Prevalence and Implications of a β-Amyloid–Negative, Tau-Positive CSF Biomarker Profile in AD
This cohort study assesses the memory clinic prevalence and prognosis of individuals with a β-amyloid–negative, tau-positive cerebrospinal fluid biomarker profile. (Source: JAMA Neurology)
Source: JAMA Neurology - July 31, 2023 Category: Neurology Source Type: research
Considering Patient Sex in Prescribing CGRP Receptor Antagonists for Migraine
This Viewpoint describes the relevance of sex-specific differences in the treatment of migraine, including in evidence from trials of CGRP therapeutics, and the clinical implications for decision-making in practice and trial design. (Source: JAMA Neurology)
Source: JAMA Neurology - July 24, 2023 Category: Neurology Source Type: research
Exome Sequencing and the Identification of New Genes and Shared Mechanisms in Polymicrogyria
This genetic association study assesses germline genetic causes of polymicrogyria in a large cohort and considers novel polymicrogyria gene associations. (Source: JAMA Neurology)
Source: JAMA Neurology - July 24, 2023 Category: Neurology Source Type: research
Association of Early-, Middle-, and Late-Life Depression With Incident Dementia in a Danish Cohort
This cohort study investigates the association of dementia with early-, middle-, and late-life depression in a Danish cohort. (Source: JAMA Neurology)
Source: JAMA Neurology - July 24, 2023 Category: Neurology Source Type: research
Association Between Thrombectomy and Functional Outcomes in Pediatric Patients With Acute Ischemic Stroke From LVO
This case-control study evaluates whether pediatric patients with acute large vessel occlusion (LVO) stroke who undergo thrombectomy have better clinical outcomes than matched patients managed conservatively. (Source: JAMA Neurology)
Source: JAMA Neurology - July 24, 2023 Category: Neurology Source Type: research
Characteristics of Emergency Department Visits Among Older Adults With Dementia
This cross-sectional study examines emergency department use among older adults with Alzheimer disease and related dementias. (Source: JAMA Neurology)
Source: JAMA Neurology - July 24, 2023 Category: Neurology Source Type: research
Dementia Risk and Disadvantaged Neighborhoods
This cohort study determines whether there is a difference in dementia incidence among Veterans Health Administration enrollees by neighborhood disadvantage as assessed by the Area Deprivation Index. (Source: JAMA Neurology)
Source: JAMA Neurology - July 19, 2023 Category: Neurology Source Type: research
Excess Mortality With Alzheimer Disease and Related Dementias as an Underlying or Contributing Cause During COVID-19
This cross-sectional study compares COVID-19 pandemic-era excess deaths associated with Alzheimer disease or related dementias between year 1 and year 2 overall and by age, sex, race and ethnicity, and place of death. (Source: JAMA Neurology)
Source: JAMA Neurology - July 17, 2023 Category: Neurology Source Type: research
Associations of Sex, Race, and Apolipoprotein E Alleles With Cognition Among Older Adults
This genetic association study analyzes data from 4 Alzheimer disease and cognitive aging cohorts to investigate whether sex and race modify associations of APOE ε4 and ε2 with cognition. (Source: JAMA Neurology)
Source: JAMA Neurology - July 17, 2023 Category: Neurology Source Type: research
Evaluation of Crowdsourced Fundraising for Neurological Conditions
This cross-sectional study characterizes the use of and rationale for crowdsourced fundraising by patients with neurological illnesses and their family members. (Source: JAMA Neurology)
Source: JAMA Neurology - July 17, 2023 Category: Neurology Source Type: research
E-Cigarettes and Stroke Risk —Present Uncertainties and Future Directions
This Viewpoint describes the need for epidemiological studies of the association between e-cigarette use and risk of stroke to inform decision-making among patients, health care practitioners, and policy makers. (Source: JAMA Neurology)
Source: JAMA Neurology - July 10, 2023 Category: Neurology Source Type: research
Initiation Patterns of Disease-Modifying Therapies for Multiple Sclerosis Among US Adults and Children, 2001-2020
This study evaluates patterns in disease-modifying therapy initiations between 2001 and 2020 among commercially insured US adults and children with multiple sclerosis. (Source: JAMA Neurology)
Source: JAMA Neurology - July 10, 2023 Category: Neurology Source Type: research
Safety and Efficacy of Tenecteplase vs Alteplase in Patients With Large Vessel Occlusion Stroke
This prespecified secondary analysis of the ACT randomized clinical trial evaluates the safety and efficacy of tenecteplase compared to alteplase among patients with large vessel occlusion stroke. (Source: JAMA Neurology)
Source: JAMA Neurology - July 10, 2023 Category: Neurology Source Type: research
Mapping Lesion-Related Epilepsy to a Human Brain Network
This case-control study evaluates the locations of epilepsy-associated lesions with respect to specific brain regions and networks. (Source: JAMA Neurology)
Source: JAMA Neurology - July 3, 2023 Category: Neurology Source Type: research
Popeye Sign in Hereditary Transthyretin Amyloidosis
This case report describes a 63-year-old man who developed dysesthesia in his feet and was misdiagnosed with chronic inflammatory demyelinating polyradiculoneuropathy. (Source: JAMA Neurology)
Source: JAMA Neurology - July 3, 2023 Category: Neurology Source Type: research
