JAMA Neurology
Mission Statement: The mission of JAMA Neurology is to publish and disseminate scientific information primarily important for physicians caring for people with neurologic disorders and for those interested in the structure and function of the normal and diseased human nervous system. The specific aims are to (1) publish timely original research, including clinical trials that will directly improve clinical neurologic care and that will inform efforts to improve neurological health and promote health care equity; (2) report translational research that is pertinent to the understanding of neurologic disease; (3) address topi...
Source: JAMA Neurology - December 1, 2023 Category: Neurology Source Type: research
When Pregnancy Becomes an Inclusion Criterion in Neuroscience Research
This Viewpoint discusses the inclusion of pregnant patients in clinical trials for antiseizure medication. (Source: JAMA Neurology)
Source: JAMA Neurology - November 27, 2023 Category: Neurology Source Type: research
Multiple Sclerosis Progression and Relapse in Children
This cohort study assesses the occurrence of progression independent of relapse activity and relapse-associated worsening in pediatric and adult patients with multiple sclerosis. (Source: JAMA Neurology)
Source: JAMA Neurology - November 27, 2023 Category: Neurology Source Type: research
Endovascular Therapy Outcomes by ASPECTS and Infarct Core Volume in Patients With Large Infarct
This secondary analysis of the ANGEL-ASPECT randomized clinical trial examines outcomes of endovascular therapy vs medical management across varying Alberta Stroke Program Early Computed Tomography Score (ASPECTS) and infarct core volume strata in patients with large infarct. (Source: JAMA Neurology)
Source: JAMA Neurology - November 27, 2023 Category: Neurology Source Type: research
Potential Medicare and Medicaid Savings on Anti-CD20 Therapy for Multiple Sclerosis
This cross-sectional study compares price data for ocrelizumab and rituximab to estimate the savings to Medicare and Medicaid if rituximab were used in the treatment of multiple sclerosis instead of the higher-priced ocrelizumab. (Source: JAMA Neurology)
Source: JAMA Neurology - November 27, 2023 Category: Neurology Source Type: research
A Young Woman With Hypertonia, Severe Scoliosis, and Encephalopathy
A 31-year-old woman was seen with contractures in her fingers and toes, carpal inversion, dysarthria, dysphagia, hypertonia, decreased tendon reflexes, absence of Babinski sign, and no psychiatric problems and significant global atrophy. What is your diagnosis? (Source: JAMA Neurology)
Source: JAMA Neurology - November 27, 2023 Category: Neurology Source Type: research
Streamlining Prior Authorization to Improve Care
This Viewpoint addresses the challenges of prior authorization: decreased access, delayed care, decreased patient satisfaction and outcomes, and increased clinician burnout. (Source: JAMA Neurology)
Source: JAMA Neurology - November 20, 2023 Category: Neurology Source Type: research
Holding Onto Our Hats —A Hmong Medical Student’s Reflection
This On the Brain describes a Hmong student ’s experience in medical school. (Source: JAMA Neurology)
Source: JAMA Neurology - November 20, 2023 Category: Neurology Source Type: research
Behavioral Outcomes and Neurodevelopmental Disorders Among Children of Women With Epilepsy
This cohort study examines the association of fetal exposure to antiseizure medications with subsequent adaptive, behavioral or emotional, and neurodevelopmental disorder outcomes at 2, 3, and 4.5 years of age. (Source: JAMA Neurology)
Source: JAMA Neurology - November 20, 2023 Category: Neurology Source Type: research
Comparative Efficacy of Disease-Modifying Treatments for Relapsing Multiple Sclerosis —Variations in Real-World Experience—Reply
In Reply We thank Dr Wolf and colleagues for highlighting the importance of clinical context when evaluating effectiveness of multiple sclerosis (MS) therapies. As demonstrated in the comparative effectiveness of natalizumab and fingolimod, where seemingly discordant results emerged from different registries, characteristics of the study population play a central role in study findings. It is, therefore, important to differentiate between studies of treatment efficacy and effectiveness. (Source: JAMA Neurology)
Source: JAMA Neurology - November 20, 2023 Category: Neurology Source Type: research
Comparative Efficacy of Disease-Modifying Treatments for Relapsing Multiple Sclerosis —Variations in Real-World Experience
With great interest we read the study by Roos et al comparing the efficacy of 2 anti-CD20 disease-modifying therapies (DMTs) commonly used for relapsing multiple sclerosis (MS). As no head-to-head randomized clinical trials (RCTs) have been completed, the comparative effectiveness of ocrelizumab and rituximab on relapse reduction was evaluated in patients from the MSBase and Danish MS registries. Over a mean follow-up of 1.4 years, the annualized relapse rate (ARR) for patients treated with rituximab was 0.20, whereas for ocrelizumab it was 0.09. Noninferiority was not demonstrated for treatment with rituximab when compare...
Source: JAMA Neurology - November 20, 2023 Category: Neurology Source Type: research
Reversible Cortical and Basal Ganglia Lesions in Late-Onset Methylmalonic Aciduria
This case report describes reversible cortical and basal ganglia lesions in late-onset methylmalonic aciduria in a man in his mid-40s. (Source: JAMA Neurology)
Source: JAMA Neurology - November 20, 2023 Category: Neurology Source Type: research
Patient and Family Outcomes of Community Neurologist Palliative Education and Telehealth Support in Parkinson Disease
This pragmatic trial evaluates whether palliative care training for neurologists and remote access to a palliative care team can improve outcomes in patients with Parkinson disease and related disorders in community settings. (Source: JAMA Neurology)
Source: JAMA Neurology - November 13, 2023 Category: Neurology Source Type: research
Risk of Suicidal Ideation and Behavior in Individuals With Parkinson Disease
This study addresses inconsistent results from studies of suicidal ideation and behavior in patients with Parkinson PD. (Source: JAMA Neurology)
Source: JAMA Neurology - November 13, 2023 Category: Neurology Source Type: research
Neuroimaging Reveals and Guides Treatment of a Middle Cerebral Artery Web
This case report describes how neuroimaging was used to determine treatment for episodic sudden-onset weakness and numbness in the left limbs. (Source: JAMA Neurology)
Source: JAMA Neurology - November 13, 2023 Category: Neurology Source Type: research
