Autoimmune diseases and female-specific cancer risk: A systematic review and meta-analysis
CONCLUSIONS: RA seems to reduce the risk of breast and uterine cancers, while PsO appears to increase breast cancer risk. Further large studies are required to investigate potential therapy-effects and detailed biological mechanisms.PMID:38428110 | DOI:10.1016/j.jaut.2024.103187 (Source: Journal of Autoimmunity)
Source: Journal of Autoimmunity - March 1, 2024 Category: Allergy & Immunology Authors: Simone Fischer Christa Meisinger Dennis Freuer Source Type: research
miR-146a and miR-146b regulate the expression of ICAM-1 in giant cell arteritis
J Autoimmun. 2024 Feb 29;144:103186. doi: 10.1016/j.jaut.2024.103186. Online ahead of print.ABSTRACTGiant cell arteritis (GCA) is an inflammatory disease of large/medium-sized arteries. MiRNAs are small, non-coding RNAs that inhibit gene expression at post-transcriptional level. Several miRNAs have been shown to be dysregulated in temporal artery biopsies (TABs) from GCA patients, but their role is unknown. The aims of the present work were: to gain insight into the link between inflammation and miRNA up-regulation in GCA; to identify the role of miR-146a and miR-146b. Primary cultures from TABs were treated with IL-1β, I...
Source: Journal of Autoimmunity - March 1, 2024 Category: Allergy & Immunology Authors: Martina Bonacini Alessandro Rossi Ilaria Ferrigno Francesco Muratore Luigi Boiardi Alberto Cavazza Alessandra Bisagni Luca Cimino Luca De Simone Angelo Ghidini Giuseppe Malchiodi Marc Corbera-Bellalta Maria Cinta Cid Alessandro Zerbini Carlo Salvarani Ste Source Type: research
Modulation of PKM2 inhibits follicular helper T cell differentiation and ameliorates inflammation in lupus-prone mice
CONCLUSIONS: Our results demonstrate the involvement of PKM2-mediated glycolysis in Tfh cell differentiation and SLE pathogenesis, and PKM2 could be a key therapeutic target for the treatment of SLE.PMID:38428341 | DOI:10.1016/j.jaut.2024.103198 (Source: Journal of Autoimmunity)
Source: Journal of Autoimmunity - March 1, 2024 Category: Allergy & Immunology Authors: Manna Lin Liuting Huang Junxia Huang Jia Yu Xue Yang Ji Yang Source Type: research
Impact of muscle biopsy on the clinical decision-making process in patients with suspected idiopathic inflammatory myopathy
CONCLUSION: In patients with clinically suspected IIM, approximately 50% of biopsies revealed features indicative of IIM. Diagnostic performance of muscle biopsy was moderate to high depending on clinical pre-test probability.PMID:38428109 | DOI:10.1016/j.jaut.2024.103185 (Source: Journal of Autoimmunity)
Source: Journal of Autoimmunity - March 1, 2024 Category: Allergy & Immunology Authors: Kastriot Kastrati Nasim Nakhost Lotfi Marwa G Tawfik Ellen Gelpi Simon Hametner Romana H öftberger Fritz Zimprich Hakan Cetin Elisabeth Lindeck-Pozza Peter Maximilian Heil Hans P Kiener Leonhard X Heinz Daniel Mrak Daniel Aletaha Michael Bonelli Helga Ra Source Type: research
Autoimmune diseases and female-specific cancer risk: A systematic review and meta-analysis
CONCLUSIONS: RA seems to reduce the risk of breast and uterine cancers, while PsO appears to increase breast cancer risk. Further large studies are required to investigate potential therapy-effects and detailed biological mechanisms.PMID:38428110 | DOI:10.1016/j.jaut.2024.103187 (Source: Journal of Autoimmunity)
Source: Journal of Autoimmunity - March 1, 2024 Category: Allergy & Immunology Authors: Simone Fischer Christa Meisinger Dennis Freuer Source Type: research
miR-146a and miR-146b regulate the expression of ICAM-1 in giant cell arteritis
J Autoimmun. 2024 Feb 29;144:103186. doi: 10.1016/j.jaut.2024.103186. Online ahead of print.ABSTRACTGiant cell arteritis (GCA) is an inflammatory disease of large/medium-sized arteries. MiRNAs are small, non-coding RNAs that inhibit gene expression at post-transcriptional level. Several miRNAs have been shown to be dysregulated in temporal artery biopsies (TABs) from GCA patients, but their role is unknown. The aims of the present work were: to gain insight into the link between inflammation and miRNA up-regulation in GCA; to identify the role of miR-146a and miR-146b. Primary cultures from TABs were treated with IL-1β, I...
Source: Journal of Autoimmunity - March 1, 2024 Category: Allergy & Immunology Authors: Martina Bonacini Alessandro Rossi Ilaria Ferrigno Francesco Muratore Luigi Boiardi Alberto Cavazza Alessandra Bisagni Luca Cimino Luca De Simone Angelo Ghidini Giuseppe Malchiodi Marc Corbera-Bellalta Maria Cinta Cid Alessandro Zerbini Carlo Salvarani Ste Source Type: research
Modulation of PKM2 inhibits follicular helper T cell differentiation and ameliorates inflammation in lupus-prone mice
CONCLUSIONS: Our results demonstrate the involvement of PKM2-mediated glycolysis in Tfh cell differentiation and SLE pathogenesis, and PKM2 could be a key therapeutic target for the treatment of SLE.PMID:38428341 | DOI:10.1016/j.jaut.2024.103198 (Source: Journal of Autoimmunity)
Source: Journal of Autoimmunity - March 1, 2024 Category: Allergy & Immunology Authors: Manna Lin Liuting Huang Junxia Huang Jia Yu Xue Yang Ji Yang Source Type: research
Impact of muscle biopsy on the clinical decision-making process in patients with suspected idiopathic inflammatory myopathy
CONCLUSION: In patients with clinically suspected IIM, approximately 50% of biopsies revealed features indicative of IIM. Diagnostic performance of muscle biopsy was moderate to high depending on clinical pre-test probability.PMID:38428109 | DOI:10.1016/j.jaut.2024.103185 (Source: Journal of Autoimmunity)
Source: Journal of Autoimmunity - March 1, 2024 Category: Allergy & Immunology Authors: Kastriot Kastrati Nasim Nakhost Lotfi Marwa G Tawfik Ellen Gelpi Simon Hametner Romana H öftberger Fritz Zimprich Hakan Cetin Elisabeth Lindeck-Pozza Peter Maximilian Heil Hans P Kiener Leonhard X Heinz Daniel Mrak Daniel Aletaha Michael Bonelli Helga Ra Source Type: research
Autoimmune diseases and female-specific cancer risk: A systematic review and meta-analysis
CONCLUSIONS: RA seems to reduce the risk of breast and uterine cancers, while PsO appears to increase breast cancer risk. Further large studies are required to investigate potential therapy-effects and detailed biological mechanisms.PMID:38428110 | DOI:10.1016/j.jaut.2024.103187 (Source: Journal of Autoimmunity)
Source: Journal of Autoimmunity - March 1, 2024 Category: Allergy & Immunology Authors: Simone Fischer Christa Meisinger Dennis Freuer Source Type: research
miR-146a and miR-146b regulate the expression of ICAM-1 in giant cell arteritis
J Autoimmun. 2024 Feb 29;144:103186. doi: 10.1016/j.jaut.2024.103186. Online ahead of print.ABSTRACTGiant cell arteritis (GCA) is an inflammatory disease of large/medium-sized arteries. MiRNAs are small, non-coding RNAs that inhibit gene expression at post-transcriptional level. Several miRNAs have been shown to be dysregulated in temporal artery biopsies (TABs) from GCA patients, but their role is unknown. The aims of the present work were: to gain insight into the link between inflammation and miRNA up-regulation in GCA; to identify the role of miR-146a and miR-146b. Primary cultures from TABs were treated with IL-1β, I...
Source: Journal of Autoimmunity - March 1, 2024 Category: Allergy & Immunology Authors: Martina Bonacini Alessandro Rossi Ilaria Ferrigno Francesco Muratore Luigi Boiardi Alberto Cavazza Alessandra Bisagni Luca Cimino Luca De Simone Angelo Ghidini Giuseppe Malchiodi Marc Corbera-Bellalta Maria Cinta Cid Alessandro Zerbini Carlo Salvarani Ste Source Type: research
Modulation of PKM2 inhibits follicular helper T cell differentiation and ameliorates inflammation in lupus-prone mice
CONCLUSIONS: Our results demonstrate the involvement of PKM2-mediated glycolysis in Tfh cell differentiation and SLE pathogenesis, and PKM2 could be a key therapeutic target for the treatment of SLE.PMID:38428341 | DOI:10.1016/j.jaut.2024.103198 (Source: Journal of Autoimmunity)
Source: Journal of Autoimmunity - March 1, 2024 Category: Allergy & Immunology Authors: Manna Lin Liuting Huang Junxia Huang Jia Yu Xue Yang Ji Yang Source Type: research
P2RX7 gene variants associate with altered inflammasome assembly and reduced pyroptosis in chronic nonbacterial osteomyelitis (CNO)
This study investigated CNO-associated variants in P2RX7, encoding for the ATP-dependent trans-membrane K+ channel P2X7, and their effects on NLRP3 inflammasome assembly. Whole exome sequencing in two related transgenerational CNO patients, and target sequencing of P2RX7 in a large CNO cohort (N = 190) were conducted. Results were compared with publicly available datasets and regional controls (N = 1873). Findings were integrated with demographic and clinical data. Patient-derived monocytes and genetically modified THP-1 cells were used to investigate potassium flux, inflammasome assembly, pyroptosis, and cytokine release....
Source: Journal of Autoimmunity - February 24, 2024 Category: Allergy & Immunology Authors: Amandine Charras Sigrun R Hofmann Allison Cox Felix Schulze Susanne Russ Sarah Northey Xuan Liu Yongxiang Fang Sam Haldenby Hella Hartmann Alexander G Bassuk Ana Carvalho Francesca Sposito Lev Grinstein Angela R ösen-Wolff Almut Meyer-Bahlburg Michael W Source Type: research
P2RX7 gene variants associate with altered inflammasome assembly and reduced pyroptosis in chronic nonbacterial osteomyelitis (CNO)
This study investigated CNO-associated variants in P2RX7, encoding for the ATP-dependent trans-membrane K+ channel P2X7, and their effects on NLRP3 inflammasome assembly. Whole exome sequencing in two related transgenerational CNO patients, and target sequencing of P2RX7 in a large CNO cohort (N = 190) were conducted. Results were compared with publicly available datasets and regional controls (N = 1873). Findings were integrated with demographic and clinical data. Patient-derived monocytes and genetically modified THP-1 cells were used to investigate potassium flux, inflammasome assembly, pyroptosis, and cytokine release....
Source: Journal of Autoimmunity - February 24, 2024 Category: Allergy & Immunology Authors: Amandine Charras Sigrun R Hofmann Allison Cox Felix Schulze Susanne Russ Sarah Northey Xuan Liu Yongxiang Fang Sam Haldenby Hella Hartmann Alexander G Bassuk Ana Carvalho Francesca Sposito Lev Grinstein Angela R ösen-Wolff Almut Meyer-Bahlburg Michael W Source Type: research
P2RX7 gene variants associate with altered inflammasome assembly and reduced pyroptosis in chronic nonbacterial osteomyelitis (CNO)
This study investigated CNO-associated variants in P2RX7, encoding for the ATP-dependent trans-membrane K+ channel P2X7, and their effects on NLRP3 inflammasome assembly. Whole exome sequencing in two related transgenerational CNO patients, and target sequencing of P2RX7 in a large CNO cohort (N = 190) were conducted. Results were compared with publicly available datasets and regional controls (N = 1873). Findings were integrated with demographic and clinical data. Patient-derived monocytes and genetically modified THP-1 cells were used to investigate potassium flux, inflammasome assembly, pyroptosis, and cytokine release....
Source: Journal of Autoimmunity - February 24, 2024 Category: Allergy & Immunology Authors: Amandine Charras Sigrun R Hofmann Allison Cox Felix Schulze Susanne Russ Sarah Northey Xuan Liu Yongxiang Fang Sam Haldenby Hella Hartmann Alexander G Bassuk Ana Carvalho Francesca Sposito Lev Grinstein Angela R ösen-Wolff Almut Meyer-Bahlburg Michael W Source Type: research
P2RX7 gene variants associate with altered inflammasome assembly and reduced pyroptosis in chronic nonbacterial osteomyelitis (CNO)
This study investigated CNO-associated variants in P2RX7, encoding for the ATP-dependent trans-membrane K+ channel P2X7, and their effects on NLRP3 inflammasome assembly. Whole exome sequencing in two related transgenerational CNO patients, and target sequencing of P2RX7 in a large CNO cohort (N = 190) were conducted. Results were compared with publicly available datasets and regional controls (N = 1873). Findings were integrated with demographic and clinical data. Patient-derived monocytes and genetically modified THP-1 cells were used to investigate potassium flux, inflammasome assembly, pyroptosis, and cytokine release....
Source: Journal of Autoimmunity - February 24, 2024 Category: Allergy & Immunology Authors: Amandine Charras Sigrun R Hofmann Allison Cox Felix Schulze Susanne Russ Sarah Northey Xuan Liu Yongxiang Fang Sam Haldenby Hella Hartmann Alexander G Bassuk Ana Carvalho Francesca Sposito Lev Grinstein Angela R ösen-Wolff Almut Meyer-Bahlburg Michael W Source Type: research
