Extracellular microRNAs induce dendritic cell-dependent joint inflammation and potentiate osteoclast differentiation via TLR7/8 engagement

CONCLUSIONS: This work represents a proof of concept that the pool of extracellular miRNAs overexpressed in RA joints can act as a physiological activator of inflammation via the stimulation of TLR8 expressed by human DCs, which in turn exert arthritogenic functions. In this scenario, pharmacological inhibition of TLR8 might offer a new therapeutic option to reduce inflammation and osteoclast-mediated bone destruction in RA.PMID:38442677 | DOI:10.1016/j.jaut.2024.103189

Source: Journal of Autoimmunity - March 5, 2024 Category: Allergy & Immunology Authors: Carolina Gaudenzi Tiziana Schioppa Mauro Passari Giovanni Zucchi Laura Tiberio Yasmin Vahidi Sara Scutera Tiziana Musso Silvano Sozzani Annalisa Del Prete Valentina Salvi Daniela Bosisio Source Type: research