Error in Figure 3
This article was corrected online. (Source: JAMA Neurology)
Source: JAMA Neurology - March 27, 2023 Category: Neurology Source Type: research

JAMA Neurology Peer Reviewers in 2022
We sincerely thank the 749 peer reviewers who completed manuscript reviews for JAMA Neurology in 2022. (Source: JAMA Neurology)
Source: JAMA Neurology - March 20, 2023 Category: Neurology Source Type: research

Stroke, Death, and MI After Transcarotid Artery Revascularization vs Carotid Endarterectomy
This cohort study compares risk of 30-day stroke, death, or myocardial infarction or 1-year ipsilateral stroke among patients with standard surgical risk undergoing transcarotid artery revascularization vs carotid endarterectomy. (Source: JAMA Neurology)
Source: JAMA Neurology - March 20, 2023 Category: Neurology Source Type: research

Association Between Magnitude of Differential Blood Pressure Reduction and Secondary Stroke Prevention
This meta-analysis and meta-regression of randomized clinical trials evaluates the association of magnitude of differential blood pressure reduction and recurrent stroke in patients with stroke or transient ischemic attack. (Source: JAMA Neurology)
Source: JAMA Neurology - March 20, 2023 Category: Neurology Source Type: research

Transcarotid Artery Revascularization for Stroke Prevention —Multiple Elephants in the Room
In the saga of carotid revascularization procedures, carotid endarterectomy (CEA) has a track record of longer than 65 years. CEA has been shown in clinical trials to be useful for stroke prevention in select patients with symptomatic internal carotid artery stenosis and to a lesser extent, asymptomatic stenosis. (Source: JAMA Neurology)
Source: JAMA Neurology - March 20, 2023 Category: Neurology Source Type: research

JAMA Neurology —The Year in Review, 2022
Reflecting on the last 12 months here at JAMA Neurology, I am struck by just how much the journal continues to thrive, thanks in large part to all of you. While we continued to receive a number of high-quality submissions related to COVID-19, it felt more like prepandemic business as usual, as we published a wide-range of articles across a diverse set of neurologic disorders. I want to deeply thank all of the journal ’s editors, editorial board members, authors, and peer reviewers (who are listed elsewhere) for their tremendous contributions in 2022. (Source: JAMA Neurology)
Source: JAMA Neurology - March 20, 2023 Category: Neurology Source Type: research

Quantification of Penumbral Volume in Association With Time From Stroke Onset in Acute Ischemic Stroke
This cross-sectional study examines changes in the penumbral and core volumes over time to imaging in patients with acute ischemic stroke. (Source: JAMA Neurology)
Source: JAMA Neurology - March 20, 2023 Category: Neurology Source Type: research

Lecanemab and APOE Genotyping in Clinical Practice —Navigating Uncharted Terrain
This Viewpoint discusses the findings of the Clarity AD trial, which studied lecanemab for patients with early-stage Alzheimer disease. (Source: JAMA Neurology)
Source: JAMA Neurology - March 13, 2023 Category: Neurology Source Type: research

A Step Forward in the Fight Against Dementia
This Viewpoint reports on the results of the Clarity AD trial, a phase 3 randomized clinical trial of lecanemab for patients with early Alzheimer disease, in which lecanemab ’s clinical efficacy was demonstrated using well-established outcome measures. (Source: JAMA Neurology)
Source: JAMA Neurology - March 13, 2023 Category: Neurology Source Type: research

Physical Frailty, Genetic Predisposition, and Incident Parkinson Disease
This cohort study attempts to examine the longitudinal association of frailty phenotype with the development of Parkinson disease and to explore the modification role of genetic risk of Parkinson disease in such association. (Source: JAMA Neurology)
Source: JAMA Neurology - March 13, 2023 Category: Neurology Source Type: research

Perinatal Outcomes for Women With and Without Epilepsy
This systematic review and meta-analysis compares data for women with and without epilepsy to investigate maternal, fetal, and neonatal complications and their associations with epilepsy and use of antiseizure medications. (Source: JAMA Neurology)
Source: JAMA Neurology - March 13, 2023 Category: Neurology Source Type: research

Multimodal Neuroimaging of Intimal Flap in a Basilar Artery Dissection
This case report describes a spontaneous dissection of the basilar artery in a 53-year-old man presenting with ischemic stroke. (Source: JAMA Neurology)
Source: JAMA Neurology - March 13, 2023 Category: Neurology Source Type: research

Alzheimer Disease Blood Biomarkers in Patients With Out-of-Hospital Cardiac Arrest
This case-control study evaluates the potential role of blood phosphorylated tau and amyloid- β peptides in neurological prognostication following cardiac arrest. (Source: JAMA Neurology)
Source: JAMA Neurology - March 6, 2023 Category: Neurology Source Type: research

Benefits and Risks of Preconceptional Folic Acid Supplementation —Reply
In Reply We thank Voinescu and colleagues for their comments on our recent article in JAMA Neurology. We agree that there is no study to date to help in determining the optimal dose of folic acid supplementation for women with epilepsy. Our findings of an increased risk of cancer in children of mothers with epilepsy who are taking antiseizure medication and are exposed to high-dose folic acid indicate that there could be an upper dose limit above which the risks outweigh the benefits. This suggests an upper limit below the 4 to 5 mg per day recommended dosage to mothers with epilepsy by some major guidelines (eg, National ...
Source: JAMA Neurology - March 6, 2023 Category: Neurology Source Type: research

Benefits and Risks of Periconceptional Folic Acid Supplementation
To the Editor Vegrim et al conducted an observational population-based study from 3 northern European countries and concluded that prenatal exposure to high-dose folic acid is associated with a 2.7-fold increased risk of pediatric cancer in children of mothers with epilepsy who were taking antiseizure medications. These findings are based on 18 children with cancer who were born to mothers with epilepsy taking high-dose folic acid (mean dose, 4.3 mg). The study exonerates epilepsy alone as a risk factor, but because of insufficient numbers, the contribution of antiseizure medications remains unclear. Children of mothers wi...
Source: JAMA Neurology - March 6, 2023 Category: Neurology Source Type: research