Epidemiology of Creutzfeldt-Jakob Disease in the US
This cross-sectional study uses Centers for Disease Control and Prevention multiple cause of death data to examine recent US trends in Creutzfeldt-Jakob disease. (Source: JAMA Neurology)
Source: JAMA Neurology - December 11, 2023 Category: Neurology Source Type: research

Plasma Biomarker Strategy for Selecting Patients With Alzheimer Disease for Antiamyloid Immunotherapies
This cohort study analyzes data from participants with cognitive concerns to determine whether plasma biomarkers can identify amyloid β–positive individuals who do not yet have a high tau burden in the brain and would be suitable candidates for treatment with antiamyloid immunotherapies in Alzheimer disease. (Source: JAMA Neurology)
Source: JAMA Neurology - December 4, 2023 Category: Neurology Source Type: research

Neuronally Derived Extracellular Vesicle α-Synuclein as a Serum Biomarker for Individuals at Risk of Developing Parkinson Disease
This study investigate whether α-synuclein in neuronally derived serum-extracellular vesicles identifies individuals at risk of developing Parkinson disease and related dementia. (Source: JAMA Neurology)
Source: JAMA Neurology - December 4, 2023 Category: Neurology Source Type: research

Trends in Traumatic Brain Injury Mortality in the US
This cohort study characterizes US trends in traumatic brain injury –related mortality by age, sex, and race and ethnicity. (Source: JAMA Neurology)
Source: JAMA Neurology - December 4, 2023 Category: Neurology Source Type: research

Mirror Hand Movements Caused by a Deletion of the DCC Gene
This case report describes the evaluation of 16-year-old twins with chromosomal microarray and mirror movements. (Source: JAMA Neurology)
Source: JAMA Neurology - December 4, 2023 Category: Neurology Source Type: research

JAMA Neurology
Mission Statement: The mission of JAMA Neurology is to publish and disseminate scientific information primarily important for physicians caring for people with neurologic disorders and for those interested in the structure and function of the normal and diseased human nervous system. The specific aims are to (1) publish timely original research, including clinical trials that will directly improve clinical neurologic care and that will inform efforts to improve neurological health and promote health care equity; (2) report translational research that is pertinent to the understanding of neurologic disease; (3) address topi...
Source: JAMA Neurology - December 1, 2023 Category: Neurology Source Type: research

When Pregnancy Becomes an Inclusion Criterion in Neuroscience Research
This Viewpoint discusses the inclusion of pregnant patients in clinical trials for antiseizure medication. (Source: JAMA Neurology)
Source: JAMA Neurology - November 27, 2023 Category: Neurology Source Type: research

Multiple Sclerosis Progression and Relapse in Children
This cohort study assesses the occurrence of progression independent of relapse activity and relapse-associated worsening in pediatric and adult patients with multiple sclerosis. (Source: JAMA Neurology)
Source: JAMA Neurology - November 27, 2023 Category: Neurology Source Type: research

Endovascular Therapy Outcomes by ASPECTS and Infarct Core Volume in Patients With Large Infarct
This secondary analysis of the ANGEL-ASPECT randomized clinical trial examines outcomes of endovascular therapy vs medical management across varying Alberta Stroke Program Early Computed Tomography Score (ASPECTS) and infarct core volume strata in patients with large infarct. (Source: JAMA Neurology)
Source: JAMA Neurology - November 27, 2023 Category: Neurology Source Type: research

Potential Medicare and Medicaid Savings on Anti-CD20 Therapy for Multiple Sclerosis
This cross-sectional study compares price data for ocrelizumab and rituximab to estimate the savings to Medicare and Medicaid if rituximab were used in the treatment of multiple sclerosis instead of the higher-priced ocrelizumab. (Source: JAMA Neurology)
Source: JAMA Neurology - November 27, 2023 Category: Neurology Source Type: research

A Young Woman With Hypertonia, Severe Scoliosis, and Encephalopathy
A 31-year-old woman was seen with contractures in her fingers and toes, carpal inversion, dysarthria, dysphagia, hypertonia, decreased tendon reflexes, absence of Babinski sign, and no psychiatric problems and significant global atrophy. What is your diagnosis? (Source: JAMA Neurology)
Source: JAMA Neurology - November 27, 2023 Category: Neurology Source Type: research

Streamlining Prior Authorization to Improve Care
This Viewpoint addresses the challenges of prior authorization: decreased access, delayed care, decreased patient satisfaction and outcomes, and increased clinician burnout. (Source: JAMA Neurology)
Source: JAMA Neurology - November 20, 2023 Category: Neurology Source Type: research

Holding Onto Our Hats —A Hmong Medical Student’s Reflection
This On the Brain describes a Hmong student ’s experience in medical school. (Source: JAMA Neurology)
Source: JAMA Neurology - November 20, 2023 Category: Neurology Source Type: research

Behavioral Outcomes and Neurodevelopmental Disorders Among Children of Women With Epilepsy
This cohort study examines the association of fetal exposure to antiseizure medications with subsequent adaptive, behavioral or emotional, and neurodevelopmental disorder outcomes at 2, 3, and 4.5 years of age. (Source: JAMA Neurology)
Source: JAMA Neurology - November 20, 2023 Category: Neurology Source Type: research

Comparative Efficacy of Disease-Modifying Treatments for Relapsing Multiple Sclerosis —Variations in Real-World Experience—Reply
In Reply We thank Dr Wolf and colleagues for highlighting the importance of clinical context when evaluating effectiveness of multiple sclerosis (MS) therapies. As demonstrated in the comparative effectiveness of natalizumab and fingolimod, where seemingly discordant results emerged from different registries, characteristics of the study population play a central role in study findings. It is, therefore, important to differentiate between studies of treatment efficacy and effectiveness. (Source: JAMA Neurology)
Source: JAMA Neurology - November 20, 2023 Category: Neurology Source Type: research