A 51-Year-Old Woman With Abnormal Corpus Callosum Signal
A 51-year-old woman presented with a 2-year history of progressive memory loss and left limb numbness. Imaging showed multifocal restricted diffusion in the corpus callosum and diffuse subcortical white matter hyperintensities and corpus callosum atrophy. What is your diagnosis? (Source: JAMA Neurology)
Source: JAMA Neurology - December 18, 2023 Category: Neurology Source Type: research

Ownership and Interoperability Challenges of Alzheimer Monoclonal Antibody Registries
This Viewpoint addresses the challenges that the Centers for Medicare and Medicaid Services faces to collect real-world data on the effectiveness and safety of lecanemab from external registries to achieve its coverage with evidence development objectives. (Source: JAMA Neurology)
Source: JAMA Neurology - December 11, 2023 Category: Neurology Source Type: research

How Much Good I Can Afford
This essay describes the author ’s experience balancing the different necessities in medical practice, in particular writing perfect patient notes vs establishing a face-to-face connection. (Source: JAMA Neurology)
Source: JAMA Neurology - December 11, 2023 Category: Neurology Source Type: research

Diagnostic Performance of Cortical Lesions and the Central Vein Sign in MS
This cross-sectional study evaluates the use of cortical lesions and central vein sign in distinguishing multiple sclerosis from other conditions. (Source: JAMA Neurology)
Source: JAMA Neurology - December 11, 2023 Category: Neurology Source Type: research

Epidemiology of Creutzfeldt-Jakob Disease in the US
This cross-sectional study uses Centers for Disease Control and Prevention multiple cause of death data to examine recent US trends in Creutzfeldt-Jakob disease. (Source: JAMA Neurology)
Source: JAMA Neurology - December 11, 2023 Category: Neurology Source Type: research

Plasma Biomarker Strategy for Selecting Patients With Alzheimer Disease for Antiamyloid Immunotherapies
This cohort study analyzes data from participants with cognitive concerns to determine whether plasma biomarkers can identify amyloid β–positive individuals who do not yet have a high tau burden in the brain and would be suitable candidates for treatment with antiamyloid immunotherapies in Alzheimer disease. (Source: JAMA Neurology)
Source: JAMA Neurology - December 4, 2023 Category: Neurology Source Type: research

Neuronally Derived Extracellular Vesicle α-Synuclein as a Serum Biomarker for Individuals at Risk of Developing Parkinson Disease
This study investigate whether α-synuclein in neuronally derived serum-extracellular vesicles identifies individuals at risk of developing Parkinson disease and related dementia. (Source: JAMA Neurology)
Source: JAMA Neurology - December 4, 2023 Category: Neurology Source Type: research

Trends in Traumatic Brain Injury Mortality in the US
This cohort study characterizes US trends in traumatic brain injury –related mortality by age, sex, and race and ethnicity. (Source: JAMA Neurology)
Source: JAMA Neurology - December 4, 2023 Category: Neurology Source Type: research

Mirror Hand Movements Caused by a Deletion of the DCC Gene
This case report describes the evaluation of 16-year-old twins with chromosomal microarray and mirror movements. (Source: JAMA Neurology)
Source: JAMA Neurology - December 4, 2023 Category: Neurology Source Type: research

JAMA Neurology
Mission Statement: The mission of JAMA Neurology is to publish and disseminate scientific information primarily important for physicians caring for people with neurologic disorders and for those interested in the structure and function of the normal and diseased human nervous system. The specific aims are to (1) publish timely original research, including clinical trials that will directly improve clinical neurologic care and that will inform efforts to improve neurological health and promote health care equity; (2) report translational research that is pertinent to the understanding of neurologic disease; (3) address topi...
Source: JAMA Neurology - December 1, 2023 Category: Neurology Source Type: research

When Pregnancy Becomes an Inclusion Criterion in Neuroscience Research
This Viewpoint discusses the inclusion of pregnant patients in clinical trials for antiseizure medication. (Source: JAMA Neurology)
Source: JAMA Neurology - November 27, 2023 Category: Neurology Source Type: research

Multiple Sclerosis Progression and Relapse in Children
This cohort study assesses the occurrence of progression independent of relapse activity and relapse-associated worsening in pediatric and adult patients with multiple sclerosis. (Source: JAMA Neurology)
Source: JAMA Neurology - November 27, 2023 Category: Neurology Source Type: research

Endovascular Therapy Outcomes by ASPECTS and Infarct Core Volume in Patients With Large Infarct
This secondary analysis of the ANGEL-ASPECT randomized clinical trial examines outcomes of endovascular therapy vs medical management across varying Alberta Stroke Program Early Computed Tomography Score (ASPECTS) and infarct core volume strata in patients with large infarct. (Source: JAMA Neurology)
Source: JAMA Neurology - November 27, 2023 Category: Neurology Source Type: research

Potential Medicare and Medicaid Savings on Anti-CD20 Therapy for Multiple Sclerosis
This cross-sectional study compares price data for ocrelizumab and rituximab to estimate the savings to Medicare and Medicaid if rituximab were used in the treatment of multiple sclerosis instead of the higher-priced ocrelizumab. (Source: JAMA Neurology)
Source: JAMA Neurology - November 27, 2023 Category: Neurology Source Type: research

A Young Woman With Hypertonia, Severe Scoliosis, and Encephalopathy
A 31-year-old woman was seen with contractures in her fingers and toes, carpal inversion, dysarthria, dysphagia, hypertonia, decreased tendon reflexes, absence of Babinski sign, and no psychiatric problems and significant global atrophy. What is your diagnosis? (Source: JAMA Neurology)
Source: JAMA Neurology - November 27, 2023 Category: Neurology Source Type: research