Cerebral Amyloid Angiopathy and Risk of Isolated Nontraumatic Subdural Hemorrhage
This cohort study of participants in the UK Biobank cohort and the All of Us Research Program cohort investigates whether cerebral amyloid angiopathy is an independent risk factor for isolated nontraumatic subdural hemorrhage. (Source: JAMA Neurology)
Source: JAMA Neurology - December 26, 2023 Category: Neurology Source Type: research
Retinal Hemorrhage Associated with Human Granulocytic Anaplasmosis
This case report describes a 51-year-old female with presented to the emergency department with high-grade fever, headache, nausea, vomiting, dizziness, diffuse arthralgias, and new-onset worsened vision that had developed over 3 days. (Source: JAMA Neurology)
Source: JAMA Neurology - December 26, 2023 Category: Neurology Source Type: research
Direct to Consumer Biomarker Testing for Alzheimer Disease —Are We Ready for the Insurance Consequences?
This Viewpoint discusses direct-to-consumer biomarker tests for Alzheimer disease and their implications on future insurance coverage. (Source: JAMA Neurology)
Source: JAMA Neurology - December 18, 2023 Category: Neurology Source Type: research
Hypothermia vs Normothermia in Patients With Cardiac Arrest and Nonshockable Rhythm
This study attempts to assess whether hypothermia at 33 °C increases survival and improves function when compared with controlled normothermia in unconscious adults resuscitated from out-of-hospital cardiac arrest with initial nonshockable rhythm. (Source: JAMA Neurology)
Source: JAMA Neurology - December 18, 2023 Category: Neurology Source Type: research
Neprilysin Inhibition for Alzheimer Disease
This exploratory analysis of a randomized clinical trial evaluates the effect of neprilysin inhibition on Alzheimer disease blood biomarkers in patients with heart disease. (Source: JAMA Neurology)
Source: JAMA Neurology - December 18, 2023 Category: Neurology Source Type: research
Hypothermia to 33 °C Following Cardiac Arrest
For more than 20 years, since the widespread introduction of therapeutic hypothermia to critical care, questions remain regarding whether certain patients benefit from targeted temperature management (TTM) following cardiac arrest. Early studies suggested improved outcomes with TTM to 33 °C; however, these had significant methodological limitations, including small sample sizes, lack of blinding and standardized neuroprognostication, and inadequate fever management in control groups. Furthermore, inclusion criteria allowed for enrollment of only shockable rhythms. Improving on thes e early investigations were the TTM stud...
Source: JAMA Neurology - December 18, 2023 Category: Neurology Source Type: research
A 51-Year-Old Woman With Abnormal Corpus Callosum Signal
A 51-year-old woman presented with a 2-year history of progressive memory loss and left limb numbness. Imaging showed multifocal restricted diffusion in the corpus callosum and diffuse subcortical white matter hyperintensities and corpus callosum atrophy. What is your diagnosis? (Source: JAMA Neurology)
Source: JAMA Neurology - December 18, 2023 Category: Neurology Source Type: research
Ownership and Interoperability Challenges of Alzheimer Monoclonal Antibody Registries
This Viewpoint addresses the challenges that the Centers for Medicare and Medicaid Services faces to collect real-world data on the effectiveness and safety of lecanemab from external registries to achieve its coverage with evidence development objectives. (Source: JAMA Neurology)
Source: JAMA Neurology - December 11, 2023 Category: Neurology Source Type: research
How Much Good I Can Afford
This essay describes the author ’s experience balancing the different necessities in medical practice, in particular writing perfect patient notes vs establishing a face-to-face connection. (Source: JAMA Neurology)
Source: JAMA Neurology - December 11, 2023 Category: Neurology Source Type: research
Diagnostic Performance of Cortical Lesions and the Central Vein Sign in MS
This cross-sectional study evaluates the use of cortical lesions and central vein sign in distinguishing multiple sclerosis from other conditions. (Source: JAMA Neurology)
Source: JAMA Neurology - December 11, 2023 Category: Neurology Source Type: research
Epidemiology of Creutzfeldt-Jakob Disease in the US
This cross-sectional study uses Centers for Disease Control and Prevention multiple cause of death data to examine recent US trends in Creutzfeldt-Jakob disease. (Source: JAMA Neurology)
Source: JAMA Neurology - December 11, 2023 Category: Neurology Source Type: research
Plasma Biomarker Strategy for Selecting Patients With Alzheimer Disease for Antiamyloid Immunotherapies
This cohort study analyzes data from participants with cognitive concerns to determine whether plasma biomarkers can identify amyloid β–positive individuals who do not yet have a high tau burden in the brain and would be suitable candidates for treatment with antiamyloid immunotherapies in Alzheimer disease. (Source: JAMA Neurology)
Source: JAMA Neurology - December 4, 2023 Category: Neurology Source Type: research
Neuronally Derived Extracellular Vesicle α-Synuclein as a Serum Biomarker for Individuals at Risk of Developing Parkinson Disease
This study investigate whether α-synuclein in neuronally derived serum-extracellular vesicles identifies individuals at risk of developing Parkinson disease and related dementia. (Source: JAMA Neurology)
Source: JAMA Neurology - December 4, 2023 Category: Neurology Source Type: research
Trends in Traumatic Brain Injury Mortality in the US
This cohort study characterizes US trends in traumatic brain injury –related mortality by age, sex, and race and ethnicity. (Source: JAMA Neurology)
Source: JAMA Neurology - December 4, 2023 Category: Neurology Source Type: research
Mirror Hand Movements Caused by a Deletion of the DCC Gene
This case report describes the evaluation of 16-year-old twins with chromosomal microarray and mirror movements. (Source: JAMA Neurology)
Source: JAMA Neurology - December 4, 2023 Category: Neurology Source Type: research
