Healthy Lifestyle and Cognition in Older Adults With Common Neuropathologies of Dementia
This cohort study examines data from Rush Memory and Aging Project, including autopsy results and up to 24 years of follow-up, to determine the association between lifestyle and cognitive function independently of Alzheimer disease pathology burden. (Source: JAMA Neurology)
Source: JAMA Neurology - February 5, 2024 Category: Neurology Source Type: research
Harnessing Brain Pathology for Dementia Prevention
Alzheimer disease (AD) and related dementia (ADRD) are devastating diseases that affect over 55 million people worldwide and impose an estimated economic burden of over $800 billion annually. This figure is projected to increase as the global population ages, with the prevalence of AD/ADRD expected to triple over the next 30 years. To date, there is no cure to stop or reverse disease progression, underscoring the critical need for the development of primary or secondary prevention strategies that target modifiable risk factors to delay or prevent the onset of clinical symptoms. (Source: JAMA Neurology)
Source: JAMA Neurology - February 5, 2024 Category: Neurology Source Type: research
JAMA Neurology
Mission Statement: The mission of JAMA Neurology is to publish and disseminate scientific information primarily important for physicians caring for people with neurologic disorders and for those interested in the structure and function of the normal and diseased human nervous system. The specific aims are to (1) publish timely original research, including clinical trials that will directly improve clinical neurologic care and that will inform efforts to improve neurological health and promote health care equity; (2) report translational research that is pertinent to the understanding of neurologic disease; (3) address topi...
Source: JAMA Neurology - February 1, 2024 Category: Neurology Source Type: research
Change to Open Access Status
This article was corrected online. (Source: JAMA Neurology)
Source: JAMA Neurology - February 1, 2024 Category: Neurology Source Type: research
Building CRISPR Gene Therapies for the Central Nervous System
This narrative review discusses several types of gene editing using clustered regularly interspaced short palindromic repeats (CRISPR), how these are applied to different genetic variants, challenges of delivering genome editors to the central nervous system, ways to minimize the potential in vivo genotoxic effects of genome editors, the ethical considerations of germline editing, and the regulatory challenges of human-specific therapy. (Source: JAMA Neurology)
Source: JAMA Neurology - January 29, 2024 Category: Neurology Source Type: research
Endovascular Treatment of Acute Ischemic Stroke After Cardiac Interventions
This cohort study examines data from the National Inpatient Sample to determine trends in the use of endovascular thrombectomy among ischemic stroke patients with and without cardiac interventions. (Source: JAMA Neurology)
Source: JAMA Neurology - January 29, 2024 Category: Neurology Source Type: research
Multiomic Analysis of Infection in Sudden Infant Death Syndrome
This case-control study investigates if a subset of sudden infant deaths are associated with undiagnosed neuroinflammation and occult infection. (Source: JAMA Neurology)
Source: JAMA Neurology - January 29, 2024 Category: Neurology Source Type: research
Brainstem Encephalitis as a Cause of Sudden Infant Death Syndrome
Sudden unexpected infant death or sudden infant death syndrome (SIDS) are terms used for children younger than 1 year of age who die suddenly without an obvious cause before investigation. SIDS often occurs during sleep and affects nearly 3500 children in the US each year. Despite many measures taken to prevent the illness, the incidence remains unchanged since the year 2000. In this issue of JAMA Neurology, Ramachandran et al report an investigation of 64 cases of SIDS. The authors found elevated levels of neopterin in the cerebrospinal fluid of 6 cases. Because the major source of neopterin is activated macrophages, it i...
Source: JAMA Neurology - January 29, 2024 Category: Neurology Source Type: research
Diagnostic Accuracy of a Plasma Phosphorylated Tau 217 Immunoassay for Alzheimer Disease Pathology
This cohort study examines data from 3 single-center observational cohorts to test the capabilities of a commercially available plasma phosphorylated tau 217 immunoassay to identify Alzheimer disease pathophysiology. (Source: JAMA Neurology)
Source: JAMA Neurology - January 22, 2024 Category: Neurology Source Type: research
Concomitant Medications for Progressive Supranuclear Palsy
This secondary analysis of a randomized clinical trial examines changes in the progression of progressive supranuclear palsy (PSP) associated with 31 concomitant medication classes used by study participants over 1 year. (Source: JAMA Neurology)
Source: JAMA Neurology - January 22, 2024 Category: Neurology Source Type: research
Diffusely Enhancing Lesions on MRI in DPPX Antibody-Associated Encephalitis
This case report describes a diagnosis of dipeptidyl-peptidaselike protein-6 antibody-associated encephalitis in a woman aged 51 years who presented with progressive gait instability, memory impairment, and weight loss. (Source: JAMA Neurology)
Source: JAMA Neurology - January 22, 2024 Category: Neurology Source Type: research
Psychedelics in Addiction Treatment —Navigating a Sociopolitical Rift
This Viewpoint discusses the use of psychedelics in treatment for substance use disorders. (Source: JAMA Neurology)
Source: JAMA Neurology - January 16, 2024 Category: Neurology Source Type: research
SARS-CoV-2 Vaccination and Neuroimmunological Disease
This narrative review evaluates the potential association between the adenovirus-vectored vaccines and neuroimmunological diseases, including Guillain-Barr é syndrome, Bell palsy, myasthenia gravis, multiple sclerosis, and neuromyelitis optica spectrum disorders. (Source: JAMA Neurology)
Source: JAMA Neurology - January 16, 2024 Category: Neurology Source Type: research
Allogeneic Stem Cell Therapy for Acute Ischemic Stroke
This randomized clinical trial examines the efficacy and safety of MultiStem allogeneic stem cell therapy for acute ischemic stroke. (Source: JAMA Neurology)
Source: JAMA Neurology - January 16, 2024 Category: Neurology Source Type: research
MOG-IgA as a Potential Marker of Germinal Center Activity —Reply
In Reply We thank Handel and colleagues for their interest and thoughtful comments on our article. The authors addressed the role of autoantigen-reactive immunoglobulin A (IgA) antibodies as markers of germinal center (GC) –based immunoglobulin class-switching and the importance of longitudinal testing for myelin oligodendrocyte glycoprotein (MOG) immunoglobulin G (IgG) and M (IgM) in patients seropositive for MOG-IgA. (Source: JAMA Neurology)
Source: JAMA Neurology - January 16, 2024 Category: Neurology Source Type: research
