for researchers in areas lacking relevant studies. These findings have important implications for clinicians managing the course of PsA and for health policymakers in resource allocation.PMID:38493674 | DOI:10.1016/j.jaut.2024.103202 (Source: Journal of Autoimmunity)
Source: Journal of Autoimmunity - March 17, 2024 Category: Allergy & Immunology Authors: Zijian Kang Xueliang Zhang Yu Du Sheng-Ming Dai Source Type: research
Neutrophil activation biomarker pentraxin 3 for diagnosis and monitoring of macrophage activation syndrome occurrence in adult-onset Still's disease
In this study, we demonstrated that pentraxin 3 (PTX3), an acute phase protein, was associated with AOSD disease activity and served as a biomarker for AOSD-MAS. PTX3 levels were significantly increased in AOSD patients compared to other autoimmune diseases and healthy controls. Plasma PTX3 levels showed positive correlations with inflammatory markers, the systemic score and the HScore. In active AOSD with MAS, PTX3 levels were higher compared to those in non-AOSD haemophagocytic lymphohistiocytosis (HLH) patients. Moreover, the PTX3's area under the curve value for distinguishing AOSD with MAS exceeded that of soluble int...
Source: Journal of Autoimmunity - March 9, 2024 Category: Allergy & Immunology Authors: Dehao Zhu Longfang Chen Jianfen Meng Mengyan Wang Yuning Ma Xia Chen Yu Xiao Da Yi Hui Shi Yue Sun Honglei Liu Xiaobing Cheng Yutong Su Junna Ye Huihui Chi Zhuochao Zhou Chengde Yang Jialin Teng Jinchao Jia Qiongyi Hu Source Type: research
Neutrophil activation biomarker pentraxin 3 for diagnosis and monitoring of macrophage activation syndrome occurrence in adult-onset Still's disease
In this study, we demonstrated that pentraxin 3 (PTX3), an acute phase protein, was associated with AOSD disease activity and served as a biomarker for AOSD-MAS. PTX3 levels were significantly increased in AOSD patients compared to other autoimmune diseases and healthy controls. Plasma PTX3 levels showed positive correlations with inflammatory markers, the systemic score and the HScore. In active AOSD with MAS, PTX3 levels were higher compared to those in non-AOSD haemophagocytic lymphohistiocytosis (HLH) patients. Moreover, the PTX3's area under the curve value for distinguishing AOSD with MAS exceeded that of soluble int...
Source: Journal of Autoimmunity - March 9, 2024 Category: Allergy & Immunology Authors: Dehao Zhu Longfang Chen Jianfen Meng Mengyan Wang Yuning Ma Xia Chen Yu Xiao Da Yi Hui Shi Yue Sun Honglei Liu Xiaobing Cheng Yutong Su Junna Ye Huihui Chi Zhuochao Zhou Chengde Yang Jialin Teng Jinchao Jia Qiongyi Hu Source Type: research
Neutrophil activation biomarker pentraxin 3 for diagnosis and monitoring of macrophage activation syndrome occurrence in adult-onset Still's disease
In this study, we demonstrated that pentraxin 3 (PTX3), an acute phase protein, was associated with AOSD disease activity and served as a biomarker for AOSD-MAS. PTX3 levels were significantly increased in AOSD patients compared to other autoimmune diseases and healthy controls. Plasma PTX3 levels showed positive correlations with inflammatory markers, the systemic score and the HScore. In active AOSD with MAS, PTX3 levels were higher compared to those in non-AOSD haemophagocytic lymphohistiocytosis (HLH) patients. Moreover, the PTX3's area under the curve value for distinguishing AOSD with MAS exceeded that of soluble int...
Source: Journal of Autoimmunity - March 9, 2024 Category: Allergy & Immunology Authors: Dehao Zhu Longfang Chen Jianfen Meng Mengyan Wang Yuning Ma Xia Chen Yu Xiao Da Yi Hui Shi Yue Sun Honglei Liu Xiaobing Cheng Yutong Su Junna Ye Huihui Chi Zhuochao Zhou Chengde Yang Jialin Teng Jinchao Jia Qiongyi Hu Source Type: research
