Ectopic CD4 < sup > + < /sup > T cells in choroid plexus mediate neuropsychiatric lupus symptoms in mice via interferon- γ induced microglia activation

In conclusion, CP-resident lupus CD4+ T cells contribute to NPSLE-like symptoms in mice via Interferon-γ induced microglia activation. Depleting CP-resident lupus CD4+ T cells, interferon-γ, or activated microglia may be potential therapeutic targets for NPSLE.PMID:38452512 | DOI:10.1016/j.jaut.2024.103199
Source: Journal of Autoimmunity - Category: Allergy & Immunology Authors: Source Type: research